Tag: M.W=150-200

Joshi, Medha published the artcilePoly (urethane-urea)-epoxy glass fiber reinforced composites, Quality Control of 95-24-9, the publication is International Journal of ChemTech Research (2021), 14(1), 199-205, database is CAplus.

A series of poly(urethane-urea)s (PUU)s were synthesized using toluene 2, 4- diisocyanate, various 2-amino benzothiazoles and 3-amino phenol. All the PUUs were characterized by elemental anal., spectral studies, number average mol. weight (Mn) and thermogravimetry. Further reaction of PUUs was carried out with an epoxy resin (i.e.DGEBA). The curing study of prepared resins was monitored by DSC. Based on DSC thermograms glass fiber reinforced composites have been laminated and characterized by chem., mech. and elec. properties. The unreinforced cured resins were subjected to thermogravimetric anal.

International Journal of ChemTech Research published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Quality Control of 95-24-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Singh, Manjula published the artcileVisible-light photoredox catalytic approach for the direct synthesis of 2-aminobenzothiazoles from anilines, Application of 6-Chlorobenzothiazol-2-ylamine, the publication is Tetrahedron Letters (2020), 61(13), 151700, database is CAplus.

A novel, highly efficient and convenient approach for the visible-light-promoted direct synthesis of 2-aminobenzothiazoles from anilines and ammonium thiocyanate is presented. The reaction involves addition/cyclization cascade of SCN radical and anilines under photoredox catalysis with Ru(bpy)3Cl₂. The salient features of the protocol include the utilization of atm. oxygen and visible light as clean, inexpensive and sustainable resources at room temperature

Tetrahedron Letters published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C8H14O2, Application of 6-Chlorobenzothiazol-2-ylamine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Shetgar, Sanjay Shesha published the artcileDevelopment and validation of UPLC method for quantitative estimation of related impurities in tizanidine hydrochloride tablets, Quality Control of 30536-19-7, the publication is Journal of Applied Pharmaceutical Science (2021), 11(8), 043-053, database is CAplus.

Tizanidine hydrochloride is known to have several related impurities depending on the manufacturing process. There is no published ultra-performance liquid chromatog. (UPLC) method which can simultaneously quantify these impurities. The current work is to design, develop, and validate an UPLC method for simultaneous estimation of all known impurities. Forced degradation studies performed on tablet formulation did not show any purity flags. To achieve sensitive and optimal separation of all the six impurities from the main moiety of Tizanidine, gradient UPLC system with ethylene bridged hybrid C8 column, 230 nm UV detection provided an optimum separation The developed method was quick, with all six impurities eluting within 11 min. Low level of impurities could be quantified with limit of detection in the range 0.008%-0.028% and limit of quantitation in the range 0.037%-0.057%. Recoveries of all spiked impurities in Tizanidine hydrochloride were well within the range of 85%-115%. Thus, the developed UPLC method is sensitive, fast, and provides precise and accurate quantitation of all known impurities in Tizanidine hydrochloride tablets. The developed method is very useful for quant. estimation of impurities in Tizanidine hydrochloride tablets in routine quality control as well as stability monitoring programs. The method can easily be extended to quant. cleaning residue determination in pharmaceutical industry.

Journal of Applied Pharmaceutical Science published new progress about 30536-19-7. 30536-19-7 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Chloride,Amine, name is 5-Chlorobenzo[c][1,2,5]thiadiazol-4-amine, and the molecular formula is C42H63O3P, Quality Control of 30536-19-7.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Yamano, Tomoyoshi published the artcileAire-expressing ILC3-like cells in the lymph node display potent APC features, Computed Properties of 95-24-9, the publication is Journal of Experimental Medicine (2019), 216(5), 1027-1037, database is CAplus and MEDLINE.

The autoimmune regulator (Aire) serves an essential function for T cell tolerance by promoting the “promiscuous” expression of tissue antigens in thymic epithelial cells. Aire is also detected in rare cells in peripheral lymphoid organs, but the identity of these cells is poorly understood. Here, we report that Aire protein-expressing cells in lymph nodes exhibit typical group 3 innate lymphoid cell (ILC3) characteristics such as lymphoid morphol., absence of “classical” hematopoietic lineage markers, and dependence on RORγt. Aire+ cells are more frequent among lineage-neg. RORγt+ cells of peripheral lymph nodes as compared with mucosa-draining lymph nodes, display a unique Aire-dependent transcriptional signature, express high surface levels of MHCII and costimulatory mols., and efficiently present an endogenously expressed model antigen to CD4+ T cells. These findings define a novel type of ILC3-like cells with potent APC features, suggesting that these cells serve a function in the control of T cell responses.

Journal of Experimental Medicine published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C8H11BO2, Computed Properties of 95-24-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Hodgson, Herbert H. published the artcileSome derivatives of benz-1-thia-2,3-diazole, the nature of the thiadiazole ring, and a note on the thiolation of 2-chloro-5-nitroaniline, Application of Benzo[d][1,2,3]thiadiazol-5-amine, the publication is Journal of the Chemical Society (1948), 870-4, database is CAplus.

2,5-Cl(O₂N)C₆H₃NH₂ (I) results in about 45% yield on treatment of 20.25 g. 2,4-(O₂N)₂C₆H₃Cl in 40 cc. boiling AcOH with 57 g. SnCl₂ and distillation with steam; an equal quantity of 4,3-Cl(O₂N)C₆H₃NH₂ is nonvolatile with steam. I (17.5 g.) in 250 cc. boiling EtOH, treated gradually with 36 g. Na₂S.9H₂O and 12.6 g. NaHCO₃ in 100 cc. H₂O, the mixture heated 1 h. on the water bath, treated with 20 cc. 20% NaOH, added to 750 cc. ice and H₂O, and 7 g. NaNO₂ added to the filtrate, which was poured into a mixture of 25 cc. concentrated H₂SO₄ and 250 g. ice, gives 97% 5-nitrobenzothiadiazole (II), m. 143-5°, sublimes at 80-100°/atm. pressure, volatility with steam about 1 g./l.; II in Me₂CO, treated with a drop aqueous NaOH, gives a violet color which is discharged by acid and restored by alkali; on standing the color slowly changes to brown. I. (1.725 g.) in 6 cc. boiling EtOH, treated with 1.8 g. Na₂S.9H₂O and 0.36 g. S in 2 cc. H₂O, the mixture heated 1 h. on the steam bath, and treated as above, gives 1.3 g. impure II. The above alk. mixture, shaken with 20% aqueous NaOH and Me₂SO₄, gives 4,2-O₂N(H₂N)C₆H₃SMe, m. 105° (Ac derivative, pale lemon-yellow, m. 157°); (2-methylmercapto-5-nitro-2-phenylazo)-2-naphthol, scarlet, m. 236°. A solution of 4,2-O₂N(H₂N)C₆H₃SNa, shaken at room temperature with Ac₂O, gives 4-nitro-2-(acetamidomercapto)phenyl acetate, pale cream, m. 150°. I (1.725 g.) in 96 cc. hot EtOH, treated with 0.36 g. S and 1.8 g. Na₂S.9H₂O in 2 cc. H₂O and the mixture refluxed 5 h., gives [4,2-O₂N(H₂N)C₆H₃]₂S, m. 218°. Reduction of 0.45 g. II in 20 cc. hot aqueous NaOH with 2 g. Na₂S₂O₄ gives 0.15 g. 5-aminobenzothiadiazole (III), yellow, m. 95°; reduction of 0.02 g.-mol. II with 0.24 g.-mol. Fe powder in 1 cc. H₂SO₄, 30 cc. H₂O, and 100 cc. EtOH (refluxed 3 h.) gives 82% III; diazotization of the filtrate and coupling with 2-naphthol gave 17% benzothiadiazol-5-ylazo-2-naphthol, bright red, m. 209°; H₂SO₄ gives a reddish pink color, changing to pale pink on dilution with H₂O. III, through the diazo reaction, yields 5-bromobenzothiadiazole, m. 106°, and the 5-I derivative, m. 103° (solubility of the latter in H₂O at room temperature 0.3 g./l.). The yields of thiol and monosulfide from I and Na₂S, Na₂S₂, Na₂S_2.5, and NaSH are given; Na₂S₂O₃ does not react with I. A cyclic structure is preferred for the thiadiazole ring in contrast to the quinonoid resonance structure of the analogous diazoöxides.

Journal of the Chemical Society published new progress about 1753-29-3. 1753-29-3 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Amine, name is Benzo[d][1,2,3]thiadiazol-5-amine, and the molecular formula is C6H5N3S, Application of Benzo[d][1,2,3]thiadiazol-5-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Haasnoot, Willem published the artcileMonoclonal antibodies against a sulfathiazole derivative for the immunochemical detection of sulfonamides, Application of Methyl 2-(2-aminothiazol-4-yl)acetate, the publication is Food and Agricultural Immunology (2000), 12(2), 127-138, database is CAplus.

To prepare monoclonal antibodies (mAbs) against the generic part of sulfonamides, a sulfathiazole derivative was chem. linked to carrier proteins in such a way that the aromatic amino group, common to all sulfonamides, was distal to the proteins. Four mice were immunized with the sulfathiazole-protein derivatives The spleen cells of one of the mice were fused with myeloma cells to produce hybridomas of which the supernatants were screened in an indirect ELISA (iELISA) for the presence of sulfathiazole antibodies. After cloning, pos. supernatants were tested in a competitive iELISA (ciELISA) for inhibition with 18 sulfonamides. This resulted in four different mAbs (all IgG1 kappa light chain) which recognized several sulfonamides. By use of the best monoclonal (27G3) and an optimized ciELISA protocol, eight structurally different sulfonamides showed 50% inhibition at concentrations less than 100 ng ml^-1 or 5 ng/well. However, other relevant sulfonamides (such as sulfadimidine, sulfatroxazole and sulfachloropyrazine) were detected at a high level only with this mAb. This means that the ciELISA (with the best Mab) showed a broad specificity for sulfonamides but the sensitivity towards the different sulfonamides varied too much to call it a generic sulfonamide ELISA.

Food and Agricultural Immunology published new progress about 64987-16-2. 64987-16-2 belongs to thiazole, auxiliary class Thiazole,Amine,Ester, name is Methyl 2-(2-aminothiazol-4-yl)acetate, and the molecular formula is C6H8N2O2S, Application of Methyl 2-(2-aminothiazol-4-yl)acetate.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Hou, Yue published the artcileRewritable optical data storage based on mechanochromic fluorescence materials with aggregation-induced emission, COA of Formula: C7H5ClN2S, the publication is Dyes and Pigments (2019), 830-838, database is CAplus.

In this work, the synthesis and aggregation-induced emission (AIE) properties of a new mol. system are reported. This system composes of three positional isomers, which are fabricated by attaching a methoxy group in different locations. The isomeric effects on the AIE properties as well as the intramol. charge transfer (ICT) processes were studied. Addnl. the new isomers exhibit mechanochromic fluorescence (MCF). Among the three isomers, (E)-2-(((6-chlorobenzo[d]thiazol-2-yl)imino)methyl)-5-methoxyphenol (CHM3) exhibits the most remarkable MCF performance with emission that decreases in intensity and red-shifts in wavelength under mech. stimuli. The emission changes are caused by crystalline-amorphous transition as verified by Powder X-ray diffraction (PXRD) anal. The mechano-induced state can be easily recovered through a recrystallization process, which can be activated by solvent fumigation or solvent immersion. Furthermore, the switching between two emission states shows nice reversibility. Based on the MCF material with high fatigue resistance, a new type of rewritable optical data storage (ODS) is developed. Binary data, comprised of “0” and “1” state, can be matched well with the two emission states, resp. The data could thus be written or erased on the ODS device, demonstrating feasibility and practicability.

Dyes and Pigments published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, COA of Formula: C7H5ClN2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Xie, Zengyang published the artcileCopper-catalyzed one-pot coupling reactions of aldehydes (ketones), tosylhydrazide and 2-amino(benzo)thiazoles: An efficient strategy for the synthesis of N-alkylated (benzo)thiazoles, Application In Synthesis of 95-24-9, the publication is Applied Organometallic Chemistry (2019), 33(10), n/a, database is CAplus.

An efficient and practical C-N bond formation methodol. for the synthesis of N-(alkyl)benzothiazoles I [R = H, 4-Me, 6-Br, etc.; R¹ = n-Pr, Ph, 4-MeOC₆H₄, etc.] and N-(alkyl)thiazoles II [R² = H, Me; R³ = Ph, 2-MeC₆H₄, 2-naphthyl, etc.; R²R³ = (CH₂)₅; R⁴ = H, 4-Me, 5-Me] was developed via Cu-catalyzed one-pot two-step cross-coupling of 2-aminobenzothiazoles/2-aminothiazoles and aldehydes/ketones with tosylhydrazide. This cross-coupling reaction proceeded smoothly and tolerated a broad range of functional groups. A variety of functionalized benzothiazoles/thiazoles were obtained in moderate to high yields. Notably, gram-scale synthesis of fanetizole (anti-inflammatory drug) was also realized through this protocol.

Applied Organometallic Chemistry published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C15H23BO2, Application In Synthesis of 95-24-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Bai, Shuya published the artcileSpindle and kinetochore-associated complex subunit 3 (SKA3) promotes stem cell-like properties of hepatocellular carcinoma cells through activating Notch signaling pathway, Application of 6-Chlorobenzothiazol-2-ylamine, the publication is Annals of Translational Medicine (2021), 9(17), 1361, database is CAplus and MEDLINE.

Cancer stemness contributes to hepatocellular carcinoma (HCC) initiation, metastasis, drug resistance, and recurrence. The spindle and kinetochore-associated (SKA) complex has been shown to be involved in tumor progression; however, its effects on cancer stem cell-like properties have not yet been examined This research sought to study each subunit of the SKA complex in HCC systematically. Bioinformatic analyses were carried out to examine the expression and clin. data of the SKA complex′s each subunit in HCC. The expression of the target genes was detected by quant. reverse transcription-polymerase chain reaction and Western blot assays. Clone formation and Transwell assays were performed to assess the proliferation and migration abilities of the SKA complex′s each subunit. Sphere formation assays and s.c. xenograft experiments were performed to investigate the effects of SKA complex subunit 3 (SKA3) on the self-renewal and tumorigenic abilities of HCC. Each subunit of the SKA complex was highly expressed in HCC, but only SKA complex subunit 1 (SKA1) and SKA3 were associated with the poor overall survival of HCC patients. Addnl., the HCC cells overexpressing SKA3 exhibited increased migration, invasion, proliferation, self-renewal, Sorafenib resistance and tumorigenic abilities. Notch signaling played a vital role in the process by which SKA3 promoted HCC stemness. SKA3 promotes HCC stem cell-like properties via the Notch signaling pathway. As SKA3 appears to act as a regulator of stemness in HCC, it might be a potential mol. target for HCC.

Annals of Translational Medicine published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Application of 6-Chlorobenzothiazol-2-ylamine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Zhang, Lei published the artcileDiscovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase, Category: thiazole, the publication is European Journal of Medicinal Chemistry (2012), 624-639, database is CAplus and MEDLINE.

Dual-target-directed agents simultaneously inhibiting glycogen phosphorylase (GP) and activating glucokinase (GK) could decelerate the inflow of glucose from glycogenolysis and accelerate the outflow of glucose in the liver, and therefore allow for better control over hyperglycemia in a synergetic manner. A series of hybrid compounds were designed by structure-assisted and ligand-based strategies. In vitro bioassays found two novel compounds I and II worthy of further optimization on balance of dual action to GP and GK. In addition, for single-target activity, two compounds exhibited more potent GP inhibitory activity and four compounds showed better GK activation than their corresponding references

European Journal of Medicinal Chemistry published new progress about 64987-16-2. 64987-16-2 belongs to thiazole, auxiliary class Thiazole,Amine,Ester, name is Methyl 2-(2-aminothiazol-4-yl)acetate, and the molecular formula is C14H10O4, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica