Tag: M.W=200-250

Wang, Gao-peng; Wang, Li-ping; Qin, Shuang-lin; Huang, Fei-fei; Huang, Shuang-Ping; Wang, Xiao-Ji published the artcile< Construction of chiral hydroxyl of the intermediate of Strictifolione by using Evans auxiliary>, Recommanded Product: (S)-4-Benzylthiazolidine-2-thione, the main research area is benzyl thioxothiazolidinyl hydroxyphenylpentanone preparation.

An economical way for the synthesis of Evans auxiliary and chiral hydroxyl of the key intermediate of strictifolione by using Evans chiral auxiliary was reported.

Advanced Materials Research (Durnten-Zurich, Switzerland)published new progress about Chiral auxiliary. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Recommanded Product: (S)-4-Benzylthiazolidine-2-thione.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Uppal, Archana; Kothiyal, Preeti; Singh, Anita published the artcile< Hybrid Class Phenylthiazole and 1,2,3,4-Tetrahydronaphthalene Target Sertraline Transporter for Antidepressant Action Revealed by Molecular Docking Studies>, Application of C9H7N3O2S, the main research area is phenylthiazolyltetrahydronaphthalene derivative preparation antidepressant activity; epoxytetrahydronaphthalene preparation amine addition.

Phenylthiazolyl-substituted 1,2,3,4-tetrahydronaphthalene derivatives e. g., I, were synthesized, and their chem. structures were elucidated by Fourier transform IR, 1H-NMR, 13C-NMR spectral data and elemental analyses. Antidepressant-like activities of these compounds were screened using both Porsolt’s behavioral despair on albino mice and tail suspension tests. Open field test was also performed for the examination of probable neurol. deficits, which may interfere with the test results. The test compounds exhibited different levels of antidepressant activities. Addnl., the key ligand was further substantiated by docking experiment to explore plausible mode of binding in mol. dynamics overflow. The studies elucidates role of a hydrophilic H-bonding region and pi-cation binding as a major driving force for biol. activity.

Journal of Heterocyclic Chemistrypublished new progress about Addition reaction. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Application of C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lyashchuk, S. N.; Enya, V. I.; Doroshenko, T. F.; Skrypnik, Yu. G. published the artcile< Study of reaction routes in sulfonation of 2-aminothiazoles with chlorosulfonic acid>, Electric Literature of 57493-24-0, the main research area is thiazole amine sulfonation thermal isomerization thiazolesulfonic thiazolesulfamic acid preparation; charge distribution thiazole amine AM1 calculation sulfonation mechanism.

The sulfonation of 4-substituted 2-aminothiazoles with chlorosulfonic acid under mild conditions afforded primarily C-sulfonation product, 2-amino-5-thiazolesulfonic acids, which undergo thermal isomerization by heating in sulfuric acid into the corresponding stable 2-thiazolesulfamic acids. Reaction of 4-R-thiazole-2-amines (9-12) with ClSO3H gave 2-amino-4-R-thiazole-5-sulfonic acids (1-4; R = Me, 4-BrC6H4, 3-O2NC6H4, 4-ClC6H4); heating of 1-4 at 110° in concentrate H2SO4 gave 4-R-thiazole-2-sulfamic acids (5-8). Quantum chem. calculations at AM1 level revealed the presence of considerable neg. charge on the C-5 atom of the thiazole ring of 9-12, which accounts for the opposite sulfonation patterns for the aminothiazoles and aniline.

Russian Journal of Organic Chemistrypublished new progress about AM1 (molecular orbital method). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Electric Literature of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica