Tag: M.W:100-200

1452-16-0, 2-Cyanothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A 2.5 M solution of nBuLi (2.0 eq) in hexane was added under argon to a solution of 2,2-dimethoxyethanamine (2.0 eq) in THF at -78C. After stirring for 30 min, thiazole-2-carbonitrile (2-Im-2, 3.0 g, 1.0 eq) was added and the resulting solution was stirred at 0 C for 2h, then quenched with 20 mL of 5% MeOH in water. The volatiles were removed and 6N HC1 was added to adjust to pH=l. The acidic solution was refluxed overnight, cooled to rt then poured into a mixture of ice and aqueous a2C03. This was extracted with EtOAc and the organic layer was concentrated to give Imadazole 2. LCMS (0.01% Ammonia): 152.1 m/z (M+H)+; ?-NMR (DMSO-d6, 500MHz): delta: 13.19 (bs, 1H), 7.98 (d, 1H, J=3.0Hz), 7.82 (d, 1H, J=3.0Hz), 7.36 (s, 1H), 7.14 (s, 1H)., 1452-16-0

As the paragraph descriping shows that 1452-16-0 is playing an increasingly important role.

Reference£º
Patent; ELAN PHARMACEUTICALS, INC.; GALEMMO, Robert, A., Jr.; ARTIS, Dean, Richard; YE, Xiaocong, Michael; AUBELE, Danielle, L.; TRUONG, Anh, P.; BOWERS, Simeon; HOM, Roy, K.; ZHU, Yong-Liang; NEITZ, R., Jeffrey; SEALY, Jennifer; ADLER, Marc; BEROZA, Paul; ANDERSON, John, P.; WO2011/79114; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

934-34-9, Benzothiazolone is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Intermediates 19-26 were prepared following literature procedures, with slight modifications [50]. A solution of 10-14 (6.6mmol) in acetone (20mL) was mixed with K2CO3 (10mmol) and stirred at room temperature for 10min. After addition of the appropriate 1-bromo-omega-chloroalkane or 1,omega-dibromoalkane (7.3mmol), the mixture was stirred for further 24h. Inorganic materials was removed by filtration, then the solvent was removed in vacuum to obtain a residue which was used without any further purification for the next step. For analytical purpose, crude 23-26 were purified by flash chromatography or by recrystallization.

934-34-9, As the paragraph descriping shows that 934-34-9 is playing an increasingly important role.

Reference£º
Article; Salerno, Loredana; Pittala, Valeria; Romeo, Giuseppe; Modica, Maria N.; Marrazzo, Agostino; Siracusa, Maria A.; Sorrenti, Valeria; Di Giacomo, Claudia; Vanella, Luca; Parayath, Neha N.; Greish, Khaled; European Journal of Medicinal Chemistry; vol. 96; (2015); p. 162 – 172;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55661-33-1,Thiazol-2-ylmethanamine,as a common compound, the synthetic route is as follows.

Example 1286-Chloro-2-oxo-8-(2-oxo-2-((thiazol-2-ylmethyl)amino)ethyl)-1 ,2-dihydroquinoline- 3-carboxylic acid a) Methyl 6-chloro-2-methoxy-8-(2-oxo-2-(thiazol-2-ylmethylamino)ethyl)- quinoline-3-carboxylate[00366] Thiazol-2-yl-methylamine (104 muIota, 1 .10 mmol, 2.0 equiv.) is added to a suspension of (CO)sMoCINEt (220 mg, 0.55 mmol) in ethanol (5 mL). The resulting mixture is stirred under a nitrogen atmosphere for 2 h. Diglyme (5 mL) is added to the mixture and heated to 120 C with evaporation of ethanol. Tributylamine (144 muIota, 0.60 mmol, 1 .10 equiv.) and methyl 8-(bromomethyl)-6-chloro-2-methoxyquinoline-3- carboxylate (170 mg, 0.49 mmol, 0.9 equiv.) are added and the mixture is heated at 130 C for 2 h. The reaction mixture is filtered over kieselguhr and the filtrate is concentrated in vacuo. The residue is taken on hydromatrix and purified by flash column chromatography (silica, 1 -10% MeOH in DCM) to afford 89 mg (44%) of the title compound as a solid. 1H NMR (400 MHz, CDCI3), delta (ppm) 3.90 (s, 3H), 3.96 (s, 3H), 4.08 (s, 2H), 4.36 (d, 2H), 6.56 (br s, 1 H), 7.07-7.13 (m, 2H), 7.22-7.29 (m, 3H), 7.72 (s, 2H), 8.54 (s, 1 H). LC-MS: 399 [M+H] [35CI]., 55661-33-1

The synthetic route of 55661-33-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Merz Pharma GmbH & Co. KGaA; ABEL, Ulrich; HANSEN, Angela; WOLTER, Falko Ernst; KRUEGER, Bjoern; KAUSS, Valerjans; ROZHKOVS, Jevgenijs; SEMENIHINA, Valentina; PISKUNOVA, Irena; PELSS, Juris; WO2012/164085; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

41731-52-6, Ethyl 2-chlorothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Sodium borohydride (690 mg, 18 mmol) was added as a single portion to a solution of ethyl 2-chloro-4-thiazolecarboxylate (1.6 g, 9 mmol) in ethanol (70 ml) at 0 C., then the mix was allowed to warm to room temperature with stirring overnight. The reaction was acidified to pH 5 with IN HCl and concentrated under vacuum, then the white residue was partitioned between water (125 ml) and ethyl acetate (3*300 ml). The organic phase was washed with brine and dried (Na2SO4), then the solvents were removed. Chromatography of the residue on silica gel (15 g, eluent 15%/-30% hexane/ethyl acetate) gave 2-chloro-4-hydroxymethylthiazole (850 mg, 5.5 mmol) in 63% yield as a clear oil, 1H nmr, 4.72 (s, 2H), 7.11 (s, 1H)., 41731-52-6

The synthetic route of 41731-52-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Biota Scientific Management Pty Ltd.; US7078403; (2006); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2933-29-1,2-Amino-4,5,6,7-tetrahydrobenzothiazole,as a common compound, the synthetic route is as follows.

General procedure: The solution of (15) (1 mmol) in anhydrous dichloromethane (10 mL) was supplemented with the appropriate isocyanate or isothiocyanate (1.1 mmol) and refluxed for 5 h. The solid product was washed with water and purified by re-crystallizationfrom aqueous ethanol, and air-dried to give the corresponding urea or thiourea compounds (16a-h). 5.3.2.2.2 1-isopropyl-3-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)urea (16b) 60% yield; mp = 92-94 C. IR (KBr) (numax/cm-1): 3294, 3070, 2927, 1679, 1569, 1234. 1H NMR (DMSO) (delta/ppm): 1.09 (d, J = 6.6 Hz, 6H, (CH3)2), 1.73 (br s, 4H, CH2), 2.47 (br s, 2H, CH2), 2.56 (br s, 2H, CH2), 3.75 (m, 1H, CH), 6.41 (d, J = 7.3 Hz, 1H, NH), 9.83 (br s, 1H, NH). 13C NMR (DMSO) (delta/ppm): (CH3): 22.76; (CH2): 22.04, 22.63, 22.98, 25.94; (CH): 41.23; (Cq): 141.45, 142.74, 151.97, 167.83. Anal. (C11H17N3OS) theoretical: 55.20% C, 7.16% H, 17.56% N, 13.39% S; found: 55.55% C, 7.21% H, 17.30% N, 12.99% S.

2933-29-1, 2933-29-1 2-Amino-4,5,6,7-tetrahydrobenzothiazole 18046, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Harrouche, Kamel; Renard, Jean-Francois; Bouider, Nafila; De Tullio, Pascal; Goffin, Eric; Lebrun, Philippe; Faury, Gilles; Pirotte, Bernard; Khelili, Smail; European Journal of Medicinal Chemistry; vol. 115; (2016); p. 352 – 360;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53332-78-8,Thiazol-2-ylmethanamine dihydrochloride,as a common compound, the synthetic route is as follows.

53332-78-8, A mixture of 5-bromo-3-(pyrrolidin-l-ylsulfonyl)-lH-indole-2-carboxylic acid (37 mg,0.1 mmol), PS-DCC (170 mg, 0.20 mmol) and EtaOBt (14 mg, 0.1 mmol), (l,3-thiazol-2-ylmethyl)amine (dihydrochloride salt, 39 mg, 0.2 mmol), and DIEA (100 uL) in TEtaF/DCM (1:1, 2 mL) was shaken for 16 hours at room temperature. After this time, the resin was filtered and washed with DCM/MeOEta (1:1, 4 x 1.5 mL). The combined organic solution was concentrated and the residue was purified by LCMS to give the title product (TFA salt) as slightly yellow solidAnalytical LCMS: single peak (214 nm), 3.254 min, ES MS (M+l) = 469; lEta NuMR (500 MHz, d6-DMSO) delta 13.02 (br, IH), 9.61 (t, J= 6.1 Hz, IH),8.12 (d, J= 1.8 Hz, IH), 7.77 (d, J= 3.2 Hz, IH), 7.70 (d, J= 3.2 Hz, IH), 7.53 (d, J= 8.7 Hz, IH), 7.48 (dd, J= 8.7, 1.8 Hz, IH), 4.88 (d, J= 6.1 Hz, IH ), 3.16-3.12 (m, 4H), 1.67-1.63 (m, 4H); HRMS, calc’d for Ci7HisBrNu4theta3S2 (M+H), 468.9998; found 469.0015.

53332-78-8 Thiazol-2-ylmethanamine dihydrochloride 44890709, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK & CO., INC.; WO2007/2368; (2007); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

5398-36-7, Ethyl 2-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5398-36-7

To a solution of ethyl 2-aminothiazole-4-carboxylate (100 g, 581 mmol) and copper (II) bromide (195 g,871 mmol) in acetonitrile (1000 ml) at 0 C, tert-butylnitrite (104 ml, 871 mmol) was added dropwise. The reaction mixture was warmed to room temperature and stirred for 12h. After completion of thereaction, the reaction mixture was diluted with a mixture of ethyl acetate (1000 ml) and water (3000 ml) and then acidified to pH 2 using iN hydrochloric acid. The two layers were separated and the aqueous layer was again extracted three times with ethyl acetate (500 ml). The combined organic layers were dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by recrystallization from hexane to obtain pure ethyl 2-bromo-1,3-thiazole-4-carboxylate (115 g,84% yield).?H-NMR (400 MHz, DMSO-d6) 8.52 (s, IH), 4.29 (q, J 7.1 Hz, 2H), 1.29 (t,J 7.1 Hz, 3H)MS: m/z235.90. [M+1].

As the paragraph descriping shows that 5398-36-7 is playing an increasingly important role.

Reference£º
Patent; PI INDUSTRIES LTD.; SHANBHAG, Gajanan; DODDA, Ranga Prasad; KAMBLE, Ganesh Tatya; KALE, Yuvraj Navanath; RENUGADEVI, G.; MANJUNATHA, Sulur G; S.P., Mohan Kumar; AUTKAR, Santosh Shridhar; GARG, Ruchi; VENKATESHA, Hagalavadi M; MAVINAHALLI, Jagadeesh Nanjegowda; KLAUSENER, Alexander G.M.; (161 pag.)WO2018/193387; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1603-91-4,4-Methylthiazol-2-amine,as a common compound, the synthetic route is as follows.

To a round bottom flask containing 40 mL CHUCK was added I (695 mg, 6.09 mmol), 4-DMAP (52.3 MG, 0.43 mmol), and BOC20 (1.374 g, 6.29 mmol). The reaction mixture was stirred overnight at room temperature. Concentration of the solution in vacuo was followed by purification by column chromatography (silica gel, hexanes: EtOAc, 10: 1), affording the product as white crystals (54 %)., 1603-91-4

As the paragraph descriping shows that 1603-91-4 is playing an increasingly important role.

Reference£º
Patent; NORTHWESTERN UNIVERSITY; WO2005/26111; (2005); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.101258-16-6,1-(2-Aminothiazol-4-yl)ethanone,as a common compound, the synthetic route is as follows.

To a DMF (5 mL) solution of (trans)- 3-((3-bromobenzofuran-7- yl)oxy)cyclobutanecarboxylic acid (Intermediate 1 12) (100 mg, 0.321 mmol) was added HATU (147 mg, 0.386 mmol) and N,N-diisopropylethylamine (0.17 mL, 0.96 mmol). After 5 minutes, 1 -(2-aminothiazol-4-yl)ethanone (50 mg, 0.35 mmol) was added, and the mixture was stirred for 12 h, poured into water, and extracted with EtOAc (3X). The combined organic layers were dried over Na2SC>4, filtered and concentrated. This residue was purified on silica gel, eluting with 0%-100% EtOAc: EtOH (3:1 ) in hexanes to give the title compound (97 mg, 58%). 1H NMR (400 MHz, CD3SOCD3) delta 2.37-2.44 (m, 2 H), 2.66 (s, 3 H), 2.67-2.75 (m, 2 H), 3.42 (d, J = 5 Hz, 1 H), 5.03 (t, J = 6 Hz, 1 H), 6.72 (d, J = 8.40 Hz, 1 H), 6.82-6.94 (m, 1 H), 7.32-7.41 (m, 1 H), 8.03-8.15 (m, 2 H), 12.50 (s, 1 H); LC-MS (LC-ES) M+H = 435, 437 (Br pattern)., 101258-16-6

As the paragraph descriping shows that 101258-16-6 is playing an increasingly important role.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; DEATON, David Norman; GUO, Yu; HANCOCK, Ashley Paul; SCHULTE, Christie; SHEARER, Barry George; SMITH, Emilie Despagnet; STEWART, Eugene L.; THOMSON, Stephen Andrew; (556 pag.)WO2018/69863; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1452-15-9, 4-Cyanothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1452-15-9, Preparation of Products; To a mixture of nitrile (60 mg) and substituted aniline (leq) was added AlCl3 (leq). The mixture was heated up to 2000C and stirred for 20 min under N2. The mixture was cooled and the product purified by preparative HPLC.

As the paragraph descriping shows that 1452-15-9 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME LIMITED; WO2007/138343; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica