Zhang, Zhi-Hua’s team published research in Journal of Chemistry in 2018 | 57493-24-0

Journal of Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Quality Control of 57493-24-0.

Zhang, Zhi-Hua; Wu, Hong-Mei; Deng, Sai-Nan; Cai, Xiao-Yu; Yao, Yu; Mwenda, Muriira Cyrus; Wang, Jin-Yin; Cai, Dong; Chen, Yu published the artcile< Design, synthesis, and anticancer activities of novel 2-amino-4-phenylthiazole scaffold containing amide moieties>, Quality Control of 57493-24-0, the main research area is morpholinoacetamido thiazolylphenyl benzamide preparation anticancer activity.

Appropriately substituted 2-amino-4-phenylthiazole derivatives I (R = 3-CH3C6H4, 4-BrC6H4, 2-furyl, cyclohexyl, CH3OCH2, ClCH2, etc.) were designed and synthesized according to the structural characteriztics of crizotinib. The target compounds I were evaluated for their in vitro antiproliferative activity against A549, HeLa, HT29, and Karpas299 human cancer cell lines. Based on results of biol. studies, some of these compounds exhibited significant antiproliferative activity. Compound I (R = 3,4-Cl2C6H3) possessed outstanding growth inhibitory effects on the four cell lines, especially for HT29 cell with IC50 value of 2.01 μM. Along with the biol. assay data, a mol. docking study suggests that the target compounds were a potential inhibitor.

Journal of Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Quality Control of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Vagadia, F J’s team published research in Pharma Science Monitor in 2012 | 57493-24-0

Pharma Science Monitor published new progress about Antibacterial agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole.

Vagadia, F. J.; Bhuva, D. A.; Jiladia, M. A. published the artcile< Synthesis and antimicrobial evaluation of some novel substituted thiazole derivatives>, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is thiazole azetidinone preparation antibacterial antifungal.

2-Aminothiazoles were prepared by condensation reaction of acetophenones and thiourea. Subsequent reaction with aromatic aldehydes gave Schiff bases, which were were cyclized with ClCH2COCl and Et3N to yield 2-azetidinones. The synthesized compounds were screened for antibacterial (E. coli, S. aureus) and antifungal (C. albicans) activity by disk diffusion and showed weak to moderate activity.

Pharma Science Monitor published new progress about Antibacterial agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lu, Cuifen’s team published research in Canadian Journal of Chemistry in 2009-01-31 | 171877-39-7

Canadian Journal of Chemistry published new progress about Aldol condensation, stereoselective. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Category: thiazole.

Lu, Cuifen; Nie, Junqi; Yang, Guichun; Chen, Zuxing published the artcile< An improved synthesis of sitophilure>, Category: thiazole, the main research area is asym synthesis sitophilure aldol reaction chiral auxiliary.

The asym. synthesis of sitophilure (I) was carried out in 8 steps, with 42% overall yield and 97% enantiomeric excess from propionaldehyde. The synthesis relied on an approach employing an asym. acyl-thiazolidinethione propionate aldol reaction to establish two stereogenic centers.

Canadian Journal of Chemistry published new progress about Aldol condensation, stereoselective. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Category: thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Brito, Camila C Bitencourt’s team published research in Journal of Enzyme Inhibition and Medicinal Chemistry in 2019 | 57493-24-0

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about Leishmaniasis. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, HPLC of Formula: 57493-24-0.

Brito, Camila C. Bitencourt; Carneiro da Silva, Helder Vinicius; Brondani, Daci Jose; Rodolfo de Faria, Antonio; Ximenes, Rafael Matos; Mangueira da Silva, Ivanildo; de Albuquerque, Julianna F. C.; Castilho, Marcelo Santos published the artcile< Synthesis and biological evaluation of thiazole derivatives as LbSOD inhibitors>, HPLC of Formula: 57493-24-0, the main research area is thiazole derivative preparation LbSOD inhibitor Leishmaniasis; Leishmania; superoxide dismutase; thermal shift assay; thiazole derivatives.

Leishmaniasis is considered as one of the major neglected tropical diseases due to its magnitude and wide geog. distribution. Leishmania braziliensis, responsible for cutaneous leishmaniasis, is the most prevalent species in Brazil. Superoxide dismutase (SOD) belongs to the antioxidant pathway of the parasites and human host. Despite the differences between SOD of Leishmania braziliensis and human make this enzyme a promising target for drug development efforts. No medicinal chem. effort has been made to identify LbSOD inhibitors. Herein, we show that thermal shift assays (TSA) and fluorescent protein-labeled assays (FPLA) can be employed as primary and secondary screens to achieve this goal. Moreover, we show that thiazole derivatives bind to LbSOD with micromolar affinity.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about Leishmaniasis. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, HPLC of Formula: 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Kitir, Betul’s team published research in Tetrahedron in 2014-10-21 | 171877-39-7

Tetrahedron published new progress about Acylation. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Name: (S)-4-Benzylthiazolidine-2-thione.

Kitir, Betul; Baldry, Mara; Ingmer, Hanne; Olsen, Christian A. published the artcile< Total synthesis and structural validation of cyclodepsipeptides solonamide A and B>, Name: (S)-4-Benzylthiazolidine-2-thione, the main research area is cyclodepsipeptide solonamide A B total enantioselective synthesis antimicrobial; macrocycle virulence gene expression Staphylococcus aureus inhibitor cyclodepsipeptide; hydroxy acid stereoselective aldol reaction esterification acylation macrolactamization.

Microorganisms are an attractive source of new natural products with antimicrobial properties, and the marine environment constitutes a prolific resource of bioactive microorganisms. During a global research expedition (Galathea III), two depsipeptides, solonamide A and solonamide B, were isolated from the marine bacterium Photobacterium halotolerance and were found to inhibit virulence gene expression in the serious human pathogen, Staphylococcus aureus. They act by interfering with the agr quorum sensing system and show resemblance to the endogenous S. aureus quorum sensing peptide, autoinducing peptide I (AIP-I). To enable more comprehensive studies, we embarked on the chem. synthesis of solonamides A and B. The key synthetic steps were formation of the (R)-β-hydroxy-fatty-acids by stereoselective aldol reactions and a cyclative macrolactamization, which proceeded under highly dilute conditions. Thus, the first total syntheses of the solonamides corroborated the originally assigned structures, and by changing the stereochem. of the auxiliary in the aldol steps we gained access to the natural products as well as their β3-epimers.

Tetrahedron published new progress about Acylation. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Name: (S)-4-Benzylthiazolidine-2-thione.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Zhu, Yan-Ping’s team published research in Tetrahedron in 2012 | 57493-24-0

Tetrahedron published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Category: thiazole.

Zhu, Yan-Ping; Yuan, Jing-Jing; Zhao, Qin; Lian, Mi; Gao, Qing-He; Liu, Mei-Cai; Yang, Yan; Wu, An-Xin published the artcile< I2/CuO-catalyzed tandem cyclization strategy for one-pot synthesis of substituted 2-aminothiazole from easily available aromatic ketones/α,β-unsaturated ketones and thiourea>, Category: thiazole, the main research area is aminothiazole preparation thiourea aromatic ketone butenone cyclization.

A concise and efficient one-pot process from easily available Me ketones or unsaturated Me ketones and thiourea was developed for the synthesis of 2-aminothiazoles with I2/CuO as catalyst. The method gave the E-isomers of 4-ethenyl-2-aminothiazoles. All these target mols. were characterized by NMR, HRMS and IR spectra.

Tetrahedron published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Category: thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nath, J P’s team published research in Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry in 1981-07-31 | 57493-24-0

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Fungicides. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Safety of 2-Amino-4-(3-nitrophenyl)thiazole.

Nath, J. P.; Dash, Manjula; Satrusallya, S. C.; Mahapatra, G. N. published the artcile< Synthesis of some 7-substituted 8-hydroxyquinoline derivatives of thiazoles and oxazoles as potential pesticides>, Safety of 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is hydroxyquinoline fungicide bactericide pesticide preparation; aminomethylhydroxyquinoline thiazolyl oxazolyl; Mannich hydroxyquinoline.

Mannich reaction of 8-hydroxyquinoline with PhCHO and I (R = H, Cl, Br; R1 = Ph, 4-ClC6H4, 4-BrC6H4, 4-HOC6H4, 4-MeO(C6H4, 3-O2NC6H4, 4-O2NC6H4, 4-MeC6H4, α-,β-naphthyl; X = O, S) gave the title compounds (II). II showed bactericidal and fungicidal activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Fungicides. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Safety of 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

He, Bai’s team published research in Journal of Medicinal Chemistry in 2009-11-26 | 57493-24-0

Journal of Medicinal Chemistry published new progress about Enzyme functional sites. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Synthetic Route of 57493-24-0.

He, Bai; Velaparthi, Subash; Pieffet, Gilles; Pennington, Chris; Mahesh, Aruna; Holzle, Denise L.; Brunsteiner, Michael; van Breemen, Richard; Blond, Sylvie Y.; Petukhov, Pavel A. published the artcile< Binding Ensemble Profiling with Photoaffinity Labeling (BEProFL) Approach: Mapping the Binding Poses of HDAC8 Inhibitors>, Synthetic Route of 57493-24-0, the main research area is histone deacetylase HDAC8 photoaffinity labeling BEProFL.

A binding ensemble profiling with (f)photoaffinity labeling (BEProFL) approach that utilizes photolabeling of HDAC8 with a probe containing a UV-activated aromatic azide, mapping of the covalent modifications by liquid chromatog.-tandem mass spectrometry, and a computational method to characterize the multiple binding poses of the probe is described. By use of the BEProFL approach, two distinct binding poses of the HDAC8 probe were identified. The data also suggest that an “”upside-down”” pose with the surface binding group of the probe bound in an alternative pocket near the catalytic site may contribute to the binding.

Journal of Medicinal Chemistry published new progress about Enzyme functional sites. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Synthetic Route of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Komanova, E’s team published research in Journal of Chromatography in 1971 | 10574-69-3

Journal of Chromatography published new progress about Linear free energy relationship. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, SDS of cas: 10574-69-3.

Komanova, E.; Knoppova, V.; Koman, V.; Malinova, A. published the artcile< Gas chromatography of isothiocyanates and 3-substituted rhodanines>, SDS of cas: 10574-69-3, the main research area is retention time isothiocyanates; gas chromatog rhodanines.

Retention times in the gas chromatog. separation of 3-substituted alkyl- or arylrhodanines were 5.9 min higher than for the corresponding isothiocyanates, indicating a successful separation of a mixture of these compounds by gas-liquid chromatog. For example, the retention time observed for 4-ethoxyphenyl isothiocyanate was 18.03 min while that of 4-(ethoxyphenyl)-3-rhodanine (I) was 24.02 min. A plot of Hammett constants vs. retention times for 4-substituted isothiocyanates and 3-substituted rhodanines was not linear. Electron-releasing substituents shifted their retention times to lower values while electron-withdrawing substituents had the opposite effect.

Journal of Chromatography published new progress about Linear free energy relationship. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, SDS of cas: 10574-69-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Wu, Yikang’s team published research in Journal of Organic Chemistry in 2004-11-12 | 171877-39-7

Journal of Organic Chemistry published new progress about Aldol condensation, stereoselective. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, SDS of cas: 171877-39-7.

Wu, Yikang; Sun, Ya-Ping; Yang, Yong-Qing; Hu, Qi; Zhang, Qi published the artcile< Removal of thiazolidinethione auxiliaries with benzyl alcohol mediated by DMAP. [Erratum to document cited in CA141:295695]>, SDS of cas: 171877-39-7, the main research area is erratum acylthiazolidinethione benzyl alc substitution DMAP; benzyl ester preparation erratum; DMAP substitution mediator erratum.

All of the starting thiazolidine-thiones (compounds 1, 1′, 3, 5, 7, 9, 11, 13, 13′, 15, 17, 19, 21, 23, 27, and 29) are yellow oils, not colorless ones.

Journal of Organic Chemistry published new progress about Aldol condensation, stereoselective. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, SDS of cas: 171877-39-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica