Tag: M.W=200-250

Reshi, Noor U. Din; Kathuria, Lakshay; Samuelson, Ashoka G. published the artcile< Chemoselective Reduction of Imines Catalyzed by Ruthenium(II) Half-Sandwich Complexes: A Mechanistic Study>, Product Details of C10H11NS2, the main research area is reduction imine hydrosilane ruthenium catalyst mechanism preparation amine; ruthenium cymene half sandwich catalyst hydrosilane reduction imine; potential energy surface reduction imine hydrosilane ruthenium catalyst.

Ruthenium half-sandwich complexes ligated to chiral 2-oxazolidinethiones or 2-thiazolidinethiones have been examined in the reduction of N-benzylideneaniline using silyl hydrides as reductants. The chemoselective reduction of imines takes place under mild conditions to afford the corresponding amines in nearly quant. yield. Mechanistic studies indicate that dissociation of the ancillary ligands generate the active catalyst in all the complexes studied, which is the same species generated by [Ru(p-cymene)(Cl)2]2 under the reaction conditions. This results in the formation of a single catalytic species irresp. of the starting half-sandwich complex. Detailed mechanistic studies involving trapping of intermediates, in situ studies using mass spectrometry and NMR spectroscopy were carried out using the active catalyst generated by [Ru(p-cymene)(Cl)2]2. The mechanism of the reaction is dependent on the number of the hydrogen atoms in the reducing silane. The reaction proceeds via Gade-Hoffman pathway or Zheng-Chan pathway when a dihydro or trihydrosilane is the reductant. However, the use of a monohydrosilane, leads to longer reaction times presumably due to a change in the reaction pathway.

European Journal of Inorganic Chemistry published new progress about Amines Role: SPN (Synthetic Preparation), PREP (Preparation). 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Product Details of C10H11NS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Tapadar, Subhasish; He, Rong; Luchini, Doris N.; Billadeau, Daniel D.; Kozikowski, Alan P. published the artcile< Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: Effects on HDAC biology and antiproliferative activity>, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is histone deacetylase inhibitor preparation isoxazole moiety linker antitumor.

A series of hydroxamic acid based histone deacetylase inhibitors 6-15, containing an isoxazole moiety adjacent to the Zn-chelating hydroxamic acid, is reported herein. Some of these compounds showed nanomolar activity in the HDAC isoform inhibitory assay and exhibited micromolar inhibitory activity against five pancreatic cancer cell lines.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Andrade, Carlos Kleber Z.; Rocha, Rafael O.; Vercillo, Otilie E.; Silva, Wender A.; Matos, Ricardo Alexandre F. published the artcile< DCC/DMAP-mediated coupling of carboxylic acids with oxazolidinones and thiazolidinethiones>, Computed Properties of 171877-39-7, the main research area is DCC DMAP mediated coupling carboxylic acid oxazolidinone thiazolidinethione; acylation oxazolidinone thiazolidinethione DMAP catalyst dicyclohexylcarbodiimide reagent.

Dicyclohexylcarbodiimide and catalytic dimethylaminopyridine were successfully used in the coupling of carboxylic acids with oxazolidinones and thiazolidinethiones. The acylated products were obtained in good yields.

Synlett published new progress about Acylation. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Computed Properties of 171877-39-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Chen, Ning; Du, Hongguang; Liu, Weidong; Wang, Shanshan; Li, Xinyao; Xu, Jiaxi published the artcile< Synthesis and Fungicidal Activity of Simple Structural 1,3-Thiazolidine-2-Thione Derivatives>, Category: thiazole, the main research area is vicinal aminoalc carbon disulfide cyclization coupling; thiazolidinethione preparation SAR antifungal activity.

A series of simple structural 1,3-thiazolidine-2-thione derivatives I and II [R1 = H, (s)-Me, (s)-Ph, etc; R2 = H, Me, (s)-Ph] with various substituents on the S-, N-, 4-, and 5-positions was synthesized with high yields from various vicinal amino alcs. via two steps and screened for their antifungal activity. Bioassay results reveal that some thiazolidine-2-thione derivatives show strong antifungal activities against P. capsici, G. zeae, S. sclerotiorum, A. alternata, B. cinerea, or R. solani. The SAR anal. indicates that N-acyl substituted and 4-alkyl substituents can enhance the antifungal activity. Notably, I [R1 = (s)-iPr, R2 = H] shows excellent activity against B. cinerea and G. zeae with IC50 values at 3.7 μg/mL and 6.5 μg/mL, resp., and I [ R1 = (s)-iBu, R2 = H] shows remarkable fungicidal activity against R. solani, S. sclerotiorum, and G. zeae with IC50 values at 1.0 μg/mL, 12.1 μg/mL, and 11.0 μg/mL, resp.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Category: thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Rinaldi, Marta; Tintori, Cristina; Franchi, Luigi; Vignaroli, Giulia; Innitzer, Anna; Massa, Silvio; Este, Jose A.; Gonzalo, Encarna; Christ, Frauke; Debyser, Zeger; Botta, Maurizio published the artcile< A Versatile and Practical Synthesis toward the Development of Novel HIV-1 Integrase Inhibitors>, Safety of 3-Benzyl-2-thioxothiazolidin-4-one, the main research area is preparation antiviral HIV1 integrase inhibitor.

As a continuation of our previous work, which resulted in the identification of a new hit compound as an HIV-1 integrase inhibitor, three novel series of salicylic acid derivatives were synthesized using three versatile and practical synthetic strategies and were assayed for their capacity to inhibit the catalytic activity of HIV-1 integrase. Biol. evaluations revealed that some of the synthesized compounds possess good inhibitory potency in enzymic assays and are able to inhibit viral replication in MT-4 cells at low micromolar concentrations Finally, docking studies were conducted to analyze the binding mode of the synthesized compounds within the DNA binding site of integrase in order to refine their structure-activity relationships.

ChemMedChem published new progress about Antiviral agents. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Safety of 3-Benzyl-2-thioxothiazolidin-4-one.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Kamble, Sonali S.; Hese, Shrikant V.; Dawane, Bhaskar S.; Gacche, Rajesh N. published the artcile< Anti-breast cancer and antiangiogenic potential of substituted thiazolo[2,3-b] quinazoline derivatives: synthesis, in vitro and in vivo analysis>, Safety of 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is thiazolo quinazoline derivative antibreast cancer antiangiogenic potential.

Herein, a series of novel substituted thiazolo[2,3-b]quinazoline derivatives has been synthesized. The capability of the synthesized compounds 3a-i to hinder the viability of human breast cancer cell line (MCF-7) was assessed. The compounds were evaluated as possible inhibitors of angiogenesis by using in vivo chorioallantoic membrane (CAM) model. Amongst the compounds 3a-i screened, 3d and 3f exhibited excellent cytotoxicity with IC50 values 6.0±0.03μM & 5.0±0.36μM resp. Compounds were further tested to evaluate potential to inhibit the pro-angiogenic cytokines associated with tumor development. Both the compounds were found to be potent antiangiogenic agents against VEGF, TNFa, IL6, TGFb, and EGF. The outcome of the present study reveals that, compound 3d and 3f showed the promising inhibitory activity on the viability of MCF-7 cells. In the in vivo CAM model, treatment with all the compounds resulted in the significant decrease in blood vessels d. The findings of the study suggest that, compounds 3d & 3f may act as potential anti-breast cancer and antiangiogenic agents.

Chemistry & Biology Interface published new progress about Angiogenesis. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Safety of 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Din Reshi, Noor U.; Senthurpandi, Dineshchakravarthy; Samuelson, Ashoka G. published the artcile< Asymmetric transfer hydrogenation of ketones using Ru(0) nanoparticles modified by Chiral Thiones>, Electric Literature of 171877-39-7, the main research area is ketone asym transfer hydrogenation; oxazolidinethione thiozolidinethione ruthenium half sandwich complex catalyst preparation.

The catalytic asym. transfer hydrogenation (ATH) of acetophenone in isopropanol by Ru(0) nanoparticles (NPs) obtained by the in-situ reduction of Ru(II) half-sandwich complexes of chiral 2-oxazolidinethiones and 2-thiozolidinethiones was examined and compared with the catalytic activity of Ru(0) NPs formed in-situ by the reduction of [Ru(p-cymene)(Cl)2]2 in presence of optically active ligands such as (S)-4-isobutylthiazolidine-2-thione, (S)-4-isopropyl-2(-2-pyridinyl)-2-oxazoline, (8S, 9R)-(-)-cinchonidine, (S)-leucinol, (S)-phenylalaninol, and (S)-leucine. Three of the best catalytic systems were then examined for ATH of thirteen aromatic ketones with different electronic and steric properties. A maximum of 24% ee was obtained using NPs generated from the Ru (II) half-sandwich complex with (S)-4-isobutylthiazolidine-2-thione in the TH of acetophenone. The NPs were characterized by TEM and DLS measurements. Kinetic studies and poisoning experiments confirmed that the reaction is catalyzed by the chiral NPs formed in-situ. Complete characterization of the complexes, including the X-ray crystallog. characterization of two complexes, was also carried out.

Applied Organometallic Chemistry published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Electric Literature of 171877-39-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Vydzhak, R. N.; Brovarets, V. S.; Pil’o, S. G.; Drach, B. S. published the artcile< Synthesis and Transformations of Two Types of 4-Phosphorylated Aldehydes of the Oxazole Series>, Name: 3-Benzyl-2-thioxothiazolidin-4-one, the main research area is formylpiperidinyloxazolyl phosphonate preparation; formyloxazolyl phosphonate preparation; piperidinyl formyloxazolyl phosphonate preparation; morpholinyl formyloxazolyl phosphonate preparation; phosphonium oxothiazolylideneoxazolyl preparation; thiazolylhydrazonooxazolyl phosphonate preparation.

The reaction of 2,2-dichloro-N-(1,2,2,2-tetrachloroethyl)acetamide with trialkyl phosphites and triphenylphosphine gave [2,2-dichloro-1-[(dichloroacetyl)amino]ethenyl]triphenylphosphonium chloride and [2,2,2-trichloro-1-(dichloroacetyl)amino]phosphonic acid di-Me ester and [2,2,2-trichloro-1-(dichloroacetyl)amino]phosphonic acid di-Et ester. Cyclocondensation of the latter in the presence of amines gave [2-formyl-5-(1-piperidinyl)-4-oxazolyl]phosphonic acid di-Me ester (I), [2-formyl-5-(1-piperidinyl)-4-oxazolyl]phosphonic acid di-Et ester (II) and [2-formyl-5-(4-morpholinyl)-4-oxazolyl]phosphonic acid di-Me ester (III) and [2-formyl-5-(4-morpholinyl)-4-oxazolyl]phosphonic acid di-Et ester (IV). Their structure of products was determined by spectroscopy and also by chem. transformations into phenylhydrazones, thiosemicarbazones, aminals, and other functional derivatives of I-IV.

Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) published new progress about Condensation reaction. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Name: 3-Benzyl-2-thioxothiazolidin-4-one.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Condon, F. E.; Shapiro, D.; Sulewski, P.; Vasi, I.; Waldman, R. published the artcile< Facile and uniform procedure for the large-scale preparation of some N-alkylrhodanines>, Synthetic Route of 10574-69-3, the main research area is rhodanine alkyl; chloroacetic acid thiocarbamate cyclization.

3-Methyl-, ethyl-, allyl-, and benzylrhodanine were prepared by treating the appropriate primary amine with CS2 in the presence of NH3 and the resulting ammonium alkyldithiocarbamate with ClCH2CO2H.

Organic Preparations and Procedures International published new progress about 10574-69-3. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Synthetic Route of 10574-69-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Shah, Mayuri Nilesh; Joshi, Vidya published the artcile< Synthesis of substituted N-(3,5-dimethoxyphenyl/ styryl)-N1-(thiazol-2-yl)ureas>, SDS of cas: 57493-24-0, the main research area is thiazolylurea styryl dimethoxyphenyl; urea thiazolyl.

4-Substituted 2-aminothiazoles, obtained by condensation of substituted ω-bromoacetoketones with thiourea, on reaction with 3,5-dimethoxyphenyl isocyanate gave new N-(3,5-dimethoxyphenyl)-N1-(4-substituted thiazol-2-yl)ureas, e.g. I. Similarly, the 4-substituted 2-aminothiazoles on treatment with styryl isocyanate gave N-styryl-N1-(4-substituted thiazol-2-yl)ureas, e.g. II.

Indian Journal of Heterocyclic Chemistry published new progress about 57493-24-0. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, SDS of cas: 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica