Tag: M.W=200-250

Lei, Ying-jie published the artcileSynthesis of 2-(4-aminophenyl)-6-benzothiazoles derivatives in the presence of manganese(III) acetate, COA of Formula: C14H12N2S, the publication is Huaxue Yanjiu Yu Yingyong (2012), 24(10), 1596-1599, database is CAplus.

Several 4-nitrophenybenzothiazole intermediates were prepared by condensation reaction of 2-aminothiophenol and(substituted) 4-nitrobenzaldehyde in the presence of manganese(III) acetate and the procedure was shown to be mild and easy, which was followed with a reduction under the Pd/C catalyst to afford the desired amino derivatives and resulted in yields of 63-79%. The formation of the corresponding products was confirmed by IR, ¹HNMR and elemental anal.

Huaxue Yanjiu Yu Yingyong published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, COA of Formula: C14H12N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Goya-Jorge, Elizabeth published the artcileDiscovery of 2-aryl and 2-pyridinylbenzothiazoles endowed with antimicrobial and aryl hydrocarbon receptor agonistic activities, Application In Synthesis of 92-36-4, the publication is European Journal of Pharmaceutical Sciences (2020), 105386, database is CAplus and MEDLINE.

Benzothiazole is a privileged scaffold in medicinal chem. present in diverse bioactive compounds with multiple pharmacol. applications such as analgesic, anticonvulsant, antidiabetic, anti-inflammatory, anticancer and radioactive amyloidal imagining agents. We reported in this work the study of sixteen functionalized 2-aryl and 2-pyridinylbenzothiazoles as antimicrobial agents and as aryl hydrocarbon receptor (AhR) modulators. The antimicrobial activity against Gram-pos. (S. aureus and M. luteus) and Gram-neg. (P. aeruginosa, S. enterica and E. coli) pathogens yielded MIC ranging from 3.13 to 50μg/mL and against the yeast C. albicans, the benzothiazoles displayed MIC from 12.5 to 100μg/mL. All compounds showed promising antibiofilm activity against S. aureus and P. aeruginosa. The arylbenzothiazole 12 displayed the greatest biofilm eradication in S. aureus (74%) subsequently verified by fluorescence microscopy. The ability of benzothiazoles to modulate AhR expression was evaluated in a cell-based reporter gene assay. Six benzothiazoles (7, 8-10, 12, 13) induced a significant AhR-mediated transcription and interestingly compound 12 was also the strongest AhR-agonist identified. Structure-activity relationships are suggested herein for the AhR-agonism and antibiofilm activities. Furthermore, in silico predictions revealed a good ADMET profile and druglikeness for the arylbenzothiazole 12 as well as binding similarities to AhR compared with the endogenous agonist FICZ.

European Journal of Pharmaceutical Sciences published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Application In Synthesis of 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Abdelhamid, Abdou O. published the artcileReactions with hydrazonoyl halides. XIII. Synthesis of some new thiadiazoline, arylazothiazole and pyrazole derivatives, COA of Formula: C13H10N2S, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (1996), 181-191, database is CAplus.

Hydrazonoyl halide RCOCBr:NNHAr (I, R = 1-naphthyl, Ar = Ph, 4-MeC₆H₄, 4-ClC₆H₄) reacts with sodium thiophenolate and sodium benzenesulfinate to give the corresponding hydrazones. I also, reacts with thiourea, potassium thiocyanate and β-ketosulfones, to give arylazothiazoles II, thiadiazolines III, and pyrazole IV, resp. R’COCCl:NNHAr (R’ = OEt, Ar = Ph; R’ = Me, Ar = Ph, 4-MeC₆H₄, 4-ClC₆H₄; R’ = Ar = Ph) reacts with substituted thioanilide to afford pyrazoles V. The structures of the newly synthesized compounds were assigned and confirmed on the basis of their elemental analyses, spectral data and alternate synthesis whenever possible.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, COA of Formula: C13H10N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Watson, Keith J. published the artcileToward Polymeric Anticancer Drug Cocktails from Ring-Opening Metathesis Polymerization, Synthetic Route of 92-36-4, the publication is Macromolecules (2001), 34(11), 3507-3509, database is CAplus.

Exo-5-norbornene-2-ol was used to modify 3 anticancer drugs (i.e., indomethacin, 2-(4-aminophenyl)-6-methylbenzothiazole, and chlorambucil) with respect to preparation of polymer-based drug delivery systems. The modified drugs were polymerized using a Ru carbene (Cl₂(PCy₃)₂Ru=CHPh) as initiator in a living ring-opening metathesis polymerization The norbornene-derived drugs were amenable to the synthesis of either block copolymers in combination with each other or random copolymers in combination with a norbornenyl-modified triethylene glycol monomer.

Macromolecules published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C5H9IO2, Synthetic Route of 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Biedermann, Frank published the artcilePostpolymerization Modification of Hydroxyl-Functionalized Polymers with Isocyanates, Formula: C14H12N2S, the publication is Macromolecules (Washington, DC, United States) (2011), 44(12), 4828-4835, database is CAplus.

The postpolymn. functionalization of hydroxyl-group terminated polymers (M_n in the range of 1000-6000 g mol^-1) such as poly(ethylene glycol) (PEG), poly(N-isopropylacrylamide) (PNIPAM), poly(N,N-dimethylacrylamide) (PDMAM), and poly(tert-Bu acrylate) (PtBA) with a wide range of functional isocyanate derivatives such as azobenzene, viologen, and anthracene was studied. It was shown by ¹H and ¹³C NMR, GPC, Fourier transform IR spectroscopy (FTIR), and electrospray ionization mass spectrometry (ESI-MS) that a high degree of end-group conversion, typically >98%, with little or no formation of side products can be achieved at ambient temperature PNIPAM, PDMAM, PtBA, and PHEAM polymers were obtained by reversible addition-fragmentation chain transfer (RAFT) radical polymerization from a hydroxyl-group containing chain transfer agent (CTA). The formation of the carbamate was compatible with the trithiocarbonate end-group of the RAFT polymers. Addnl., this approach allows for the direct functionalization of RAFT polymers without the need of addnl. steps such as deprotection or aminolysis of the CTA. This route was subsequently used for the preparation of a variety of side-chain functional polymers from poly(N-hydroxyethyl acrylamide) (PHEAM). Three different high yielding methods were employed to prepare the isocyanates (R-NCO). Either amino or carboxylic acid precursors were converted into the desired R-NCO or hydroxyl group moieties were reacted with an excess of 1,6-hexamethylene diisocyanate (HDI) to statistically form the monofunctional product.

Macromolecules (Washington, DC, United States) published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Formula: C14H12N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Kusama, Hitoshi published the artcileInfluence of aminothiazole additives in I^–/I₃^– redox electrolyte solution on Ru(II)-dye-sensitized nanocrystalline TiO₂ solar cell performance, Related Products of thiazole, the publication is Solar Energy Materials and Solar Cells (2004), 82(3), 457-465, database is CAplus.

The influence of aminothiazole additives in acetonitrile solution of an I^–/I₃^– redox electrolyte on the performance of a bis(tetrabutylammonium) cis-bis(thiocyanato)bis(2,2′-bipyridine-4-carboxylic acid, 4′-carboxylate)ruthenium(II) (N719) dye-sensitized TiO₂ solar cell was studied. The current-voltage characteristics were investigated under air-mass 1.5 (100 mW/cm²) for nine different aminothiazole compounds The aminothiazole additives tested had varying influences on the solar cell performance. Most of the additives enhanced the open-circuit voltage, but reduced the short-circuit c.d. of the solar cell. Both the phys. and chem. properties of the aminothiazoles were calculated in order to determine the reasons for influence the additives have on solar cell performance. The larger the calculated partial charge of the nitrogen atom in the thiazole, the higher the open-circuit voltage value. The open-circuit voltage value increased as the dipole moment of aminothiazoles in acetonitrile increased. Moreover, the open-circuit voltage of the solar cells also increased as the size of the aminothiazole mols. decreased. These results suggest that the electron donating ability of the aminothiazole additives influenced the interaction with the TiO₂ photoelectrode, which altered the dye-sensitized solar cell performance.

Solar Energy Materials and Solar Cells published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Related Products of thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica