Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1011-40-1,2-Phenylthiazole-5-carbaldehyde,as a common compound, the synthetic route is as follows.

EXAMPLE 82.2.2-Trinuoro-l-(2-phenyl-1.3-thiazol-5-vnethanone (H2) Step 1: 2,2,2-Trifluoro-l-(2-phenyl-l,3-thiazol-5-yl)ethanol (Hl)A solution (0.15 M) of 2-phenyl-l,3-thiazole-5-carbaldehyde (1.0 eq.) and CsF (0.2 eq.) in DME was treated with CF3SiMe3 (1.5 eq.) and then stirred for 3 h at RT. The reaction mixture was quenched by adding IN HCl and stirred for 30 min. The mixture was diluted with EtOAc, the organic phase was separated, washed with sat. aq. NaHCO3 solution and dried (Na2SO4). Evaporation of the solvent under reduced pressure afforded the product as an yellow oil. MS (ES+) CnH8F3NOS requires: 259, found: 260 (M+H)+., 1011-40-1

As the paragraph descriping shows that 1011-40-1 is playing an increasingly important role.

Reference：
Patent; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA; WO2007/93827; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3034-53-5,2-Bromothiazole,as a common compound, the synthetic route is as follows.

3034-53-5, To a reaction flask were added a solution of n-butyl lithium in cyclohexane (60 mL,150 mmol, 2.5 mol/L) and anhydrous ethyl ether (100 mL). The mixture was stirred at -78 ocunder nitrogen protection, then 2-bromothiazole (20 g, 122 mmol) was added dropwise slowlyinto the mixture for 1 h. The mixture was heated to 70 oc and stirred for 30 min, then DMF(14.26 g, 195 mmol) was added for 1 h. The mixture was cooled to -40 oc and stirred for 1 h.The reaction mixture was warmed to 0 oc and to the reaction mixture was added HCl (4 M) (100mL), and the resulting mixture was partitioned. The aqueous layer was adjusted with saturatedaqueous potassium carbonte to pH about 7 to 8. The mixture was extracted with ethyl ether (100mL x 3). The combined organic layers were washed with saturated brine (100 mL), dried overanhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuo to give the titlecompound as brownish red oil (7 .0 g, 51 percent ).MS (ESI, pos. ion) m/z: 114.1 [M+Ht.

The synthetic route of 3034-53-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; SUNSHINE LAKE PHARMA CO., LTD.; TANG, Changhua; REN, Qingyun; YIN, Junjun; YI, Kai; LEI, Yibo; WANG, Yejun; ZHANG, Yingjun; (303 pag.)WO2018/108125; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

40283-41-8, 2-Aminothiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a reaction flask equipped with a stirrer, a condenser and a thermometer, 7.4 g of propionic acid was added, and 100 mL of dichloromethane was further added. Add EDC · HCl19.2g, then add 16g of triethylamine, stirring at room temperature for some time, adding DMAP1.5g, stirring for some time,Then, 45.8 g of oleanolic acid was added, and the reaction was stirred at room temperature. TLC was used to control the progress of the reaction.After the completion of the reaction, an appropriate amount of EDC · HCl (15.4 g) and triethylamine (12.8 g)After stirring for a while at room temperature, 14.4 g of 2-amino-4-carboxythiazole was added and the reaction was continued at room temperature. TLC controlled the progress of the reaction. After completion of the reaction, the reaction solution was washed with 3 x 100 mL of dilute hydrochloric acid aqueous solution and then washed with 3 x 100 mL of saturated brine, dried, evaporated to dryness, and purified by ethyl acetate-petroleum ether to give 43.8 g of a white solid product(HPLC: 99.5%), Rf = 0.21 [single point, developing solvent: v (petroleum ether): v (ethyl acetate) = 4: 1]The total yield was 68.5%

40283-41-8, The synthetic route of 40283-41-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Tianjin Institute of pharmaceutical research; Liu, Ying; Liu, DengKe; Zhang, Dashuai; Niu, Duan; Wu, jiang; Zou, meixiang; (7 pag.)CN103265607; (2016); B;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-35-3,Benzo[d]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of benzo[d]thiazole-6-carboxylic acid (2.5 g,13.95 mmol) in anhydrous CH2Cl2 (30 mL) was added triethylamine(1.95 mL, 13.95 mmol). The mixture was stirred at 10 C and a solution of ethyl chloroformate (1.33 mL, 13.95 mmol) in CH2Cl2(3 mL) was added dropwise. The resulting solution was stirred at10 C for an hour before addition of N-methoxymethylamine(1.36 g, 22.32 mmol) and triethylamine (1.95 mL, 13.95 mmol). Themixture was stirred 1 h 30 at 10 C, quenched with water, andextracted with CH2Cl2. The combined organic layers were driedover MgSO4, filtered, and evaporated under reduced pressure. Purification of the residue was performed by alumina column chromatography using CH2Cl2 as eluent to give compound 6 (1.22 g,39%) as a pale yellow oil.1H NMR (300 MHz, CDCl3) d 9.10 (s, 1H, CHS), 8.35 (d, 1H,J 1.5 Hz, H7), 8.14 (d, 1H, J 8.7 Hz, H4), 7.86 (dd, 1H, J 8.7,1.5 Hz, H5), 3.55 (s, 3H, CH3O), 3.41 (s, 3H, CH3N). 13C NMR (75 MHz,CDCl3) d 169.0, 156.1, 154.4, 133.4, 131.2, 126.4, 123.0, 122.6, 61.1,33.7.

3622-35-3, The synthetic route of 3622-35-3 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Moine, Esperance; Dimier-Poisson, Isabelle; Enguehard-Gueiffier, Cecile; Loge, Cedric; Penichon, Melanie; Moire, Nathalie; Delehouze, Claire; Foll-Josselin, Beatrice; Ruchaud, Sandrine; Bach, Stephane; Gueiffier, Alain; Debierre-Grockiego, Francoise; Denevault-Sabourin, Caroline; European Journal of Medicinal Chemistry; vol. 105; (2015); p. 80 – 105;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

64987-16-2,64987-16-2, Methyl 2-(2-aminothiazol-4-yl)acetate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

thyl 2-(2-bromothiazol-4-yl)acetate Methyl 2-(2-aminothiazol-4-yl)acetate (5g, 26.8mmol) was added under nitrogen to a solution of copper(ll) bromide (6.77g, 30mmol) and f-butyl nitrite (4.79ml, 40mmol) in acetonitrile (20ml) at -20C. The reaction mixture was slowly warmed to room temperature and stirred for two hours. The solution was then diluted with diethyl ether and washed with 25ml of 10 percent hydrochloric acid solution; the aqueous phase was extracted with 20ml of diethyl ether. The combined organic phases were dried and evaporated to dryness. The residue was purified by a standard method to yield the title compound. LC-MS : m/z (M+H) = = 235.9

The synthetic route of 64987-16-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; AGIOS PHARMACEUTICALS, INC.; LEMIEUX, Rene M.; POPOVICI-MULLER, Janeta; SALITURO, Francesco G.; SAUNDERS, Jeffrey O.; TRAVINS, Jeremey; CHEN, Yongsheng; WO2014/79150; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

64987-16-2, Methyl 2-(2-aminothiazol-4-yl)acetate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,64987-16-2

A solution of methyl 2-(2-aminothiazol-4-yl)acetate (1.044 g, 5.00 mmol) and Na2CO3 (0.530 g, 5.00 mmol) in DMF (20 mL) was stirred at room temperature for 15 min. 2,2,2-Trichloro-1-(4,5-dibromo-1H-pyrrol-2-yl)ethan-1-one (1.852 g, 5.00 mmol) was added and mixture was stirred at 80 C overnight. Solvent was removed under reduced pressure, residue was suspended in ethyl acetate (60 mL) and successively washed with 10% citric acid (2 × 30 mL), saturated aqueous NaHCO3 solution (2 × 30 mL) and brine (30 mL), dried over Na2SO4, filtered and the solvent removed under reduced pressure. The crude product was recrystallized from methanol. Yield: 1.630 g (77.0%); white crystals; m.p. 200-202 C; 1H NMR (400 MHz, DMSO-d6): delta 3.63 (s, 3H, CH3), 3.75 (s, 2H, CH2), 7.04 (s, 1H, thiazole-H), 7.45 (d, 1H, J = 2.6 Hz, pyrrole-H), 12.42 (s, 1H, NH), 13.12 (s, 1H, NH) ppm; 13C NMR (100 MHz, DMSO-d6): delta 36.4, 51.7, 98.8, 107.8, 110.8, 115.4, 125.8, 143.7, 156.6, 157.8, 170.5 ppm.

64987-16-2 Methyl 2-(2-aminothiazol-4-yl)acetate 738059, athiazole compound, is more and more widely used in various fields.

Reference：
Article; Campos, Ludmila E.; Garibotto, Francisco M.; Angelina, Emilio; Kos, Jiri; Toma?i?, Tihomir; Zidar, Nace; Kikelj, Danijel; Gonec; Marvanova, Pavlina; Mokry, Petr; Jampilek; Alvarez, Sergio E.; Enriz, Ricardo D.; Bioorganic Chemistry; vol. 91; (2019);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

14779-17-0, 2-Amino-5-methylbenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A benzene solution of hepta-O-benzo- b-D-lactosylisocyanate (0.001 mol, 1.1g) in 10 ml was mixed withsuspension of 2-amino benzothiazole (0.001 mol,0.15g) in 5 ml and mixture was refluxed over waterbath for 6 hr. Benzene was distilled off and stickymass obtained as a residue was triturated severaltimes with petroleum ether (60-800) to afford a whitesolid. It was crystallized from eq. ethanol.This reaction of 1-hepta-O-benzoyl- b-D-lactosylisocyanate was also extended to several other 2-aminobenzothiazoles and the corresponding 1-hepta-Obenzoyl- b-D-lactosyl-3-(2) benzothiazolyl carbamides(3b-f) have been isolated.3a: IR (KBr): 3449 (-N-H stretch), 3061 (Ar C-H),(Ar C=C), 1269 (C-N), 1174 (C-O), 1101 & 1026(Characteristic of Lactose), 852 (C-S); 1H NMR(CDCl3): 8.16-7.17 (39H, m, ArH), 6.18 (1H, s, NH),6.01 (1H, s, NH), 5.74-4.21 (14H, m, lactosyl protons);Mass : m/z 1245 (M+), 1053, 947, 931, 917, 135,121, 105., 14779-17-0

As the paragraph descriping shows that 14779-17-0 is playing an increasingly important role.

Reference：
Article; Pande, Kedar P.; Ghayalkar, Renu B.; Indian Journal of Heterocyclic Chemistry; vol. 25; 1; (2015); p. 45 – 46;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

118452-02-1, 2-Aminothiazole-4-carboxamide is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3: Synthesis of 3-[1-(4-Carbamoyl-thiazol-2-yl)-5-(4-methoxy-phenyl)-1H-pyrrol-2-yl]-propionic acid ethyl ester (1C, R1=4-carbamoyl-thiazol-2-yl, R2=4-methoxy-phenyl) (0161) To a solution of 7-(4-methoxy-phenyl)-4,7-dioxo-heptanoic acid ethyl ester (0.5 mmol), see scheme 1, in ethanol (2 mL) were added the amine (1.5 equivalents) and p-toluenesulfonic acid monohydrate (0.5 eq.). The reaction was run using the Biotage Microwave Initiator for 1 to 3 hours at 150 C. The solvent was removed in vacuo to obtain the crude mixture which was purified by prep silica gel plate to obtain the final product (70 mg, 38%).

118452-02-1, As the paragraph descriping shows that 118452-02-1 is playing an increasingly important role.

Reference：
Patent; Nivalis Therapeutics, Inc.; Wasley, Jan; Rosenthal, Gary J.; Sun, Xicheng; Strong, Sarah; Qiu, Jian; US9138427; (2015); B2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3034-53-5, 2-Bromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A flask which in 2-bromothiazole (16.4 g) and 50 ml of THF solution were put was cooled in an iced bath, and then 55 ml of a THF solution of 2 M isopropylmagnesium chloride was added dropwise there to under in a in nitrogen atmosphere while stirring the solution. After dropewise addition the rection mixture was stirred for 1 hour, and then a zinc chloride-tetramethylethylenediamine complex (30.3 g) was added. the resuting mixture was stirring for 1 hour at room temperature, and then 1-bromo-4-iodobenzene (28.3 g) and Pd(PPh3)4 (3.5 g) were added and then heated and stirred for 1.5 hours at reflux temperature. After cooling the reaction solution to room temperature, to remove the metal ions of the catalyst, a solution prepared by dissolving the compound ethylenediamine Inc. acid, use the sodium salt dihydrate equivalent to approximately 2-fold molar with respect to the objective to the appropriate amount of water (after and it stirred to fall abbreviated) EDTA · 4Na in an aqueous solution. Then, after removing also separated by adding toluene, and the solvent was distilled off under reduced pressure to the solution, and purified by silica gel column chromatography (eluent: toluene / ethyl acetate = 50/1 (volume ratio)) to give 2-(4-bromophenyl)thiazole (18.3g)., 3034-53-5

The synthetic route of 3034-53-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; JNC Co. Ltd.; Baba, Daisuke; Ono, Yohei; (128 pag.)KR2015/138163; (2015); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-35-3,Benzo[d]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.

Reference Production Example 9To a mixture of 5.0 g of benzothiazole-6-carboxylic acid and 50 ml of DMF was added 7.4 g of 2-fluoro-3-hydroxybenzylamine hydrobromide, 12.0 g of BOP reagent and 11.0 g of triethylamine, and the mixture was stirred at room temperature for 30 minutes. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate . The organic layer was washed with saturated saline, then, dried over magnesium sulfate and concentrated under reduced pressure . The resultant residue was subjected to silica gel chromatography, and 9.0 g of N- (2-fluoro-3-hydroxyphenyl) methyl-benzothiazole-6-carboxam ide was obtained.N- (2-fluoro-3-hydroxyphenyl )methyl-benzothiazole-6-c arboxamide 1H-NMR (DMSO-d6) delta: 9.78 (IH, s) , 9.54 (IH, s) , 9.13 (IH, t, J= 5.7 Hz), 8.70 (IH, d, J= I.7 Hz), 8.16 (IH, d, J= 8.5 Hz), 8.05 (IH, dd, J=8.5, 1.7Hz), 6.93 (IH, t, J=7.8Hz), 6.87-6.77 (2H, m) , 4.53 (2H, d, J = 5.6 Hz).

3622-35-3, As the paragraph descriping shows that 3622-35-3 is playing an increasingly important role.

Reference：
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2009/157527; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica