Tag: M.W:100-200

4175-72-8, 4-Chlorothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4175-72-8

[00258] To a thoroughly degassed stirred solution of tert-butyl (3fl)-4-(5,6-dichloro-2- iodo-pyrimidin-4-yl)-3-methyl-piperazine-1 -carboxylate (3-012, prepared in Scheme 3) (19.0 g, 40.2 mmol), 4-chlorothiazole (4.8 g, 40.2 mmol) and cesium carbonate (19.6 g, 60.2 mmol) in tert-butanol (200 mL) was added tri-tert-butylphosphonium tetrafluoroborate (1 .16 g, 4.01 mmol) and palladium acetate (0.45 g, 2.014 mmol). The reaction was heated to 80 C for 72 h. The reaction mixture was cooled to room temperature, filtered and the filtrate concentrated to dryness to afford a brown oil. This was purified by flash column chromatography on silica gel (eluting with a mixture of ethyl acetate in cyclohexane 0-60%) to give the title compound (3.80 g, 20%) as a yellow powder. LCMS: RT 3.34 min, Ml 466, Method (4LCMS6); NMR (400 MHz, CDCI3) delta 8.75 (s, 1 H), 4.70 (s, 1 H), 4.32 – 3.84 (m, 4H), 3.41 (td, J = 13.9, 13.0, 3.3 Hz, 1 H), 3.17 (s, 1 H), 1 .49 (s, 9H), 1 .37 (d, J = 6.7 Hz, 3H).

4175-72-8 4-Chlorothiazole 13517394, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; CARSWELL, Emma L.; CHARLES, Mark David; EKWURU, Chukuemeka Tennyson; ELUSTONDO, Fred; FOWLER, Catherine M.; OTT, Gregory R.; ROFFEY, Jonathan R; BROOKFIELD, Joanna L.; FORD, Daniel; CALDER, Mathew L.; (159 pag.)WO2018/87527; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.167366-05-4,4-Bromo-2-formylthiazole,as a common compound, the synthetic route is as follows.

167366-05-4, To a solution of 4-bromo-1 ,3-thiazole-2-carbaldehyde (192 mg, 1.0 mmol) in DCM (4.0 ml_) was added acetic acid (3 drops) and 2,2,2-trifluoroethanamine (120 mul_, 1.5 mmol). The reaction was stirred overnight. Sodium triacetoxyborohydride (335 mg, 1.5 mmol) was then added and reaction was stirred for 6 h. It was then quenched with sodium bicarbonate to yield 3-[1 -(ethylsulfonyl)-4-piperidinyl]-5-(4,4,5,5-tetramethyl-1 ,3,2- dioxaborolan-2-yl)-1/-/-indole-7-carboxamide.

The synthetic route of 167366-05-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/5534; (2007); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-35-3,Benzo[d]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.

Production Example 22 of the invented Compound; To a mixture of 0.26 g of benzothiazole-6- carboxylic acid, 0.23 g of 3, 7-dimethyl-2-octenylamine and 3 ml of DMF were added 0.86 g of BOP reagent and then 0.19 g of triethylamine, and the resultant mixture was stirred at room temperature for 20 hours. Water was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed successively with a saturated aqueous sodium hydrogencarbonate solution, water and a saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was subjected to silica gel chromatography to obtain 0.45 g of N- (3, 7-dimethyl-2- octenyl) -benzothiazole-6-carboxamide (hereinafter referred to as the invented compound 22) . The invented compound 221H-NMR (CDC13) 6: 0.86-0.91 (6H, m) , 1.13-1.21 (2H, m) , 1.38-1.58 (3H, m) , 1.73-1.76 (3H, m) , 2.01-2.13 (2H, m) , 4.07-4.13 (2H, m) , 5.30-5.35 (IH, m) , 6.15 (IH, br s) , 7.85-7.88 (IH, m) , 8.16 (IH, d, J = 8.5 Hz) , 8.48 (IH, d, J = 1.7 Hz) , 9.11 (IH, s)

3622-35-3, As the paragraph descriping shows that 3622-35-3 is playing an increasingly important role.

Reference：
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2009/57668; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

943-03-3, 6-Methoxybenzo[d]thiazole-2-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,943-03-3

Pyridine hydrochloride (2.32 g) was added to 2-cyano-6-methoxybenzothiazole 31 (51.4 mg, 0.271 mmol) and heated to 200°C in an argon atmosphere to dissolve the pyridine hydrochloride, and the reaction mixture was stirred for 30 minutes. The reaction mixture was allowed to cool, and then 1 M hydrochloric acid (50 ml) was added. After extraction with ethyl acetate (3 x 50 ml) and drying of the organic layer with anhydrous sodium sulfate, the result was concentrated in vacuo. The resulting residue was purified by preparative thin-layer silica gel chromatography {one 20 cm x 20 cm x 1.75 mm plate; hexane-ethyl acetate (1:1)}, yielding 2-cyano-6-hydroxybenzothiazole 32 (47.2 mg, 99percent) as a pale yellow solid. 1H NMR (270 MHz, CD3OD) delta 7.17 (1H, dd, J = 2.7, 9.2 Hz), 7.41 (1H, d, J = 2.7 Hz), 7.99 (1H, d, J = 9.2 Hz)

The synthetic route of 943-03-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; The University of Electro-Communications; NISHIYAMA Shigeru; SAITO Tsuyoshi; MAKI Shojiro; NIWA Haruki; EP2754657; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-35-3,Benzo[d]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.

Step A. Benzothiazole-6-carbonyl chloride. Under anhydrous conditions, a mixture of benzothiazole-6-carboxylic acid (1.0 g, 5.6 mmol) and oxalyl chloride (0.5 mL, 5.6 mmol) in dichloromethane (25 mL) containing a catalytic amount of N,N-dimethylformamide was stirred at ambient temperature for 3 hours. Removal of the solvent in vacuo provided a quantitative yield of the acid chloride as a light brown solid, which was used as such in the next step., 3622-35-3

The synthetic route of 3622-35-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; American Home Products; US6344451; (2002); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14779-17-0,2-Amino-5-methylbenzothiazole,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 2a,b (5 mmol) in phosphorus oxychloride (10 ml) was added a solution of the appropriate amine (5 mmol) and phosphorus pentoxide (5 mmol) in phosphorus oxychloride (5 ml), and the mixture was refluxed for 5 h. After cooling, the reaction mixture was poured onto ice/water and neutralized with 5% sodium hydroxide solution; the formed precipitate was filtered, washed with water and crystallized from the ethanol.

14779-17-0, The synthetic route of 14779-17-0 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Abbas, Safinaz E.; Abdel Gawad, Nagwa M.; George, Riham F.; Akar, Yahya A.; European Journal of Medicinal Chemistry; vol. 65; (2013); p. 195 – 204;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3034-53-5,2-Bromothiazole,as a common compound, the synthetic route is as follows.

Step 1 thiazol-2-ylmethanol To a solution of n-BuLi (8.4 ml , 1.6 mol/1 , 13.4 mmol) in THF (30 mL) was added 2- bromothiazole (377 mg, 2.12 mmol) dropwise under nitrogen atmosphere at -70 °C, and the mixture was stirred at the temperature for 1 h. Then DMF (1.4 ml, 18.3 mmol) was added into the solution dropwise under nitrogen atmosphere at -70 °C. The resulting mixture was stirred at the temperature for 1 h. Then the mixture was quenched with aqueous saturated ammonium chloride, diluted with ethyl acetate and water, and the phases were separated. The organic phase was washed with brine, dried over sodium sulfate, filtered and concentrated to give yellow oil. The yellow oil was dissolved in methanol (15 ml) , cooled to -60 °C, ans sodium borohydride (463 mg , 12.2 mmol) was added portionwise under nitrogen atmosphere. The mixture was stirred at the temperature for 1 h. The reaction was quenched with acetone and concentrated. The residue was diluted with ethyl acetate and water, and the phases were separated. The organic layer was dried over sodium sulfate, filtered and concentrated, then purified by silica gel chromatography eluting with petroleum/ ethyl acetate= 3: 1 to give thiazol-2-ylmethanol (230 mg, 16.4 percent yield) as brown oil . LCMS MH+ 1 16.

3034-53-5, As the paragraph descriping shows that 3034-53-5 is playing an increasingly important role.

Reference：
Patent; HYDRA BIOSCIENCES, INC.; CHENARD, Bertrand; GALLASCHUN, Randall; WO2014/143799; (2014); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15448-99-4,2-Methylbenzo[d]isothiazol-3(2H)-one 1,1-dioxide,as a common compound, the synthetic route is as follows.

EXAMPLE 10 Employing the procedure of Example 9, and starting with N-methylsaccharin and the indicated N-(2-pyridyl)haloacetamide, hydride, temperature and solvent, 4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide (Piroxicam) is prepared:

15448-99-4, 15448-99-4 2-Methylbenzo[d]isothiazol-3(2H)-one 1,1-dioxide 27290, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Pfizer Inc.; US4376204; (1983); A;; ; Patent; Pfizer Inc.; US4483982; (1984); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

40283-41-8, 2-Aminothiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,40283-41-8

[00324] To a solution of N1-(2-chloro-6-phenylpyrimidin-4-yl)cyclohexane-1,3-diamine (63 mg, 0.21 mmol) in a mixed solvent of tetrahydrofuran (4 mL) and dimethyl sulfoxide (1 mL) was added N,N-diisopropylethylamine (0.08 mL, 0.62 mmol) and 2-aminothiazole-4-carboxylic acid (59 mg, 0.42 mmol). The mixture was stirred at rt overnight. To the reaction mixture was added water (10 mL), and the resulting mixture was extracted with ethyl acetate (10 mL x 3).The combined organic layers were washed with saturated brine (10 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuo to give the title compound as a white solid (89 mg, 100%).MS (ESI, pos. ion) m/z: 429.2[M+H]1H NMR (400 MHz, CD3OD) (ppm): 7.92 (s, 2H), 7.49 (s, 3H), 7.26 (s, 1H), 6.77 (s, 1H), 4.59 (s, 1H), 2.68 (s, 1H), 2.32 (d, J 11.1 Hz, 1H), 2.11- 1.90 (m, 4H), 1.59 (d, J 13.1 Hz, 1H).

As the paragraph descriping shows that 40283-41-8 is playing an increasingly important role.

Reference：
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; REN, Qingyun; TANG, Changhua; LIN, Xiaohong; YIN, Junjun; YI, Kai; (270 pag.)WO2017/97234; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31785-05-4,Ethyl 5-amino-2-methylthiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

B) 5-Amino-2-methyl-thiazole-4-carboxylic acid ethyl ester (0.200 g, 1.07 mmol) was dissolved in 10 mL dry DMF. Potassium carbonate (0.45 g, 3.26 mmol) and cyclopropyl methylbromide (0.166 g, 1.23 mmol) were added and the reaction mixture was stirred at 80 C. overnight. The reaction mixture was diluted with 100 mL water and extracted three times with ethyl acetate (50 mL each). The organic phases were pooled, dried with sodium sulfate and evaporated. The crude product was flash-chromatographed on silica gel with heptane/ethyl acetate 100:0?0:100 gradient to yield 5-(cyclopropylmethoxycarbonyl-(cyclopropylmethyl)-amino)-2-methyl-thiazole-4-carboxylic acid ethyl ester (140 mg, 39%)., 31785-05-4

31785-05-4 Ethyl 5-amino-2-methylthiazole-4-carboxylate 13329095, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Buettelmann, Bernd; Ceccarelli, Simona Maria; Jaeschke, Georg; Kolczewski, Sabine; Porter, Richard Hugh Philip; Vieira, Eric; US2006/160857; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica