Tag: M.W=200-250

Liang, Xiao; Fu, Huansheng; Xiao, Peng; Fang, Hao; Hou, Xuben published the artcile< Design, synthesis and biological evaluation of imidazolidine-2,4-dione and 2-thioxothiazolidin-4-one derivatives as lymphoid-specific tyrosine phosphatase inhibitors>, Name: 3-Benzyl-2-thioxothiazolidin-4-one, the main research area is thioxothiazolidinone preparation docking lymphoid tyrosine phosphatase inhibitor autoimmunity; imidazolidinedione preparation diastereoselective docking lymphoid tyrosine phosphatase inhibitor autoimmunity; Autoimmune diseases; Inhibitor; Lymphoid-specific tyrosine phosphatase.

Synthesized imidazolidine-2,4-dione derivatives I [R = carboxymethyl, Ph, benzyl, (4-carboxyphenyl)methyl, (4-phenylphenyl)methyl] and 2-thioxothiazolidin-4-one derivatives II (R1 = Bu, cyclohexyl, 2-chlorophenyl, thiazol-2-yl, etc.; R2 = carboxy, 4-carboxyphenyl, 2-carboxyeth-1-en-1-yl, etc.) as new LYP inhibitors were designed. Among them, the cinnamic acids-based inhibitors II [R1 = 2-methoxyphenyl, R2 = ((4-((1E)-2-carboxyeth-1-en-1-yl)phenyl)methyl)oxidanyl; R1 = 4-chlorophenyl, R2 = ((4-((1E)-2-carboxyeth-1-en-1-yl)phenyl)methyl)oxidanyl (III)] displayed good LYP inhibitory activities (IC50 = 2.85-6.95μM). Especially, the most potent inhibitor III was identified as competitive inhibitor (Ki = 1.09μM) and bind LYP reversibly. Meanwhile, III exhibited better selectivity over other phosphatases than known LYP inhibitor A15. Furthermore, compound III could regulate TCR associated signaling pathway in Jurkat T cell.

Bioorganic Chemistry published new progress about Aralkyl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Name: 3-Benzyl-2-thioxothiazolidin-4-one.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Roosta, Atefeh; Alizadeh, Abdolali; Rezaiyehraad, Reze; Khanpour, Mojtaba published the artcile< Efficient and Chemoselective Procedure for Conversion of Rhodanine Derivatives into 1,3-Thiazolidine-2,4-diones via 1,3-Dipolar Cycloaddition Reaction and Rearrangement Sequences>, Recommanded Product: 3-Benzyl-2-thioxothiazolidin-4-one, the main research area is thiazolidinedione preparation chemoselective; alkalinity arylidene rhodanine preparation cycloaddition rearrangement.

A chemoselective 1,3-dipolar cycloaddition reaction between 5-alkylidene- or 5-arylidene rhodanine derivatives I (R1 = n-Pr, n-Bu, allyl, Bn; R2 = Ph, COOMe, 4-chloropheny, 4-methylpheny, 4-bromopheny) and nitrile oxide generated in situ from dibromoformaldoxime to construct 1,3-thiazolidine-2,4-diones II scaffold under mild conditions was reported. This strategy exhibits a distinguished manner to afford thiazolidine derivatives II in a simple, rapid and practical route. The results proved that the reaction proceeds through an unpredictable rearrangement and no spirocyclic product is generated. The structures of the target mols. were confirmed by IR, 1H NMR, 13C NMR, mass spectra and unambiguously X-ray crystal structure anal.

ChemistrySelect published new progress about 1,3-Dipolar cycloaddition reaction (chemoselective). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Recommanded Product: 3-Benzyl-2-thioxothiazolidin-4-one.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Knoppova, V.; Antos, K.; Drobnica, L.; Kristian, P. published the artcile< Isothiocyanates. XXX. Synthesis, ultraviolet, and infrared spectra of 3-substituted rhodanines>, Application of C10H9NOS2, the main research area is rhodanine derivative IR UV.

Twenty-five rhodanine derivatives I (R = Me, Bu, p-BrC6H4, Ph, p-MeC6H4, 1-naphthyl, etc.) were prepared by treating the appropriate RNHCS2- or RNCS with ClCH2CO2H and HSCH2CO2H, resp. The products were characterized by uv absorptions at ∼250 and ∼290 nm, and an ir signal at 1725-1728 cm-1. The effect of substituents on the spectra was discussed.

Chemicke Zvesti published new progress about IR spectra. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Application of C10H9NOS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Muthal, Bn published the artcile< Transition metal ion CoII, NiII, CuII & ZnII complexes of tridentate ligands (NNO) their synthesis, characterization and biological activities>, Formula: C9H7N3O2S, the main research area is nitrophenylthiazole hydroxybenzylideneimine transition metal Schiff base preparation antibacterial antifungal.

A series of new Schiff bases were synthesized by combination of 4(-3-nitrophenyl) thiazol-2-amine with hydroxy aldehyde (R-H, 5CH3 and 5Cl). Schiff bases and their transition metal complexes where characterized by elemental anal., UV-visible, IR spectra, magnetic susceptibility and conductivity measurement. The transition metal complexes are monomeric and 1:2 stoichem. having octahedral geometry. The ligands coordinated through oxygen atom of phenolic -OH group and also from thiazole ring nitrogen. The Schiff bases and their metal complexes were screen for antibacterial and antifungal activity.

Pharma Innovation published new progress about Antibacterial agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Formula: C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Delaunay, Dominique; Toupet, Loiec; Corre, Maurice Le published the artcile< Reactivity of β-Amino Alcohols with Carbon Disulfide Study on the Synthesis of 2-Oxazolidinethiones and 2-Thiazolidinethiones>, Safety of (S)-4-Benzylthiazolidine-2-thione, the main research area is oxazolidinethione thiazolidinethione preparation.

Reaction of carbon disulfide with β-amino alcs. was examined to determine parameters directing the cyclization to oxazolidinethiones or thiazolidinethiones. By operating in mild conditions, i.e. in a low alk. medium, for a limited reaction time and in the presence of a stoichiometric quantity of CS2, oxazolidinethiones were preferentially obtained. On the other hand, thiazolidinethiones were prepared under drastic conditions by operating in a more basic medium, with an excess of CS2 and for a long reaction time. The formation of thiazolidinethiones occurred with an inversion of configuration of the carbon bearing the oxygen; furthermore, conversion of oxazolidinethiones into thiazolidinethiones was in some cases possible.

Journal of Organic Chemistry published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Safety of (S)-4-Benzylthiazolidine-2-thione.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

L’abbe, Gerrit; Yu, Chih-Chou published the artcile< Trapping of thiaziridinimines with thiocarbonyl compounds>, Formula: C10H9NOS2, the main research area is thiaziridinimine thiocarbonyl trap; dithiazolidine spirothiazolidine; thiazolidine spirodithiazolidine; thiatriazoline thermolysis; dithiazolidinimine.

Thermolysis of 4-benzyl-5-tosylimino-1,2,3,4-thiatriazoline (I; Ts = 4-MeC6H4SO2) at 60-70° in the presence of representative C=S unsaturated compounds furnished 1,2,4-dithiazolidin-5-imines in moderate yields. An intermediate unstable thiaziridinimine which is trapped by the C=S compound in a regiospecific manner is postulated. Among the thiocarbonyl compounds used are p,p’-dimethoxythiobenzophenone, xanthates and 3-benzylrhodanine, the latter giving a spiro adduct II.

Journal of Heterocyclic Chemistry published new progress about 10574-69-3. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Formula: C10H9NOS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Qi, Qingqing; Shen, Qilong; Lu, Long published the artcile< Polyfluoroalkylation of 2-aminothiazoles>, Product Details of C9H7N3O2S, the main research area is thiazolamine polyfluoroalkylation.

An efficient, highly selective method for polyfluoroalkylation of 2-aminothiazole derivatives is described. Interestingly, defluorinated 2-amino-5-(1,1,1,3,3,3-hexafluoroprop-2-yl)thiazole derivative was obtained in moderate yields when 2-aminothiazole was reacted with (CF3)2CFI.

Journal of Fluorine Chemistry published new progress about Fluoroalkylation. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Product Details of C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Rezania, Hamidreza published the artcile< Synthesis and characterization of novel functional hyperbranched polyamides from AB2 units: effect of extra functional groups>, Name: 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is hyperbranched polyamide preparation thermal property; Novel AB2 monomers; functional groups; hyperbranched polymers; polyamide.

Hyperbranched polymers (HPs), which in terms of structure may be compared to the branching structure of trees, are referred to as tree-like materials, but role of leave in these tree-like polymers is neglected and much attention has only been paid to their branches. In fact, functional groups in these polymers play a vital role the same as the role of leaves in trees. Therefore, in this paper, an attempt has been made to design and synthesize three AB2 monomers containing extra hydroxyl and nitro groups. The benefits of their presence in the structure of produced hyperbranched polyamides (HPs) are investigated. The polymer structure was characterized by FT-IR and 1 H NMR. The solubility of synthesized HPs was studied in different protic and aprotic solvents. The thermal stability of the prepared HPs was investigated by thermogravimetric and differential scanning calorimetric analyses. The photoluminescent properties of the HPs were also investigated.

Designed Monomers and Polymers published new progress about Branched polymers Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Name: 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Crimmins, Michael T.; Christie, Hamish S.; Hughes, Colin O. published the artcile< Synthesis and diastereoselective aldol reactions of a thiazolidinethione chiral auxiliary>, Category: thiazole, the main research area is thiazolidinethione chiral auxiliary; propanoyl thiazolidinethione syn aldol.

Thiazolidinethione chiral auxiliary I (R = H) is prepared from (S)-phenylalaninol and carbon disulfide. Propanoylated I [R = C(O)CH2CH3] can be used for either Evans syn aldol reactions or non-Evans syn aldol reactions with a variety of aldehydes, in good yield with good stereoselectivity.

Organic Syntheses published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Category: thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Yan, Gang; Hao, Lina; Niu, Yan; Huang, Wenjie; Wang, Wei; Xu, Fengrong; Liang, Lei; Wang, Chao; Jin, Hongwei; Xu, Ping published the artcile< 2-Substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamides as BACE1 inhibitors: Synthesis, biological evaluation and docking studies>, Application In Synthesis of 57493-24-0, the main research area is thiazolyl imidazolyl acetamide preparation mol docking BACE1 inhibitor human; Alzheimer’s disease; BACE-1 inhibitors; BBB; Docking study; PAMPA; Permeability; Surface Plasmon Resonance (SPR).

In this work, a series of 2-substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamide derivatives, I (R1 = Ph, 4-MeC6H4, 2-O2NC6H4, etc.; R2 = 2-MeOC6H4,3-MeOC6H4, 4-MeOC6H4, 3-EtOC6H4), II (R3 = Ph, 3,5-Cl2-4-NH2Ph; R4 = 3-MeOPh, 3-EtOPh), were developed as β-secretase (BACE-1) inhibitors. Supported by docking study, a small library of derivatives were designed, synthesized and biol. evaluated in vitro. In addition, the selected compounds were tested with affinity (KD) towards BACE-1, blood brain barrier (BBB) permeability and cytotoxicity. The studies revealed that the most potent analog II (R3 = Ph; R4 = 3-EtOC6H4) (IC50 = 4.6 μM) with high predicted BBB permeability and low cellular cytotoxicity, could serve as a good lead structure for further optimization.

European Journal of Medicinal Chemistry published new progress about Alzheimer disease. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Application In Synthesis of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica