Tag: M.W:200-300

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.66947-92-0, Name is Methyl 2-amino-1,3-benzothiazole-6-carboxylate, molecular formula is C9H8N2O2S. In a Patent£¬once mentioned of 66947-92-0, Recommanded Product: 66947-92-0

The present invention provides a phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt can selectively inhibit the protein-protein interaction between KRS and a laminin receptor (LR), thereby inhibiting migration of cancer cells. Therefore, the phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt may be usefully applied for preventing or treating the diseases associated with cancer cell metastasis

The present invention provides a phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt can selectively inhibit the protein-protein interaction between KRS and a laminin receptor (LR), thereby inhibiting migration of cancer cells. Therefore, the phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt may be usefully applied for preventing or treating the diseases associated with cancer cell metastasis

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 66947-92-0 is helpful to your research., Recommanded Product: 66947-92-0

Reference£º
Thiazole | C3H8381NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 61296-22-8, Name is 2-Amino-5-bromothiazole monohydrobromide,molecular formula is C3H4Br2N2S, is a conventional compound. this article was the specific content is as follows.Recommanded Product: 2-Amino-5-bromothiazole monohydrobromide

A new class of alkylsulfonyl-substituted thiazolide compounds is described. These compounds show strong activity against hepatitis virus.

A new class of alkylsulfonyl-substituted thiazolide compounds is described. These compounds show strong activity against hepatitis virus.

Do you like my blog? If you like, you can also browse other articles about this kind. Recommanded Product: 2-Amino-5-bromothiazole monohydrobromide. Thanks for taking the time to read the blog about 61296-22-8

Reference£º
Thiazole | C3H2125NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 4175-77-3, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 4175-77-3, Name is 2,4-Dibromothiazole, molecular formula is C3HBr2NS. In a Article£¬once mentioned of 4175-77-3

The synthesis and biological evaluation of a series of 12,13-aziridinyl epothilone B analogues is described. These compounds were accessed by a practical, general process that involved a 12,13-olefinic methyl ketone as a starting material obtained by ozonolytic cleavage of epothilone B followed by tungsten-induced deoxygenation of the epoxide moiety. The attachment of the aziridine structural motif was achieved by application of the Ess-Kuerti-Falck aziridination, while the heterocyclic side chains were introduced via stereoselective phosphonate-based olefinations. In order to ensure high (E) selectivities for the latter reaction for electron-rich heterocycles, it became necessary to develop and apply an unprecedented modification of the venerable Horner-Wadsworth-Emmons reaction, employing 2-fluoroethoxyphosphonates that may prove to be of general value in organic synthesis. These studies resulted in the discovery of some of the most potent epothilones reported to date. Equipped with functional groups to accommodate modern drug delivery technologies, some of these compounds exhibited picomolar potencies that qualify them as payloads for antibody drug conjugates (ADCs), while a number of them revealed impressive activities against drug resistant human cancer cells, making them desirable for potential medical applications.

The synthesis and biological evaluation of a series of 12,13-aziridinyl epothilone B analogues is described. These compounds were accessed by a practical, general process that involved a 12,13-olefinic methyl ketone as a starting material obtained by ozonolytic cleavage of epothilone B followed by tungsten-induced deoxygenation of the epoxide moiety. The attachment of the aziridine structural motif was achieved by application of the Ess-Kuerti-Falck aziridination, while the heterocyclic side chains were introduced via stereoselective phosphonate-based olefinations. In order to ensure high (E) selectivities for the latter reaction for electron-rich heterocycles, it became necessary to develop and apply an unprecedented modification of the venerable Horner-Wadsworth-Emmons reaction, employing 2-fluoroethoxyphosphonates that may prove to be of general value in organic synthesis. These studies resulted in the discovery of some of the most potent epothilones reported to date. Equipped with functional groups to accommodate modern drug delivery technologies, some of these compounds exhibited picomolar potencies that qualify them as payloads for antibody drug conjugates (ADCs), while a number of them revealed impressive activities against drug resistant human cancer cells, making them desirable for potential medical applications.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 4175-77-3 is helpful to your research., Reference of 4175-77-3

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Thiazole | C3H1261NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 16112-21-3, Name is 2-(4-Methylphenyl)benzothiazole,molecular formula is C14H11NS, is a conventional compound. this article was the specific content is as follows.Safety of 2-(4-Methylphenyl)benzothiazole

An efficient and simple procedure has been developed for the synthesis of various 2-arylbenzothiazoles by acetic acid-promoted condensation of 2 -aminothiophenol with aromatic aldehydes under microwave irradiation and solvent-free conditions in high yields.

An efficient and simple procedure has been developed for the synthesis of various 2-arylbenzothiazoles by acetic acid-promoted condensation of 2 -aminothiophenol with aromatic aldehydes under microwave irradiation and solvent-free conditions in high yields.

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Thiazole | C3H780NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.5331-91-9, Name is 5-Chlorobenzo[d]thiazole-2(3H)-thione, molecular formula is C7H4ClNS2. In a Article£¬once mentioned of 5331-91-9, Application In Synthesis of 5-Chlorobenzo[d]thiazole-2(3H)-thione

Indoleamine 2,3-dioxygenase (IDO) is an important therapeutic target for the treatment of diseases such as cancer that involve pathological immune escape. We have used the evolutionary docking algorithm EADock to design new inhibitors of this enzyme. First, we investigated the modes of binding of all known IDO inhibitors. On the basis of the observed docked conformations, we developed a pharmacophore model, which was then used to devise new compounds to be tested for IDO inhibition.We also used a fragment-based approach to design and to optimize small organic molecule inhibitors. Both approaches yielded several new low-molecular weight inhibitor scaffolds, the most active being of nanomolar potency in an enzymatic assay. Cellular assays confirmed the potential biological relevance of four different scaffolds.

Indoleamine 2,3-dioxygenase (IDO) is an important therapeutic target for the treatment of diseases such as cancer that involve pathological immune escape. We have used the evolutionary docking algorithm EADock to design new inhibitors of this enzyme. First, we investigated the modes of binding of all known IDO inhibitors. On the basis of the observed docked conformations, we developed a pharmacophore model, which was then used to devise new compounds to be tested for IDO inhibition.We also used a fragment-based approach to design and to optimize small organic molecule inhibitors. Both approaches yielded several new low-molecular weight inhibitor scaffolds, the most active being of nanomolar potency in an enzymatic assay. Cellular assays confirmed the potential biological relevance of four different scaffolds.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of 5-Chlorobenzo[d]thiazole-2(3H)-thione, you can also check out more blogs about5331-91-9

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Thiazole | C3H6320NS – PubChem,
Thiazole | chemical compound | Britannica

344-72-9, Name is Ethyl 2-amino-4-(trifluoromethyl)thiazole-5-carboxylate, molecular formula is C7H7F3N2O2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 344-72-9, name: Ethyl 2-amino-4-(trifluoromethyl)thiazole-5-carboxylate

Quinazolinedione derivatives useful for treating cellular proliferative disorders and disorders associated with Kif15 kinesin activity are described.

Quinazolinedione derivatives useful for treating cellular proliferative disorders and disorders associated with Kif15 kinesin activity are described.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.name: Ethyl 2-amino-4-(trifluoromethyl)thiazole-5-carboxylate. In my other articles, you can also check out more blogs about 344-72-9

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Thiazole | C3H7921NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.777-12-8, Name is 6-(Trifluoromethyl)benzo[d]thiazol-2-amine, molecular formula is C8H5F3N2S. In a Article£¬once mentioned of 777-12-8, Application In Synthesis of 6-(Trifluoromethyl)benzo[d]thiazol-2-amine

A family of highly emissive benzo[4,5]thiazolo[3,2-c][1,3,5,2]oxadiazaborinines, conjugated with the donor 4-dimethylaminophenyl group, was designed and synthesized. Their photophysical, both in solution and in the solid state, and structural properties were investigated. The influence of donor and acceptor substituents (R) in the benzothiazole unit on photophysical properties of complexes was found out. The tetrafluorobenzothiazole analogue exhibits nonbonded nuclear spin-spin coupling between fluorines from the BF2 group and alpha-fluorine atom at the benzene ring. Additionally, this boron complex demonstrates a comparatively high solid-state fluorescence quantum yield (phi = 0.34).

A family of highly emissive benzo[4,5]thiazolo[3,2-c][1,3,5,2]oxadiazaborinines, conjugated with the donor 4-dimethylaminophenyl group, was designed and synthesized. Their photophysical, both in solution and in the solid state, and structural properties were investigated. The influence of donor and acceptor substituents (R) in the benzothiazole unit on photophysical properties of complexes was found out. The tetrafluorobenzothiazole analogue exhibits nonbonded nuclear spin-spin coupling between fluorines from the BF2 group and alpha-fluorine atom at the benzene ring. Additionally, this boron complex demonstrates a comparatively high solid-state fluorescence quantum yield (phi = 0.34).

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 777-12-8 is helpful to your research., Application In Synthesis of 6-(Trifluoromethyl)benzo[d]thiazol-2-amine

Reference£º
Thiazole | C3H6740NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of 2103-99-3. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 2103-99-3, Name is 4-(4-Chlorophenyl)thiazol-2-amine. In a document type is Patent, introducing its new discovery.

Amides of heterocyclic compounds as Transient Receptor Potential subfamily A (TRPA) modulators are provided In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1) Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1. (I)

Amides of heterocyclic compounds as Transient Receptor Potential subfamily A (TRPA) modulators are provided In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1) Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1. (I)

If you are interested in 2103-99-3, you can contact me at any time and look forward to more communication.Electric Literature of 2103-99-3

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Thiazole | C3H10248NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.5304-21-2, Name is 6-Bromo-2-methylbenzo[d]thiazole, molecular formula is C8H6BrNS. In a Patent£¬once mentioned of 5304-21-2, Computed Properties of C8H6BrNS

PROBLEM TO BE SOLVED: nucleomedical uninvasively technique of obtaining in vivo imaging Tauprotein, new acryloyldimethyltauric protein imaging. SOLUTION: the present invention, represented by a general formula of radioactive iodine labeled styrylacrylic substituted aromatic heterocyclic compound or salt thereof, or radioactive pharmaceutical containing the same. Selected drawing: no (by machine translation)

PROBLEM TO BE SOLVED: nucleomedical uninvasively technique of obtaining in vivo imaging Tauprotein, new acryloyldimethyltauric protein imaging. SOLUTION: the present invention, represented by a general formula of radioactive iodine labeled styrylacrylic substituted aromatic heterocyclic compound or salt thereof, or radioactive pharmaceutical containing the same. Selected drawing: no (by machine translation)

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 5304-21-2 is helpful to your research., Computed Properties of C8H6BrNS

Reference£º
Thiazole | C3H6810NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.69812-29-9, Name is 2-Acetamido-4-methylthiazole-5-sulfonyl chloride, molecular formula is C6H7ClN2O3S2. In a Article£¬once mentioned of 69812-29-9, Formula: C6H7ClN2O3S2

Background: Despite a massive industry endeavor to develop RORgamma-modulators for autoimmune disorders, there has been no indication of efforts to target the close family member RORalpha for similar indications. This may be due to the misconception that RORalpha is redundant to RORgamma, or the inherent difficulty in cultivating tractable starting points for RORalpha. RORalpha-selective modulators would be useful tools to interrogate the biology of this understudied orphan nuclear receptor. Objective: The goal of this research effort was to identify and optimize synthetic ligands for RORalpha starting from the known LXR agonist T0901317. Methods: Fourty-five analogs of the sulfonamide lead (1) were synthesized and evaluated for their ability to suppress the transcriptional activity of RORalpha, RORgamma, and LXRalpha in cell-based assays. Analogs were characterized by1H-NMR,13C-NMR, and LC-MS analysis. The pharmacokinetic profile of the most selective RORalpha inverse agonist was evaluated in rats with intraperitoneal (i.p.) and per oral (p.o.)dosing. Results: Structure-activity relationship studies led to potent dual RORalpha/RORgamma inverse agonists as well as RORalpha-selective inverse agonists (20, 28). LXR activity could be reduced by removing the sulfonamide nitrogen substituent. Attempts to improve the potency of these selective leads by varying substitution patterns throughout the molecule proved challenging. Conclusion: The synthetic RORalpha-selective inverse agonists identified (20, 28) can be utilized as chemical tools to probe the function of RORalpha in vitro and in vivo.

Background: Despite a massive industry endeavor to develop RORgamma-modulators for autoimmune disorders, there has been no indication of efforts to target the close family member RORalpha for similar indications. This may be due to the misconception that RORalpha is redundant to RORgamma, or the inherent difficulty in cultivating tractable starting points for RORalpha. RORalpha-selective modulators would be useful tools to interrogate the biology of this understudied orphan nuclear receptor. Objective: The goal of this research effort was to identify and optimize synthetic ligands for RORalpha starting from the known LXR agonist T0901317. Methods: Fourty-five analogs of the sulfonamide lead (1) were synthesized and evaluated for their ability to suppress the transcriptional activity of RORalpha, RORgamma, and LXRalpha in cell-based assays. Analogs were characterized by1H-NMR,13C-NMR, and LC-MS analysis. The pharmacokinetic profile of the most selective RORalpha inverse agonist was evaluated in rats with intraperitoneal (i.p.) and per oral (p.o.)dosing. Results: Structure-activity relationship studies led to potent dual RORalpha/RORgamma inverse agonists as well as RORalpha-selective inverse agonists (20, 28). LXR activity could be reduced by removing the sulfonamide nitrogen substituent. Attempts to improve the potency of these selective leads by varying substitution patterns throughout the molecule proved challenging. Conclusion: The synthetic RORalpha-selective inverse agonists identified (20, 28) can be utilized as chemical tools to probe the function of RORalpha in vitro and in vivo.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Formula: C6H7ClN2O3S2, you can also check out more blogs about69812-29-9

Reference£º
Thiazole | C3H1802NS – PubChem,
Thiazole | chemical compound | Britannica