Tag: M.W=200-250

Kottawar, S. S.; Goswami, S. V.; Thorat, P. B.; Bhusare, S. R. published the artcile< L-Proline as an efficient catalyst for synthesis of aldimines at ambient temperature condition>, Electric Literature of 57493-24-0, the main research area is thiazolamine aromatic aldehyde condensation proline catalyst; aldimine green preparation.

Some new aldimines were synthesized from substituted 2-aminothiazoles and different aromatic aldehydes using L-proline as an efficient catalyst. Easy work up, higher yields, and shorter reaction time are the advantages of the method.

E-Journal of Chemistry published new progress about Aldimines Role: SPN (Synthetic Preparation), PREP (Preparation). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Electric Literature of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lakhan, Ram; Singh, Om Prakash published the artcile< Local anesthetics. Part-III: synthesis of 2-(N-substituted or N,N-disubstituted aminoacetamido)-4 arylthiazoles>, COA of Formula: C9H7N3O2S, the main research area is aminoacetamidothiazole aryl local anesthetic preparation; phenylthiazole aminoacetamido local anesthetic preparation.

Title compounds I [R = 4-O2NC6H4, 3-O2NC6H4, 2,5-(MeO)2C6H3; R1 = Et, Me2CH, Me2CHCH2, MeEtCH; R2 = H, Et; R1R2 = piperidino] were prepared E.g., cyclocondensation of 4-O2NC6H4COMe with thiourea gave thiazole II, chloroacetylation of which followed by amination with EtNH2 gave I (R = 4-O2NC6H4, R1 = Et, R2 = H). I HCl (R = 3-O2NC6H4, R1 = MeEtCH, R2 = H) showed local anesthetic activity superior to that of procaine HCl.

Journal of the Indian Chemical Society published new progress about Local anesthetics. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, COA of Formula: C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nizamuddin, N. D.; Abdul Ahad, Hindustan; Devanna, Nayakanti published the artcile< Synthesis and molecular docking studies of some 1,2-dimethyl-3(4-substituted phenyl-1,3-thiazol-2-yl)2,3-dihydroquinazolin-4(1H)-ones as anticancer agents>, Synthetic Route of 57493-24-0, the main research area is dimethyl phenyl thiazolyl dihydroquinazolinone preparation mol docking.

Synthesis of 1, 2-dimethyl-3(4-substituted phenyl-1,3-thiazol-2-yl)2,3-dihydro quinazolin-4(1H)-ones derivatives I [R = 4-Me, 2-OH, 4-Cl, etc.] was effected by refluxing 1,2-dimethylbenzoxazine-4-one with different 4-substituted phenyl-1,3-thiazol-2-amines. Synthesized compoundsI were characterized through elemental anal., IR, proton NMR, and Carbon-13 NMR. Mol. docking studies were carried out using Schrodinger Glide (version 2020_1) which was docked into selective P38alpha and Activin A Receptor Type 1 (ACVR1) Activin receptor-like kinase-2 (ALK2) kinase with Protein Data Bank (PDB) code 3GC7, 6GI6. Based on the docking score of synthesized quinazolin-4-one derivatives, I co-crystallized ligands interaction was evaluated with 5-fluorouracil (5-FU) as a reference drug. Compounds I [R = H, 4-MeO, 3-NH2, 2,4-OH] with P38alpha, I [R = 2-OH, 3-NH2, 4-Cl, 2,4-OH] with ACVR1 (ALK2) kinase score were -7.265, -7.078, -7.058 and -6.836; -8.929, -8.749, -8.735 and -8.464 Kcal/mol against enzymes responsible for cancer treatment. The results indicated that quinazolin-4-one derivatives I scored better than ligand and 5-FU.

Indian Journal of Heterocyclic Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Synthetic Route of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Bumbu, Valentina D.; Yang, Xing; Birman, Vladimir B. published the artcile< Kinetic Resolution of N-Acyl-Thiolactams via Catalytic Enantioselective Deacylation>, Application of C10H11NS2, the main research area is kinetic resolution acyl thiolactam catalytic enantioselective deacylation benzotetramisole.

Methanolysis of N-acylthiazolidin-2-thiones and -oxazolidin-2-thiones in the presence of acyl transfer catalyst benzotetramisole (BTM) proceeds in a highly enantioselective fashion thus enabling kinetic resolution of these substrates [e.g., treatment of thiolactam (±)-I with MeOH, catalyst II and PhCO2H afforded (S)-III + (R)-I with s = 84].

Organic Letters published new progress about Acylation catalysts (stereoselective). 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Application of C10H11NS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Patel, Vimal I.; Patel, Harsha U.; Patel, Chhaganbhai N.; Suthar, Kiran J. published the artcile< Synthesis and anti-bacterial study of 4-(4-substituted phenyl)-5,6-disubstituted-1-(4-substituted phenylthiazol-2-yl)pyridin-2(1H)-one>, Reference of 57493-24-0, the main research area is pyridinone arylthiazolyl preparation antibacterial.

4-(4-Substituted phenyl)-5,6-disubstituted-1-(4-substituted phenylthiazol-2-yl)pyridin-2(1H)-ones have been prepared from citric acid. It is treated with concentrate H2SO4 and then with phenetole to give β-arylglutaconic acid which on fusion with 2-amino 4-substituted phenylthiazole gave 4-(substituted phenyl)-1-1(4-substituted phenylthiazol-2-yl)pyridine-2,6(1H,3H)-dione. Then reaction with phosphorus oxychloride gave 5,6-dichloro-4-(4-substituted phenyl)-1-(4-substituted phenylthiazol-2-yl)pyridin-2(1H)-one. This, on treatment with secondary amines, yields 4-(4-substituted phenyl)-5,6-disubstituted-1-(4-substituted-phenylthiazol-2-yl)pyridin-2(1H)-one. All the title compounds characterized on the basis of their IR, MASS, 1H NMR spectroscopic data anal.

Asian Journal of Research in Chemistry published new progress about Antibacterial agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Reference of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Peixoto, Philippe A.; Richard, Jean-Alexandre; Severin, Rene; Chen, David Y.-K. published the artcile< Total Synthesis of Echinopines A and B: Exploiting a Bioinspired Late-Stage Intramolecular Cyclopropanation>, Related Products of 171877-39-7, the main research area is echinopine A B synthesis intramol cyclopropanation.

Total synthesis of echinopine A and B have been accomplished, based on a strategy that involved two transition-metal-mediated ene-yne cycloisomerizations. A modified Pd-catalyzed enyne cycloisomerization/intramol. Diels-Alder cascade rendered a more streamlined synthesis of tricyclic ketone I, and a Ru-catalyzed ene-yne cycloisomerization/cyclopropanation resembled the late-stage [5/7] → [3/5/5/7] ring-forming sequence in the proposed biosynthetic pathway.

Organic Letters published new progress about Cycloisomerization. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Related Products of 171877-39-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Potewar, Taterao M.; Ingale, Sachin A.; Srinivasan, Kumar V. published the artcile< Catalyst-free efficient synthesis of 2-aminothiazoles in water at ambient temperature>, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is bromomethyl aryl ketone substituted thiourea heterocyclization catalyst free; aryl aminothiazole fanetizole preparation.

A highly efficient and facile method has been described for the synthesis of substituted 2-aminothiazoles, e.g., I, in water without any added catalyst or co-organic solvent. The reaction was carried out at ambient temperature and the products were obtained in excellent isolated yields. The developed protocol is successfully applied for the preparation of an anti-inflammatory drug, fanetizole.

Tetrahedron published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent) (bromo). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Wu, Yikang; Sun, Ya-Ping; Yang, Yong-Qing; Hu, Qi; Zhang, Qi published the artcile< Removal of thiazolidinethione auxiliaries with benzyl alcohol mediated by DMAP>, SDS of cas: 171877-39-7, the main research area is acylthiazolidinethione benzyl alc substitution DMAP; benzyl ester preparation; DMAP substitution mediator.

In the presence of DMAP, a range of N-acylthiazolidinethiones carrying different substituents were smoothly converted into benzyl esters, e.g., I. All the benzyl esters were obtained in good yields.

Journal of Organic Chemistry published new progress about Aldol condensation, stereoselective. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, SDS of cas: 171877-39-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Marson, Charles M.; Matthews, Christopher J.; Yiannaki, Elena; Atkinson, Stephen J.; Soden, Peter E.; Shukla, Lena; Lamadema, Nermina; Thomas, N. Shaun B. published the artcile< Discovery of Potent, Isoform-Selective Inhibitors of Histone Deacetylase Containing Chiral Heterocyclic Capping Groups and a N-(2-Aminophenyl)benzamide Binding Unit>, Product Details of C10H11NS2, the main research area is aminophenylbenzamide pyrimidine imidazolinone thiazoline capped preparation histone deacetylase inhibition; thiazoline capped HDAC3 NCoR1 inhibitor preparation antitumor activity apoptosis.

The synthesis of a novel series of potent chiral inhibitors of histone deacetylase (HDAC) is described that contain a heterocyclic capping group and a N-(2-aminophenyl)benzamide unit that binds in the active site. In vitro assays for the inhibition of HDAC1, HDAC2, HDAC3-NCoR1, and HDAC8 by the N-(2-aminophenyl)benzamide I gave resp. IC50 values of 930, 85, 12, and 4100 nM, exhibiting class I selectivity and potent inhibition of HDAC3-NCoR1. Both imidazolinone and thiazoline rings are shown to be effective replacements for the pyrimidine ring present in many other 2-(aminophenyl)benzamides previously reported, an example of each ring system at 1 μM causing an increase in histone H3K9 acetylation in the human cell lines Jurkat and HeLa and an increase in cell death consistent with induction of apoptosis. Inhibition of the growth of MCF-7, A549, DU145, and HCT116 cell lines by I was observed, with resp. IC50 values of 5.4, 5.8, 6.4, and 2.2 mM.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Product Details of C10H11NS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Sunnapu, Ranganayakulu; Banoth, Saikumar Naik; Reyno, R. S.; Thomas, Aleena; Venugopal, Navyasree; Rajendar, Goreti published the artcile< Stereoselective Total Synthesis of (-)-(2S,4R)-3'-Methoxyl Citreochlorol: Preparation and Use of New Proline-Based Auxiliary for Asymmetric Acetate Aldol Reaction>, Synthetic Route of 171877-39-7, the main research area is methoxyl citreochlorol stereoselective total synthesis asym aldol.

The first stereoselective total synthesis of (-)-(2S,4R)-3′-methoxy citreochlorol and (+)-(2S,4S)-3′-methoxy citreochlorol, I (R = OH, R1 = H; R = H, R1 = OH, resp.) is demonstrated. A proline-based imidazolidinone, II, was synthesized and used as chiral auxiliary for the asym. acetate aldol reaction to generate initial chirality in the targeted mol. The geminal dichloromethane functionality was introduced by the addition of in situ-generated dichloromethyllithium to Weinreb’s amide functional group.

Journal of Organic Chemistry published new progress about Aldol addition, stereoselective. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Synthetic Route of 171877-39-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica