Tag: M.W:100-200

3034-53-5, 2-Bromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3034-53-5, 2-Bromothiazole (13.0 g, 1.0 eq), 1-methyl-imidazole (2.0 eq), Cul (0.05 eq) and K4[Fe(CN)6] (0.1 eq) were combined in 80 mL of dry NMP and heated in a sealed tube at 140 C for 16h. This mixture was extracted with EtOAc and solvent was removed from the organic fraction to give thiazole-2-carbonitrile (compound2-Im-2).

3034-53-5 2-Bromothiazole 76430, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; ELAN PHARMACEUTICALS, INC.; GALEMMO, Robert, A., Jr.; ARTIS, Dean, Richard; YE, Xiaocong, Michael; AUBELE, Danielle, L.; TRUONG, Anh, P.; BOWERS, Simeon; HOM, Roy, K.; ZHU, Yong-Liang; NEITZ, R., Jeffrey; SEALY, Jennifer; ADLER, Marc; BEROZA, Paul; ANDERSON, John, P.; WO2011/79114; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3034-53-5,2-Bromothiazole,as a common compound, the synthetic route is as follows.

The (4-formylphenyl)boronic acid 118 (0.30 g, 2.0 mmol), 2-bromo-l,3-thiazole 119a (0.33 g, 2.0 mmol), Pd(PPh3)4(0.12 g, 0.1 mmol), aqueous solution of potassium carbonate (0.4 M, 5 mL), ethanol (5 mL) and toluene (2mL) were added to a 50 mL flask under nitrogen. The reaction mixture was stirred at 115 C for 24 hours and then cooled to room temperature. After removing the solvent, the crude residue was purified by column chromatography on silica gel using EA/hexane (1/5) as eluent. The product 120a was obtained as a white solid at a yield of 95%.

3034-53-5, 3034-53-5 2-Bromothiazole 76430, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; SHIH, Chuan; NATIONAL HEALTH RESEARCH INSTITUTES; ACADEMIA SINICA; CHEN, Chih-Hao; CHEN, Chiung-Tong; WANG, Hwei-Jiung; HUANG, Kai-Fa; (130 pag.)WO2020/47360; (2020); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.921927-88-0,Methyl 2-formylthiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

(0283) A solution of DIEA (15.8 mL, 110 mmol) in anhydrous ether (200 mL) was cooled to -78 C. n-BuLi (2M, 55 ml, 110 mmol) was added drop wise. The resulting mixture was warmed to 0 C. then continued to be stirred for 45 min at 0 C. The mixture was recooled to -78 C. and a solution of sulfinamide 51 (10 g, 52 mmol) in ether (100 mL) was added dropwise. The reaction mixture and stirred at -78 C. for 1 h. Chlorotitanium triisopropoxide (31.7 g, 121 mmol) was added and resulting reaction mixture was continue stirred at -78 C. for 1 h. Compound 48 (9 g, 52 mmol) was added in one portion and the resulting reaction mixture was continue stirred at -78 C. overnight. The reaction mixture was quenched with 20% acetic acid in THF and allowed to warm to RT. Water (2.5 mL) was added and the resulting solution was filtered through a pad of CELITE. The pad was washed thoroughly with ethyl acetate. The filtrate was extracted with ethyl acetate (3×). The combined organic extracts were washed 1× with saturated aq. NaCl. The organic fraction was dried with anhydrous Na2SO4 and filtered. The filtrate concentrated in vacuo. The residue was purified by flash chromatography (230-400 mesh silica) with a gradient of 15-20% ethylacetate-petroleum ether mixture to afford methyl 2-((R,E)-3-(((R)-tert-butylsulfinyl)imino)-1-hydroxy-4-methylpentyl)thiazole-4-carboxylate 52 (9.0 g, 47%) as a pale yellow viscous oil. 1H NMR (CDCl3) (400 MHz) delta 1.17-1.06 (m, 6H), 1.23 (s, 9H), 2.88-2.84 (m, 1H), 3.37-3.34 (m, 2H), 3.94 (s, 3H), 5.17-5.09 (m, 1H), 6.63 (d, 1H, J=13.2 Hz), 8.16-8.13 (d, 1H, J=13.2 Hz); MS (ESI+) m/z 361.0 (M+H)+.

921927-88-0, As the paragraph descriping shows that 921927-88-0 is playing an increasingly important role.

Reference：
Patent; Bristol-Myers Squibb Company; PEREZ, Heidi L.; WEI, Donna; BORZILLERI, Robert M.; GANGWAR, Sanjeev; SCHROEDER, Gretchen M.; CHENG, Heng; SCHMIDT, Robert J.; (58 pag.)US2016/130299; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3622-35-3, Benzo[d]thiazole-6-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Benzothiazole-6-carboxylic acid (0.0717 g, 0.582 mmol) and 1-hydroxybenzotriazole (118 mg, 0.874 mmol) were dissolved in N,N-dimethylformamide (8 mL, 100 mmol). N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (0.168 g, 0.874 mmol) was added and the reaction was stirred at rt for 20 min. Methyl-[4-(quinolin-2-ylmethoxy)-phenyl]-amine (0.153 g, 0.582 mmol) was added followed by triethylamine (0.244 mL, 1.75 mmol). The reaction was stirred at room temperature for 20 h. H2O (20 mL) was added to the reaction and the mixture was extracted with ethyl acetate (40 mL * 3). The combined organic phases were washed with satd aq NaHCO3 (40 mL), dried with magnesium sulfate, filtered and evaporated. The crude product was purified using column chromatography. The product fractions were combined and evaporated and the residue crystallised from ethyl acetate/heptane to yield the title compound as an off white solid (20% yield). 1H NMR: (600 MHz, CDCl3) delta 9.00 (s, 1H), 8.17 (d, J = 8.7 Hz, 1H), 8.05 (d, J = 8.7 Hz, 1H), 8.01 (s, 1H), 7.87 (d, J = 8.7 Hz, 1H), 7.83 (d, J = 8.2 Hz, 1H), 7.73 (dt, J = 1.4 Hz, J = 7.4 Hz, 1H), 7.59-7.53 (m, 2H), 7.35 (d, J = 8.2 Hz, 1H), 6.98 (d, J = 8.4 Hz, 2H), 6.86 (d, J = 8.8 Hz, 2H), 5.29 (s, 2H), 3.49 (s, 3H). [M+H+]: 426.1., 3622-35-3

3622-35-3 Benzo[d]thiazole-6-carboxylic acid 601670, athiazole compound, is more and more widely used in various fields.

Reference：
Article; Kilburn, John Paul; Kehler, Jan; Langgard, Morten; Erichsen, Mette N.; Leth-Petersen, Sebastian; Larsen, Mogens; Christoffersen, Claus Tornby; Nielsen, Jacob; Bioorganic and Medicinal Chemistry; vol. 21; 19; (2013); p. 6053 – 6062;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1123-55-3,Benzo[d]thiazol-7-amine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of aniline 1a (0.45 g, 0.005 mol), triethyl orthoformate (30 mL) and 2 mol of diphenyl phosphite (1.91 g, 0.01 mol) was stirred at 130 C for 2.5 h with continuous removal of ethanol formed. The reaction was monitored by TLC on silica gel using petroleum ether and ethyl acetate (1:2 v/v). After cooling, the volatiles were removed in vacuo. The residue was chromatographed on silica gel using CHCl3-MeOH (9:1).

1123-55-3, The synthetic route of 1123-55-3 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Balakrishna; Narayana Reddy, M. Veera; Rao, P. Visweswara; Kumar, M. Anil; Kumar, B. Siva; Nayak; Reddy, C. Suresh; European Journal of Medicinal Chemistry; vol. 46; 5; (2011); p. 1798 – 1802;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42270-37-1,2-(Piperazin-1-yl)thiazole,as a common compound, the synthetic route is as follows.

The product from Example 33A (0.2 g, 1.18 mmol), the product from Example 33B (0.25 g, 1.48 mmol) and N,N-diisopropylethylamine (0.41 mL, 2.3 mmol) were combined in toluene (25 mL) and heated at reflux overnight. The reaction was allowed to cool to room temperature, filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (elution with 50% ethyl acetate:hexanes) to provide 0.08 g (22%) of the desired material as a white solid. mp 151-153 C.; 1H NMR (300 MHz, DMSO-d6) ? 2.28 (s, 3H), 2.65 (m, 4H), 3.20 (s, 2H), 3.48 (m, 4H), 6.85 (m, 2H), 7.18 (m, 2H), 7.48 (m, 2H), 9.65 (s, 1H); MS (DCI/NH3) m/e 317 (M+H)+; Anal calcd for C16H20N4OS: C, 60.73; H, 6.37; N, 17.71. Found: C, 60.66; H, 6.24; N, 17.35.

42270-37-1, The synthetic route of 42270-37-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Stewart, Andrew O.; Kolasa, Teodozyj; US2003/232836; (2003); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118452-02-1,2-Aminothiazole-4-carboxamide,as a common compound, the synthetic route is as follows.

To a solution of 2-(S)-(2-tert-butoxycarbonylamino-2-phenyl-acetylamino)-3-phenyl-propionic acid (239 mg, 0.6 mmol) and 2-amino-thiazole-4-carboxylic acid amide (71.5 mg, 0.5 mmol) in N,N-dimethylformamide (5 mL) was added diisopropylethylamine (174 muL, 9.99 mmol) and O-benzotriazol-1-yl-N,N,N’,N’-tetramethyluronium hexaflurorophosphate (455 mg, 1.2 mmol) and the mixture stirred at ambient temperature overnight. The reaction was quenched with saturated aqueous ammonium chloride solution (10 mL), the mixture poured into water (50 mL) and extracted with ethyl acetate (3×20 mL). The combined organic extracts were washed with water (3×10 mL), brine (20 mL), dried over sodium sulfate and concentrated in vacuo. The residue was purified by chromatography over silica gel eluted with ethyl acetate to give {[1-((S)-4-carbamoyl-thiazol-2-ylcarbamoyl)-2-phenyl-ethylcarbamoyl]-phenyl-methyl}-carbamic acid tert-butyl ester as a glassy solid (31 mg, 12%). LR-MS: Obs. Mass, 524.25. Calcd. Mass, 524.1967 (M+H)., 118452-02-1

As the paragraph descriping shows that 118452-02-1 is playing an increasingly important role.

Reference：
Patent; Goodnow,, Robert Alan; Huby, Nicholas J.S.; Kong, Norman; McDermott, Lee Apostle; Moliterni, John Anthony; Zhang, Zhuming; US2006/63814; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

40283-41-8, 2-Aminothiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of compound 120 (1 g, 6.93 mmol) in DMF (50 mL) was added compound121 (0.97 g, 7.73 mmol), DIPEA (3.5 mL, 21.1 mmol) and HATU (2.93 g, 7.7 mmol). Theresultingsolution was stirred at room temperature overnight. The reaction solution was evaporatedin vacuo at 85oC to dryness which was treated with 30mL of THF, and stirred at room temperature for about 0.5 hour, then filtered, washed with a little of ethanol and dried to give compound122 (0.7 g, 46.9%) as a yellow solid. 1H NMR (300 MHz, DMSO): 8 8.07 (t, 1H, J = 6.0 Hz),7.22 (s, 1H), 7.12 (brs, 1H), 3.97(d, 2H, J = 6.0 Hz), 3.64 (s, 3H).Preparation of [ (2-{3-[2-(3-tert-butoxycarbonylamino-propoxy, 40283-41-8

40283-41-8 2-Aminothiazole-4-carboxylic acid 1501882, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; F. HOFFMANN-LA ROCHE AG; GOODNOW JR., Robert Alan; HAMILTON, Matthew Michael; KOWALCZYK, Agnieszka; SIDDURI, Achyutharao; WO2013/110578; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3034-53-5, 2-Bromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a cooled solution (-78°C) of n-butyllithium (1.7M in pentane, 323mL,550.8 mmol, 1.5 eq) in tetrahydrofuran (150 mL) under nitrogen was added 2- bromothiazole (60 g, 367.2mmol). The resulting suspension was stirred below – 78°C for 45 min. The lithiated thiazole solution was transferred via cannula to a solution of dimethylformamide (25 mL) in tetrahydrofuran (200 mL) at -78°C. The reaction was allowed to warm to room temperature over 3 h and quenched by the addition of water (100 mL). The aqueous phase was extracted with ethyl acetate (3*100 mL). Combined organic extracts were dried over anhydrous magnesium sulfate, filtered and reduced to afford 2-formylthiazole as a crude oil.

3034-53-5, 3034-53-5 2-Bromothiazole 76430, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; BIOENERGENIX; MCCALL, John; KELLY, Robert, C.; ROMERO, Donna, L.; WO2014/66795; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.615-20-3,2-Chlorobenzothiazole,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 2-chloro-5-methyl-benzimidazole (10.2 g, 61.2 mmol) and hydrazine monohydrate (59 mL, 1.22 mol) was stirred at 100 C overnight. After being cooled to ambient temperature, to the reaction mixture was added to water (60 mL). After stirring under ice cooling, the resulting precipitates were collected by filtration. The precipitates were washed with water 3 times, and then dried in vacuo to give 2-hydrazino-5-methyl-benzimidazole (8.4 g, 84.6%)., 615-20-3

615-20-3 2-Chlorobenzothiazole 11987, athiazole compound, is more and more widely used in various fields.

Reference：
Article; Nakao, Syuhei; Mabuchi, Miyuki; Shimizu, Tadashi; Itoh, Yoshihiro; Takeuchi, Yuko; Ueda, Masahiro; Mizuno, Hiroaki; Shigi, Naoko; Ohshio, Ikumi; Jinguji, Kentaro; Ueda, Yuko; Yamamoto, Masatatsu; Furukawa, Tatsuhiko; Aoki, Shunji; Tsujikawa, Kazutake; Tanaka, Akito; Bioorganic and Medicinal Chemistry Letters; vol. 24; 4; (2014); p. 1071 – 1074;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica