Tag: M.W=200-250

Azzem, M. Abdel published the artcileElectroactive film of polyaniline substituted with heterocyclic benzothiazole ring, Name: 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is European Polymer Journal (1995), 31(2), 205-8, database is CAplus.

Voltammetric studies of 2-(4-aminophenyl)-6-methylbenzothiazole (ABT) were carried out in MeCN and acidic aqueous solutions Potential sweep electrolysis of 0.05 M ABT at a glassy C electrode in MeCN containing 0.1 M LiClO₄ and 0.05 M pyridine produced a polymeric film. The film coated electrode showed an electrochem. response in acidic aqueous solution The elec. conductivity measurement on pressed pellets of poly-ABT prepared by constant current electrolysis was 3.8 × 10^-5 S/cm. Based on IR spectroscopic characterization and elec. conductivity measurement, a polymerization mechanism was proposed.

European Polymer Journal published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Name: 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Guzaev, Andrei P. published the artcileReactivity of 3H-1,2,4-dithiazole-3-thiones and 3H-1,2-dithiole-3-thiones as sulfurizing agents for oligonucleotide synthesis, Related Products of thiazole, the publication is Tetrahedron Letters (2011), 52(3), 434-437, database is CAplus.

The reactivity of 5-amino-3H-1,2,4-dithiazole-3-thiones substituted at their amino group and 5-amino-3H-1,2-dithiole-3-thiones substituted at their amino group and C4 toward compounds containing P(III) atoms has been studied. N,N-Di-substituted-N’-(3-thioxo-3H-1,2,4-dithiazol-5-yl)methanimidamides were selected as novel efficient sulfur transfer reagents suitable for DNA and RNA synthesis.

Tetrahedron Letters published new progress about 1192027-04-5. 1192027-04-5 belongs to thiazole, auxiliary class Other Aliphatic Heterocyclic,Amine, name is N,N-Dimethyl-N’-(3-thioxo-3H-1,2,4-dithiazol-5-yl)formimidamide, and the molecular formula is C5H7N3S3, Related Products of thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Law, K. P. published the artcileSurface-assisted laser desorption/ionization mass spectrometry on nanostructured silicon substrates prepared by iodine-assisted etching, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is International Journal of Mass Spectrometry (2010), 290(1), 47-59, database is CAplus.

Surface-assisted laser desorption/ionization (SALDI) is a matrix-free mass spectrometry (MS) approach that utilizes the unique properties of a nanostructured surface to promote desorption and ionization. However, there are still questions on what constitutes a suitable SALDI substrate for mass spectrometric application. A range of SALDI substrates prepared by anodization with an oxidizing electrolyte was investigated. The laser desorption/ionization (LDI) performance was examined on a reflectron time-of-flight (ToF) mass spectrometer. The physicochem. properties of the substrates were characterized by a number of surface anal. techniques including SEM, at. force microscopy (AFM), secondary ion mass spectrometry (SIMS), XPS and water contact angle measurement. Examination of surface cleaning technologies and methods for surface chem. modification were carried out. Correlation between the substrate physicochem. properties and the LDI performance was determined It was found that only the substrate, which had a thick nanostructured layer, was effective for LDI-MS. SALDI substrate was found to have a high surface potential. However, this unique property offered no advantage for the application of LDI-MS. Surface chem. is also an important factor in affecting the LDI performance. Plasma etching can effectively remove the surface contamination but it also increases the thickness of the oxide layer. Fluorine and hydroxyl termination is advantageous. Fluorine passivation increases the surface hydrophobicity, which confines the analyte solution droplet to a smaller area and also withdraws the electronic d. from the surface, and acidifies the surface Si-OH moieties, which is believed a major proton source. The effect of laser etching was investigated by SIMS and XPS imaging and provided new insight of the SALDI ionization mechanism.

International Journal of Mass Spectrometry published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Mahapatra, G. N. published the artcileBromination of 2-aminothiazoles and their use as possible fungicides and bactericides, Product Details of C13H10N2S, the publication is Journal of the Indian Chemical Society (1956), 527-31, database is CAplus.

Seventeen 4-aryl-2-aminothiazoles (I) were prepared and brominated to 5-bromo-4-aryl-2-aminothiazoles (II). The aryl group and the m.ps., resp., are : Ph, 153-4°, 103°; p-MeC₆H₄, 123-4°, 106°; p-EtC₆H₄, 107-8°, 112°; 3,4-Me₂C₆H₃, 135-6°, 107°; 2,5-Me₂C₆H₃, 177-8°, 187°; p-MeOC₆H₄, 204-5°, 152°; p-EtOC₆H₄, 230-1°, 98°; ο-HOC₆H₄, 139-40°, 221°; p-HOC₆H₄, 198-9°, 235°; p-BrC₆H₄, 176-7°, 192°; m-H₂NC₆H₄, 170-1°, 207°; p-H₂NC₆H₄, 174-5°, 200°; α-C₁₀H₇, 130-1°, 111°; β-C₁₀H₇, 150-1°, 168°; 2-thienyl, 107-8°, 217°; PhCH₂CH₂, 90-1°, 201°; and MeOC₆H₄CH₂CH₂, 97-8°, 197° (decomposition). The bactericidal activity was determined in terms of the maximum effective dilution (M. E.D.) at 10 min. exposure. The M.E.D. for Escherichia coli was 1:1000 (maximum) for I and 1:1000 to 1:4000 for II; for Staphylococcus aureus was 1:8000 (maximum) for I and 1:10,000 to 1:20,000 for II. The fungicidal activity against Alternaria brassicae was: II at 50 p.p.m. and I at 80 p.p.m. inhibited spore germination; II at 40 p.p.m. reduced spore germination to 15-20%.

Journal of the Indian Chemical Society published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Product Details of C13H10N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Okamiya, Jiro published the artcile2-Amino-4(or 5)-arylthiazoles. II. Ultraviolet absorption spectra of α-naphthyl, biphenyl, and hydroxyaryl substituted compounds, Application In Synthesis of 56503-96-9, the publication is Nippon Kagaku Zasshi (1959), 903-6, database is CAplus.

cf. CA 55, 4486c. Ultraviolet absorption spectra of 2-amino-4(α-naphthyl)thiazole, m. 162°, 2-amino-4-(α-naphthyl)-5-methylthiazole, m. 195°, 2-amino-5-(α-naphthyl)thiazole, m. 129°, 2-amino-4-methyl-5-(α-naphthyl)thiazole, m. 163°, 2-amino-4-(α-naphthyl)-5-phenylthiazole, m. 223°, 2-amino-4-phenyl-5-(α-naphthyl)thiazole, m. 248°, 2-amino-4,5-bis(α-naphthyl)thiazole, m. 260° (decomposition), 2-amino-4-biphenylylthiazole, 2-amino-4-biphenylyl-5-phenylthiazole, m. 201°, 2-amino-4-(p-hydroxyphenyl)thiazole, m. 212°, 2-amino-4-(p-hydroxyphenyl)-5-methylthiazole-HCl, HCl, 208-10°, 2-amino-4-(o-hydroxyphenyl)thiazole, 2-amino-4-(o-hydroxyphenyl)-5-methylthiazole, m. 120°, 2-amino-4-(p-hydroxyphenyl)-5-phenylthiazole, m. 284°, 2-amino-4-(o-hydroxyphenyl)-5-phenylthiazole, m. 171°, and 2-amino-4-(2-hydroxy-1-naphthyl)thiazole, m. 198°, were reported. The naphthyl group, due to its steric hindrance, exerted less effect on spectra, but was bathochromic at 5 position when compared with that at 4 position. The o-hydroxyphenyl group gave a red shift to the maximum at shorter wave length in spite of its expected steric effects. This must be attributed to the existence of chelation. Intermediate ketones of above thiazoles were prepared α-Bromonaphthalene (27.6 g.) was converted to Grignard reagent, 1.33 g. CdCl₂ added, the solvent replaced by C₆H₆, and 8.3 g. AcCl added to give 11 g. α-acetonaphthone. Similarly, α-propionaphthone, α-naphthyl benzyl ketone, ω-(α-naphthyl)acetophenone and ω-(α-naphthyl)acetonaphthone were prepared in 55, 60, 59 and 36% yields, resp. Naphthalene (100 g.), 250 cc. CS₂, and 130 g. AlCl₃ treated with ethylene oxide from 70 cc. ClCH₂CH₂OH gave 29 g. α-naphthylethanol which was oxidized with CrO₃ in AcOH to α-naphthylacetaldehyde. EtOMgCH(CO₂Et)₂ prepared from 9 g. CH₂(CO₂Et)₂, 1.3 g. Mg, and 7 cc. EtOH was treated with α-naphthylacetyl chloride prepared from 9.5 g. α-naphthylacetic acid and SOCl₂, and the product hydrolyzed to give 5 g. α-naphthylacetone.

Nippon Kagaku Zasshi published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Application In Synthesis of 56503-96-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Riesz, E. published the artcileSome new benzothiazole derivatives and comparison dyeing with such compounds, Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Textilveredlung (1991), 26(12), 403-5, database is CAplus.

The yellow dye primuline, prepared by heating p-toluidine with S, was separated into 3 bases, having the structure I (x = 0, 1, or 2), which were then converted into the corresponding Na sulfonate salts and used to dye viscose and cotton fabrics. For the I (x = 0) Na sulfonate, the fibers remained practically undyed, displaying only a light yellow tinge; with the sulfonates of I (x = 2) and I (x = 3) yellow and deep yellow dyeings were produced, resp. To evaluate the shade-deepening and affinity effects of the benzothiazole (II) groups, the 3 Na sulfonates were diazotized and coupled with β-naphthol on the fibers. Most of the dye was taken up by the fibers because of an increase in affinity, but a certain contribution by the shade-deepening effect of the II groups could not be excluded. Reaction of the 3 sulfonates with p-dimethylaminobenzaldehyde produced dyes containing a weaker chromophore, i.e., azomethine, than the azo group. These compounds dyed cellulosic fibers widely different shades of yellow and orange and, as free bases, gave basic dyes which dyed fibers from an HOAc solution without pretreatment. Conversion of the amino groups of the 3 bases into SH groups yielded the 1st purely synthetic S dyes for dyeing cellulosic fibers yellow shades.

Textilveredlung published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Sekar, N. published the artcileThiazole – containing monoazo direct dyes, Formula: C14H12N2S, the publication is Colourage (2005), 52(3), 95-98, database is CAplus.

A review. Chem. of monoazo direct dyes based on dehydrothio-p-toluidine and its higher analogs and the others containing thiazolyl residue is discussed in the light of structures documented in color index.

Colourage published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C8H5F3O2S, Formula: C14H12N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Du, Zhi published the artcileSelf-triggered click reaction in an Alzheimer’s disease model: in situ bifunctional drug synthesis catalyzed by neurotoxic copper accumulated in amyloid-beta plaques, Category: thiazole, the publication is Chemical Science (2019), 10(44), 10343-10350, database is CAplus and MEDLINE.

Cu is one of the essential elements for life. Its dyshomeostasis has been demonstrated to be closely related to neurodegenerative disorders, such as Alzheimer’s disease (AD), which is characterized by amyloid-beta (Abeta) aggregation and Cu accumulation. It is a great challenge as to how to take advantage of neurotoxic Cu to fight disease and make it helpful. Herein, we report that the accumulated Cu in Abeta plaques can effectively catalyze an azide-alkyne bioorthogonal cycloaddition reaction for fluorophore activation and drug synthesis in living cells, a transgenic AD model of Caenorhabditis elegans CL2006, and brain slices of triple transgenic AD mice. More importantly, the in situ synthesized bifunctional drug 6 can disassemble Abeta-Cu aggregates by extracting Cu and photo-oxygenating Abeta synergistically, suppressing Abeta-mediated paralysis and diminishing the locomotion defects of the AD model CL2006 strain. Our results demonstrate that taking the accumulated Cu ions in the Abeta plaque for an in situ click reaction can achieve both a self-triggered and self-regulated drug synthesis for AD therapy. To the best of our knowledge, a click reaction catalyzed by local Cu in a physiol. environment has not been reported. This work may open up a new avenue for in situ multifunctional drug synthesis by using endogenous neurotoxic metal ions for the treatment of neurodegenerative diseases.

Chemical Science published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Yanachkov, Ivan published the artcileSelf-neutralizing oligonucleotides with enhanced cellular uptake, Product Details of C5H7N3S3, the publication is Organic & Biomolecular Chemistry (2017), 15(6), 1363-1380, database is CAplus and MEDLINE.

There is tremendous potential for oligonucleotide (ON) therapeutics, but low cellular penetration due to their polyanionic nature is a major obstacle. We addressed this problem by developing a new approach for ON charge neutralization in which multiple branched charge-neutralizing sleeves (BCNSs) are attached to the internucleoside phosphates of ON by phosphotriester bonds. The BCNSs are terminated with pos. charged amino groups, and are optimized to form ion pairs with the neighboring phosphate groups. The new modified ONs can be prepared by standard automated phosphoramidite chem. in good yield and purity. They possess good solubility and hybridization properties, are not involved in non-standard intramol. aggregation, have low cytotoxicity, adequate chem. stability, improved serum stability, and above all, display significantly enhanced cellular uptake. Thus, the new ON derivatives exhibit properties that make them promising candidates for the development of novel therapeutics or research tools for modulation of the expression of target genes.

Organic & Biomolecular Chemistry published new progress about 1192027-04-5. 1192027-04-5 belongs to thiazole, auxiliary class Other Aliphatic Heterocyclic,Amine, name is N,N-Dimethyl-N’-(3-thioxo-3H-1,2,4-dithiazol-5-yl)formimidamide, and the molecular formula is C8H5IO, Product Details of C5H7N3S3.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Guan, Ai-jiao published the artcileEthyl-substitutive Thioflavin T as a highly-specific fluorescence probe for detecting G-quadruplex structure, Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Scientific Reports (2018), 8(1), 1-12, database is CAplus and MEDLINE.

G-quadruplex has attracted considerable attention due to their prevalent distribution in functional genomic regions and transcripts, which can importantly influence biol. processes such as regulation of telomere maintenance, gene transcription and gene translation. Artificial receptor study has been developed for accurate identification of G-quadruplex from DNA species, since it is important for the G-quadruplex related basic research, clin. diagnosis, and therapy. Herein, fluorescent dye ThT-E, a derivative of the known fluorescence probe Thioflavin T (ThT), was designed and synthesized to effectively differentiate various G-quadruplex structures from other nucleic acid forms. Compared with Me groups in ThT, three Et groups were introduced to ThT-E, which leads to strengthened affinity, selectivity and little inducing effect on the G-quadruplex formation. More importantly, ThT-E could be served as a visual tool to directly differentiate G-quadruplex solution even with naked eyes under illumination of UV light. Thus, this probe reported herein may hold great promise for high-throughput assay to screen G-quadruplex, which may widely apply to G-quadruplex-based potential diagnosis and therapy.

Scientific Reports published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica