Tag: M.W=200-250

Vyzhdak, R. N.; Danielova, A. A.; Kiselev, V. V.; Drach, B. S. published the artcile< Derivatives of 5-(Dimethylamino)-4-tosyl-1,3-oxazole-2-carbaldehyde and Its Analogs>, Category: thiazole, the main research area is oxazolecarbaldehyde amino tosyl preparation condensation.

Treatment of N-(2,2,2-trichloro-1-tosylethyl)dichloroacetamide with excess Me2NH, piperidine, or morpholine gave substituted aminals of the oxazole series, whose facile acid hydrolysis provided 5-(dimethylamino)-4-tosyl-1,3-oxazole-2-carbaldehyde and its analogs having the piperidino and morpholino group in the 5-position of the oxazole ring. The resulting aldehydes and their aminals were condensed with PhN2H3, thiosemicarbazide, N-alkylrhodanines, and 1,3-dimethylbarbituric acid to obtain 2,5-disubstituted 4-tosyl-1,3-oxazoles.

Russian Journal of General Chemistry published new progress about Cyclization. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Category: thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Matsui, Masaki; Asamura, Yoshinori; Kubota, Yasuhiro; Funabiki, Kazumasa; Jin, Jiye; Yoshida, Tsukasa; Miura, Hidetoshi published the artcile< Highly efficient substituted triple rhodanine indoline dyes in zinc oxide dye-sensitized solar cell>, Recommanded Product: 3-Benzyl-2-thioxothiazolidin-4-one, the main research area is rhodanine indoline dye zinc oxide dye sensitized solar cell.

Substituted triple rhodanine indoline dyes showed higher performance than known triple rhodanine derivative (D150). A few triple rhodanine indoline derivatives showed comparable conversion efficiency to D149.

Tetrahedron published new progress about Dye-sensitized solar cells (triple rhodanine indoline dyes-based). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Recommanded Product: 3-Benzyl-2-thioxothiazolidin-4-one.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Bodireddy, Mohan Reddy; Mohinuddin, P. Khaja Md.; Gundala, Trivikram Reddy; Reddy, N. C. Gangi published the artcile< Lactic acid-mediated tandem one-pot synthesis of 2-aminothiazole derivatives: a rapid, scalable, and sustainable process>, SDS of cas: 57493-24-0, the main research area is acetophenone thiourea lactic acid catalyst tandem bromination Hantzsch reaction; aminothiazole regioselective preparation green chem.

Environmentally benign and biodegradable lactic acid was identified as alternative solvent and catalyst for the tandem one-pot synthesis of Hantzsch 2-aminothiazole derivatives from readily available aralkyl ketones through in-situ regioselective α-bromination using N-bromosuccinimide followed by heterocyclization using thiourea at 90-100°. The major advantages of the present method include short reaction times (10-15 min), practical, simple to perform, easy work-up, good yield of products (up to 96%), productive for large-scale applications, free from apply of α-bromoketones (lachrymator) as substrates, avoids column purification Hence, the present method met with the concepts of both Wender’s “”ideal synthesis”” and sustainable chem. process.

Cogent Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, SDS of cas: 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Tejchman, W.; Korohoda, M. J. published the artcile< Introduction of selenium to heterocyclic compounds. Part VII. Synthesis of 3-alkyl-5-benzylidene- and 3-alkyl-5-cinnamylidene-2-selenorhodanines>, SDS of cas: 10574-69-3, the main research area is selenylation rhodanine benzylidene cinnamylidene.

Five new 3-alkyl-5-benzylidene- and five new 3-alkyl-5-cinnamylidene-2-selenorhodanines I (R = Ph, CH:CHPh; R1 = Et, Pr, Bu, n-pentyl, PhCH2) were obtained by methylation of the corresponding rhodanines and subsequent treatment with H2Se. The stability of 2-thiazolinium salts with SCH3 or RNCH3 group formed during methylation is determined by substituents at C-5 and N-3 atoms.

Polish Journal of Chemistry published new progress about Heterocyclic compounds, selenium Role: SPN (Synthetic Preparation), PREP (Preparation). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, SDS of cas: 10574-69-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Royo, Santiago; Rodriguez, Santiago; Schirmeister, Tanja; Kesselring, Jochen; Kaiser, Marcel; Gonzalez, Florenci V. published the artcile< Dipeptidyl Enoates As Potent Rhodesain Inhibitors That Display a Dual Mode of Action>, Electric Literature of 171877-39-7, the main research area is dipeptidyl enoate derivative preparation rhodesain inhibitor trypanosomicides; dipeptidyl enoates; inhibitors; rhodesain; sleeping sickness; trypanosomiasis.

Dipeptidyl enoates were prepared through a high-yielding two-step synthetic route. They have a dipeptidic structure with a 4-oxoenoate moiety as a warhead with multiple reactive sites. Dipeptidyl enoates were screened against rhodesain and human cathepsins B and L, and were found to be potent and selective inhibitors of rhodesain. Among them (S,E)-Et 5-((S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanamido)-7-methyl-4-oxooct-2-enoate (6) was the most potent, with an IC50 value of 16.4 nΜ and kinact/Ki=1.6×106 Μ-1 s-1 against rhodesain. These dipeptidyl enoates display a reversible mode of inhibition at very low concentrations and an irreversible mode at higher concentrations Inhibition kinetics data, supported by docking studies, suggest a dual mode of action via attack of cysteine thiolate at two reactive positions.

ChemMedChem published new progress about Enzyme inhibitors (rhodesain). 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Electric Literature of 171877-39-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Chen, Yufeng; He, Rong; Chen, Yihua; D’Annibale, Melissa A.; Langley, Brett; Kozikowski, Alan P. published the artcile< Studies of Benzamide- and Thiol-Based Histone Deacetylase Inhibitors in Models of Oxidative-Stress-Induced Neuronal Death: Identification of Some HDAC3-Selective Inhibitors>, Product Details of C9H7N3O2S, the main research area is histone deacetylase inhibitor preparation neuroprotective structure activity.

Less stress: We compare three structurally different classes of histone deacetylase (HDAC) inhibitors that contain benzamide, hydroxamate, or thiol groups as the zinc binding group (ZBG) for their ability to protect cortical neurons in culture from cell death induced by oxidative stress. Novel benzamide-based ligands selectively inhibit HDAC3 but provide no neuroprotection in the HCA-cortical neuron model of oxidative stress. We compare three structurally different classes of histone deacetylase (HDAC) inhibitors that contain benzamide, hydroxamate, or thiol groups as the zinc binding group (ZBG) for their ability to protect cortical neurons in culture from cell death induced by oxidative stress. This study reveals that none of the benzamide-based HDAC inhibitors (HDACIs) provides any neuroprotection whatsoever, in distinct contrast to HDACIs that contain other ZBGs. Some of the sulfur-containing HDACIs, namely the thiols, thioesters, and disulfides present modest neuroprotective activity but show toxicity at higher concentrations Taken together, these data demonstrate that the HDAC6-selective mercaptoacetamides that were reported previously provide the best protection in the homocysteic acid model of oxidative stress, thus further supporting their study in animal models of neurodegenerative diseases.

ChemMedChem published new progress about Cell death. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Product Details of C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Akbarzadeh, Elaheh; Shockravi, Abbas; Vatanpour, Vahid published the artcile< Efficient thiazole-based polyimines as selective and reversible chemical absorbents for CO2 capture and separation: Synthesis, characterization and application>, Computed Properties of 57493-24-0, the main research area is thiazole thioether polyimine chem absorbent carbon dioxide capture separation.

A new series of polyimines (PIMs-1-9) including ortho-linked thiazole units and flexible thioether linkages were synthesized from diamine monomers (DA-1-3) and some com. available aromatic dialdehydes (terephthalaldehyde, isophthalaldehyde and 2,5-thiophenedicarboxaldehyde) via Schiff-base condensation reaction. The synthesized polymers as amorphous solids were obtained with high efficiency (74-89%), inherent viscosities in the range of 0.98-1.33 dL g-1 in DMF and high solubility in aprotic polar solvents (DMSO, DMAc, DMF, NMP, and Py). The PIMs were characterized via viscosimetry, elemental anal., FT-IR spectroscopy, X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), thermogravimetric anal. (TGA) and differential scanning calorimetry (DSC). High thermal resistance revealed for PIMs as glass transition temperatures (Tgs) ranging in 104-189 °C along with 10% weight loss temperatures exceeding 268-390 °C in air and 310-430 °C in nitrogen atm. The polymers were examined for CO2 absorption at 298 K as well as 318 K and high absorption capacity exhibited (maximum 3.72 mmol/g or 163.68 mg/g at 1 bar and 298 K for PIM-4) after 2 h and desorption at 373 K under vacuum conditions (100 mbar) in 20 min. More importantly, remarkable ideal selectivity ratios of CO2/N2 (77.3) and CO2/CH4 (13.7) at 1 bar and 298 K were obtained and recyclability of PIM-4 for CO2 capturing was determined without considerable loss of gas absorption.

Polymer published new progress about Absorbents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Computed Properties of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Shi, Min; Jiang, Jian-Kang published the artcile< Synthesis of novel chiral Cu or Ag/S,N cluster complexes and absolute stereostructures as determined by X-ray crystallography>, Recommanded Product: (S)-4-Benzylthiazolidine-2-thione, the main research area is copper silver chiral thiazolidinethione ligand complex preparation structure; crystal structure copper silver chiral thiazolidinethione ligand complex.

Novel chiral Cu(I) and Ag(I) metal complexes were synthesized from the reaction of chiral (S)-(-)-4-benzyl-1,3-thiazolidine-2-thione ligand with CuCl and AgOAc in CH2Cl2 in the presence of Et3N and DMAP at room temperature Their unique crystal structures were determined by x-ray anal. Four Cu(I) atoms and four 1,3-thiazolidine-2-thione ligands form a butterfly-type metal cluster. Six Ag(I) atoms and six 1,3-thiazolidine-2-thione ligands form another butterfly-type cluster.

Chirality published new progress about Crystal structure. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Recommanded Product: (S)-4-Benzylthiazolidine-2-thione.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Huang, Xian; Zhu, Qing; Zhang, Ji-Zhen published the artcile< Synthesis of a new polymer-supported reagent-poly{[4-hydroxy(tosyloxy)iodo]styrene} and its application to the synthesis of 2-amino-4-arylthiazoles>, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is polymer supported reagent hydroxytosyloxyiodobenzene synthesis; solid phase synthesis arylthiazole cyclization.

A new polymer-supported reagent-poly{[4-hydroxy(tosyloxy)iodo]styrene} prepared by substitution from poly[styrene(iodoso diacetate)] has good reactivity in the formation of 2-amino-4-arylthiazoles, e.g. I, from acetophenones and thioureas via cyclization, and the procedure of regeneration and recycle are also described.

Chinese Journal of Chemistry published new progress about Cyclization. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Li, Xiaokai; Srinivasan, Sharan R.; Connarn, Jamie; Ahmad, Atta; Young, Zapporah T.; Kabza, Adam M.; Zuiderweg, Erik. R. P.; Sun, Duxin; Gestwicki, Jason E. published the artcile< Analogues of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, As Anti-Cancer Agents>, Product Details of C10H9NOS2, the main research area is benthiazolyl cationic rhodacyanine preparation allosteric Hsp70 inhibitor antitumor; Hsp90; breast cancer; mortalin; p53; proteostasis.

The rhodacyanine, MKT-077, has antiproliferative activity against cancer cell lines through its ability to inhibit members of the heat shock protein 70 (Hsp70) family of mol. chaperones. However, MKT-077 is rapidly metabolized, which limits its use as either a chem. probe or potential therapeutic. The synthesis and characterization of MKT-077 analogs designed for greater stability is reported. The most potent mols., such as I (JG-98), were at least 3-fold more active than MKT-077 against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50 values of 0.4 ± 0.03 and 0.7 ± 0.2 μM, resp.). The analogs modestly destabilized the chaperone clients, Akt1 and Raf1, and induced apoptosis in these cells. Further, the microsomal half-life of JG-98 was improved at least 7-fold (t1/2 = 37 min) compared to MKT-077 (t1/2 < 5 min). Finally, NMR titration experiments suggested that these analogs bind an allosteric site that is known to accommodate MKT-077. These studies advance MKT-077 analogs as chem. probes for studying Hsp70s roles in cancer. ACS Medicinal Chemistry Letters published new progress about Antiproliferative agents. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Product Details of C10H9NOS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica