Tag: M.W=200-250

Schlitzer, Martin published the artcileSynthesis of potential aldose reductase inhibitors based on minimal pharmacophore requirements, Synthetic Route of 92-36-4, the publication is Journal of Pharmacy and Pharmacology (2001), 53(6), 831-839, database is CAplus and MEDLINE.

A series of 17 compounds was synthesized based on the premise that the minimal pharmacophore for aldose reductase inhibition requires the presence of both an aryl group and a polar group connected by a linking structure. Three groups of compounds were synthesized, the first possessing a 4-(6-methyl-2-benzothiazolyl)aniline or 2-aminobenzothiazole group as the aryl group, the second possessing a 2-naphthyl as the aryl group and the third possessing either a 2-phenyl-4-thiazolyl or 5-(2-nitrophenyl)-2-furanyl as the aryl group. In all three of these groups the carboxylate or its Me ester are linked to the aryl group through various lengths of methylene carbons and amide or cinnamide groups. Optimal activity was observed when the carboxyl group was separated from the aryl group by a linking structure of five atoms in length. Both a double bond and an amide moiety are well tolerated in the linking structure.

Journal of Pharmacy and Pharmacology published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Synthetic Route of 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Chung, Byung-Ho published the artcileSynthesis and biological evaluation of new allylamine antimycotics, Category: thiazole, the publication is Yakhak Hoechi (1996), 40(5), 507-512, database is CAplus.

Benzothiazolyl-substituted allylamines were prepared as potential antimycotics. Thus, intermediate Schiff bases, obtained by condensation of 2-aminobenzothiazoles and trans-cinnamaldehyde, were reduced and then methylated to give the benzothiazolyl-substituted allylamines. These compounds, which were tested in vitro against five fungal cell lines containing Trichophyton mentagrophytes, showed no activity in the 0.1-100 μg/mL range.

Yakhak Hoechi published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Shaikh, Asif R. published the artcileAntimycobacterial and antimicrobial studies of newly synthesized 3-(4-(6-methylbenzo[d]thiazol-2-yl) phenyl)quinazolin-4(3H)-ones, HPLC of Formula: 92-36-4, the publication is Indian Journal of Research in Pharmacy and Biotechnology (2014), 2(1), 935-942, 8 pp., database is CAplus.

The 7-chloro-2-(substituted)-3-(4-(6-methylbenzo[d]thiazol-2-yl)phenyl) quinazolin-4(3H)-ones e.g., I (R = furan-2-yl) have been prepared from the substituted acids, which were converted to substituted acetyl chlorides and cyclized with 4-chloro anthranilic acid afforded substituted benzoxazines 4(3H)-ones e.g., II and its further reaction with 4-(6-methylbenzo[d]thiazol-2-yl)aniline a gives desired compounds I. In vitro antitubercular activity was carried out against Mycobacterium tuberculosis H₃₇Rv strain using Lowenstein-Jensen medium (conventional method) and antimicrobial activity against various bacteria and fungi using broth microdilution method. The compounds II, I were emerged as promising antimicrobials. It was also observed that the promising antimicrobials have proved to be better antituberculars. The compounds II, I showed better antitubercular activities compared to rifampicin and isoniazid.

Indian Journal of Research in Pharmacy and Biotechnology published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C7H6Cl2, HPLC of Formula: 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Dash, B. published the artcileSome new Schiff base derivatives derived from vanillin as possible fungicides, Recommanded Product: 4-(Naphthalen-1-yl)thiazol-2-amine, the publication is Journal of the Indian Chemical Society (1983), 60(8), 772-4, database is CAplus.

Schiff bases I (R, R¹ = H, Ph, 4-MeC₆H₄, 4-ClC₆H₄, 4-BrC₆H₄, 4-MeOC₆H₄, naphthyl; R² = H) derived from 4-substituted and 4,5-disubstituted-2-amino thiazoles and vanillin were prepared Cycloaddition of I with HSCH₂CO₂H yielded thiazolidones II. Condensation of the Schiff bases with ClCH₂COCl and subsequent reaction with piperidine and morpholine yielded corresponding acetoxy derivatives I (R² = morpholinoacetyl, piperidinoacetyl). The compounds were characterized by elemental anal. and IR spectra and were screened for fungicidal activity.

Journal of the Indian Chemical Society published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Recommanded Product: 4-(Naphthalen-1-yl)thiazol-2-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Blackwell, Helen E. published the artcileDecoding products of diversity pathways from stock solutions derived from single polymeric macrobeads, Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Angewandte Chemie, International Edition (2001), 40(18), 3421-3425, database is CAplus and MEDLINE.

A combinatorial library of nonracemic dihydropyrancarboxamides such as I [prepared on solid phase by the enantioselective Diels-Alder cycloaddition of resin-bound vinyl ethers with allyl β,γ-unsaturated-α-ketoesters in the presence of nonracemic bisoxazoline ligands and copper (II) triflate] using a novel tagging technique for the labeling and identification of members of combinatorial libraries. Chloroarom. diazoketones II (n = 1, 7, 14; R = H, Cl) were used as tagging agents to identify the sequence of reactions to which a resin bead had been subjected; treatment of a resin bead with II in the presence of dirhodium tetrakis(triphenylacetate) yielded a polystyrene resin containing a fraction of chloroaralkyl cycloheptatriene moieties (formed by ring expansion of the polystyrene Ph groups). Oxidative cleavage of the tags with ceric ammonium nitrate liberated the chloroarom. portion of the tags; treatment of the tags with N,O-bis(trimethylsilyl)acetamide and gas chromatog. yielded masses corresponding to the sequence of reactions to which beads were subjected and thus their identities. The tags could be decoded either directly from a bead before compound cleavage, from a bead after compound cleavage, or from compound stock solutions (generated by compound cleavage and dissolution of a fraction of the liberated compounds in THF/H₂O). Decoding compound stock solutions was the most effective method of identifying library members; compounds were identified by tag cleavage of solutions containing 1 or 5% of the compound cleaved from a single bead. Stock solutions were decoded most effectively because a fraction of the library member on a given bead was tagged with the chloroarom. diazoketone in addition to the polystyrene resin (due to the high-loading resin used) and because oxidative cleavage of the tags with CAN proceeded more readily in solution than on solid support. A sublibrary of 108 beads chosen from the larger combinatorial library was decoded by this procedure; of the 108 compounds, 107 were successfully decoded. Four different synthetic pathways were found to be compatible with the diazoketone tagging methodol. (no data). The use of stock solutions for the decoding and deconvolution of combinatorial libraries is amenable to robotic methods for combinatorial library synthesis and testing, minimizes the storage requirements for combinatorial libraries, and allows for simpler and faster compound identification.

Angewandte Chemie, International Edition published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Gadre, J. N. published the artcileSynthesis of pyridone based azo disperse dyes, COA of Formula: C14H12N2S, the publication is Indian Journal of Heterocyclic Chemistry (2006), 16(1), 43-46, database is CAplus.

Pyridone derivatives have proved to be the best heterocyclic couplers as they provide proper nucleophilic center. In the present project N-aryl imides (pyridine-2,6-dione) were coupled with diazotized substituted aniline derivatives to yield azo disperse dyes.

Indian Journal of Heterocyclic Chemistry published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, COA of Formula: C14H12N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Li, Shasha published the artcileMerging Late-Stage Diversification with Solid-Phase Peptide Synthesis Enabled by High-Throughput On-Resin Reaction Screening, Safety of (4-(Thiazolidine-3-carbonyl)phenyl)boronic acid, the publication is ACS Catalysis (2022), 12(5), 3201-3210, database is CAplus.

An integrated workflow is described that combines micromole-scale high-throughput experimentation (HTE) reaction screening and solid-phase peptide synthesis (SPPS) to enable rapid synthetic method development for on-resin peptide diversification. Using this new approach, we have identified several sets of robust Suzuki-Miyaura coupling conditions with complementary scope that collectively display broad coverage with respect to both resin-bound peptide substrates containing aryl halide side chains and (hetero)arylboronic acid coupling partners. We have also demonstrated the utility of this integrated SPPS/chem. diversification method by synthesizing a multidimensional library of diverse peptides in high yields.

ACS Catalysis published new progress about 850589-33-2. 850589-33-2 belongs to thiazole, auxiliary class Thiazolidine,Boronic acid and ester,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (4-(Thiazolidine-3-carbonyl)phenyl)boronic acid, and the molecular formula is C10H12BNO3S, Safety of (4-(Thiazolidine-3-carbonyl)phenyl)boronic acid.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Lopez, Rosana published the artcileThe apparent dipole moments and molar volumes of 1,3-benzothiazole and some derivatives, in nonpolar solvents, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1999), 2225-2229, database is CAplus.

The apparent mol. polarizations at infinite dilution, P_2∞, mol. refractions, R_D, dipole moments, μ₂, polarizabilities, α, partial molar volumes, V ⁰_2,m, of 1,3-benzothiazole and some derivatives at position 2 or 3, were determined from relative permittivity, d. and refractive index measurements in n-hexane or 1,4-dioxane solutions at 25°. The R_D and V ⁰_2,m values correlate well for all substances studied, independently of the solvent used. The P_2∞ values appear to be slightly dependent on the solvent showing the presence of specific interactions as H bond. The apparent relative permittivity, ε₂‘, and the refraction index extrapolated at the IR region, n_IR, were estimated for all solutes. In the case of 1,3-benzothiazole and its 2-Me derivative, these results were compared with the relative permittivities measured at 25° at low and high frequencies, resp., by the Cole-Cole dynamic method, showing a good agreement. The apparent dipole moments and their changes with the corresponding substituent group were determined by 3 different methods. From the measurement of dipole moment it was unambiguously established that the tautomeric equilibrium between 2-mercapto-1,3-benzothiazole and 2-thioxo-3H-1,3-benzothiazole is strongly displaced to the latter. Changes in the apparent molar solution volumes and apparent molar polarizations of the solutes in the considered solvents are qual. discussed. Comparison between pK_a values reported in the literature and the corresponding μ values for free base benzothiazole derivatives were carried out as well as the appropriate qual. discussion.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Ukrainets, I. V. published the artcile4-hydroxy-2-quinolones. 122. 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid hetarylamides as potential antitubercular agents, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2007), 43(7), 863-870, database is CAplus.

An improved method is reported for the synthesis of a series of 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid hetarylamides, e.g., I. The antitubercular activity of all of the compounds prepared has been studied. The structure-biol. activity dependence revealed is discussed.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C40H35N7O8, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Hazra, Dipak K. published the artcileAb initio powder structure analysis and theoretical study of two thiazole derivatives, Related Products of thiazole, the publication is Journal of Molecular Structure (2013), 153-159, database is CAplus.

Crystal structures of 2-amino-5-methylthiazole (1) and 4-(6-methyl-2-benzothiazolyl) aniline (2) have been determined from laboratory X-ray powder diffraction data along with an anal. of the Hirshfeld surfaces and 2D-fingerprint plots, facilitating a comparison of intermol. interactions. The DFT optimized mol. geometries in (1) and (2) agree closely with those obtained from the crystallog. studies. An interplay of NH···N/S hydrogen bonds and C/NH···π interactions connects the mols. of (1) and (2) into two-dimensional framework. Hirshfeld surface anal. of (1) indicates that the H···H and H···π contacts can account for 56.9% of the Hirshfeld surface area, whereas the corresponding fraction in (2) is 80.5%.

Journal of Molecular Structure published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Related Products of thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica