Tag: M.W:100-200

182344-56-5, 2-Chloro-4-fluorobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of (lS,3S)-3-((3-(tetrahydro-2H-pyran-4-yl)pyrazin-2- yl)oxy)cyclobutanamine hydrochloride (see PREPARATION 5D, 200 mg, 0.8 mmol) in NMP (4 mL) was added 2-chloro-4-fluoro-benzothiazole (150 mg, 0.8 mmol) and DIEA (229 mg, 1.6 mmol), then heated to 180C for 2 h in microwave. The reaction mixture was diluted with water (10 mL), extracted with ethyl acetate (20 mL), washed with water and brine, dried over Na2S04 and concentrated. The residue was purification by prep-HP C to give the title compound (30 mg, yield 9%)., 182344-56-5

182344-56-5 2-Chloro-4-fluorobenzo[d]thiazole 2049864, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; AMGEN INC.; ALLEN, Jennifer; FROHN, Michael; HARRINGTON, Paul; PICKRELL, Alexander; RZASA, Robert; SHAM, Kelvin; HU, Essa; WO2011/143366; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3622-35-3, Benzo[d]thiazole-6-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

At -78 C,11BuLi/Hex(2.5M) (28.5 mL, 71.4 mmol) was added dropwise into the solution of 6- carboxybenzothiazole (6.57 g, 37 mmol) in THF (450 mL) over 25 minutes. After the mixture was stirred for additional half an hour, the solution of Boc-HN-Arg(Mtr) Weinreb amide (1.63 g, 3.08 mmol) in THF (60 mL) was added slowly over 20 minutes at -78 C. After the addition then the mixture was stirred at -24 C to -20 C for 1.5 hours. The reaction was quenched with saturated aqueous NH4C1 (270 mL). The layers were separated and the aqueous layer was extracted with AcOEt. The organic phase was collected and washed with water, 5% citric acid, then dried with Na2SO4 and concentrated. The resulting residue was purified by silica gel chromatography with CH2C12/MeOH combination as eluent to give the title compound (0.91 g) in 46% yield. ?H NMR (400 MHz, METHANOL-d4) oe ppm 1.43 (s, 9 H) 1.66 (m, 4 H) 2.03 (s, 3 H) 2.54 (s, 3 H) 2.60 (s, 3 H) 3.22 – 3.29 (m, 2 H) 3.80 (s, 3 H)5.18 – 5.41 (m, 1 H) 6.55 (s, 1 H) 8.20 (m, 2 H) 8.79 (s, 1 H). MS(ESI): found: [M + Hj,648.4., 3622-35-3

The synthetic route of 3622-35-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; WASHINGTON UNIVERSITY; JANETKA, James,, W.; HAN, Zhenfu; HARRIS, Peter; KARMAKAR, Partha; (163 pag.)WO2016/144654; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.850429-61-7, Name is Methyl2-chloro-4-thiazolecarboxylate, molecular formula is C5H4ClNO2S. In a Article，once mentioned of 850429-61-7, Computed Properties of C5H4ClNO2S

Dibenzyloxydihydrobenzoxathiin 1, which resisted debenzylation with SiCl4/LiI, was effectively debenzylated with SiCl4/LiI in the presence of a catalytic amount of BF3. The HCl salt of the bis-debenzylated product 2 was isolated in 90% yield and 99% purity. This enhanced dealkylation activity has also been observed with other substrates.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Computed Properties of C5H4ClNO2S, you can also check out more blogs about850429-61-7

Reference：
Thiazole | C3H8608NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.23031-78-9, Name is Benzo[d]isothiazol-3-amine, molecular formula is C7H6N2S. In a Article，once mentioned of 23031-78-9, Safety of Benzo[d]isothiazol-3-amine

Background: The purpose of this study was to investigate the diabetic effect of phytocompounds synthesized from Hunteria umbellata using GC-MS analysis and molecular docking studies. Objective: Peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonists are beneficial in the treatment of diabetes by stimulating insulin sensitivity and antagonizing hepatic gluconeogenesis. The aim of the present study was to investigate the PPAR-gamma agonist property of phytocompounds from Hunteria umbellata using an in-silico approach. Methods: Molecular docking of Hunteria umbellata on human PPAR-gamma protein was determined by Auto/Vina in Pymol 4.2 and compared with Gilbenclamide, a known agonist of PPAR-gamma. Results: Our present study reports the phytochemical analysis of the extracts of the seeds and leaves of Hunteria umbellata. 21 compounds were revealed through GC-MS analysis and screened using AutoDock/Vina against PPAR-gamma. Docking studies recommended that 2,2-Benzylidenebis (3-methylbenzofuran) an existing phytochemical from the seed of Hunteria umbellata had the highest fitness score of ?11.3 kcal/mol and hence could be a potent antidiabetic drug. Conclusions: Hunteria umbellata seed extract and its compound 2,2-Benzylidenebis (3-methylbenzofuran) have a significant antidiabetic activity against PPAR-gamma. The molecular binding interaction of an in-silico data demonstrated that 2,2-Benzylidenebis (3-methylbenzofuran) has more specificity towards the PPAR-gamma binding site and could be a potent antidiabetic compound.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Safety of Benzo[d]isothiazol-3-amine, you can also check out more blogs about23031-78-9

Reference：
Thiazole | C3H7471NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.79265-30-8, Name is 2-(Trimethylsilyl)thiazole, molecular formula is C6H11NSSi. In a Patent，once mentioned of 79265-30-8, HPLC of Formula: C6H11NSSi

The present invention relates to novel heterocyclic thiosubstituted alkanol derivatives, to processes for preparing these compounds, to compositions comprising these compounds and to their use as biologically active compounds, in particular for controlling harmful microorganisms in crop protection and in the protection of materials and as plant growth regulators.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.HPLC of Formula: C6H11NSSi, you can also check out more blogs about79265-30-8

Reference：
Thiazole | C3H1049NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 348-40-3, Name is 6-Fluorobenzo[d]thiazol-2-amine, molecular formula is C7H5FN2S. In a Article，once mentioned of 348-40-3, Computed Properties of C7H5FN2S

A series of pyridobenzothiazine acid derivatives was synthesized and their in vitro antibacterial activity was evaluated.The 1,4-benzothiazine intermediates, which by Gould-Jacobs quinoline synthesis produced pyridobenzothiazine acids, were prepared by hydrolytic basic cleavage of substituted 2-aminobenzothiazoles and successive cyclocondensation with 1-bromo-2-chloroethane or alternatively with monochloroacetic acid, hence reduction by LiAlH4.The pyridobenzothiazine acids 10c, 30, and 31 show potent antibacterial activities against Gram-positive and Gram-negative pathogens.Structure-activity relationships are discussed.The compound 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido<1,2,3-de><1,4>benzothiazine-6-carboxylic acid (31) (MF-934) has been found to possess, together with the antibacterial activity, a weak acute toxicity and interesting pharmacokinetic characteristics in several animal species (rat, dog, monkey, man).

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Computed Properties of C7H5FN2S. In my other articles, you can also check out more blogs about 348-40-3

Reference：
Thiazole | C3H10547NS – PubChem,
Thiazole | chemical compound | Britannica

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 5464-79-9, Name is 2-Amino-4-methoxybenzothiazole, Computed Properties of C8H8N2OS.

The present invention relates to compounds, compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1 or 2 or encompassed by formulas I, Ia, II, III, and IV) or compositions comprising these compounds, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Computed Properties of C8H8N2OS. In my other articles, you can also check out more blogs about 5464-79-9

Reference：
Thiazole | C3H1963NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 20485-41-0, Name is 4-Methylthiazole-5-carboxylic acid,molecular formula is C5H5NO2S, is a conventional compound. this article was the specific content is as follows.Recommanded Product: 20485-41-0

The present invention provides: a novel alpha-substituted glycineamide derivative or a pharmacologically acceptable salt thereof; a pharmaceutical composition containing the alpha-substituted glycineamide derivative or a pharmacologically acceptable salt thereof; and a use of the alpha-substituted glycineamide derivative or a pharmacologically acceptable salt thereof for medical purposes. The present invention provides a compound which has an inhibitory activity on TRPM8 and is represented by general formula (I) [wherein A1 represents a C6-10 aryl group or the like; A2 represents a C6-10 aryl group or the like; X represents CH or the like; Y represents -CR1R2- or the like; R1 and R2 independently represent a hydrogen atom or the like; R3 and R4 independently represent a halogen atom or the like; and n represents 1 or 2] or a pharmacologically acceptable salt thereof. The compound (I) according to the present invention can be used as a therapeutic or prophylactic agent for diseases or conditions associated with afferent nerve hyperexcitability or injury.

Do you like my blog? If you like, you can also browse other articles about this kind. Recommanded Product: 20485-41-0. Thanks for taking the time to read the blog about 20485-41-0

Reference：
Thiazole | C3H5811NS – PubChem,
Thiazole | chemical compound | Britannica

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 3364-80-5, Name is Thiazole-4-carboxaldehyde, Application In Synthesis of Thiazole-4-carboxaldehyde.

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are antagonists of leukotriene B4 receptor 1 (BLT1) and may be useful in the treatment, prevention and suppression of diseases mediated by the leukotriene B4 receptor 1 (BLT1). The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, insulin resistance, hyperglycemia, dyslipidemia, lipid disorders, obesity, hypertension, Non-alcoholic fatty liver disease/nonalcoholic steatohepatitis, metabolic syndrome, atherosclerosis, and cancer.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of Thiazole-4-carboxaldehyde. In my other articles, you can also check out more blogs about 3364-80-5

Reference：
Thiazole | C3H9311NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.848501-90-6, Name is 2-Bromo-4-cyanothiazole, molecular formula is C4HBrN2S. In a Patent，once mentioned of 848501-90-6, name: 2-Bromo-4-cyanothiazole

Provided are benzoxazolinone sulfonamide derivatives that inhibit Na v1.7 activity, pharmaceutical compositions containing them and their use in therapy for the treatment of diseases mediated by Na v1.7 activity.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.name: 2-Bromo-4-cyanothiazole, you can also check out more blogs about848501-90-6

Reference：
Thiazole | C3H2435NS – PubChem,
Thiazole | chemical compound | Britannica