Tag: M.W:100-200

121-66-4, 5-Nitrothiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

121-66-4, 5-Nitro-2-aminothiazole (1 eq)And triethylamine (1.2 eq) were dissolved in CH 2 Cl 2,Chloroacetyl chloride (1.2 eq) was added dropwise at 0 C,After the addition was completed, the reaction was continued for 5h,The reaction was checked by TLC, leaving no residue of the starting material and stopping the reaction.To the reaction mixture were added 100 ml of distilled water, the aqueous phase was extracted three times with CH 2 Cl 2 (3 ¡Á 100 ml), the organic phase was washed twice with saturated NaCl (2 ¡Á 100 ml), dried over anhydrous magnesium sulfate and then concentrated by evaporation to obtain a crude product. The crude product was purified by column chromatography on silica gel (methylene chloride: methanol = 150: 1, v: v) to give pure yellow solid in 82% yield.

As the paragraph descriping shows that 121-66-4 is playing an increasingly important role.

Reference£º
Patent; Shandong University; Hu Wei; Li Xun; Wang Chuandong; Li Xing; Wang Yan; Wu Yibo; Lu Di; Wu Hao; Zhang Yunxi; (8 pag.)CN106588813; (2017); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

121-66-4, 5-Nitrothiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2-amino-5-nitro-1,3-thiazole (0.0015 mol) in dichloromethane, was added triethylamine (1.2 equiv). The reaction mixture was stirred at 5 C for 15 min. After that, a solution of ethyl chlorooxoacetate (0.0018 mol, 1.2 equiv) was added droopingly. The reaction mixture was stirred at room temperature for 6 h. After complete conversion as indicated by TLC, the solvent was removed in vacuo, the residue was neutralized with saturated NaHCO3 solution, and the aqueous layer was extracted with ethyl acetate (3 x 15 mL), washed with water (3 * 20 mL), and dried over anhydrous Na2SO4. The solvent was evaporated in vacuo and the precipitated solids were recrystallized from a mixture of acetonitrile/methanol. Yield: 90%, mp: 252-255 C. 1H NMR (400 MHz, DMSO-d6) delta: 8.67 (1H, s, H-4), 4.32 (2H, q, O-CH2) 1.31 (3H, t, CH3) ppm; 13C NMR (100 MHz, DMSO-d6) delta: 161.7 (C-2), 158.4 (CO-OR), 157.7 (RNH-CO), 143.3 (C-5), 142.7 (C-4), 63.4 (O-CH2), 14.1 (CH3) ppm; MS (FAB+) m/z 246 (M+H+). Anal. Calcd for C7H7N3O5S: C, 34.29; H, 2.88; N, 17.14. Found: C, 34.19; H, 2.83; N, 17.09.

121-66-4, The synthetic route of 121-66-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nava-Zuazo, Carlos; Chavez-Silva, Fabiola; Moo-Puc, Rosa; Chan-Bacab, Manuel Jesus; Ortega-Morales, Benjamin Otto; Moreno-Diaz, Hermenegilda; Diaz-Coutino, Daniel; Hernandez-Nunez, Emanuel; Navarrete-Vazquez, Gabriel; Bioorganic and Medicinal Chemistry; vol. 22; 5; (2014); p. 1626 – 1633;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

399-74-6, 2-Chloro-6-fluorobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Procedure: 50 mg, 0.33 mmol of benzo[c][1,2]oxaborol-1,5(3H)-diol was dissolved in 5 mL of N-methylpyrrolidine, then 75 mg, 0.40 mmol was added. 2-Chloro-6-fluorobenzothiazole and 162.9 mg, 0.5 mmol of cesium carbonate, the mixture was stirred at room temperature overnight, then treated with ammonium chloride, extracted with ethyl acetate, washed with brine, dried and concentrated. Purified by preparative high-performance liquid phase separation to give 5-(6-fluorobenzothiazol-2-oxy)benzo[c][1,2]oxaborol-1(3H)-ol, white solid 15 mg, yield 15%., 399-74-6

The synthetic route of 399-74-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Guangzhou Baiting Pharmaceutical Technology Co., Ltd.; Wu Zhong; Li Jingrong; (16 pag.)CN108997394; (2018); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

38205-66-2, 1-(4-Thiazolyl)ethanone is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 50 ml round-bottomed flask, 8 ml of anhydrous diethyl ether and 0.311 ml (2.2 mmol) of diisopropylamine were added, the solution was cooled to -60C, and then 2.5 N of n-hexane solution of BuLi (2.2 mmol) was added dropwise to the upper reaction system.The reaction system was warmed to 0C and stirred for 15 minutes. Then, drosalactone (500 mg, 2.0 mmol) was added dropwise at -60C.The ether solution was stirred for a further 40 min and then a solution of 4-acetylthiazole (254.3.4 mg, 2.0 mmol) in diethyl ether was added dropwise to the upper reaction system.The reaction system was stirred at this temperature for 50 min. The reaction was quenched with water. The organic layer was separated, washed with saturated sodium chloride, dried over anhydrous sodium sulfate, filtered, and the solvent was distilled off under reduced pressure. The residue was separated by silica gel column chromatography to give CYL-2- QX-3C, yield 55.0%., 38205-66-2

The synthetic route of 38205-66-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sichuan China National Tobacco Industry Co., Ltd.; Chongqing China National Tobacco Industry Co., Ltd.; Tao Feiyan; Yang Wenmin; Feng Guanglin; Dai Ya; Li Chaorong; Ding Wei; Wang Yao; Zhou Sheng; Zhou Zhigang; Qiu Guangming; Liu Rucan; Zhang Ting; (11 pag.)CN105061418; (2017); B;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3829-80-9, Methyl 2-amino-4-methylthiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

PREPARATION 9 To a mixture of methyl 2-amino-4-methylthiazole-5-carboxylate (3.72 g) and pyridine (25 ml) was added mesyl chloride (1.6 ml) over the period of 5 minutes under cooling with stirring, and the mixture was stirred for 1 hour at ambient temperature and for 3 hours for 40 C. After the reaction mixture was concentrated, ethyl acetate (50 ml) and tetrahydrofuran (20 ml) were added to the residue and the mixture was adjusted to pH 3 with diluted hydrochloric acid. The separated organic layer was washed with brine, dried over magnesium sulfate and concentrated. The residue was pulverised with diethyl ether to give methyl 2-mesylamino-4-methylthiazole-5-carboxylate (3.5 g). mp: 216-218 C. IR (Nujol): 3150, 3100, 1705, 1610, 1515, 1500 cm-1 NMR (DMSO-d6, delta): 2.46 (3H, s), 2.98 (3H, s), 3.80 (3H, s), 3829-80-9

3829-80-9 Methyl 2-amino-4-methylthiazole-5-carboxylate 713653, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Fujisawa Pharmaceutical Co., Ltd.; US4988698; (1991); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

78364-55-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78364-55-3,6-Fluoro-2-hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.

General procedure: 1-(6-Fluorobenzothiazol-2-yl)-3-methyl-4-(2-(substituted phenyl)hydrazono)pyrazol-5(4H)-ones 4a-e. General Procedure B. A solution of 6-fluoro-2-hydrazinobenzothiazole (2) (0.549 g, 0.003 mol) in glacial acetic acid (10 mL) was added to a solution of the appropriate ethyl 3-oxo-2-(2-(substituted phenyl)hydrazono)butanoate 3a-e (0.003 mol) in glacial acetic acid (10 mL). The mixture was heated at reflux temperature for 10-16 h, then cooled and allowed to stand overnight. The precipitated solid was collected by filtration, washed with water, dried and crystallized from ethanol to give compounds 4a-e.

78364-55-3 6-Fluoro-2-hydrazinylbenzo[d]thiazole 2049844, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Shaaban, Mona I.; Chinese Chemical Letters; vol. 26; 12; (2015); p. 1522 – 1528;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76874-79-8,2-Amino-4-chlorothiazole-5-carbaldehyde,as a common compound, the synthetic route is as follows.

76874-79-8, [0184] Into a 1,4-dioxane solution (250 ml) containing 2-amino-4-chlorothiazol-5-carbaldehyde (10.83 g) was added 4-(dimethylamino)pyridine (1 g). Then, a 1,4-dioxane solution (100 ml) containing di-tert-butyl dicarbonate (29 g) was gradually added dropwise under heating at 60[deg.] C., and then the whole was continued to stir for about 30 minutes. After the reaction solution was cooled upon standing, the solvent was evaporated under reduced pressure and an appropriate amount of 5% potassium hydrogen sulfate aqueous solution was poured to the thus obtained residue, followed by extraction with ethyl acetate. After the organic layer was washed with water and dried over anhydrous magnesium sulfate, the crude product formed by solvent evaporation was purified by silica gel column chromatography to obtain tert-butyl (4-chloro-5-formylthiazol-2-yl)-carbamate (10.73 g) as pale brown crystals from the fractions eluted with ethyl acetate-toluene (2:3 (v/v)).

As the paragraph descriping shows that 76874-79-8 is playing an increasingly important role.

Reference£º
Patent; Hirano, Masaaki; Kawaminami, Eiji; Toyoshima, Akira; Moritomo, Hiroyuki; Seki, Norio; Wakayama, Ryutaro; Okada, Minoru; Kusayama, Toshiyuki; US2003/191164; (2003); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.349-49-5,4-(Trifluoromethyl)thiazol-2-amine,as a common compound, the synthetic route is as follows.

To a solution of 5-(1-methylsulfanyl-ethyl)2-trifluoromethylpyridine (0.5 g, 2.25 mmol) and 2-amino-4-trifluoromethyl thiazole (0.42 g, 2.48 mmol) in dichloromethane (8 ml) cooled to -25¡ã C. was slowly added N-chlorosuccinamide (0.33 g, 2.48 mmol) while maintaining the internal temperature of the reaction between -22¡ã C. and -28¡ã C. The reaction was slowly warmed to room temperature and stirred an additional hour. The reaction mixture was washed with water and the dichloromethane layer was dried (MgSO4), filtered and concentrated to dryness. The crude product was purified by chromatography on silica gel (eluent: 50percent EtOAc/hexanes, 100percent EtOAc) to give 3-[1-ethyl(N-(2-(4-trifluromethyl)thiazole)-sulfinyl)(methyl)]-6-trifluoromethylpyridine (G) as a yellow solid (0.81 g, 93percent ); M+H=288.1., 349-49-5

The synthetic route of 349-49-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Dow AgroSciences LLC; US2009/29863; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53137-27-2,2,4-Dimethylthiazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.

53137-27-2, EXAMPLE 3 (Compound No. 3) To a solution of imidazole (2.27 g; 40 mmol) in dry tetrahydrofuran (60 ml) was added dropwise thionyl chloride (1.20 g; 10 mmol) under ice-cooling while stirring. After the resultant mixture was turned to room temperature, 2,4-dimethyl-5-thiazolecarboxylic acid (1.57 g; 10 mmol) was added thereto at once, and stirring was continued for 30 minutes. To the mixture was added dropwise a solution of 2-(2-thienyl)aminoacetonitrile (1.65 g; 12 mmol) in dry tetrahydrofuran under ice-cooling, and the resultant mixture was stirred at room temperature for 1 hour. After completion of the reaction, tetrahydrofuran was removed under reduced pressure to separate the residue. Water was added to the residue, which was extracted with ethyl acetate. The ethyl acetate layer was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give crude oil. The oil was purified by silica-gel column chromatography (eluent:n-hexane:ethyl acetate=2:1 volume) to give crude crystals. Recrystallization from n-hexane/ethyl acetate gave 1.80 g of 2-(2,4-dimethylthiazole-5-carboxamido)-2-(2-thienyl)acetonitrile as colorless crystals. m.p., 127.5-128.5 C. Yield, 65%.

As the paragraph descriping shows that 53137-27-2 is playing an increasingly important role.

Reference£º
Patent; Sumitomo Chemical Company Limited; US4918089; (1990); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.262444-15-5,(4-Bromothiazol-5-yl)methanol,as a common compound, the synthetic route is as follows.

To a pale yellow solution of (4-bromothiazol-5-yl)methanol (870 mg) in DCM (25 mL) was added DMP (2.16 g) at RT. The resulting yellow suspension was stirred at RT under argon for 18 h. EA and aq. sat. NaHCO3 were added to the reaction mixture and stirred for 5 min. Water was added and the mixture was extracted with DCM three times. The combined org. layers were dried over MgSO4, filtrated off and evaporated in vacuo. CC (Biotage, SNAP 50 g cartridge, solvent A: Hept; solvent B: EA; gradient in % B: 10 for 5CV, 10 to 30 over 2CV, 30 for 3CV) afforded 708 mg of yellow solid. 1H-NMR (CDCl3): 10.0 (s, 1H); 9.04 (s, 1H), 262444-15-5

The synthetic route of 262444-15-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Caroff, Eva; Keller, Marcel; Kimmerlin, Thierry; Meyer, Emmanuel; US2014/371204; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica