Tag: M.W=200-250

Lartia, Remy published the artcileVersatile Introduction of Azido Moiety into Oligonucleotides through Diazo Transfer Reaction, HPLC of Formula: 1192027-04-5, the publication is Organic Letters (2011), 13(20), 5672-5675, database is CAplus and MEDLINE.

The use of a diazo transfer (DZT) reagent enables clean and efficient conversion of amino oligodeoxyribonucleotides (ODNs) into their azido counterparts under mild conditions. ODNs bearing an amino tether at the 3′, 5′, or any internal position could be modified in this manner thus demonstrating the versatility of this reaction. Easy access to such azido-modified ODNs is of great interest for conjugation in particular through click’ copper catalyzed 1,3-dipolar cycloaddition (CuAAC reaction).

Organic Letters published new progress about 1192027-04-5. 1192027-04-5 belongs to thiazole, auxiliary class Other Aliphatic Heterocyclic,Amine, name is N,N-Dimethyl-N’-(3-thioxo-3H-1,2,4-dithiazol-5-yl)formimidamide, and the molecular formula is C5H7N3S3, HPLC of Formula: 1192027-04-5.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Katritzky, Alan R. published the artcileAqueous high-temperature chemistry of carbo- and heterocycles. 11. Aquathermolysis of arylamines in the presence and absence of sodium bisulfite, Name: 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Energy & Fuels (1990), 4(5), 547-55, database is CAplus.

Thermolysis and neutral aqueous thermolysis of ring- and N-substituted anilines showed either no reaction or little conversion. In aqueous 10% H₃PO₄ the anilines underwent denitrogenation to give phenols. Friedel-Crafts alkylations and dealkylations were observed for alkyl-substituted anilines, together with the formation of diarylamines and carbazoles, both in runs with H₃PO₄ and in runs with an aqueous sulfite/bisulfite mixture Mechanistic pathways are suggested for the formation of all products. The foregoing has relevance to heteroatom elimination from coal, kerogen, and heavy oils.

Energy & Fuels published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Name: 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Phoon, C. W. published the artcileBiological evaluation of hepatitis C virus helicase inhibitors, Category: thiazole, the publication is Bioorganic & Medicinal Chemistry Letters (2001), 11(13), 1647-1650, database is CAplus and MEDLINE.

A small chem. library has been synthesized and assayed for inhibition of HCV helicase activity. This study provides the structure-activity relationship of the reported inhibitors, with emphasis placed on the aminophenylbenzimidazole moiety and the linkers. Our data highlight the importance of preserving the aminophenylbenzimidazole core and the hydrophobic linkers for biol. activity. The development of a robust HCV helicase assay is also described.

Bioorganic & Medicinal Chemistry Letters published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Tomoshige, Shusuke published the artcileDiscovery of Small Molecules that Induce the Degradation of Huntingtin, COA of Formula: C14H12N2S, the publication is Angewandte Chemie, International Edition (2017), 56(38), 11530-11533, database is CAplus and MEDLINE.

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by the aggregation of mutant huntingtin (mHtt), and removal of toxic mHtt is expected to be an effective therapeutic approach. The authors designed two small hybrid mols. by linking a ligand for ubiquitin ligase (cellular inhibitor of apoptosis protein 1; cIAP1) with probes for mHtt aggregates, anticipating that these compounds would recruit cIAP1 to mHtt and induce selective degradation by the ubiquitin-proteasome system. The synthesized compounds reduced mHtt levels in HD patient fibroblasts and appear to be promising candidates for the development of a treatment for HD.

Angewandte Chemie, International Edition published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C10H12O5, COA of Formula: C14H12N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Lynch, Daniel E. published the artcileThe hydrogen-bonding networks of 2-amino-4-phenyl-1,3-thiazole derivatives, Recommanded Product: 4-(Naphthalen-1-yl)thiazol-2-amine, the publication is Crystal Engineering (2002), 5(2), 123-136, database is CAplus.

The solid-state packing arrays of nine 4-Ph substituted 2-amino-1,3-thiazoles were examined and their H-bonding networks discussed. The nine compounds, in addition to 2-amino-1,3-thiazole 1, were 2-amino-4-phenyl-1,3-thiazole 2, 2-amino-4-phenyl-1,3-thiazolium bromide monohydrate 3, Et 2-amino-4-phenyl-1,3-thiazole-5-carboxylate 4, 2-amino-4-(3-coumarin)-1,3-thiazole 5, 2-amino-4-(4-methylphenyl)-1,3-thiazole 6, 2-amino-4-(2-hydroxyphenyl)-1,3-thiazole 7, 2-amino-4-(4-bisphenyl)-1,3-thiazole 8, 2-amino-4-(1-naphthyl)-1,3-thiazole 9, and 2-amino-4-(2-naphthyl)-1,3-thiazolium bromide 10. The single-crystal x-ray structures of 1-5 were previously reported while the structures of 6-10 are presented. A variety of different packing motifs are observed with only four (4, 5, 6 and 9) exhibiting the characteristic R₂²(8) H-bonded 2-amino-1,3-thiazole dimers. In two of these four structures (6 and 9) potential N-H…π H-bonding interactions exist whereas all remaining structures exhibit a combination of N-H…N with either N-H…O, N-H…S or N-H…Br associations in their H-bonding networks.

Crystal Engineering published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Recommanded Product: 4-(Naphthalen-1-yl)thiazol-2-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Maurya, R. C. published the artcileMagneto, spectral and thermal studies of some mixed-ligand cyanonitrosyl chromium (CrNO)⁵ complexes involving benzothiazole derivatives, COA of Formula: C14H12N2S, the publication is Journal of the Institution of Chemists (India) (1992), 64(1), 7-8, database is CAplus.

[Cr(NO)(CN)₂L₂(H₂O)] (L = 2-amino-6-ethoxy-, 2-amino-4-chloro-, 2-amino-6-nitro-, 2-amino-5,6-dimethyl-, 2-(2-tolyl)-, 2-(4-aminophenyl)-6-methylbenzothiazoles) were prepared and characterized by elemental anal., magnetic, molar conductance, TGA, and IR and ESR spectral methods. The benzothiazoles act as monodentate ligands coordinating through tertiary N.

Journal of the Institution of Chemists (India) published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, COA of Formula: C14H12N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Mohinuddin, Pinjari K. Md. published the artcileMontmorillonite K-10 Clay Mediated Green Synthesis of 2-Amino-4-aryl thiazole Derivatives from α-Brominated Aralkyl Ketones in Water, Recommanded Product: 4-(Naphthalen-1-yl)thiazol-2-amine, the publication is Current Green Chemistry (2015), 2(2), 163-169, database is CAplus.

Montmorillonite K-10 clay has been identified as an efficient and green catalyst for the synthesis of 2-amino-4-aryl thiazole derivatives I (R = 4-H₃CC₆H₄, 1-naphthyl, 2-naphthyl, etc.; R¹ = H, CH₃) in good to excellent isolated yields (80-96%) from α-brominated aralkyl ketones RC(O)C(R¹)Br and thiourea in aqueous medium at 25-30 °C. The present procedure offers advantages of short reaction time, simple work-up, high yields of products and the catalyst is environmentally benign and exhibits remarkable reusable activity by four times.

Current Green Chemistry published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Recommanded Product: 4-(Naphthalen-1-yl)thiazol-2-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Rajitha, Kamalon published the artcileSynthesis of graphene oxide-based nanofillers and their influence on the anticorrosion performance of epoxy coating in saline medium, COA of Formula: C13H10N2S, the publication is Diamond and Related Materials (2020), 107974, database is CAplus.

The present study investigated the anticorrosion performance of epoxy coating by the incorporation of two different functionalized graphene oxides as nanofillers in saline media. GO was functionalized with 2-aminothiazole (AT) and 2-amino-4-(1-Naphthyl)Thiazole (ANT) and modified compounds were characterized by X-ray diffraction (XRD), Fourier transform IR spectroscopy (FT-IR), Thermogravimetric anal. (TGA), Raman spectroscopy, and SEM. 0.2 Weight% of neat epoxy and epoxy nanocomposites (GO-AT/EP and GO-ANT/EP) were coated on mild steel substrate by a spin coating method and the formation of a protective film on the steel surface was confirmed using SEM, Atomic Force Microscopy (AFM) and contact angle test. The electrochem. impedance spectroscopy was employed to study the corrosion protection properties of nanocomposite coatings in 3.5% NaCl medium. The results signify the better anticorrosion performance of nanocomposite coatings due to their two-dimensional sheet structures, uniform dispersion and exfoliation in the epoxy matrix, hydrophobic nature and stopping up tiny pores properties. The GO-ANT/EP coating exhibited higher coating resistance (6.598 x 107 Ω cm²) than GO-AT/EP (1.017 x 105 Ω cm²) and pure epoxy (1270 Ω cm²) coating. The crowded structure of GO-ANT helps in forming highly crosslinked compact epoxy coating and therefore displays excellent corrosion protection efficiency than other coatings.

Diamond and Related Materials published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, COA of Formula: C13H10N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Bodireddy, Mohan Reddy published the artcileLactic acid-mediated tandem one-pot synthesis of 2-aminothiazole derivatives: a rapid, scalable, and sustainable process, Application of 4-(Naphthalen-1-yl)thiazol-2-amine, the publication is Cogent Chemistry (2016), 2(1), 1154237/1-1154237/13, database is CAplus.

Environmentally benign and biodegradable lactic acid was identified as alternative solvent and catalyst for the tandem one-pot synthesis of Hantzsch 2-aminothiazole derivatives from readily available aralkyl ketones through in-situ regioselective α-bromination using N-bromosuccinimide followed by heterocyclization using thiourea at 90-100°. The major advantages of the present method include short reaction times (10-15 min), practical, simple to perform, easy work-up, good yield of products (up to 96%), productive for large-scale applications, free from apply of α-bromoketones (lachrymator) as substrates, avoids column purification Hence, the present method met with the concepts of both Wender’s “ideal synthesis” and sustainable chem. process.

Cogent Chemistry published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Application of 4-(Naphthalen-1-yl)thiazol-2-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Lynch, Daniel E. published the artcileThe hydrogen-bonding networks of 2-amino-4-phenyl-1,3-thiazole derivatives, Recommanded Product: 4-(Naphthalen-1-yl)thiazol-2-amine, the publication is Crystal Engineering (2002), 5(2), 123-136, database is CAplus.

The solid-state packing arrays of nine 4-Ph substituted 2-amino-1,3-thiazoles were examined and their H-bonding networks discussed. The nine compounds, in addition to 2-amino-1,3-thiazole 1, were 2-amino-4-phenyl-1,3-thiazole 2, 2-amino-4-phenyl-1,3-thiazolium bromide monohydrate 3, Et 2-amino-4-phenyl-1,3-thiazole-5-carboxylate 4, 2-amino-4-(3-coumarin)-1,3-thiazole 5, 2-amino-4-(4-methylphenyl)-1,3-thiazole 6, 2-amino-4-(2-hydroxyphenyl)-1,3-thiazole 7, 2-amino-4-(4-bisphenyl)-1,3-thiazole 8, 2-amino-4-(1-naphthyl)-1,3-thiazole 9, and 2-amino-4-(2-naphthyl)-1,3-thiazolium bromide 10. The single-crystal x-ray structures of 1-5 were previously reported while the structures of 6-10 are presented. A variety of different packing motifs are observed with only four (4, 5, 6 and 9) exhibiting the characteristic R₂²(8) H-bonded 2-amino-1,3-thiazole dimers. In two of these four structures (6 and 9) potential N-H…π H-bonding interactions exist whereas all remaining structures exhibit a combination of N-H…N with either N-H…O, N-H…S or N-H…Br associations in their H-bonding networks.

Crystal Engineering published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Recommanded Product: 4-(Naphthalen-1-yl)thiazol-2-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica