Tag: M.W:200-300

144060-99-1, Name is 2-(4-Fluorophenyl)-4-methylthiazole-5-carboxylic acid, molecular formula is C11H8FNO2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 144060-99-1, Application In Synthesis of 2-(4-Fluorophenyl)-4-methylthiazole-5-carboxylic acid

Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents

The peroxisome proliferator activated receptors PPARalpha, PPARgamma, and PPARdelta are ligand-activated transcription factors that play a key role in lipid homeostasis. The fibrates raise circulating levels of high-density lipoprotein cholesterol and lower levels of triglycerides in part through their activity as PPARalpha agonists; however, the low potency and restricted selectivity of the fibrates may limit their efficacy, and it would be desirable to develop more potent and selective PPARalpha agonists. Modification of the selective PPARdelta agonist 1 (GW501516) so as to incorporate the 2-aryl-2-methylpropionic acid group of the fibrates led to a marked shift in potency and selectivity toward PPARalpha agonism. Optimization of the series gave 25a, which shows EC50 = 4 nM on PPARalpha and at least 500-fold selectivity versus PPARgamma and PPARgamma. Compound 25a (GW590735) has been progressed to clinical trials for the treatment of diseases of lipid imbalance.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of 2-(4-Fluorophenyl)-4-methylthiazole-5-carboxylic acid. In my other articles, you can also check out more blogs about 144060-99-1

Reference：
Thiazole | C3H579NS – PubChem,
Thiazole | chemical compound | Britannica

Related Products of 54045-76-0, An article , which mentions 54045-76-0, molecular formula is C4H2BrNO2S. The compound – 2-Bromothiazole-5-carboxylic acid played an important role in people’s production and life.

N-CYCLYL-3-(CYCLYLCARBONYLAMINOMETHYL) BENZAMIDE DERIVATIVES AS RHO KINASE INHIBITORS

The present invention relates to compounds of formula (I) : and pharmaceutically acceptable salts thereof, wherein R1and R2 are various ring systems. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of Rho Kinase mediated diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 54045-76-0, help many people in the next few years., Related Products of 54045-76-0

Reference：
Thiazole | C3H2797NS – PubChem,
Thiazole | chemical compound | Britannica

Related Products of 80945-86-4, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 80945-86-4, C7H3BrClNS. A document type is Patent, introducing its new discovery.

NOVEL COMPOUNDS

The invention relates to substituted phenoxyacetic acids (I) as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation

If you are hungry for even more, make sure to check my other article about 80945-86-4. Related Products of 80945-86-4

Reference：
Thiazole | C3H10887NS – PubChem,
Thiazole | chemical compound | Britannica

16112-21-3, Name is 2-(4-Methylphenyl)benzothiazole, molecular formula is C14H11NS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 16112-21-3, Formula: C14H11NS

Iron(II) bromide-catalyzed oxidative coupling of benzylamines with ortho-substituted anilines: Synthesis of 1,3-benzazoles

An iron(II) bromide-catalyzed oxidative coupling of benzylamines with 2-amino/hydroxy/mercapto-anilines has been developed, allowing the synthesis of a diversity of substituted 1,3-benzazoles in good to excellent yields. This transformation is compatible with a wide range of functional groups. The method is practical, economical and employs molecular oxygen as an oxidant.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Formula: C14H11NS. In my other articles, you can also check out more blogs about 16112-21-3

Reference：
Thiazole | C3H763NS – PubChem,
Thiazole | chemical compound | Britannica

2941-48-2, Name is 2,5-Dichlorobenzothiazole, molecular formula is C7H3Cl2NS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 2941-48-2, SDS of cas: 2941-48-2

A mild and efficient one-pot synthesis of 2-aminated benzoxazoles and benzothiazoles

Previous syntheses of the biologically active 2-aminated benzoxazoles have relied on forcing thermal conditions to generate the products directly from the corresponding thiols. The resulting yields have ranged from moderate to poor. A mild and high-yielding alternative one-pot chlorination-amination procedure is described. Compounds with a variety of substitution patterns are reported and the methodology has been successfully extended to benzothiazoles. Palladium catalysis on suitably activated examples has been employed to generate the desired compounds of interest.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.SDS of cas: 2941-48-2. In my other articles, you can also check out more blogs about 2941-48-2

Reference：
Thiazole | C3H1720NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 2942-23-6. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 2942-23-6, Name is 2,7-Dichlorobenzo[d]thiazole

Water-Promoted Chlorination of 2-Mercaptobenzothiazoles

Substituted benzothiazoles play an important role in medicinal chemistry due to their pharmacological properties. Their 2-substituted derivatives are often prepared from 2-chlorobenzothiazoles, which in turn can be synthesized from the 2-mercapto precursor using sulfuryl chloride. In practice, this seemingly straightforward and widely used reaction can be impeded by poor reproducibility and low reaction yields. In this communication, we report that the simple addition of water to the reaction leads to remarkable improvements in reaction efficiency. We attribute this effect to the formation of acid through partial hydrolysis of sulfuryl chloride. This hypothesis is supported by the observation that improved yields were also obtained in the presence of some anhydrous acidic additives. The simple combination of sulfuryl chloride and water reproducibly provides excellent yields for a range of chlorinated products.

If you are hungry for even more, make sure to check my other article about 2942-23-6. Synthetic Route of 2942-23-6

Reference：
Thiazole | C3H1752NS – PubChem,
Thiazole | chemical compound | Britannica

144060-99-1, Name is 2-(4-Fluorophenyl)-4-methylthiazole-5-carboxylic acid, molecular formula is C11H8FNO2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 144060-99-1, Application In Synthesis of 2-(4-Fluorophenyl)-4-methylthiazole-5-carboxylic acid

Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents

The peroxisome proliferator activated receptors PPARalpha, PPARgamma, and PPARdelta are ligand-activated transcription factors that play a key role in lipid homeostasis. The fibrates raise circulating levels of high-density lipoprotein cholesterol and lower levels of triglycerides in part through their activity as PPARalpha agonists; however, the low potency and restricted selectivity of the fibrates may limit their efficacy, and it would be desirable to develop more potent and selective PPARalpha agonists. Modification of the selective PPARdelta agonist 1 (GW501516) so as to incorporate the 2-aryl-2-methylpropionic acid group of the fibrates led to a marked shift in potency and selectivity toward PPARalpha agonism. Optimization of the series gave 25a, which shows EC50 = 4 nM on PPARalpha and at least 500-fold selectivity versus PPARgamma and PPARgamma. Compound 25a (GW590735) has been progressed to clinical trials for the treatment of diseases of lipid imbalance.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of 2-(4-Fluorophenyl)-4-methylthiazole-5-carboxylic acid. In my other articles, you can also check out more blogs about 144060-99-1

Reference：
Thiazole | C3H579NS – PubChem,
Thiazole | chemical compound | Britannica

Related Products of 54045-76-0, An article , which mentions 54045-76-0, molecular formula is C4H2BrNO2S. The compound – 2-Bromothiazole-5-carboxylic acid played an important role in people’s production and life.

N-CYCLYL-3-(CYCLYLCARBONYLAMINOMETHYL) BENZAMIDE DERIVATIVES AS RHO KINASE INHIBITORS

The present invention relates to compounds of formula (I) : and pharmaceutically acceptable salts thereof, wherein R1and R2 are various ring systems. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of Rho Kinase mediated diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 54045-76-0, help many people in the next few years., Related Products of 54045-76-0

Reference：
Thiazole | C3H2797NS – PubChem,
Thiazole | chemical compound | Britannica

Related Products of 80945-86-4, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 80945-86-4, C7H3BrClNS. A document type is Patent, introducing its new discovery.

NOVEL COMPOUNDS

The invention relates to substituted phenoxyacetic acids (I) as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation

If you are hungry for even more, make sure to check my other article about 80945-86-4. Related Products of 80945-86-4

Reference：
Thiazole | C3H10887NS – PubChem,
Thiazole | chemical compound | Britannica

16112-21-3, Name is 2-(4-Methylphenyl)benzothiazole, molecular formula is C14H11NS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 16112-21-3, Formula: C14H11NS

Iron(II) bromide-catalyzed oxidative coupling of benzylamines with ortho-substituted anilines: Synthesis of 1,3-benzazoles

An iron(II) bromide-catalyzed oxidative coupling of benzylamines with 2-amino/hydroxy/mercapto-anilines has been developed, allowing the synthesis of a diversity of substituted 1,3-benzazoles in good to excellent yields. This transformation is compatible with a wide range of functional groups. The method is practical, economical and employs molecular oxygen as an oxidant.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Formula: C14H11NS. In my other articles, you can also check out more blogs about 16112-21-3

Reference：
Thiazole | C3H763NS – PubChem,
Thiazole | chemical compound | Britannica