Tag: M.W=200-250

Mandal, Subhankar P.; Mithuna; Garg, Aakriti; Sahetya, Sanjana S.; Nagendra, S. R.; Sripad, H. S.; Manjunath, Mendon Manisha; Sitaram; Soni, Mukesh; Baig, R. Nasir; Kumar, S. Vasanth; Kumar, B. R. Prashantha published the artcile< Novel rhodanines with anticancer activity: design, synthesis and CoMSIA study>, COA of Formula: C10H9NOS2, the main research area is rhodanine anticancer agent breast cancer cell QSAR.

Three different series of some novel N-substituted rhodanines were designed for anticancer activity and prepared from the corresponding dithiocarbamates. The synthesized compounds were analyzed by IR, NMR and MASS to confirm their structures. All the titled compounds were found to be of Z configuration based on NMR spectral anal. All the synthesized rhodanines were screened for in vitro anticancer activity against MCF-7 breast cancer cells at the concentration of 10 μg. The compounds showed moderate to significant cytotoxicity. Amongst them, interestingly, compounds 10, 22 and 33 with cinnamoyl substitution at the 5th position of the thiazolidine ring system showed significant activity. Further, we subjected all these compounds to a CoMSIA study to study their 3D quant. structure activity relationships (3D QSAR). The illustration about the design of novel rhodanines, synthesis, anal., activity against MCF-7 cells and SAR via CoMSIA study are reported here.

RSC Advances published new progress about Antitumor agents. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, COA of Formula: C10H9NOS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Zhang, Xiaolin; Yang, Hongxia Ou; Ding, Yonghong published the artcile< The synthesis and characterization of potential novel active compounds, 2-aminothiazole derives Schiff bases>, Safety of 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is aromatic ketone thiourea cyclocondensation; aminothiazole preparation condensation aryl aldehyde; Schiff base preparation.

Some 4-substituted-2-aminothiazoles were prepared starting from aromatic ketones and thiourea in the presence of powered iodine. Then treating 4-substituted-2-aminothiazole with substituted benzaldehyde gave corresponding 2-aminothiazole derivatives Schiff bases in good yield.

Advanced Materials Research (Durnten-Zurich, Switzerland) published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (heteroaryl). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Safety of 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Gundala, Trivikram Reddy; Godugu, Kumar; Nallagondu, Chinna Gangi Reddy published the artcile< Citric Acid-catalyzed Synthesis of 2,4-Disubstituted Thiazoles from Ketones via C-Br, C-S, and C-N Bond Formations in One Pot: A Green Approach>, Name: 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is citric acid thiazole ketone chromatog one pot synthesis.

An improved and greener protocol has been developed for the synthesis of 2,4-disubstituted thiazoles via C-Br, C-S, and, C-N bond formations in a single step from readily available ketones, N-bromosuccinimide (NBS), and thiourea catalyzed by citric acid in a mixture of ethanol and water (3:1) under reflux conditions. This method has the advantages of freedom from the isolation of lachrymatory α-bromoketones, ease of carrying out, cleaner reaction profile, broad substrate scope, freedom from chromatog. purification, and suitability for large-scale synthesis.

Journal of the Chinese Chemical Society (Weinheim, Germany) published new progress about Chromatography. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Name: 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Bursavich, Matthew G.; Gilbert, Adam M.; Lombardi, Sabrina; Georgiadis, Katy E.; Reifenberg, Erica; Flannery, Carl R.; Morris, Elisabeth A. published the artcile< Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2)>, Synthetic Route of 10574-69-3, the main research area is thioxothiazolidinone preparation aggrecanase inhibitor SAR.

5-Benzylidene-2-thioxo-thiazolidin-4-one inhibitors of ADAMTS-5 (Aggrecanase-2) have been prepared via com. available starting materials. The identified compounds show micromolar ADAMTS-5 potency and demonstrate SAR trends for both the aryl group and thioxothiazolidinone zinc chelator. This series of compounds represents steps toward a metalloprotease inhibitor as a disease-modifying osteoarthritis drug.

Bioorganic & Medicinal Chemistry Letters published new progress about Antiarthritics. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Synthetic Route of 10574-69-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Aryanasab, F.; Shokri, A.; Saidi, M. R. published the artcile< A simple approach to the synthesis of 3-substituted rhodanines and thiazolidine-2,4-diones>, Synthetic Route of 10574-69-3, the main research area is rhodanine thiazolidinedione preparation green chem; primary amine carbon disulfide bromoacetate three component reaction.

The green synthesis of 3-substituted rhodanine and thiazolidine-2,4-dione derivs . I [R = C6H5CH2, (CH2)3CH3, C6H5, 4-ClC6H4, etc.; X = S, O] via one-pot three-component reaction of primary amines RNH2, carbon disulfide and methyl-2-bromoacetate in water or under solvent-free conditions is described.

Scientia Iranica, Transaction C: Chemistry, Chemical Engineering published new progress about Green chemistry. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Synthetic Route of 10574-69-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Gorji, Samareh; Ghorbani-Vaghei, Ramin; Alavinia, Sedigheh published the artcile< Sodium alginate: Biopolymeric catalyst for the synthesis of 2-amino-4-arylthiazole derivatives in aqueous medium>, Synthetic Route of 57493-24-0, the main research area is aryl alkyne thiourea sodium alginate catalyst heterocyclization; amino arylthiazole preparation green chem.

An efficient and recoverable bifunctional heterogeneous organocatalyst for the synthesis of 2-amino-4-arylthiazole derivatives was carried out by the reaction of substituted Ph acetylene and thiourea in an eco-friendly condition in the presence of TBBDA. Mild reaction conditions, simple reaction procedure, easy purification, high yields of products, eco-friendly catalyst usage and convenient reusability were the highlighted points of this protocol.

Journal of Molecular Structure published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Synthetic Route of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Gromek, Samantha M.; deMayo, James A.; Maxwell, Andrew T.; West, Ashley M.; Pavlik, Christopher M.; Zhao, Ziyan; Li, Jin; Wiemer, Andrew J.; Zweifach, Adam; Balunas, Marcy J. published the artcile< Synthesis and biological evaluation of santacruzamate A analogues for anti-proliferative and immunomodulatory activity>, SDS of cas: 57493-24-0, the main research area is santacruzamate A analog preparation antiproliferative immunomodulator; Anti-proliferative activity; Enzyme assays; Immune modulation; Natural product analogues; Santacruzamate A.

Santacruzamate A (SCA) is a natural product isolated from a Panamanian marine cyanobacterium, previously reported to have potent and selective histone deacetylase (HDAC) activity. To optimize the enzymic and cellular activity, 40 SCA analogs were synthesized in a systematic exploration of the zinc-binding group (ZBG), cap terminus, and linker region. Two cap group analogs inhibited proliferation of MCF-7 breast cancer cells, with analogous increased degranulation of cytotoxic T cells (CTLs), while one cap group analog reduced CTL degranulation, indicative of suppression of the immune response. Addnl. testing of these analogs resulted in reevaluation of the previously reported SCA mechanism of action. These analogs and the resulting structure-activity relationships will be of interest for future studies on cell proliferation and immune modulation.

Bioorganic & Medicinal Chemistry published new progress about Antiproliferative agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, SDS of cas: 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Aitken, R. Alan; Armstrong, David P.; Galt, Ronald H. B.; Mesher, Shaun T. E. published the artcile< Synthesis and pyrolytic behavior of thiazolidin-2-one 1,1-dioxides>, Application In Synthesis of 171877-39-7, the main research area is thiazolidinone dioxide preparation pyrolysis.

Four examples of chiral thiazolidin-2-one 1,1-dioxides I [R1 = PhCH2; R2 = H, PhCH2, Me2CH; R3 = H, Et; R1R2 = (CH2)3] have been prepared by reaction of the appropriate amino alcs. with CS2 in aqueous sodium hydroxide to give thiazolidine-2-thiones, followed by oxidation with KMnO4 under phase-transfer conditions in the presence of benzoic acid, either directly or via the thiazolidin-2-ones. Upon flash vacuum pyrolysis (FVP) at 650°C, I (R1 = PhCH2; R2 = H, PhCH2, Me2CH; R3 = H, Et) decompose mainly by loss of SO2 to give an alkene and benzyl isocyanate together with other products from fragmentation of the N-benzyl group. A significant minor pathway involves net loss of CO2 and water to give 2-phenyl-4,5-dihydrothiazoles together with their aromatization products. A mechanism for this new heterocyclic transformation is proposed involving initial expansion to a cyclic carbamic-sulfinic anhydride (2,1,4-oxathiazin-3-one 1-oxide).

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about Thermal decomposition. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Application In Synthesis of 171877-39-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Mishra, Deepak; Fatima, Atiya; Rout, Chittaranjan; Singh, Ram published the artcile< An efficient one-pot synthesis of 2-aminothiazole derivatives>, Electric Literature of 57493-24-0, the main research area is aminothiazole preparation; haloketone thioamide cyclization.

A highly efficient, rapid and catalyst free protocol has been developed for the synthesis of 2-aminothiazoles I (R = Br, NO2, OCH3, etc.; R1 = Cl, CN, OCH3, etc.) in THF. Reaction was carried out at room temperature and the products were obtained in high yields without further purification

Chemica Sinica published new progress about Cyclization. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Electric Literature of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Shruthy, V. S.; Yusuf, Shakkeela published the artcile< In silico design, docking, synthesis and evaluation of thiazole Schiff bases>, Formula: C9H7N3O2S, the main research area is thiazole Schiff base preparation antiinflammatory anticancer protein kinase docking; cinnamaldehyde thiazole condensation.

A series of substituted Schiff base derivatives of 4-Ph thiazoles designed as anticancer and anti-inflammatory agents using computational methods was synthesized. The thiazole derivatives were selected based on docking studies performed on active site of protein tyrosine kinase (PDB :1T46) for anticancer activity and protein kinase (PDB :3DPK) for anti-inflammatory activity using Schrodinger 9.3 software. Mols. with better docking score was subjected to anal. for cytotoxic activity by in vitro MTT assay on cervical cancer HeLa cell lines and anti-inflammatory activity. Among the five thiazole derivatives, (4-(4-Methoxyphenyl)-N-3-phenylprop-2-en-1-ylidene-1,3-thiazol-2-amine) was found to have highest docking score and the same exhibited maximum in vitro cytotoxic and antiinflammatory activity. Thiazole schiff bases derivatives showed good antinflammatory and cytotoxic activity as predicted using mol. docking on resp. receptors.

International Journal of Pharmacy and Pharmaceutical Sciences published new progress about Anti-inflammatory agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Formula: C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica