Tag: M.W=200-250

Vekhoff, Pierre; Duca, Maria; Guianvarc’h, Dominique; Benhida, Rachid; Arimondo, Paola B. published the artcile< Sequence-Specific Base Pair Mimics Are Efficient Topoisomerase IB Inhibitors>, Related Products of 57493-24-0, the main research area is triplex oligonucleotide DNA topoisomerase IB inhibitor.

Topoisomerase IB controls DNA topol. by cleaving DNA transiently. This property is used by inhibitors, such as camptothecin, that stabilize, by inhibiting the religation step, the cleavage complex, in which the enzyme is covalently attached to the 3′-phosphate of the cleaved DNA strand. These drugs are used in clinics as antitumor agents. Because three-dimensional structural studies have shown that camptothecin derivatives act as base pair mimics and intercalate between two base pairs in the ternary DNA-topoisomerase-inhibitor complex, we hypothesized that base pairs mimics could act like campthotecin and inhibit the religation reaction after the formation of the topoisomerase I-DNA cleavage complex. We show here that three base pair mimics, nucleobases analogs of the aminophenyl-thiazole family, once targeted specifically to a DNA sequence were potent topoisomerase IB inhibitors. The targeting was achieved through covalent linkage to a sequence-specific DNA ligand, a triplex-forming oligonucleotide, and was necessary to position and keep the nucleobase analog in the cleavage complex. In the absence of triplex formation, only a weak binding to the DNA and topoisomerase I-mediated DNA cleavage was observed The three compounds were equally active once conjugated, implying that the intercalation of the nucleobase upon triplex formation is the essential feature for the inhibition activity.

Biochemistry published new progress about DNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Related Products of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Chen, Ning; Jia, Weiyi; Xu, Jiaxi published the artcile< A Versatile Synthesis of Various Substituted Taurines from Vicinal Amino Alcohols and Aziridines>, Related Products of 171877-39-7, the main research area is taurine substituted preparation amino alc aziridine carbon disulfide; oxidation thiazolidinethione.

Taurine and structurally diverse substituted taurines have been synthesized by peroxyformic acid oxidation of the thiazolidine-2-thione intermediates generated from vicinal amino alcs. or aziridines and carbon disulfide. The stereochem. and mechanisms of the reactions are discussed. The method is a salt-free and versatile route, convenient in terms of purification, and can be used to synthesize optically active substituted taurines. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009).

European Journal of Organic Chemistry published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Related Products of 171877-39-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Singh, Kamaljit; Singh, Sarbjit; Mahajan, Aman; Taylor, John A. published the artcile< Monoazo disperse dyes. Part 3: synthesis and fastness properties of some novel 4,5-disubstituted thiazolyl-2-azo disperse dyes>, Application In Synthesis of 57493-24-0, the main research area is disperse blue azo dye preparation polyester application.

Novel blue disperse dyes from 5-nitro-2-aminothiazole diazo components have been prepared using m-aminoacetanilide-derived coupling components. These dyes have been characterized using a range of spectroscopic techniques and exhibit interesting fastness behavior on dyed polyester.

Coloration Technology published new progress about Disperse azo dyes. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Application In Synthesis of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ghorbani-Vaghei, Ramin; Alavinia, Sedigheh; Merati, Zohreh; Izadkhah, Vida published the artcile< MNPs@SiO2-Pr-AP: A new catalyst for the synthesis of 2-amino-4-aryl thiazole derivatives>, Reference of 57493-24-0, the main research area is aminopyridine functionalized silica supported iron oxide nanoparticle catalyst preparation; aryl thiazole green preparation; acetophenones thiourea condensation functionalized silica supported magnetic nanoparticle catalyst.

Magnetically recoverable nano-magnetic catalyst supported with functionalized (n-propyl)-4-amino-pyridine silica (MNPs@SiO2-Pr-AP) was synthesized and characterized using different techniques. A simple and efficient synthesis of 2-amino-4-aryl thiazoles I [R = H, 4-Cl, 3-NO2, etc, X = CH, N] was described via condensation of acetophenones and thiourea using three different types of catalytic systems including N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide [TBBDA], poly(N,N’-dibromo-N-ethylbenzene-1,3-disulfonamide) [PBBS] and a combination of TBBDA and MNPs@SiO2-Pr-AP. The results showed that, the use of TBBDA along with the MNPs@SiO2-Pr-AP gains the highest yields of the products in the shortest reaction time.

Applied Organometallic Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Reference of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Raut, Dattatraya G.; Kadu, Vikas D.; Sonawane, Vikas D.; Bhosale, Raghunath B. published the artcile< Synthesis of thiazole scaffolds by novel method and their In Vitro anthelmintic activity against Indian adult earthworm>, Application of C9H7N3O2S, the main research area is Pheretima anthelmintic thiazole scaffold synthesis.

A highly efficient and facile method has been described for the synthesis of substituted thiazoles and 2-aminothiazoles from phenacyl halide and thiourea in methanol using iodine as a catalyst at ambient temperature and product obtained in excellent yield within short time. The formation of these compounds was confirmed by IR, 1H NMR, 13C NMR and mass spectroscopy. The synthesized different substituted thiazoles (3a-3g) were taken for anthelmintic activity against Indian earthworm Pheretima posthuma at two concentration (50 mg/mL and 100 mg/mL) and results were expressed in terms of time for paralysis and time for death of worms. The albendazole (20 mg/mL) was used as reference standard The products were evaluated for anthelmintic activity to develop anthelmintic agent. Some of the compounds showed good anthelmintic activity (3g) as compared to albendazole.

European Journal of Biomedical and Pharmaceutical Sciences published new progress about Anthelmintics. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Application of C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Devi, N. S.; Devi, Nirada published the artcile< Organocatalytic synthesis of N-substituted 5-arylidene rhodanines>, Recommanded Product: 3-Benzyl-2-thioxothiazolidin-4-one, the main research area is rhodanine aryl aldehyde proline catalyst diastereoselective aldol condensation; arylidenerhodanine preparation green chem.

A simple and efficient synthesis of N-substituted 5-arylidene rhodanines was developed via aldol condensation of N-substituted rhodanines with aromatic aldehydes using L-proline as the catalyst in water at room temperature The attractive features of this protocol were simple exptl. procedures, cleaner reactions, column free, high yield and avoids the use of toxic solvents.

Asian Journal of Chemistry published new progress about Aldol condensation catalysts, stereoselective. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Recommanded Product: 3-Benzyl-2-thioxothiazolidin-4-one.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Kozikowski, Alan P.; Chen, Yufeng; Gaysin, Arsen; Chen, Bin; D’Annibale, Melissa A.; Suto, Carla M.; Langley, Brett C. published the artcile< Functional Differences in Epigenetic Modulators-Superiority of Mercaptoacetamide-Based Histone Deacetylase Inhibitors Relative to Hydroxamates in Cortical Neuron Neuroprotection Studies>, SDS of cas: 57493-24-0, the main research area is mercaptoacetamide derivative preparation structure histone deacetylase inhibitor neuroprotectant neuron.

The authors compare the ability of two structurally different classes of epigenetic modulators, namely, histone deacetylase (HDAC) inhibitors containing either a hydroxamate or a mercaptoacetamide as the zinc binding group, to protect cortical neurons in culture from oxidative stress-induced death. This study reveals that some of the mercaptoacetamide-based HDAC inhibitors are fully protective, whereas the hydroxamates show toxicity at higher concentrations The present results appear to be consistent with the possibility that the mercaptoacetamide-based HDAC inhibitors interact with a different subset of the HDAC isoenzymes [less activity at HDAC1 and 2 correlates with less inhibitor toxicity], or alternatively, are interacting selectively with only the cytoplasmic HDACs that are crucial for protection from oxidative stress.

Journal of Medicinal Chemistry published new progress about Neuron. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, SDS of cas: 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Singh, Kamaljit; Singh, Sarbjit; Taylor, John A. published the artcile< Monoazo disperse dyes-part 1: synthesis, spectroscopic studies and technical evaluation of monoazo disperse dyes derived from 2-aminothiazoles>, Application of C9H7N3O2S, the main research area is aminothiazole diazo aminoacetanilide coupling component disperse azo dye; polyester fabric disperse dyeing thiadiazole azo dye preparation.

Novel disperse dyes have been prepared from thiazolyl diazonium salts and coupling components based on m-aminoacetanilide derivatives Depending upon various substituents incorporated into the chromophore, absorption maxima varied from 495 to 591 nm in various organic solvents. These dyes were chromophorically strong as evidenced both by molar extinction coefficient in solvent and by strength and build-up on polyester.

Dyes and Pigments published new progress about Disperse azo dyes. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Application of C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Fahmy, H. T. Y.; Bekhit, A. A. published the artcile< Synthesis of some new bis-thiazoles as possible anticancer agents>, Reference of 10574-69-3, the main research area is rhodanine preparation antitumor agent.

Several new 5-(2,3-dihydrothiazol-2-ylidenyl)rhodanines I (R1 = Ph; R2 = Ph, 4-ClC6H4, 4-MeC6H4; R3 = H) and 5-(4-oxothiazolidinon-2-ylidenyl)rhodanine II were synthesized through the reaction of 5-thiocarbamoyl rhodanine III [R1 = Ph; R4 = C(S)NHPh] with phenacyl bromides or chloroacetic acid, resp. The synthesis of arylidenes IV (R5 = H, Cl, MeO) was also described. The 5-(4-amino-5-cyano-2,3-dihydrothiazol-2-ylidenyl)rhodanines I (R1 = Ph, CH2Ph; R2 = NH2; R3 = CN) were obtained through reaction of rhodanines III (R1 = Ph, CH2Ph; R4 = H) with a thiazolium salt. All the prepared compounds were screened for their anticancer activity using the in vitro anticancer screening program of the NCI. Three compounds showed promising anticancer activity against particular human cell lines used in the assay.

Pharmazie published new progress about Antitumor agents. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Reference of 10574-69-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lyashchuk, S. N.; Enya, V. I.; Doroshenko, T. F.; Skrypnik, Yu. G. published the artcile< Study of reaction routes in sulfonation of 2-aminothiazoles with chlorosulfonic acid>, HPLC of Formula: 57493-24-0, the main research area is thiazole amine sulfonation thermal isomerization thiazolesulfonic thiazolesulfamic acid preparation; charge distribution thiazole amine AM1 calculation sulfonation mechanism.

The sulfonation of 4-substituted 2-aminothiazoles with chlorosulfonic acid under mild conditions afforded primarily C-sulfonation product, 2-amino-5-thiazolesulfonic acids, which undergo thermal isomerization by heating in sulfuric acid into the corresponding stable 2-thiazolesulfamic acids. Reaction of 4-R-thiazole-2-amines (9-12) with ClSO3H gave 2-amino-4-R-thiazole-5-sulfonic acids (1-4; R = Me, 4-BrC6H4, 3-O2NC6H4, 4-ClC6H4); heating of 1-4 at 110° in concentrate H2SO4 gave 4-R-thiazole-2-sulfamic acids (5-8). Quantum chem. calculations at AM1 level revealed the presence of considerable neg. charge on the C-5 atom of the thiazole ring of 9-12, which accounts for the opposite sulfonation patterns for the aminothiazoles and aniline.

Russian Journal of Organic Chemistry published new progress about AM1 (molecular orbital method). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, HPLC of Formula: 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica