Tag: M.W:100-200

1603-91-4, 4-Methylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of appropriate 2-substituent-1H-benzimidazole-4-carboxylic acid (1 mmol), EDC¡¤HCl (0.29 g, 1.5 mmol), HOBt (0.20 g, 1.5 mmol) and Et3N (0.15 g, 1.5 mmol) in DMF (10 mL) was stirred for 1 h at 0 C. Then appropriate amine (1.05 mmol) was added to the solution. The solution was heated up to 25 C, stirred for 12 h and then evaporated to dryness. The solid was washed with water and dried. The products were purified on silica gel column using 10:1 ethyl acetate/ethanol.

1603-91-4, 1603-91-4 4-Methylthiazol-2-amine 74143, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Xue, Fei; Luo, Xianjin; Ye, Chenghao; Ye, Weidong; Wang, Yue; Bioorganic and Medicinal Chemistry; vol. 19; 8; (2011); p. 2641 – 2649;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

615-21-4, 2-Hydrazinylbenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

615-21-4, 3.0 g of a compound represented by the formula (I-6-16), 4.6 g of 1-iodohexane, 8.9 g of cesium carbonate, and 20 mL of dimethyl sulfoxide were put into a reactor and heated with stirring. After ordinary post-treatment, this was purified through column chromatography to give 2.3 g of a compound represented by the formula (I-6-17).

As the paragraph descriping shows that 615-21-4 is playing an increasingly important role.

Reference£º
Patent; DIC Corporation; Horiguchi, Masahiro; Kadomoto, Yutaka; (139 pag.)US2018/22716; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

5398-36-7, Ethyl 2-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5398-36-7, 2-Amino-thiazole-4-carboxylic acid ethyl ester (1.4 g, 8 mmol) is dissolved in acetonitrile (15 ml) and N-bromosuccinimide. (1.7 g, 9.6 mmol, 1.2 equiv.) was added in one portion. The mixture was stirred at room temp. for 3 hours, then filtered and the filtrate was evaporated. After purification on silica-gel with ethyl acetate/n-heptane as eluent, 0.71 g of an off-white solid were obtained: MS: m/e 248.9 (M-H).

As the paragraph descriping shows that 5398-36-7 is playing an increasingly important role.

Reference£º
Patent; Gubler, Marcel; Haap, Wolfgang; Hebeisen, Paul; Kitas, Eric A.; Kuhn, Bernd; Minder, Rudolf E.; Schott, Brigitte; Wessel, Hans P.; US2007/281979; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

615-21-4,615-21-4, 2-Hydrazinylbenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a four-neck reactor equipped with a thermometer,In a nitrogen stream,10.0 g (60.5 mmol) of 2-hydrazinobenzothiazole was dissolved in 150 ml of DMF.To this solution,39.4 g (121.0 mmol) of cesium carbonate and 9.65 g (72.5 mmol) of 1-bromo-2-butyne were added and the whole of the mixture was stirred at 25 C. for 20 hours.After completion of the reaction, the reaction solution was poured into 1000 ml of water and extracted with 500 ml of ethyl acetate. After drying the ethyl acetate layer with anhydrous sodium sulfate, sodium sulfate was filtered off. Ethyl acetate was distilled off from the filtrate under reduced pressure using a rotary evaporator to obtain a brown solid. This brown solid was purified by silica gel column chromatography (n-hexane: ethyl acetate = 85: 15) to obtain 6.25 g of Intermediate S (yield: 47.5%) as a white solid.

As the paragraph descriping shows that 615-21-4 is playing an increasingly important role.

Reference£º
Patent; ZEON CORPORATION; SAKAMOTO, KEI; OKUYAMA, KUMI; SANUKI, KANAKO; (77 pag.)JP2017/206554; (2017); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3034-55-7,5-Bromothiazole,as a common compound, the synthetic route is as follows.

A mixture of 5-bromothiazole (200 mg, 1.2 mmol), (2-nitrophenyl)boronic acid (306 mg, 1.8 mmol), Na2CO3 (259 mg, 2.4 mmol) and Pd(PPh3)4(141 mg, 0.1 mmol) in DMA (5 mL) was degassed with nitrogen, heated to 150 C. and stirred for 2 hours under nitrogen atmosphere and microwave. The reaction was cooled to r.t, filtered and concentrated in vacuo. The residue was diluted with water, extracted with EA. The combined organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography to give 5-(2-nitrophenyl)thiazole (130 mg, 52% yield) as a yellow solid. LC/MS (ESI, m/z): [M+1]+=207.2

3034-55-7, 3034-55-7 5-Bromothiazole 546059, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Kymera Therapeutics, Inc.; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (180 pag.)US2020/10468; (2020); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2634-33-5, 1,2-Benzothiazol-3-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The acid 4 (5 mmol), EDC (1.2 g, 6.26 mmol), HOBt (0.9 g,5.88 mmol), NMM (1.2 mL, 10.74 mmol), and dichloromethane (10 mL) were mixed at ice-bath and stirred at 0 C for half an hour. 1,2-Benzisothiazol-3-one 1 (800 mg, 5.3 mmol) was added to NMM (1.6 mL, 14.32 mmol) in 10 mL of dichloromethane at 0 Ct hen the above mixture was added and stirred at room temperature overnight. After stirring overnight, the mixture was diluted with CH2Cl2, and then successively through washed with water, 5% KHSO4 solution, saturated NaHCO3 solution, and brine, the extract was dried with anhydrous Na2SO4 and evaporated under vacuum. The product was isolated by column chromatography (petroleum ether/CH2Cl2, 10:1) to yield the final compound. 4.2.11 2-(2-(2-Chlorophenyl)acetyl)benzo[d]isothiazol-3(2H)-one (15) Compound 15 was prepared through 2-chlorophenylacetic acid, obtained a white solid in 79% yield. Mp 171.3-172.5 C. 1H NMR (400 MHz, DMSO-d6) delta 8.00 (dd, J = 8.0, 3.6 Hz, 2H), 7.83 (t, J = 8.0 Hz, 1H), 7.53-7.45 (m, 3H), 7.38-7.34 (m, 2H), 4.62 (s, 2H). 13C NMR (101 MHz, DMSO-d6) delta 170.3, 163.8, 141.5, 135.2, 134.3, 132.79, 132.77, 129.6, 129.5, 127.7, 127.6, 126.7, 125.5, 122.7, 41.8. IR (KBr, cm-1): 1700, 1685. HRMS-ESI (m/z) calcd for C15H10ClNO2S [M+H+] 304.0199, found 304.0197., 2634-33-5

2634-33-5 1,2-Benzothiazol-3-one 17520, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Li, Zhenghui; Pan, Yang; Zhong, Weilong; Zhu, Yunpeng; Zhao, Yongle; Li, Lixin; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6735 – 6745;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

56012-38-5,56012-38-5, (2-Methylthiazol-5-yl)methanol is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Methanesulfonyl chloride (0.066 mL, 0.85 mmol) was added to (2-methylthiazol-5-yl)methanol (100mg, 0.77 mmol) and triethylamine (0.215 mL, 1.55 mmol) in DCM (3mL) at 0C over a period of 1 minute under nitrogen. The resulting solution was stirred at 0 C for 1 hour, then evaporated, redissolved in DCM (5m1) and washed with water (5m1). The organic phase was dried using a phase separator cartridge, evaporated and dried under vacuum to give (2-methylthiazol-5 -yl)methyl methanesulfonate (124 mg, 77 %) as animpure colourless gum which was used crude in the next stage. m/z: ES+ [M+H]+ not seen.

56012-38-5 (2-Methylthiazol-5-yl)methanol 12808792, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; WARD, Richard, Andrew; GRAHAM, Mark, Andrew; SWALLOW, Steven; JONES, Clifford, David; (282 pag.)WO2016/162325; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1747-60-0,2-Amino-6-methoxybenzothiazole,as a common compound, the synthetic route is as follows.

To a black solution of Copper (II) bromide (149 mg, 0.666 mmol) in Acetonitrile(1 mL) was added t-Butyl nitrite (0.095 mL, 0.72 1 mmol) at room temperature followedby 6-methoxybenzo[d]thiazol-2-amine (100mg, 0.555 mmol). Immediate bubbling and amild exotherm was observed upon benzothiazole addition. After 3 hours, the reactionmixture was diluted with EtOAc and washed with 1.0 M HC1, saturated NaHCO3, andthen Brine. The organic phase was dried over Mg504, filtered and concentrated to areddish-brown solid. The crude material was purified by ISCO flash chromatography (0-15% EtOAc/Hex over 20 mm, 12 g silica gel cartridge, Product at 5%). The desiredfractions were combined and concentrated to yield Intermediate 253A (84 mg, 0.344mmol, 62.0 % yield) as an off-white solid. LC-MS. Method H, RT = 1.12 mm, MS (ESI)m/z: 244.0, 246.0 (M+H). ?H NMR (400MHz, CHLOROFORM-d) 7.89 (d, J9.0 Hz,1H), 7.28 (1H under CDC13), 7.09 (dd, J9.0, 2.6 Hz, 1H), 3.90 (s, 3H)

1747-60-0, The synthetic route of 1747-60-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; BATES, J. Alex; HALPERN, Oz Scott; REZNIK, Samuel Kaye; RICHTER, Jeremy M.; (1137 pag.)WO2018/13774; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2289-75-0, 4,5-Dimethylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example No. 149Preparation of (4 , 5 -Dimethyl-thiazol-2-yl) – (8-methoxy-2H- pyrazolo [3 , 4-c] quinolin-4 -yl) -amine4 , 5-dimethylthiazol-2 -amine (0.4 mmol 2 eq. , ) was dissolved in THF (dry, 3mL) in a microwave vial (2-5mL) LiHMDS 2M in THF(0.6 mmol 4eq.) was added. The mixture was stirred for 20 min at r.t. and then added to a solution of 4-chloro-8-methoxy-2-(4 -methoxybenzyl) -2H-pyrazolo [3 , 4-c] quinoline (0.16 mmol, leq.) in pyridine (2mL) . The reaction mixture was irradiated in a microwave reactor for 20 min at 200 C. The reaction mixture was evaporated and used without further purification. The residue was dissolved in TFA (3mL) . The reaction mixture was irradiated in a microwave reactor for 5 min at 140C. The reaction mixture was concentrated and purified by semi- preparative HPLC-MS and freeze dried from water/t-BuOH 4/1. exact mass: 325.1205 g/molHPLC-MS: analytical method Brt: 2.397 min – found mass: 326.1 (m/z+H), 2289-75-0

The synthetic route of 2289-75-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ORIGENIS GMBH; ALMSTETTER, Michael; THORMANN, Michael; TREML, Andreas; KOESTLER, Roland; YEHIA, Nasser; WO2012/143143; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

541-58-2, 2,4-Dimethylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

541-58-2, The 2,4-dimethylthiazol-5-ylsulphonyl chloride used as a starting material is commercially available and is also described in J. Het. Chem., 1981, 18., 997. The material may also be prepared as follows :- o Chlorosulphonic acid (20 ml) was cooled to 15C in an ice/methanol bath.2,4-Dimethylthiazole (11.32 g) was added dropwise over 45 minutes, with the evolution of hydrogen chloride gas during the addition. The mixture so obtained was heated to 140-1500C for 16 hours. The resultant mixture was cooled to 110-120C and finely powdered phosphorus pentachloride (41.6 g) was added in small portions, with the evolution of further hydrogen 5 chloride gas during the addition. The mixture so obtained was heated to 12O0C for 1 hour. The mixture was cooled to ambient temperature and poured slowly into a vigorously stirred mixture of ice (200 g) and water (200 ml). The mixture so obtained was stirred for 30 minutes. The mixture was extracted with methylene chloride. The organic extract was dried over magnesium sulphate and purified by chromatography on silica using increasingly polar Q mixtures of isohexane and diethyl ether as eluent. There was thus obtained2,4-dimethylthiazol-5-ylsulphonyl chloride as a yellow oil (18.4 g); 1H NMR Spectrum: (CDCl3) 2.76 (3H, s), 2.77 (3H, s).

As the paragraph descriping shows that 541-58-2 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/129052; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica