Tag: M.W:200-300

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.92-36-4, Name is 2-(4-Aminophenyl)-6-methylbenzothiazole, molecular formula is C14H12N2S. In a Article，once mentioned of 92-36-4, Computed Properties of C14H12N2S

T-REX on-demand redox targeting in live cells

This protocol describes targetable reactive electrophiles and oxidants (T-REX) – a live-cell-based tool designed to (i) interrogate the consequences of specific and time-resolved redox events, and (ii) screen for bona fide redox-sensor targets. A small-molecule toolset comprising photocaged precursors to specific reactive redox signals is constructed such that these inert precursors specifically and irreversibly tag any HaloTag-fused protein of interest (POI) in mammalian and Escherichia coli cells. Syntheses of the alkyne-functionalized endogenous reactive signal 4-hydroxynonenal (HNE(alkyne)) and the HaloTag-targetable photocaged precursor to HNE(alkyne) (also known as Ht-PreHNE or HtPHA) are described. Low-energy light prompts photo-uncaging (t1/2 <1-2 min) and target-specific modification. The targeted modification of the POI enables precisely timed and spatially controlled redox events with no off-target modification. Two independent pathways are described, along with a simple setup to functionally validate known targets or discover novel sensors. T-REX sidesteps mixed responses caused by uncontrolled whole-cell swamping with reactive signals. Modification and downstream response can be analyzed by in-gel fluorescence, proteomics, qRT-PCR, immunofluorescence, fluorescence resonance energy transfer (FRET)-based and dual-luciferase reporters, or flow cytometry assays. T-REX targeting takes 4 h from initial probe treatment. Analysis of targeted redox responses takes an additional 4-24 h, depending on the nature of the pathway and the type of readouts used. Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Computed Properties of C14H12N2S, you can also check out more blogs about92-36-4

Reference：
Thiazole | C3H508NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.153719-23-4, Name is N-(3-((2-Chlorothiazol-5-yl)methyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene)nitramide, molecular formula is C8H10ClN5O3S. In a Patent，once mentioned of 153719-23-4, Product Details of 153719-23-4

LIQUID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES

Disclosed are suspension concentrate compositions comprising by weight based on the total weight of the composition, about 0.1 to about 40% of at least one carboxamide arthropodicide; 0 to about 20% of at least one other biologically active agent; about 30 to about 95% of at least one water-immiscible liquid carrier; about 2 to about 50% of at least one emulsifier; about 0.01 to about 10% of a silica thickener; about 0.1 to about 10% of at least one protic solvent selected from water, a C1-C12 alkanol and a C2-C3 glycol; and about 0.001 to about 5% of at least one water-soluble carboxylic acid. This invention also relates to a method for controlling an arthropod pest comprising diluting said suspension concentrate composition with water, and optionally adding an adjuvant to form a diluted composition, and contacting the arthropod pest or its environment with an effective amount of said diluted composition.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Product Details of 153719-23-4, you can also check out more blogs about153719-23-4

Reference：
Thiazole | C3H8928NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 4845-58-3. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 4845-58-3, Name is 6-Nitrobenzo[d]thiazole-2(3H)-thione

Syntheses, characterizations and crystal structures of new organotin complexes with 2-mercapto-6-nitrobenzothiazole

A series of organotin(IV) complexes with 2-mercapto-6-nitrobenzothiazole (HMNBT) of the type, [RnSn(MNBT)4-n] (n = 2, R = Me, 4; n = 3, R = Me, 5; n-Bu, 6; Ph, 7; PhCH2, 8) were synthesized. All the complexes 4-8 have been characterized by elemental, IR and 1H NMR analyses. Among them, complexes 4, 7 and 8 were also characterized by X-ray crystallography diffraction analyses, which revealed that the structures of both complexes 7 and 8 are penta-coordinated with R3Sn coordinated to the thiol S and heterocyclic N atoms, and the structural distortion for each is a displacement from tetragonal towards trigonal bipyramidal geometry. For complex 4, the geometry of the center tin atom is a distorted trapezoidal bipyramid. Besides, intermolecular S?S and Sn?S non-bonded interactions were recognized in crystal structures of complexes 4 and 7, respectively. The IR and 1H NMR spectral data indicate such an inclination that those structures of trialkyltin derivatives are apt to be penta-coordinated and those dialkyltin derivatives are likely in six-coordination.

If you are hungry for even more, make sure to check my other article about 4845-58-3. Application of 4845-58-3

Reference：
Thiazole | C3H7382NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 2941-48-2, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 2941-48-2, Name is 2,5-Dichlorobenzothiazole, molecular formula is C7H3Cl2NS. In a Article，once mentioned of 2941-48-2

II. Synthesis and biological evaluation of some bioisosteres and congeners of the antitumor agent, 2-{4-[(7-chloro-2-quinoxalinyl)oxylphenoxy}propionic acid (XK469)

XK469 (1) is among the most highly and broadly active antitumor agents to have been evaluated in our laboratories. Subsequent developmental studies led to the entry of (R)-(+) 1 (NSC 698215) into phase 1 clinical trials (NIH UO1-CA62487). The antitumor mechanism of action of 1 remains to be elucidated, which has prompted a sustained effort to elaborate a pharmacophoric pattern of 1. The present study focused on a strategy of synthesis and biological evaluation of topologically based, bioisosteric replacements of the quinoxaline moiety in the lead compound (1) by quinazoline (4a-d), 1,2,4-benzotriazine (12a-18b), and quinoline (21a-g) ring systems. The synthetic approach to each of the bioisosteres of I utilized the methodology developed in previous work (see Hazeldine, S. T.; Polin, L.; Kushner, J.; Paluch, J.; White, K.; Edelstein, M.; Palomino, E.; Corbett, T. H.; Horwitz, J. P. Design, Synthesis, and Biological Evaluation of Analogues of the Antitumor Agent 2-{4-[(7-Chloro-quinoxalinyl)oxy]phenoxy}propionic acid (XK469). J. Med. Chem. 2001, 44, 1758-1776.), which is extended to the procurement of the benzoxazole (23a,b), benzthiazole (23c,d), pyridine (25a,b), and pyrazine (27) congeners of 1. Only quinoline analogues, bearing a 7-halo (21a,b,d,e) or a 7-methoxy substituent (21g), showed antitumor activities (Br > Cl > CH3O > F ? 1), at levels comparable to or greater than the range of activities manifested by 1 and corresponding analogues. At high individual dosages, the (S)-(-) enantiomers of I and 21b,d all produce a reversible slowing of nerve-conduction velocity in the mice, the onset of which is characterized by a distinctive dysfunction of the hind legs, causing uncoordinated movements. The condition resolves within 5-10 min. However, at higher dosages, which approach a lethal level, the behavior extended to the front legs, lasting from 20 min to 1 h. By contrast, the (R)-(+) forms of these same agents did not induce the phenomenon of slowing of nerve-conduction velocity.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2941-48-2 is helpful to your research., Reference of 2941-48-2

Reference：
Thiazole | C3H1705NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.317318-97-1, Name is 5-(Chloromethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole, molecular formula is C12H9ClF3NS. In a Patent，once mentioned of 317318-97-1, COA of Formula: C12H9ClF3NS

Aniline derivatives, their manufacture and use as pharmaceuticals

This invention relates to compounds of the formula wherein X is N and Y is S or O; or X is S or O and Y is N; Ris hydrogen or C1-7-alkyl; Rand Rindependently from each other are selected from the group consisting of hydrogen, C1-7-alkyl and C1-7-alkoxy; R, R, R, and Rindependently from each other are selected from the group consisting of hydrogen, C1-7-alkyl, C3-7-cycloalkyl, halogen, C1-7-alkoxy, C1-7-alkyl-C1-7-alkoxy-C1-7-alkyl, C2-7-alkenyl, C2-7-alkinyl, fluoro-C1-7-alkyl and cyano; Ris selected from the group consisting of hydrogen, C1-7-alkyl, C3-7-cycloalkyl and fluoro-C1-7-alkyl; Ris selected from the group consisting of hydrogen, C1-7-alkyl, C2-7-alkinyl, C3-7-cycloalkyl and fluoro-C1-7-alkyl; Ris selected from the group consisting of hydrogen, C1-7-alkyl, C2-7-alkinyl, C3-7-cycloalkyl and fluoro-C1-7-alkyl; Ris aryl or heteroaryl; N is 0, 1 or 2; and all enantiomers and pharmaceutically acceptable salts and/or esters thereof and their use as PPAR activators.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.COA of Formula: C12H9ClF3NS, you can also check out more blogs about317318-97-1

Reference：
Thiazole | C3H5984NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.677304-89-1, Name is Ethyl 2-aminobenzo[d]thiazole-7-carboxylate, molecular formula is C10H10N2O2S. In a Article，once mentioned of 677304-89-1, Quality Control of: Ethyl 2-aminobenzo[d]thiazole-7-carboxylate

Molecular design, synthesis, and structure-activity relationships leading to the potent and selective p56lck inhibitor BMS-243117

A series of structurally novel benzothiazole based small molecule inhibitors of p56lck were prepared to elucidate their structure-activity relationships (SARs), selectivity and cell activity in the T-cell proliferation assay. BMS-243117 (compound 2) is identified as a potent, and selective Lck inhibitor with good cellular activity (IC50=1.1 muM) against T-cell proliferation.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Quality Control of: Ethyl 2-aminobenzo[d]thiazole-7-carboxylate, you can also check out more blogs about677304-89-1

Reference：
Thiazole | C3H7962NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 302964-02-9, Name is 2-Boc-Aminothiazole-5-carboxylic acid, molecular formula is C9H12N2O4S. In a Patent，once mentioned of 302964-02-9, COA of Formula: C9H12N2O4S

AN IMPROVED PROCESS FOR THE PREPARATION OF DASATINIB POLYMORPH

The present invention is related to an improved process for the preparation of dasatinib anhydrous crystalline Neat form N-6 with high purity and high yield. The present invention also relates to purification of dasatinib crystalline Neat form N-6.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.COA of Formula: C9H12N2O4S, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 302964-02-9, in my other articles.

Reference：
Thiazole | C3H2381NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 16582-59-5, Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.16582-59-5, Name is 2-Amino-4,6-dichlorobenzothiazole, molecular formula is C7H4Cl2N2S. In a patent, introducing its new discovery.

Substituted 2-benzothiazolamines as sodium flux inhibitors: Quantitative structure-activity relationships and anticonvulsant activity

Thirty-two aryl-substituted 2-benzothiazolamines have been tested for their ability to modulate sodium flux in rat cortical slices. A QSAR analysis, applied to these derivatives, showed a trend toward increasing potency as sodium flux inhibitors with increasing lipophilicity, decreasing size, and increasing electron withdrawal of the benzo ring substitutents. Additionally, 4- or 5-substitution of the benzo ring was found to decrease potency. The combination of increased lipophilicity, small size, and electron withdrawal severely limited which groups were tolerated on the benzo ring, thus suggesting that the optimal substitution patterns have been prepared within this series. Nine of these compounds were potent inhibitors of veratridine-induced sodium flux (NaFl). These nine compounds also proved to be anticonvulsant in the maximal electroshock (MES) assay. Fourteen additional 2-benzothiazolamines demonstrated activity in the MES screen, yet exhibited no activity in the NaFl assay. These derivatives may be interacting at the sodium channel in a manner not discernible by the flux paradigm, or they may be acting by an alternative mechanism in vivo.

If you are interested in 16582-59-5, you can contact me at any time and look forward to more communication.Application of 16582-59-5

Reference：
Thiazole | C3H1888NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 153719-23-4, Name is N-(3-((2-Chlorothiazol-5-yl)methyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene)nitramide, molecular formula is C8H10ClN5O3S. In a Patent，once mentioned of 153719-23-4, Application In Synthesis of N-(3-((2-Chlorothiazol-5-yl)methyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene)nitramide

CLATHRATE COMPOUND, METHOD OF CONTROLLING CONCENTRATION OF AQUEOUS SOLUTION OF AGRICULTURAL-CHEMICAL ACTIVE INGREDIENT, AND AGRICULTURAL-CHEMICAL PREPARATION

The present invention provides a clathrate compound characterized by containing: a polymolecular host compound as a host compound; and an agricultural chemical active ingredient having a saturated solubility in water at 25C of not less than 500 ppm as a guest compound. The present invention also provides a method for controlling the concentration of an aqueous agricultural chemical active ingredient solution, characterized by containings a step of including an agricultural chemical active ingredient having high saturated solubility in an interior space formed of a polymolecular host compound, thereby maintaining the saturated solubility of the agricultural chemical active ingredient in water within a predetermined concentration range. The present invention also provides an agricultural chemical formulation containing the clathrate compound. The present invention also provides an agricultural active composition containing the clathrate compound and a synthetic pyrethroid.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of N-(3-((2-Chlorothiazol-5-yl)methyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene)nitramide. In my other articles, you can also check out more blogs about 153719-23-4

Reference：
Thiazole | C3H8769NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1187928-41-1, Name is Methyl 6-bromobenzo[d]thiazole-2-carboxylate, molecular formula is C9H6BrNO2S. In a Article，once mentioned of 1187928-41-1, Computed Properties of C9H6BrNO2S

Direct C-H carboxylation with carbon dioxide using 1,2,3-triazol-5-ylidene copper(I) complexes

1,2,3-Triazol-5-ylidene copper(I) complexes (tzNHC-Cu) efficiently catalyzed the direct C-H carboxylation of benzoxazole and benzothiazole derivatives with CO2 to give the corresponding esters in excellent yields after treatment with alkyl iodide. The tzNHC copper(I) complex, i.e., [(TPr)CuCl], worked somewhat more effectively than the corresponding imidazol-2-ylidene copper(I) complex [(IPr)CuCl] to give the carboxylation product in higher yields.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Computed Properties of C9H6BrNO2S. In my other articles, you can also check out more blogs about 1187928-41-1

Reference：
Thiazole | C3H8505NS – PubChem,
Thiazole | chemical compound | Britannica