Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.687636-93-7,2-Bromothiazole-5-methanol,as a common compound, the synthetic route is as follows.

687636-93-7, To a solution of (2-bromothiazol-5-yl)methanol (900 mg, 4.6 mmol) and triphenylphosphine (1300 mg, 5.1 mmol) in DCM (20 ml) was added a DCM solution of CBr4 (1500 mg, 4.6 mmol) at 0C. The reaction was allowed to warm to RT after 30 minutes. LCshowed good reaction after 1 hour. About 20 mL of hexanes was added to the reaction, and the white precipitate was filtered off. The filtration was adsorbed onto silica gel, and purified by MPLC with a 40G ISCO column, eluting with hexanes and EtOAc. LC-MS [M+H]: 256.0

As the paragraph descriping shows that 687636-93-7 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; TANG, Haifeng; YANG, Shu-Wei; MANDAL, Mihir; SU, Jing; LI, Guoqing; PAN, Weidong; TANG, Haiqun; DEJESUS, Reynalda; PAN, Jianping; HAGMANN, William; DING, Fa-Xiang; XIAO, Li; PASTERNAK, Alexander; HUANG, Yuhua; DONG, Shuzhi; YANG, Dexi; WO2015/171474; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

51640-36-9, 2-Chlorothiazole-5-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,51640-36-9

2-({6-[4-(morpholin-4-ylacetyl)piperazin-1-yl]pyrimidin-4-yl}amino)-1,3-thiazole-5-carbonitrile (42-4) 42-3 (0.36 g, 1.18 mmol), sodium hydride (0.094 g, 2.35 mmol) and 2-chloro-1,3-thiazole-5-carbonitrile 2-2 (0.17 g, 1.18 mmol) were treated as in Scheme 4 above. The reaction was cooled, quenched with methanol and water, evaporated to dryness and partitioned between methylene chloride, methanol and water. The organic layers were evaporated to dryness and purified on a C18 preparative hplc column and isolated via lyophilization to afford 42-4. Hi-Res MS: calc: 415.1659 found: 415.1638. 1H-NMR (CD3OD): 8.44(s, 1H); 8.01(s, 1H); 6.20(s, 1H); 4.36(s, 2H); 4.05(br s, 2H); 3.88(br s, 2H); 3.82(m, 2H); 3.76(m, 2H); 3.71(m, 2H); 3.56(m, 4H); 3.25(br s, 2H).

51640-36-9 2-Chlorothiazole-5-carbonitrile 1485222, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Bilodeau, Mark T.; Hartman, George D.; Hoffman JR., Jacob M.; Sisko, John T.; Manley, Peter J.; Smith, Anthony M.; Tucker, Thomas J.; Lumma JR., William C.; Rodman, Leonard; US2002/137755; (2002); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

59608-97-8,59608-97-8, 4-(Chloromethyl)thiazol-2-amine hydrochloride is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

O-(2-Amino-1 ,3-thiazol-4-yl)methyl-(3-methylpyridin-2-yl)-(1-methyltetrazol-5-yl)methanone oxime (compound 157)To a solution of 1-methyl-5-[(3-methylpyridin-2-yl)carbohydroximoyl]tetrazole (2.6 g, 11.9 mmol) in dichloromethane are added resin PL-TBD 1.81 mmol/g (13.2 g) and 4-chloromethyl-2-amino-1 ,3- thiazole hydrochloride (2.4 g, 13.1 mmol). The mixture is stirred for two days and filtered. The resin is washed successively with dichloromethane, methanol and dichloromethane. The combined filtrates are concentrated. Silica-gel chromatography of the residue affords 1.3 g of compound 157 [yield 33 percent ; HPLC/MS : m/z = 331 (M+H) ; LogP = 1.04].

59608-97-8 4-(Chloromethyl)thiazol-2-amine hydrochloride 73228, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; BAYER CROPSCIENCE SA; WO2008/6874; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3364-78-1,2-(Chloromethyl)thiazole,as a common compound, the synthetic route is as follows.

To a solution of dimethylphosphine borane 1-25 (200 mg, 2.6 mmol) in THF (30 mL) at 0C was added NaH (60% dispersion in mineral oil, 1 12 mg, 2.8 mmol) in one portion whereupon effervescence was observed. The opaque reaction was stirred at rt for 10 min then cooled back to 0C whereupon 2-(chloromethyl)thiazole 1-45 (341 mg, 2.6 mmol) and Nal (383 mg, 2.6 mmol) were added. The mixture was allowed to warm to rt O/N, then water (10 mL) and DCM (10 mL) were added and the phases separated. The aqueous phase was extracted with DCM (2 x 15 mL) and the combined organic extracts washed with brine (20 mL) before passing through a phase separator cartridge (Biotage). Concentration in vacuo gave the crude product which was purified by column chromatography (Biotage Isolera 4, KP-Sil 25 g) eluting with DCM to 3% MeOH in DCM to provide the title compound as a yellow oil (73 mg, 0.4 mmol, 16%)., 3364-78-1

As the paragraph descriping shows that 3364-78-1 is playing an increasingly important role.

Reference£º
Patent; AUSPHERIX LIMITED; HOLMES, Ian; NAYLOR, Alan; ALBER, Dagmar; POWELL, Jonathan Raymond; MAJOR, Meriel Ruth; NEGOITA-GIRAS, Gabriel; ALLEN, Daniel Rees; GUETZOYAN, Lucie Juliette; KING, Nigel Paul; (199 pag.)WO2017/93543; (2017); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

911052-85-2, (5-Bromothiazol-2-yl)methanol is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

911052-85-2, (4-Bromo-thiazol-2-yl)-methanol (L. LG, 5.7 mmol) in DMF (15 ml) is treated at room temperature under nitrogen atmosphere with TRIFLUOROMETHANESULFONYL chloride (0.61 ml, 1 equivalent), and Et3N (0.8 ml, 1 equivalent). The reaction mixture is stirred for 3 hours at room temperature before the addition of sodium azide (1. 11 g, 3 equivalents), followed by overnight stirring at the same temperature. The reaction mixture is diluted with water and extracted with DCM and diethyl ether. The combined organic extracts are dried (MGSO4) and concentrated under reduced pressure to afford the crude product, which is used without purification in the next step.

The synthetic route of 911052-85-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ARRAY BIOPHARMA, INC.; WO2004/46101; (2004); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3364-80-5, Thiazole-4-carboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3.3.C 3.3[0210] (S)-3-Phenyl-N-(3-(pyridin-4-yl)isoxazol-5-yl)-2-(thiazol-4- ylmethylamino)propanamide (3.3). To a 20 ml vial were added (S)-2-amino-3-phenyl-N- (3-(pyridin-4-yl)isoxazol-5-yl)propanamide 3.3.C (40 mg, 0.13 mmole), thiazole-4- carbaldehyde (18 mg, O.lbetammole), sodium triacetoxyborohydride (55 mg, 0.26mmole) and 10 ml of DCE. The reaction was stirred at 700C for 12 hours. The crude material was partitioned between DCM and water and then purified by reverse phase preparative HLPC to give (S)-3-phenyl-N-(3-(pyridin-4-yl)isoxazol-5-yl)-2-(thiazol-4- ylmethylamino)propanamide TFA salt 3.3 as a white solid (14.2 mg, 27 percent yield). LCMS ESI (pos.) m/e: 406.1 (M+l): IH NMR (500 MHz, MeOH-J) delta ppm 9.09 (d, J=I.96 Hz, 1 H), 8.87 (br. s., 2 H), 8.27 (d, J=5.38 Hz, 2 H), 7.77 (d, J=I.96 Hz, 1 H), 7.27 – 7.35 (m, 3 H), 7.20 – 7.25 (m, 2 H) 7.07 (s, 1 H), 4.42 – 4.55 (m, 2 H), 4.35 (dd, J=8.80, 5.87 Hz, 1 H), 3.44 (dd, J=13.57, 5.99 Hz, 1 H), 3.26 (dd, J=13.69, 8.80 Hz, 1 H).

3364-80-5, As the paragraph descriping shows that 3364-80-5 is playing an increasingly important role.

Reference£º
Patent; AMGEN INC.; DU, Xiaohui; FU, Zice; HOUZE, Jonathan, B.; JIAO, Xianyun; KIM, Yong-jae; LI, Leping; LIU, Jinqian; LIZARZABURU, Mike; MEDINA, Julio; SHEN, Wang; TURCOTTE, Simon; YU, Ming; WO2010/93849; (2010); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.556-90-1,2-aminothiazol-4(5H)-one,as a common compound, the synthetic route is as follows.

556-90-1, General procedure: To a solution of the pseudothiohydantoin 6a (139 mg, 1.2 mmol), and sodium acetate (328 mg, 4.0 mmol) in acetic acid (5 ml) was added 5-phenyl-2-furaldehyde 5a (172 mg,1.0 mmol) at 25C. The solution was refluxed at 135C for 12 h. The precipitate was filtered and washed with water and diethyl ether. The filter cake was dried under high vacuum to afford 230 mg (85%) of compound 7a as an orange solid.

556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Jung, Michael E.; Ku, Jin-Mo; Du, Liutao; Hu, Hailiang; Gatti, Richard A.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 19; (2011); p. 5842 – 5848;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.28620-12-4,6-Nitro-2-benzothiazolinone,as a common compound, the synthetic route is as follows.

Compound 47 (0.5?mmol) was dissolved in 1?mL dry DMF. Potassium carbonate (0.75?mmol) and 1-bromopentyl chloride (1.2?mmol) were added to the solution. The mixture was stirred at 80?C overnight. The solvent was evaporated under reduced pressure. The residue was dissolved in ethyl acetate (10?mL) and washed with water (2?*?10?mL). The organic layer was dried over MgSO4 and evaporated under reduced pressure. The product was purified by silica gel column chromatography (dichloromethane/petroleum ether 50:50, v/v). A yellow powder was obtained: yield 69%; mp 55?+-?1?C; 1H NMR (CDCl3) delta 8.37 (d, J?=?2.3?Hz, 1H), 8.25 (dd, J?=?2.3; 8.9?Hz, 1H), 7.14 (d, J?=?8.9?Hz, 1H), 4.01 (t, J?=?7.5?Hz, 2H), 1.75 (m, 2H), 1.40 (m, 4H), 0.90 (t, J?=?7.0?Hz, 3H); LC-MS (APCI+) m/z 267.1 (MH+).

28620-12-4, 28620-12-4 6-Nitro-2-benzothiazolinone 641571, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Leleu-Chavain, Natascha; Baudelet, Davy; Heloire, Valeria Moas; Rocha, Diana Escalante; Renault, Nicolas; Barczyk, Amelie; Djouina, Madjid; Body-Malapel, Mathilde; Carato, Pascal; Millet, Regis; European Journal of Medicinal Chemistry; vol. 165; (2019); p. 347 – 362;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1477-42-5,4-Methylbenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.,1477-42-5

Step 1: 4-methyl-3H-benzothiazol-2-one 5.00 g (30.5 mmol) 2-amino-4-methylbenzothiazole in 15.0 mL formic acid, 6.10 mL glacial acetic acid and 112 mL conc. hydrochloric acid were cooled to -5 C. with stirring and slowly combined with a solution of 2.10 g (30.5 mmol) sodium nitrite in 5.0 mL water. The reaction mixture was stirred for 20 min at this temperature, then heated to RT and then refluxed overnight. The cooled mixture was then mixed with water and extracted several times with EtOAc. The combined organic phases were washed with saturated sodium chloride solution, dried on sodium sulphate, filtered and the filtrate was evaporated down. Yield: 3.70 g (74% of theoretical) ESI-MS: m/z=164 (M-H)-

The synthetic route of 1477-42-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2011/59954; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3364-78-1,2-(Chloromethyl)thiazole,as a common compound, the synthetic route is as follows.

(5- (4-Bromophenoxy) pyridin-2-yl) carbamic acid tert-butyl ester (1.460 g, 4 mmol) was dissolved in 12 mL DMFStir at room temperature, add sodium hydride (0.24g, 10mmol),After the addition was complete, the reaction was continued for 30 minutes.Then, chloromethylthiazole (1.344 g, 8 mmol) in DMF solvent (5 mL) was slowly added dropwise, and the temperature was raised to 50 C for reaction overnight.Then, 15 mL of ice water was added to the reaction, and the mixture was extracted with ethyl acetate.Combined organic phasesThe organic phase was washed with saturated brine,Dried over magnesium sulfate,Concentrated to give an oil.The oil obtained above was dissolved in 15 mL of dichloromethane.Trifluoroacetic acid (0.912g, 8mmol) was slowly added dropwise at room temperature.After the dropwise addition was completed, the mixture was stirred at 40 C and reacted overnight;The reaction was then concentrated and an aqueous potassium carbonate solution was added,Adjust the pH to 8, extract with ethyl acetate, and wash the organic phase with water.Dried, concentrated,Column chromatography [petroleum ether / ethyl acetate (v / v) = 6/4],The target compound was obtained (0.852 g, yield: 54%)., 3364-78-1

As the paragraph descriping shows that 3364-78-1 is playing an increasingly important role.

Reference£º
Patent; Dongguan Dongyangguang Pesticide Research And Development Co., Ltd.; Li Yitao; Lin Jian; Xu Junxing; Xiao Yu; Yao Wenqiang; Liu Xinshuo; (44 pag.)CN110452238; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica