Tag: M.W:100-200

62266-81-3, 6-Chlorobenzo[d]thiazol-2(3H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,62266-81-3

Reference example 13 6-chloro-3-[2-(dimethylamino)ethyl]-2-benzothiazolone (XIIe) A solution of compound (VIII) (9.28 g, 50 mmol), N,N-dimethylaminoethylchloride hydrochloride (XIe) (7.92 g, 55 mmol), and K2 CO3 (16.58 g, 120 mmol) in acetone (93 ml) was refluxed for 20 hours with stirring. After the reaction was complete, the reaction mixture was concentrated in vacuo. The residue was extracted with ethyl acetate. The layer of ethyl acetate was dried over MgSO4 and subjected to column chromatography on silica gel. From the elude eluted with ethyl acetate, compound (XIIe) (3.3 g, yield=64.3%) was obtained as an oil. IRnumax(nujol)(cm-1):1680,1168. NMR (CDCl3)delta:2.31 (6H, S), 2.59 (2H, t, J=7.2), 4.03 (2H, t, J=7.2), 7.01(1H,d,J=8.6),7.29(1H,d,d,J=8.6,2.2),7.41(1H,d,J=2.2).

As the paragraph descriping shows that 62266-81-3 is playing an increasingly important role.

Reference£º
Patent; Shionogi & Co., Ltd.; US5473066; (1995); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95453-58-0,2-Chlorothiazole-5-carbaldehyde,as a common compound, the synthetic route is as follows.

95453-58-0, Example 262A 1-{[(2-chloro-1,3-thiazol-5-yl)methylene]amino}-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxyquinolin-2(1H)-one The product of Example 226D (0.070 g, 0.196 mmol) was reacted with 2-chloro-1,3-thiazole-5-carbaldehyde (0.157 mL, 1.06 mmol) in N,N-dimethylacetamide (1.2 mL) in a sealed tube at 110 C. for 35 minutes in a microwave reactor. The reaction mixture was cooled to 25 C. and concentrated. The resulting residue was triturated with ethyl acetate and filtered to give the title compound.

As the paragraph descriping shows that 95453-58-0 is playing an increasingly important role.

Reference£º
Patent; Pratt, John K.; Betebenner, David A.; Donner, Pamela L.; Green, Brian E.; Kempf, Dale J.; McDaniel, Keith F.; Maring, Clarence J.; Stoll, Vincent S.; Zhang, Rong; US2004/162285; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10200-59-6,2-Thiazolecarboxaldehyde,as a common compound, the synthetic route is as follows.

To a stirred solution of 1.00 g of 1,3-thiazole-2-carboxaldehyde in 10 mL of tetrahydrofuran was added 0.334 g of sodium borohydride at room temperature. To the mixture was dropped 1 mL of methanol, and the mixture was stirred at the same temperature for 30 minutes. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give 0.344 g of 1,3-thiazol-2-ylmethanol.1H-NMR (CDCl3) delta ppm: 3.11 (1H, br s), 4.97 (2H, s), 7.32 (1H, d, J=3.2Hz), 7.75 (1H, d, J=3.2Hz)

10200-59-6, The synthetic route of 10200-59-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Kissei Pharmaceutical Co., Ltd.; EP1443041; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18903-18-9,Ethyl 5-aminothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

18903-18-9, Intermediate 4 5-Amino-thiazole-4-carboxylic acid ethyl ester (250mg, 1.453mmol) and triethylamine (1 .02ml_, 7.265mmol) were dissolved in 1 ,4-dioxan (6ml_). To this, 2- chloro-5-(trifluoromethyl)benzene-1 -sulfonyl chloride (0.3mL, 1 .744mmol) was added at room temperature and stirred for 16 hours. The mixture was concentrated in vacuo and extracted with ethyl acetate. The organic layer was washed with 1 N hydrochloric acid solution and water. The organic layer was dried with Na2S04, filtered and concentrated in vacuo. The residue was triturated with n-pentane, the product collected by filtration and dried under vacuum to give Intermediate 4 (340mg). LCMS (Method 26) Rt 2.63 min; m/z(M+H)+ 415

18903-18-9 Ethyl 5-aminothiazole-4-carboxylate 12620181, athiazole compound, is more and more widely used in various.

Reference£º
Patent; ANTABIO SAS; LEMONNIER, Marc; DAVIES, David; PALLIN, David; WO2014/198849; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10200-59-6,2-Thiazolecarboxaldehyde,as a common compound, the synthetic route is as follows.

A stirred and cooled (-60 0C) sol. of thiazole-2-carbaldehyde (3.97 g, 35.1 mmol) in MeOH (35 mL) was treated with NaBH4 (1.33 g, 35.1 mmol). The reaction mixture was stirred at -60 0C for 2 h, then carefully quenched with acetone (2.7 mL), warmed to rt, and the solvents were removed in vacuo. Purification of the crude by FC (EtOAc) yielded the title compound (3.00 g, 74percent) as an orange oil that crystallized at -20 0C and remained a solid upon warming to rt., 10200-59-6

As the paragraph descriping shows that 10200-59-6 is playing an increasingly important role.

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; WO2006/92268; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica