Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3364-78-1,2-(Chloromethyl)thiazole,as a common compound, the synthetic route is as follows.

To a stirred solution of 2-(chloromethyl)thiazole (D) (0.97 g, 6.46 mmol), tert-butyl 4-9(4,4,5 ,5-tetramethyl- 1 ,3 ,2-dioxaborolan-2-yl)-5 ,6-dihydropyridine- 1 (2H)-carboxylate (E) (1 g, 3.23 mmol) in dry DMF (10 mL) was added K2C03 (1.33 g, 9.69 mmol) at 20- 35C and the mixture was degassed with N2 for 10 minutes. Then Pd(dppf)2Ci2 (260 mg, 0.32 mmol) was added, again degassed with N2 for another 10 minutes and heated at 110C for 14 h. Then the reaction mixture was cooled to 20-35C, diluted with water (100 mL) and extracted with ethyl acetate (2×100 mL). The organic layer was washed with brine (100 mL), dried over anhydrous Na2S04 and filtered. The filtrate was rotary evaporated under vacuum to get residue which was purified by column chromatography using a mixture of 30% ethyl acetate/hexane as an eluent to get the desired compound as a light brown liquid (400 mg, 44%); NMR (400MHz, DMSO-<) delta 7.70 (d, J=3.4 Hz, 1H), 7.60 (d, J=3.5 Hz, 1H), 5.60 (s, 1H), 3.82 (s, 2H), 3.71 (s, 2H), 3.38 (t, J=5.9 Hz, 2H), 2.06-1.96 (m, 2H), 1.40 (s, 9H). 3364-78-1, The synthetic route of 3364-78-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; UM PHARMAUJI SDN. BHD; TAKHI, Mohamed; HOSAHALLI, Subramanya; PANIGRAHI, Sunil Kumar; WO2014/195844; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

120740-08-1, 2-Chloro-5-aminomethylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 25 5-(Aminomethyl)-2-chlorothiazole (1.49 g, 10.0 mmol) was dissolved in diluted hydrochloric acid (15 ml, 10.0 mmol), and O-methyl-N-nitroisourea (1.31 g, 11.0 mmol) and sodium chloride (1.17 g, 20.0 mmol) were added. pH was 2.1 at this time. This reaction mixture was adjusted to pH 6.2 with aqueous sodium hydroxide solution (0.1 N, 3.8 ml, 0.38 mmol) using pH meter. Water (1.2 ml) was added to increase the whole volume to 20 ml. After 16 hours of stirring at room temperature (pH was 6.8 at this time), the resulting white crystals were collected by filtration under reduced pressure, and washed with water. The washed crystals were dried under reduced pressure (80 C., 2 hours) to provide 1.72 g (68.6% yield) of O-methyl-N-(2-chloro-5-thiazolylmethyl)-N’-nitroisourea., 120740-08-1

As the paragraph descriping shows that 120740-08-1 is playing an increasingly important role.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; US6008363; (1999); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

533-30-2, 6-Aminobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

533-30-2, General procedure: Dialkyl/diaryl phosphite (1.0 mmol) was added portion wise over a period of 5 min to the stirred mixture of heterocyclic aldehyde (1.0 mmol) and benzothiazole amine (1.0 mmol) at room temperature. Further 5 mol percent of TNT was added to the reaction mixture and the stirring was continued for 15 min. After the completion of the reaction as monitored through TLC, the reaction mixture was dissolved in EtOAc (2 mL) and the catalyst was separated by centrifugation followed by subsequent washings with EtOAc. The recovered catalyst was reused for the next cycle. The filtrate was washed with brine, dried over anhydrous Na2SO4, filtered, and concentrated on a rotary evaporator and the resulting residue was purified by silica gel column chromatography (70:30, hexane/EtOAc) to afford the corresponding pure alpha-aminophosphonate. The novel alpha-aminophosphonates were structurally assigned by their IR, NMR (1H, 13C & 31P), and mass spectral (HRMS) analyses.

As the paragraph descriping shows that 533-30-2 is playing an increasingly important role.

Reference£º
Article; Reddy, Bhoomireddy Rajendra Prasad; Reddy, Motakatla Venkata Krishna; Reddy, Peddiahgari Vasu Govardhana; Kumar, Dharani Praveen; Shankar, Muthukonda V.; Tetrahedron Letters; vol. 57; 6; (2016); p. 696 – 702;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

20485-41-0, 4-Methylthiazole-5-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 69 (250 mg, 0.81 mmol), HATU (460 mg, 1.2 mmol), dry N,N-dimethylformamide (5 mL), diisopropylethylamine (0.4 mL) and trimethylacetic acid (165 mg, 1.62 mmol) was stirred at room temperature for 12 h. The reaction mixture was poured into water (40 mL), extracted with ethyl acetate (3 x 30 mL), organic phases combined, washed with water (3 x 50 mL), a saturated aqueous solution of brine (20 mL), dried (magnesium sulfate), filtered and concentrated. The crude material was purified by Flashmaster II chromatography (eluent 0-90 percent ethyl acetate/dichloromethane). The purified material was taken up in diethyl ether (10 mL), washed with water (2 x 10 mL) to remove any trace N,N-dimethylformamide, dried (magnesium sulfate), filtered and concentrated to give 1-{4-[(4-Chloro-2-fluorophenyl)(pyridin-3-yl)methyl]piperazin-1-yl}-2,2-dimethylpropan-1-one (13) (53 mg, 17 percent) as a yellow oil.#10;, 20485-41-0

As the paragraph descriping shows that 20485-41-0 is playing an increasingly important role.

Reference£º
Article; Keenan, Martine; Alexander, Paul W.; Diao, Hugo; Best, Wayne M.; Khong, Andrea; Kerfoot, Maria; Thompson, R. C. Andrew; White, Karen L.; Shackleford, David M.; Ryan, Eileen; Gregg, Alison D.; Charman, Susan A.; Von Geldern, Thomas W.; Scandale, Ivan; Chatelain, Eric; Bioorganic and Medicinal Chemistry; vol. 21; 7; (2013); p. 1756 – 1763;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

53266-94-7, Ethyl 2-(2-aminothiazol-4-yl)acetate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

53266-94-7, EXAMPLE 65; Step A; A neat mixture of 54 g (0.29 mole) ethyl (2-aminothiazol-4-yl)acetate and 50 g (0.276 mole) benzophenone imine was stirred at 190¡ã C. for 5 h and then cooled at RT and diluted with 100 mL of CH2Cl2. The entire mixture was transferred onto a silica gel column and eluted with 20percent EtOAc/Hexane. The title compound was obtained as light-yellow solid (70 g, 69percent yield). 1H NMR (300 MHz, CDCl3): 1.26 (t, 3H), 3.74 (s, 2H), 4.15 (q, 2H), 6.87 (s, 1H), 77.25-7.86 (m, 10H); MassSpectrum (NH3-Cl): m/z 351 (M+1).

The synthetic route of 53266-94-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Butora, Gabor; Goble, Stephen D.; Pastemak, Alexander; Yang, Lihu; Zhou, Changyou; Moyes, Christopher R.; US2008/81803; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3034-57-9, 2-Amino-5-bromo-4-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

i) 4-Methyl-5-methylsulfanyl-thiazol-2-ylamine 5-Bromo-4-methyl-thiazol-2-ylamine (1.35 g, 7 mmol,) was dissolved in methanol abs. (13.5mL) and sodium methanethiolate (0.6g, 7.7 mmol) 1.1 equiv.) was added portionwise at rt. After stirring overnight, the dark colored mixture was concentrated under reduced pressure and purified over a 50 g silica cartridge (NH2-modified) with ethyl acetate as eluent. The desired fractions were evaporated to give the title compound as a light yellow solid: 180 mg, MS (ISP): m/e 161.1 (M+H)+, 3034-57-9

3034-57-9 2-Amino-5-bromo-4-methylthiazole 12954373, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Hebeisen, Paul; Kitas, Eric A.; Minder, Rudolf E.; Mohr, Peter; Wessel, Hans Peter; US2009/143448; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14542-12-2,Thiazol-2-ylmethanol,as a common compound, the synthetic route is as follows.

2-azidomethyl thiazole Diphenylphosphoryl azide (3.25 mL, 0.015 mol) and 1,8-diazabicyclo[5.4.0] undec-7-ene (2.25 mL, 0.025 mol) were added to a solution of thiazol-2-yl-methanol (1.44 g, 0.013 mol) in toluene (20 mL) at 0 C. After 1 hour, the reaction was warmed to room temperature and stirred overnight. The mixture was diluted with toluene (20 mL) and washed with H2 O (3*) brine (1*), dried (Na2 SO4), filtered and concentrated in vacuo. The residue was purified by flash chromatography (30% ethyl acetate/hexanes) to afford the azide as a tan oil (1.1 g, 63%). IR: 2098 cm-1. 1 H NMR (250 MHz, CDCl3) delta7.8 (d, 1H, J=2.0 Hz); 7.4 (d, 1H, J=2.0 Hz); 4.7 (s, 2H).

14542-12-2, As the paragraph descriping shows that 14542-12-2 is playing an increasingly important role.

Reference£º
Patent; Pfizer Inc.; US5698526; (1997); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.73150-67-1,2-(2-Aminothiazol-4-yl)-2-oxoacetic acid,as a common compound, the synthetic route is as follows.

This compound was then treated at 20C with a solution of 2-amino-4-thiazoleglyoxylic acid (2.61 g, 15.2 mmole) in dimethylformamide (50 ml), followed by 5 ml of water. The reaction was stirred at 20C for 20 hours, and was then chilled and diluted with 250 ml of water. Stirring of the resulting gum gave a granular solid which was filtered, washed with water, and then azeotroped with acetonitrile to dryness. The dry solid was slurried with 100 ml of acetonitrile, filtered, and finally washed sequentially with acetonitrile, ethyl ether, and hexane. Drying in air gave 1.97 g of the title compound., 73150-67-1

As the paragraph descriping shows that 73150-67-1 is playing an increasingly important role.

Reference£º
Patent; E.R. Squibb & Sons, Inc.; EP229012; (1991); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.615-21-4,2-Hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.

615-21-4, In a 4-neck reactor equipped with a thermometer, 10.0 g (60.5 mmol) of 2-hydrazinobenzothiazole was dissolved in 100 ml of DMF in a nitrogen stream.To this solution, 41.8 g (304 mmol) of potassium carbonate and 10.34 g (60.6 mmol) of 5-bromovaleronitrile were added and the whole of the mixture was stirred at 60 C. for 8 hours.After completion of the reaction, the reaction solution was cooled to 20 C., poured into 1000 ml of water, and extracted with 1000 ml of ethyl acetate.After drying the ethyl acetate layer with anhydrous sodium sulfate, sodium sulfate was filtered off. Ethyl acetate was distilled off under reduced pressure from the filtrate by a rotary evaporator to obtain a yellow solid.This yellow solid was purified by silica gel column chromatography (n-hexane: ethyl acetate = 60: 40)As a white solid, 6.82 g of Intermediate T was obtained (yield: 45.7%).

The synthetic route of 615-21-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ZEON CORPORATION; SAKAMOTO, KEI; OKUYAMA, KUMI; SANUKI, KANAKO; (77 pag.)JP6191793; (2017); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

440100-94-7,440100-94-7, 2-Bromothiazole-5-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 2-bromothiazole-5-carbonitrile (200 mg, 1.05 mmol), tert-butylpiperazine-1-carboxylate (800 mg, 4.3 mmol), potassium phosphate tribasic (260 mg, 1.22mmol), palladium acetate trimer (40 mg, 0.06 mmol), tri-tert-butylphosphinetetrafluoroborate (20 mg, 0.06 mmol) in toluene (4 mL), taken in a microwave vial underargon atmosphere was irradiated for 30 min at 80 C (TLC indicated complete consumptionof starting material). The reaction mixture was diluted with water (10 mL) and extracted withEtOAc (3 x 30 mL). The combined organic extracts were washed with brine (10 mL), driedover N a2S04 and concentrated under reduced pressure. The crude product obtained waspurified by column chromatography (100-200 silica gel, 20 g, 10-30% EtOAc-Hexane) toafford tert-butyl 4-(5-cyanothiazol-2-yl)piperazine-1-carboxylate (200 mg, 64%) as a whitesolid LCMS (ESI+): m/z: 295.60 [M+Ht.

The synthetic route of 440100-94-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MITOBRIDGE, INC.; TAKAHASHI, Taisuke; KLUGE, Arthur; LAGU, Bharat; JI, Nan; (162 pag.)WO2018/125961; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica