Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119778-44-8,4-Ethyl-2-methylthiazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.

EXAMPLE 16 In a similar apparatus to Example 1, 18.8 g (0.11 mole) of 2-methyl-4ethylthiazole-5carboxylic acid were suspended in 150 ml of toluene, followed by the addition of 0.1 g of N,N-dimethylformamide. Under heating and reflux, phosgene was blown at a rate of 1.5 l/hr for 4 hours (0.27 mole). After completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated to obtain 20.3 g of 2-methyl-4-ethylthiazole-5-carboxylic acid chloride. Its purity and yield were 98.0% and 97.5%, respectively.

119778-44-8, The synthetic route of 119778-44-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Mitsui Toatsu Chemicals, Inc.; US5136042; (1992); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3034-53-5, 2-Bromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a 40 ml microwave reactor was added 1.04 g of 2-formylphenylboronic acid (6.9 mmol) of 1.14 g of 2-bromothiazole(6.9 mmol), 240 mg of bistriphenyl-phosphine palladium dichloride (Pd (PPh3) 2Cl2, 0.34 mmol). then,To the mixture was added 13.8 ml of 1 M Na2CO3 (13.8 mmol) and 10 ml of CH3CN. Sealed reactor,The reaction was run under microwave at 160 C for 5 minutes.LCMS shows the desired reaction of the desired product. The reaction mixture was then poured into a separation funnel. Add 200 ml of dichloromethaneAlkane and 100 ml of water for extraction. The dichloromethane layer was dried over MgSO4. The solvent was removed to give the crude product, which was passed through siliconThe column chromatography was eluted with a hexane / ethyl acetate mixture (5/1 to 2/1)To give pure 2-thiazol-2-yl-benzaldehyde (0.5 g, yield: 38%)., 3034-53-5

As the paragraph descriping shows that 3034-53-5 is playing an increasingly important role.

Reference：
Patent; Laixiken Pharmaceutical Co., Ltd.; A Luojiyasami·dewasajiayalayi; Jin Haihong; Shi Zhicai; A Xiaoke·tunuli; Wang Ying; Zhang Chengmin; (63 pag.)CN104045626; (2017); B;,
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Thiazole | chemical compound | Britannica

939-69-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.939-69-5,6-Hydroxybenzo[d]thiazole-2-carbonitrile,as a common compound, the synthetic route is as follows.

General procedure: The hydroxy- or methoxycarbonitrile derivative (1 eq) was added to the cysteine derivative (1.05 eq) and sodium carbonate (3 eq) in 5 ml water. The mixture was stirred at room temperature for three hours before addition of dilute HCl (1 M) to pH ? 3.5 ? 4.0. The product was isolated by extraction with diethyl ether, washed by water, followed by evaporation

As the paragraph descriping shows that 939-69-5 is playing an increasingly important role.

Reference：
Article; Rothweiler, Ulli; Eriksson, Jonas; Stensen, Wenche; Leeson, Frederick; Engh, Richard A.; Svendsen, John S.; European Journal of Medicinal Chemistry; vol. 94; (2015); p. 140 – 148;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3622-35-3, Benzo[d]thiazole-6-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Production Example 1Zero point one eight (0.18) g of benzothiazole-6-carboxylic acid, 0.19 g of 2-fluoro-3-methoxybenzylamine hydrochloride, 0.23 g of WSC and3 ml of pyridine were mixed and stirred at room temperature for2 hours. To the reactionmixture was added water, and the mixture was extracted with ethyl acetate. The resultant organic layer was washed sequentially with water and saturated saline, then, dried over anhydrous sodium sulfate, and concentrated under reduced pressure . The resultant residue was washed with hexane, and 0.23 g ofN- (2-fluoro-3-methoxyphenyl)methyl-benzothiazole-6-carboxam ide (hereinafter, referred to as the compound of the present invention (I)) was obtained.The compound of the present invention (1) 1H-NMR (CDCl3) delta: 3.90 (3H, s) , 4.75 (2H, d, J = 4.9 Hz), 6.58(IH, br s), 6.92-7.09 (3H, m) , 7.88 (IH, dd, J = 8.5, 1.7 Hz), 8.16 (IH, d, J = 8.5 Hz), 8.48 (IH, d, J = 1.5 Hz), 9.11 (IH, s) ., 3622-35-3

3622-35-3 Benzo[d]thiazole-6-carboxylic acid 601670, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2009/157527; (2009); A1;,
Thiazole | C3H3NS – PubChem
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.188937-16-8,2-(2-Thiazolyl)acetic Acid,as a common compound, the synthetic route is as follows.

Intermediate 36A: N-(3-Bromo-2-methylphenyl)-2-(thiazol-2-yl)acetamide A mixture of 3-bromo-2-methylaniline (0.764 mL, 6.20 mmol), 1,3-thiazol-2-ylacetic acid (0.74 g, 5.17 mmol) and DIEA (1.63 mL, 9.30 mmol) in DMF (15 mL) was treated with HATU (2.36 g, 6.20 mmol). After stirring overnight, the mixture was diluted with EtOAc, washed twice with 10% aqueous LiCl followed by brine, and the combined aqueous layers were extracted with EtOAc. The combined organic layers were dried and concentrated, and the residue was purified by column chromatography on silica gel, eluting with EtOAc-hexanes, to give N-(3-bromo-2-methylphenyl)-2-(thiazol-2-yl)acetamide as a white solid (0.681 g, 42% yield). 1H NMR (400 MHz, chloroform-d) delta 9.84-9.65 (m, 1H), 7.91 (d, J=7.9 Hz, 1H), 7.84 (d, J=3.3 Hz, 1H), 7.42-7.35 (m, 2H), 7.07 (t, J=8.0 Hz, 1H), 4.18 (s, 2H), 2.38 (s, 3H).

188937-16-8, 188937-16-8 2-(2-Thiazolyl)acetic Acid 21220663, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Batt, Douglas G.; Bertrand, Myra Beaudoin; Delucca, George; Galella, Michael A.; Ko, Soo Sung; Langevine, Charles M.; Liu, Qingjie; Shi, Qing; Srivastava, Anurag S.; Tino, Joseph A.; Watterson, Scott Hunter; US2014/378475; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59418-09-6,Methyl 4-thiazolecarboxylate,as a common compound, the synthetic route is as follows.,59418-09-6

A solution of 1-(trans-3-aminocyclobutyl)-3-cyclopropyl-1H-imidazo[4,5-b]pyrazin-2(3H)-one hydrochloride (Intermediate 79, 1.00 g, 3.55 mmol), methyl 2-chloro-4-thiazolecarboxylate (0.820 g, 4.61 mmol), and diisopropylethylamine (3.09 mL, 17.75 mmol) in DMSO (10 mL) was stirred at 120 C. for 18 h. The reaction was allowed to cool to room temperature, diluted with water and extracted with EtOAc. EtOAc was concentrated and residue purified with ISCO using silica gel column eluting with 0-70% EtOAc/hexane to give the title compound methyl 2-((trans-3-(3-cyclopropyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyrazin-1-yl)cyclobutyl)amino)thiazole-5-carboxylate (0.380 g, 0.983 mmol, 27.7% yield). m/z: 387.0 (M+1); 1H NMR (400 MHz, DMSO-d6) delta: ppm 8.38 (d, J=6.46 Hz, 1H), 7.99 (q, J=3.26 Hz, 2H), 7.60 (s, 1H), 5.15 (t, J=8.31 Hz, 1H), 4.28-4.47 (m, 1H), 3.77 (s, 3H), 3.18-3.30 (m, 2H), 2.88-3.07 (m, 1H), 2.34-2.47 (m, 2H), 0.91-1.13 (m, 4H).

59418-09-6 Methyl 4-thiazolecarboxylate 2773414, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; AMGEN INC.; Allen, Jennifer R.; Amegadzie, Albert; Andrews, Kristin L.; Brown, James; Chen, Jian J.; Chen, Ning; Harrington, Essa Hu; Liu, Qingyian; Nguyen, Thomas T.; Pickrell, Alexander J.; Qian, Wenyuan; Rumfelt, Shannon; Rzasa, Robert M.; Yuan, Chester Chenguang; Zhong, Wenge; US2013/225552; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.167366-05-4,4-Bromo-2-formylthiazole,as a common compound, the synthetic route is as follows.

A toluene (120 mL) solution of 4-bromothiazole-2-carbaldehyde (7 g, 36.50 mmol) and ethyleneglycol (2.72 g, 43.7 mmol) in a RB flask was added catalytic amount of pTsOH (0.347 g, 1.823mmol). The RB flask was attached with Dean-Stark apparatus and reaction mixture was heated to reflux for 12h. The mixture was cooled to RT, and was partitioned with saturated aqueous NaHCO3 solution. The organic layer was separated, washed with saturated aqueous NaHCO3 (2 X 120 mL) solution and then once with brine (100 mL). The organic layer was dried over anhydroussodium sulphate, filtered and the filtrate concentrated under reduced pressure. The residue was purified by combiflash chromatography (40 g Redisep 5i02 column, eluting with 20% EtOAc in pet ether) to afford the title compound 137A (8 g, 97%) as a colourless liquid. LC-MS retention time = 1.557 mm; m/z = 236.0 [M+2Hj + K1NETIX XB-C18, (3 X 75) mm, 2.6 micron column; Flow rate: 1 mL/min; Mobile Phase A: 10mM HCO2NH4in 98% Water/ 2% ACN; Mobile PhaseB: 10 mM HCO2NH4 in 2% Water/ 98% ACN; 20% B to 100% B over 4.6 mm, then hold 0.5 mm. at 20% B with flow rate 1-1.5 mL/min; Detection: UV at 254 nm. ?H NMR (400 MHz, DMSO-d6) oe 7.94 (s, 1H), 6.08 (s, 1H), 3.99 -4.08 (m, 4H)., 167366-05-4

167366-05-4 4-Bromo-2-formylthiazole 2763187, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; BRISTOL-MYERS SQUIBB COMPANY; ZHAO, Guohua; DEVASTHALE, Pratik; YE, Xiang-Yang; SELVAKUMAR, Kumaravel; DHANUSU, Suresh; BALASUBRAMANIAN, Palanikumar; GUERNON, Leatte R.; CIVIELLO, Rita; HAN, Xiaojun; PARKER, Michael F.; JACUTIN-PORTE, Swanee E.; (290 pag.)WO2018/89353; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

14779-17-0, 2-Amino-5-methylbenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2, 3 a-Dichloro provided 1, 4 a-napthoquinone 1g (4. 4mmol) diethylether 30 ml a melting solution 2 a-Amino provided 6 a-methylbenzothiazole 1. 08g (6. 6mmol), triethylamine 610 micro l some excellent. 24 hours at room temperature then evaporated in pressure with respect to the stirring mixture. (Hexanes: EtOAc=20:1) column chromatography compound to formula 63 to a positive number (NQ 63) to compound obtained.Yield: 76%

14779-17-0, The synthetic route of 14779-17-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Chosun University Industry-Academic Cooperation Foundation; Cho, Hoon; (48 pag.)KR101761848; (2017); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2346-00-1, 2-Methyl-4,5-dihydrothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 2,4,4-Trimethyl-2-oxazoline 1 (1.50 g, 13.1 mmol, 1 eq.) was placed in a 100 mL flask, followed by dried THF (76 mL) and triethylamine (3.11 g, 30.6 mmol, 2.33 eq.). At ice bath temperature, (CF3CO)2O (6.52 g, 30.7 mmol, 2.34 eq.) was added dropwise over 23 min. The resulting suspension was refluxed for 5 h under nitrogen. Rotary evaporation was used to remove the solvent. Dichloromethane (30 mL) and saturated NaHCO3 (40 mL) were added to the residue and the mixture was stirred for 10 min. The organic layer was washed further with water (2 .x.40 mL). The organic layer was dried over anhydrous Na2SO4. After concentrating by rotary evaporation, the crude product was purified by flash column chromatography over silica gel, using mixed ethyl acetate/hexanes (2 : 1 volume ratio) as the eluting solvent. A white solid (1.34 g, 6.40 mmol) was obtained, yield 48.8percent.

2346-00-1, As the paragraph descriping shows that 2346-00-1 is playing an increasingly important role.

Reference：
Article; De Silva, Hondamuni I.; Song, Yingquan; Henry, William P.; Pittman Jr., Charles U.; Tetrahedron Letters; vol. 53; 24; (2012); p. 2965 – 2970;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2346-00-1,2-Methyl-4,5-dihydrothiazole,as a common compound, the synthetic route is as follows.

EXAMPLE 7 2-Methyl-1,3-thiazoline (1.32 g) and pyridine (2.37 g) were dissolved in dichloromethane (50 ml) and cooled in an ice-bath. Chlorodifluoroacetic anhydride (6.3 g) was added to the above solution, dropwise, over 30 minutes. The mixture was then allowed to attain ambient temperature over 18 hours. The solvent was evaporated off under reduced pressure and the residue was suspended in water (50 ml) and treated with solid sodium bicarbonate until the solution became basic. The mixture was extracted with dichloromethane (3 x 75 ml), and the combined organic extract was dried over magnesium sulphate. The solvent was removed under reduced pressure and the residue recrystallized from ethanol to give a solid (2.4 g), 2-(chlorodifluoromethylcarbonylmethylene)-1,3-thiazolidine. mp 99°C. This intermediate compound (1.15 g) was dissolved in dimethyl formamide (15 ml, dried) and cooled in an ice-bath, with stirring and under a nitrogen gas atmosphere.

2346-00-1, 2346-00-1 2-Methyl-4,5-dihydrothiazole 16867, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; SHELL INTERNATIONALE RESEARCH, MAATSCHAPPIJ B.V.; EP652215; (1995); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica