Tag: M.W=200-250

Kharidia, S. P.; Trivedi, J. J. published the artcile< Synthesis of 3-(substituted benzyl)-5-alkylrhodanines>, Related Products of 10574-69-3, the main research area is .

Preparation of benzylamines and benzylammonium dithiocarbamates (not isolated) and their condensation with α-halo fatty acids were carried out according to Raval and T. (CA 57, 12465h) to give the tabulated I (m.ps. shown). I showed no antifungal, antibacterial, or antiprotozoal activity.

Journal of the Indian Chemical Society published new progress about 10574-69-3. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Related Products of 10574-69-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Banerjee, Janmajoy; Mariappan, G.; Nepal, Aswini Kumar; Dahal, Prassana; Khanal, Hemanta published the artcile< Conventional methods of synthesis of novel amino(phenyl)thiazoles and their antibacterial and local anesthetics screening>, Synthetic Route of 57493-24-0, the main research area is acetamide thiazolylamino preparation anesthetic antibacterial.

Cyclocondensation of thiourea and substituted acetophenones RCOMe [R = Ph, 3-O2NC6H4, 4-O2NC6H4, 4-MeOC6H4, 2,5-(MeO)2C6H3] led to the formation of the corresponding 2-amino-4-R-thiazoles, which on further reaction with N-Ph 2-chloroacetamide gave N-Ph (thiazolylamino)acetamides I. The synthesized compounds I were investigated for their antibacterial activity by cup plate method against four bacterial strains. All the synthesized compounds exhibited mild to good antibacterial activities with I [R = 2,5-(MeO)2C6H3] showing promising activity against all strains of bacteria. The compounds I were also screened for local anesthetics activity taking lidocaine as standard, and all the compounds showed moderate activities.

International Journal of Pharmacy and Technology published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Synthetic Route of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Zaveri, Mehul; Kawathekar, Neha published the artcile< Synthesis, characterization and antimalarial activity of some new 3-benzyl-2-thioxothiazolidin-4-one derivatives>, Category: thiazole, the main research area is benzyl thioxothiazolidinone preparation antimalarial.

In present investigation, a series of new 3-benzyl-2-thioxothiazolidin-4-one I (Ar = Ph, 2-pyrrolyl, 4-pyridyl, etc.) derivatives, have been synthesized using conventional and microwave-assisted technique. These compounds were evaluated for in-vitro antimalarial activity by microdilution technique against resistance strains of Plasmodium falciparum. The result of antimalarial activity revealed that six compounds I (Ar = Ph, 2-furanyl, 2-pyridyl, 4-pyridyl, 4-Me2NC6H4, 2-HOC6H4) exhibited IC50 values ranging from 0.8-1.2 μg/mL, four compounds I (Ar = 4-ClC6H4, 4-FC6H4, 2-indolyl, 3-O2NC6H4) displayed antimalarial activity IC50 values in the range of 0.7-0.8 μg/mL. Compound I (Ar = 2-pyrrolyl) showed most significant result with maximum IC50 value of 0.7 μg/mL, thus it could be identified as structural lead for further development of new antimalarial agents.

International Journal of Pharmacy and Pharmaceutical Research published new progress about Antimalarials. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Category: thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Shvets, A. A.; Nelyubina, Yu. V.; Lyssenko, K. A.; Kurbatov, S. V. published the artcile< Synthesis of bis-spiro-fused thiapyrrolizidinooxindoles by 1,3-dipolar cycloaddition>, Product Details of C10H9NOS2, the main research area is thiaproline azomethine ylide arylidenerhodanine regioselective diastereoselective dipolar cycloaddition; spiro thiapyrrolizidine oxindole regioselective diastereoselective preparation.

The 1,3-dipolar cycloaddition of an unstabilized azomethine ylide, generated in situ from isatin and thiaproline, to arylidene derivatives of rhodanine affords bis-spiro-fused thiapyrrolizidinooxindoles. The 1,3-dipolar addition reactions under consideration are fully regio- and diastereoselective.

Russian Chemical Bulletin published new progress about 1,3-Dipolar cycloaddition reaction (stereoselective). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Product Details of C10H9NOS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Devi, N. S.; Devi, Nirada published the artcile< Catalyst-free aldol reaction of N-substituted rhodanines on aqueous media>, Quality Control of 10574-69-3, the main research area is rhodanine aryl aldehyde aldol reaction green chem water.

Herein, aldol reaction of N-substituted rhodanines and aromatic aldehydes on water is described. The reaction was performed at room temperature affording the products I (R1 = Me, Ph, PhCH2, 4-MeOC6H4CH2; R2 = 4-ClC6H4, 2-O2NC6H4, 3-O2NC6H4, 4-O2NC6H4, 4-NCC6H4) in good to high yields. This synthetic protocol uses simple exptl. procedures, is catalyst-free, and avoids the use of highly toxic solvents.

Journal of Chemical Sciences (Berlin, Germany) published new progress about Aldol addition. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Quality Control of 10574-69-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Takeda, Norihiko; Taguchi, Tomoyo; Nakajima, Takeshi; Azuma, Mitsuyoshi published the artcile< Design, synthesis and biological activity evaluation of thiazolidinones containing alkynyl and alkenyl furans for disrupting protein-protein interactions between HIF-1α and p300>, Reference of 10574-69-3, the main research area is thiazolidinone furanylidene preparation HIF1alpha p300 interaction inhibitor.

Based on the structure of the potent hypoxia-inducible factor (HIF) inhibitor, a novel series of furanylidene thiazolidinones I (R1 = trimethylsilylethynyl, triethylsilylethynyl, cyclopropylethynyl, etc.; R2 = C6H5,CH2NMe2, CH2C6H5, etc.) were designed and synthesized using Sonogashira or Suzuki-Miyaura cross-couplings, and subsequent Knoevenagel condensation. In particular, derivatives I (R1 = trimethylsilylethynyl, t-butylethynyl, cyclopropylethynyl, t-butylethenyl, cyclopropylethenyl; R2 = C6H5,CH2(4-methylpiperazin-1-yl)) bearing an alkynyl or alkenyl group on the furan ring, exhibited four- to five-fold higher activities than II. These potent compounds will serve as leads for the development of novel small mols. for targeting the HIF-1α/p300 complex.

Heterocycles published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Reference of 10574-69-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nitsche, Christoph; Schreier, Verena N.; Behnam, Mira A. M.; Kumar, Anil; Bartenschlager, Ralf; Klein, Christian D. published the artcile< Thiazolidinone-Peptide Hybrids as Dengue Virus Protease Inhibitors with Antiviral Activity in Cell Culture>, Application of C10H9NOS2, the main research area is thiazolidindione rhodanine peptide preparation antiviral dengue virus protease inhibitor.

The protease of dengue virus is a promising target for antiviral drug discovery. We here report a new generation of peptide-hybrid inhibitors of dengue protease that incorporate N-substituted 5-arylidenethiazolidinone heterocycles (rhodanines and thiazolidinediones) as N-terminal capping groups of the peptide moiety. The compounds were extensively characterized with respect to inhibition of various proteases, inhibition mechanisms, membrane permeability, antiviral activity, and cytotoxicity in cell culture. A sulfur/oxygen exchange in position 2 of the capping heterocycle (thiazolidinedione-capped vs rhodanine-capped peptide hybrids) has a significant effect on these properties and activities. The most promising in vitro affinities were observed for thiazolidinedione-based peptide hybrids containing hydrophobic groups with Ki values between 1.5 and 1.8 μM and competitive inhibition mechanisms. Rhodanine-capped peptide hybrids with hydrophobic substituents have, in correlation with their membrane permeability, a more pronounced antiviral activity in cell culture than the thiazolidinediones.

Journal of Medicinal Chemistry published new progress about Antiviral agents. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Application of C10H9NOS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Baiget, Jessica; Cosp, Annabel; Galvez, Erik; Gomez-Pinal, Loreto; Romea, Pedro; Urpi, Felix published the artcile< On the influence of chiral auxiliaries in the stereoselective cross-coupling reactions of titanium enolates and acetals>, Computed Properties of 171877-39-7, the main research area is acylthiazolidinethione titanium enolate coupling acetal.

Titanium enolates from chiral N-propanoyl-1,3-thiazolidine-2-thiones containing bulky substituents at C-4 turned out to be excellent platforms to get highly stereocontrolled cross-coupling reactions with acetals. Related oxazolidinethiones also afforded good results, but the corresponding oxazolidinones were completely unselective for such reactions, which proves that an exocyclic C=S bond is essential to attain a synthetically useful stereocontrol.

Tetrahedron published new progress about Acetals Role: RCT (Reactant), RACT (Reactant or Reagent). 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Computed Properties of 171877-39-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Wang, Xingyi; Zhu, Yue; Zhou, Tingting; Yang, Weiqing; Fu, Haiyan; Chen, Hua; Ma, Menglin published the artcile< Bromine-Mediated C-S Bond Formation: Synthesis of Thiazoles from α-Methylene Ketones by Using Oxone Oxidative System>, SDS of cas: 57493-24-0, the main research area is ethanone methanethioamide sodium bromide catalyst one pot bromination heterocyclization; thiazole preparation.

A novel method for the synthesis of various 2,4,5-trisubstituted thiazoles from methylketones and thiourea/thioacetamide/amidinothiourea using NaBr/Oxone oxidative system was developed. The three intimately connected advantages of this method, which form a whole, are that the reaction underwent a one-pot α-bromination/cyclization process, the use of more common methylene ketones as the raw material rather than α-halomethylene ketones and a cheap and easily available catalytic amount sodium bromide as the bromine source instead of stoichiometric bromine or NBS.

ChemistrySelect published new progress about C-S bond formation. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, SDS of cas: 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Skaanderup, Philip R.; Jensen, Thomas published the artcile< Synthesis of the Macrocyclic Core of (-)-Pladienolide B>, Product Details of C10H11NS2, the main research area is pladienolide B macrocyclic core stereoselective preparation.

An efficient synthesis of the macrocyclic core (I) of (-)-pladienolide B is disclosed. The concise route relies on a chiral auxiliary-mediated asym. aldol addition and an osmium-catalyzed asym. dihydroxylation to install the three oxygenated stereocenters of the macrocycle. This purely reagent-controlled and flexible strategy sets the stage for future analog syntheses and structure-activity relationship plotting of the appealing anticancer lead structure pladienolide B.

Organic Letters published new progress about Aldol addition, stereoselective. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Product Details of C10H11NS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica