Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-35-3,Benzo[d]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.

Example 36:; EPO To a reaction mixture of amino ethyl ester 31a (0.31 g, 1.24 mmol) and aryl carboxylic acid (0.22 g, 1.24 mmol) in DMF (4 mL), EDC (0.36 g, 1.9 mmol), DMAP (25.0 mg, 0.28 mmol) and triethyl amine (345 mul_, 3.72 mmol) were added. The reaction mixture was stirred for 16 hours at room temperature. Crude product was purified by prep-HPLC without work up (10_50_60min, 0.1% TFA in water and acetonitrile) giving 0.30 g (59%) of oil 36. 1H NMR (DMSOd6): delta 1.06 (t, 3H, J=7.06 Hz), 3.54 (s, 2H), 4.08 (dd, 3H, J=6.97, 1.13 Hz), 7.32 (dd, 1 H, J=9.04, 6.78 Hz), 7.65 (dd, 1 H, J=4.14, 0.94 Hz), 7.77 (m, 1 H, J=8.48, 7.16, 4.90, 4.90, 4.90 Hz), 7.94 (d, 1 H, J=8.48 Hz), 8.17 (d, 1 H, J=8.48 Hz), 8.63 (d, 1 H, J=1.70 Hz), 9.30 (d, 1 H, J=8.29 Hz), 9.55 (s, 1 H). LCMS 413 (M+H).

3622-35-3, As the paragraph descriping shows that 3622-35-3 is playing an increasingly important role.

Reference：
Patent; PFIZER, INC.; WO2006/40646; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.943-03-3,6-Methoxybenzo[d]thiazole-2-carbonitrile,as a common compound, the synthetic route is as follows.

943-03-3, Pyridine hydrochloride (1.8 g, 15.57 mmol) was added to a 15 mL pressure tube and heated to 200 °C until completely dissolved.Then 2-cyano-6-methoxybenzothiazole (100 mg, 0.53 mmol) was added, followed by a reaction at 200 ° C for 2 h.The above reaction solution was adjusted to pH 7 with a 10percent NaHCO3 solution under ice bath. With EtOAc (15mL × 5) mixture was extracted, the organic layer was dried over anhydrous Na2SO4 and concentrated, the solvent was removed under reduced pressure.The crude product was purified by silica gel column chromatography (silica, hexane:EtOAc, 8:1 v/v).Obtained 50 mg of a white solid.The yield was 54.0percent.

943-03-3 6-Methoxybenzo[d]thiazole-2-carbonitrile 342109, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Xuzhou Medical University; Zhang Ling; Sheng Zhijia; Xue Yunsheng; Zheng Youguang; Zhang Yiran; Kai Xiaoning; (34 pag.)CN109293653; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19989-67-4,Benzo[d]thiazole-6-carbaldehyde,as a common compound, the synthetic route is as follows.

General procedure: rhodanine or hydantoine (1 eq), the corresponding aldehyde (1 eq) and sodium acetate (3eq) were dissolved in 5mL of acetic acid and the solution heated at 110C, if necessary under microwave conditions (130W for ?10min). After cooling, the precipitate was filtered off, washed to remove all the acetic acid and dried in vacuo. The reaction has been described in Mendgen etal. [39] to be stereospecific producing the Z-isomer as confirmed by the single peak in the HPLC., 19989-67-4

19989-67-4 Benzo[d]thiazole-6-carbaldehyde 15089709, athiazole compound, is more and more widely used in various fields.

Reference：
Article; Mariano, Marica; Hartmann, Rolf W.; Engel, Matthias; European Journal of Medicinal Chemistry; vol. 112; (2016); p. 209 – 216;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1123-55-3, Benzo[d]thiazol-7-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 6-Bromo-4-chloroquinoline (1.0 equiv.) and 3,4,5-trimethoxyaniline (1.1 equiv.) were suspended in ethanol (10 mL) and refluxed for 18 h. The crude mixture was purified by flash chromatography using EtOAc:hexane followed by 1-5% methanol in EtOAc, solvent was removed under reduced pressure to afford the desired product (1, 8-11, 13-31, and 33-43)., 1123-55-3

1123-55-3 Benzo[d]thiazol-7-amine 12479792, athiazole compound, is more and more widely used in various fields.

Reference：
Article; Asquith, Christopher R.M.; Bennett, James M.; Su, Lianyong; Laitinen, Tuomo; Elkins, Jonathan M.; Pickett, Julie E.; Wells, Carrow I.; Li, Zengbiao; Willson, Timothy M.; Zuercher, William J.; Molecules; vol. 24; 22; (2019);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15448-99-4, 2-Methylbenzo[d]isothiazol-3(2H)-one 1,1-dioxide is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 3 2-Methoxyethyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide (I; Y=OCH2 CH2 OCH3) In a manner similar to Example 1B, 1.0 g. of 91% sodium hydride was added over a period of one hour to a solution of 3.0 g. (0.015 mole) of N-methylsaccharin and 2.6 g. (0.017 mole) of 2-methoxyethyl chloroacetate in 15 ml. of dimethylformamide at 35 C. The exothermic reaction (55 C.) was allowed to stir for 2 hours after the addition was complete, and was then quenched in 5% hydrochloric acid solution and the product extracted with methylene chloride. The residue, remaining after the solvent was removed, was dissolved in 10 ml. of warm dimethylformamide and added to 100 ml. of 2% hydrochloric acid. The cooled suspension was stirred for 30 minutes and filtered. Drying of the filtered material gave 1.12 g. (24%) of the product identical with that prepared in Example 1B., 15448-99-4

15448-99-4 2-Methylbenzo[d]isothiazol-3(2H)-one 1,1-dioxide 27290, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Pfizer Inc.; US4376204; (1983); A;; ; Patent; Pfizer Inc.; US4483982; (1984); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

90672-80-3,90672-80-3, 4-Bromo-2,5-dimethylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

9-((l-(2,5-Dimethylthiazol-4-yl)-4-fluoropiperidin-4-yl)methyl)-2-(2-isopropylphi dihydro-8H-purin-8-one (1-514) (2052) (2053) [00536] Note: All reagents are solutions in THF unless specifically noted. Under an atmosphere of nitrogen, a mixture of 9-((4-fluoropiperidin-4-yl)methyl)-2-(2-isopropylphenyl)- 7,9-dihydro-8H-purin-8-one (11.08 mg, 30 muiotaetaomicron), sodium tert-butoxide (5.77 mg, 60.0 muiotaetaomicron), THF (250 mu , 4-bromo-2,5-dimethylthiazole (0.2M, 165 iL, 33.0 mumol), RuPhos precatalyst (0.02M, 75 uL, 1.500 mupiiotaomicron) and RuPhos (0.02M, 75 mu, 1.500 muiotaetaomicron) was heated to 100 C for 20 h. The reaction was concentrated, treated with saturated sodium bicarbonate (600 mu.) and extracted with EtOAc (2 x 600 mu.). The combined extracts were concentrated and purified by mass-directed preparative reverse phase HPLC to afford 1.0 mg (7% yield) of 9-((l-(2,5- dimethylthiazol-4-yl)-4-fluoropiperidin-4-yl)methyl)-2-(2-isopropylphenyl)-7,9-dihydro-8H- purin-8-one (1-514). LCMS Rt (min): 1.6817, m/z 481.44 [M+H]+.

As the paragraph descriping shows that 90672-80-3 is playing an increasingly important role.

Reference：
Patent; FORMA THERAPEUTICS, INC.; BUCKMELTER, Alexandre Joseph; IOANNIDIS, Stephanos; FOLLOWS, Bruce; GUSTAFSON, Gary; WANG, Minghua; CARAVELLA, Justin A.; WANG, Zhongguo; FRITZEN, Edward L.; LIN, Jian; (414 pag.)WO2017/87837; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3034-53-5,2-Bromothiazole,as a common compound, the synthetic route is as follows.

Example 262A 2-Phenylthiazole A solution of 2-bromothiazole (1.0 g, 6.1 mmol, Aldrich) in dioxane (25 mL) was treated with phenylboronic acid (0.82 g, 6.4 mmol), Pd(PtBu3)2 (0.16 g, 0.3 mmol, Strem) and Cs2CO3 (3.97 g, 12.2 mmol). The mixture was stirred at 80 C. for 12 hours. The reaction mixture was cooled to ambient temperature, concentrated under reduced pressure, and purified by column chromatography (SiO2, 1:1 hexanes/ethyl acetate) to give provide the title compound (0.69 g, 4.3 mmol, 70%). 1H NMR (CDCl3, 300 MHz) 67.33 (m, 1H), 7.41-7.48 (m, 3H), 7.87 (d, 1H, J=3.4 Hz), 7.95-8.00 (m, 2H); MS (DCl/NH3) m/z 162 (M+H+)., 3034-53-5

The synthetic route of 3034-53-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Basha, Anwer; Bunnelle, William H.; Dart, Michael J.; Gallagher, Megan E.; Ji, Jianguo; Li, Tao; Pace, Jennifer M.; Ryther, Keith B.; Tietje, Karin R.; Mortell, Kathleen H.; Nersesian, Diana L.; Schrimpf, Michael R.; US2005/101602; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19989-67-4,Benzo[d]thiazole-6-carbaldehyde,as a common compound, the synthetic route is as follows.

General procedure: rhodanine or hydantoine (1 eq), the corresponding aldehyde (1 eq) and sodium acetate (3eq) were dissolved in 5mL of acetic acid and the solution heated at 110C, if necessary under microwave conditions (130W for ?10min). After cooling, the precipitate was filtered off, washed to remove all the acetic acid and dried in vacuo. The reaction has been described in Mendgen etal. [39] to be stereospecific producing the Z-isomer as confirmed by the single peak in the HPLC. 4.1.2 Synthesis of (Z)-5-(benzo[d]thiazol-6-ylmethylene)-2-thioxothiazolidin-4-one (16) Rhodanine (0.254 g, 1.84 mmol), 1,3-benzothiazole-6-carbaldehyde (0.300 g, 1.84 mmol) and sodium acetate (0.452 g, 5.51 mmol) were used following the general procedure A described above. Yield: 2%. Mp: > 300 C. 1H NMR (500 MHz, DMSO-d6) delta ppm 7.76 (d, J = 8.51 Hz, 1H) 7.78 (s, 1H) 8.21 (d, J = 8.51 Hz, 1H) 8.47 (s, 1H) 9.50-9.58 (m, 1H) 13.88 (br. s., 1H). 13C NMR (126 MHz, DMSO-d6) delta ppm 123.74 (s, 1C) 125.09 (s, 1C) 125.97 (s, 1C) 128.30 (s, 1C) 130.26 (s, 1C) 131.13 (s, 1C) 134.94 (s, 1C) 153.93 (s, 1C) 159.56 (s, 1C) 169.43 (s, 1C) 195.71 (s, 1C). LC-MS (ESI): m/z MH+ = 279.

19989-67-4, As the paragraph descriping shows that 19989-67-4 is playing an increasingly important role.

Reference：
Article; Mariano, Marica; Hartmann, Rolf W.; Engel, Matthias; European Journal of Medicinal Chemistry; vol. 112; (2016); p. 209 – 216;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.425392-45-6,Ethyl 5-chlorothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

20 g Ethyl 5-chlorothiazol-4-carboxylate was added to 150 ml ammonia water, and reacted at room temperature with stirring for 5 hr. The resultant reaction mixture was extracted with ethyl acetate, dried over anhydrous sodium sulfate, filtered and concentrated to obtain 9.5 g of a crude product which was recrystallized from ethyl acetate to obtain 5.8 g of a needle crystal (yield 30%) with mp 213-216C; 1H NMR (DMSO-d6) 7.69(1H,s); 7.83 (1H,s); 9.05(1H,s)., 425392-45-6

As the paragraph descriping shows that 425392-45-6 is playing an increasingly important role.

Reference：
Patent; Beijing Molecule Science and Technology Co., Ltd.; EP2039686; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-35-3,Benzo[d]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.

Benzothiazole-6-carboxylic acid (71a, 5.0 g, 27.93 mmol) was dissolved in DCM (96 mL) and MeOH (32 mL) and cooled to 0 C. A solution of trimethylsilyl-diazomethane (28 mL, 2.0M in hexane) was added dropwise and the resulting solution was gradually warmed to RT and stirred overnight. The reaction was quenched slowly by careful addition of HOAc (2 mL) and stirred for 30 min. The solution was concentrated, diluted with EtOAc and washed with saturated NaHCO3 solution. The organic extracts were dried (Na2SO4), filtered and concentrated in vacuo. The crude residue was purified by SiO2 chromatographed eluting with 15% EtOAc/hexane to afford 4.44 g (82%) of 71b as a white solid: 1H NMR (300 MHz, CDCl3): 9.15 (s, 1H), 8.68 (m, 1H), 8.16 (m, 2H), 3.97 (s, 3H).

3622-35-3, As the paragraph descriping shows that 3622-35-3 is playing an increasingly important role.

Reference：
Patent; Roche Palo Alto LLC; US2006/40927; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica