Tag: M.W:200-300

80945-86-4, Name is 6-Bromo-2-chlorobenzothiazole, molecular formula is C7H3BrClNS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 80945-86-4, Recommanded Product: 6-Bromo-2-chlorobenzothiazole

Environmentally benign ionic liquid [bmim]HSO4 was found suitable for conversion of nitriles into carboxylic acids under mild conditions with excellent purity.

Environmentally benign ionic liquid [bmim]HSO4 was found suitable for conversion of nitriles into carboxylic acids under mild conditions with excellent purity.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Recommanded Product: 6-Bromo-2-chlorobenzothiazole. In my other articles, you can also check out more blogs about 80945-86-4

Reference£º
Thiazole | C3H10914NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of 768-11-6, Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.768-11-6, Name is 5-Bromobenzothiazole, molecular formula is C7H4BrNS. In a patent, introducing its new discovery.

The present invention relates to compounds of Formula (I), which are DYRK1A and/or DYRK1B inhibitors,and their use in the treatment of neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), metabolic disorders such as Metabolic Syndrome or diabetes mellitus, and cancer.

The present invention relates to compounds of Formula (I), which are DYRK1A and/or DYRK1B inhibitors,and their use in the treatment of neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), metabolic disorders such as Metabolic Syndrome or diabetes mellitus, and cancer.

If you are interested in 768-11-6, you can contact me at any time and look forward to more communication.Electric Literature of 768-11-6

Reference£º
Thiazole | C3H6113NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 17969-20-9, Name is 2-(2-(4-Chlorophenyl)thiazol-4-yl)acetic acid, molecular formula is C11H8ClNO2S. In a Review£¬once mentioned of 17969-20-9, category: thiazole

Toxicity is a common drawback of newly designed chemotherapeutic agents. With the exception of pharmacophore-induced toxicity (lack of selectivity at higher concentrations of a drug), the toxicity due to chemotherapeutic agents is based on the toxicophore moiety present in the drug. To date, methodologies implemented to determine toxicophores may be broadly classified into biological, bioanalytical and computational approaches. The biological approach involves analysis of bioactivated metabolites, whereas the computational approach involves a QSAR-based method, mapping techniques, an inverse docking technique and a few toxicophore identification/estimation tools. Being one of the major steps in drug discovery process, toxicophore identification has proven to be an essential screening step in drug design and development. The paper is first of its kind, attempting to cover and compare different methodologies employed in predicting and determining toxicophores with an emphasis on their scope and limitations. Such information may prove vital in the appropriate selection of methodology and can be used as screening technology by researchers to discover the toxicophoric potentials of their designed and synthesized moieties. Additionally, it can be utilized in the manipulation of molecules containing toxicophores in such a manner that their toxicities might be eliminated or removed.

Toxicity is a common drawback of newly designed chemotherapeutic agents. With the exception of pharmacophore-induced toxicity (lack of selectivity at higher concentrations of a drug), the toxicity due to chemotherapeutic agents is based on the toxicophore moiety present in the drug. To date, methodologies implemented to determine toxicophores may be broadly classified into biological, bioanalytical and computational approaches. The biological approach involves analysis of bioactivated metabolites, whereas the computational approach involves a QSAR-based method, mapping techniques, an inverse docking technique and a few toxicophore identification/estimation tools. Being one of the major steps in drug discovery process, toxicophore identification has proven to be an essential screening step in drug design and development. The paper is first of its kind, attempting to cover and compare different methodologies employed in predicting and determining toxicophores with an emphasis on their scope and limitations. Such information may prove vital in the appropriate selection of methodology and can be used as screening technology by researchers to discover the toxicophoric potentials of their designed and synthesized moieties. Additionally, it can be utilized in the manipulation of molecules containing toxicophores in such a manner that their toxicities might be eliminated or removed.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.category: thiazole. In my other articles, you can also check out more blogs about 17969-20-9

Reference£º
Thiazole | C3H374NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 777-12-8, Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.777-12-8, Name is 6-(Trifluoromethyl)benzo[d]thiazol-2-amine, molecular formula is C8H5F3N2S. In a patent, introducing its new discovery.

The imidazobenzothiazole compounds 3-17 together with the imidazobenzoxazole 18, and the imidazobenzoimidazole 19 were prepared and their cytotoxic activity evaluated at the National Cancer Institute (NCI) for testing against a panel of approximately 60 tumor cell lines. Compounds 5, 7, 8, and 16 exhibited interesting in vitro cytotoxic activity. The most active imidazobenzothiazole derivative 8 was further evaluated as a cytotoxic agent in the hollow fiber assay and showed a score greater than the minimum values for xenograft testing together with a net cell kill. Comparison with the results displayed in the in vivo assay by standard antitumor drugs in clinical use revealed a significant in vivo activity of the benzothiazole compound. COMPARE analyses for compounds 4-19 against the NCI’s standard agent database show poor or no correlation, and it might suggest for these compounds a mechanism of action unrelated to that of any known drug. Furthermore, the benzothiazole 8 did not show significant antitumor activity in a panel of two xenotransplanted tumors (i.e. colon and non-small cell lung tumors). By computing the polar surface area of compounds 3-19 with the MAREA computer program it was established that the most active compounds 5, 7, 8, and 16 should experience good intestinal permeability. Copyright

The imidazobenzothiazole compounds 3-17 together with the imidazobenzoxazole 18, and the imidazobenzoimidazole 19 were prepared and their cytotoxic activity evaluated at the National Cancer Institute (NCI) for testing against a panel of approximately 60 tumor cell lines. Compounds 5, 7, 8, and 16 exhibited interesting in vitro cytotoxic activity. The most active imidazobenzothiazole derivative 8 was further evaluated as a cytotoxic agent in the hollow fiber assay and showed a score greater than the minimum values for xenograft testing together with a net cell kill. Comparison with the results displayed in the in vivo assay by standard antitumor drugs in clinical use revealed a significant in vivo activity of the benzothiazole compound. COMPARE analyses for compounds 4-19 against the NCI’s standard agent database show poor or no correlation, and it might suggest for these compounds a mechanism of action unrelated to that of any known drug. Furthermore, the benzothiazole 8 did not show significant antitumor activity in a panel of two xenotransplanted tumors (i.e. colon and non-small cell lung tumors). By computing the polar surface area of compounds 3-19 with the MAREA computer program it was established that the most active compounds 5, 7, 8, and 16 should experience good intestinal permeability. Copyright

If you are interested in 777-12-8, you can contact me at any time and look forward to more communication.Synthetic Route of 777-12-8

Reference£º
Thiazole | C3H6696NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 153719-23-4, Name is N-(3-((2-Chlorothiazol-5-yl)methyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene)nitramide,molecular formula is C8H10ClN5O3S, is a conventional compound. this article was the specific content is as follows.Safety of N-(3-((2-Chlorothiazol-5-yl)methyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene)nitramide

The present invention relates to a method to overcome negative effects of the treatment of seeds with insecticides, acaricides or nematicides on the germination of seeds and vitality of seedlings. The inventive method markedly enhances germination and vitality of seeds that are treated with insecticides, acaricides or nematicides. The present invention describes a method that at least comprises the following steps: 1) Hydration of the seed 2) Followed by drying of the seed 3) Followed by a treatment of the seed with insecticidal, acaricidal, or nematicidal compounds.

The present invention relates to a method to overcome negative effects of the treatment of seeds with insecticides, acaricides or nematicides on the germination of seeds and vitality of seedlings. The inventive method markedly enhances germination and vitality of seeds that are treated with insecticides, acaricides or nematicides. The present invention describes a method that at least comprises the following steps: 1) Hydration of the seed 2) Followed by drying of the seed 3) Followed by a treatment of the seed with insecticidal, acaricidal, or nematicidal compounds.

Do you like my blog? If you like, you can also browse other articles about this kind. Safety of N-(3-((2-Chlorothiazol-5-yl)methyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene)nitramide. Thanks for taking the time to read the blog about 153719-23-4

Reference£º
Thiazole | C3H8739NS – PubChem,
Thiazole | chemical compound | Britannica

850429-62-8, Name is Methyl 2-Boc-aminothiazole-4-carboxylate, molecular formula is C10H14N2O4S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 850429-62-8, name: Methyl 2-Boc-aminothiazole-4-carboxylate

Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) are constitutively overexpressed in many types of cancer cells and exert important immunosuppressive functions. In this article, a series of 4,6-substituted-1H-indazole derivatives were synthesized and evaluated the inhibitory activities against IDO1 and TDO, as well as their structure-activity relationships (SARs). Among these, compound 35 displayed the most IDO1 inhibitory potency with an IC50 value of 0.74 muM in an enzymatic assay and 1.37 muM in HeLa cells. Quantitative analysis of the Western blot results indicated that 35 significantly decreased the INFgamma-induced IDO1 expression in a concentration-dependent manner. In addition, 35 showed promising TDO inhibition with an IC50 value of 2.93 muM in the enzymatic assay and 7.54 muM in A172 cells. Moreover, compound 35 exhibited in vivo antitumor activity in the CT26 xenograft model. These findings suggest that 1H-indazole derivative 35 is a potent IDO1/TDO dual inhibitor, and has the potential to be developed for IDO1/TDO-related cancer treatment.

Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) are constitutively overexpressed in many types of cancer cells and exert important immunosuppressive functions. In this article, a series of 4,6-substituted-1H-indazole derivatives were synthesized and evaluated the inhibitory activities against IDO1 and TDO, as well as their structure-activity relationships (SARs). Among these, compound 35 displayed the most IDO1 inhibitory potency with an IC50 value of 0.74 muM in an enzymatic assay and 1.37 muM in HeLa cells. Quantitative analysis of the Western blot results indicated that 35 significantly decreased the INFgamma-induced IDO1 expression in a concentration-dependent manner. In addition, 35 showed promising TDO inhibition with an IC50 value of 2.93 muM in the enzymatic assay and 7.54 muM in A172 cells. Moreover, compound 35 exhibited in vivo antitumor activity in the CT26 xenograft model. These findings suggest that 1H-indazole derivative 35 is a potent IDO1/TDO dual inhibitor, and has the potential to be developed for IDO1/TDO-related cancer treatment.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.name: Methyl 2-Boc-aminothiazole-4-carboxylate. In my other articles, you can also check out more blogs about 850429-62-8

Reference£º
Thiazole | C3H8436NS – PubChem,
Thiazole | chemical compound | Britannica

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 566169-93-5, Name is 2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol, Quality Control of: 2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol.

[11C]2-(4?-(Methylamino)phenyl)-6-hydroxybenzothiazole ([11C]PIB) is a most potential PET tracer for detecting the beta-amyloid plaques in Alzheimer’s disease. Here the syntheses of three fluorinated PIB, namely 2-(4?-(methylamino)phenyl)-6-fluoroethoxybenzothiazole (O-FEt-PIB), 2-(4?-(methylamino)phenyl)-6-fluoro-benzothiazole (F-N-Me) and 2-(4?-(dimethylamino)phenyl)-6-fluorobenzo-thiazole (F-N,N-Me), and the radiosynthesis of one corresponding 18F-labeled PIB compound, [18F]O-FEt-PIB, as well as their in vitro/in vivo biological characters were reported. The structures of the products were confirmed by IR, 1H NMR, EI/ESI-MS, elemental analysis and HRMS techniques. The radiolabeled product was characterized by radio-TLC and radio-HPLC and purified by semi-preparative radio-HPLC. The suitable biological characters showed these tracers were potential to be developed as probes for detecting beta-amyloid plaques in Alzheimer’s disease.

[11C]2-(4?-(Methylamino)phenyl)-6-hydroxybenzothiazole ([11C]PIB) is a most potential PET tracer for detecting the beta-amyloid plaques in Alzheimer’s disease. Here the syntheses of three fluorinated PIB, namely 2-(4?-(methylamino)phenyl)-6-fluoroethoxybenzothiazole (O-FEt-PIB), 2-(4?-(methylamino)phenyl)-6-fluoro-benzothiazole (F-N-Me) and 2-(4?-(dimethylamino)phenyl)-6-fluorobenzo-thiazole (F-N,N-Me), and the radiosynthesis of one corresponding 18F-labeled PIB compound, [18F]O-FEt-PIB, as well as their in vitro/in vivo biological characters were reported. The structures of the products were confirmed by IR, 1H NMR, EI/ESI-MS, elemental analysis and HRMS techniques. The radiolabeled product was characterized by radio-TLC and radio-HPLC and purified by semi-preparative radio-HPLC. The suitable biological characters showed these tracers were potential to be developed as probes for detecting beta-amyloid plaques in Alzheimer’s disease.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Quality Control of: 2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol. In my other articles, you can also check out more blogs about 566169-93-5

Reference£º
Thiazole | C3H498NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 4845-58-3, Name is 6-Nitrobenzo[d]thiazole-2(3H)-thione,molecular formula is C7H4N2O2S2, is a conventional compound. this article was the specific content is as follows.category: thiazole

The nuclear peroxisome proliferator-activated receptor gammahas well-validated therapeutic potential in metabolic, inflammatory, and neurodegenerative pathologies, but its activation is also associated with marked adverse effects and novel modes of PPARgammamodulation are required. Here, we report the discovery and profiling of a new PPARgammamodulator chemotype endowed with remarkable potency and a distinct binding mode in the orthosteric PPARgammaligand-binding site. Its R-enantiomer evolved as a eutomer regarding PPARgammaactivation with a high eudysmic ratio. The new PPARgammamodulator revealed outstanding selectivity over the PPARalpha and PPARdeltasubtypes and did not promote adipogenesis in primary human fibroblasts, discriminating it from established agonists.

The nuclear peroxisome proliferator-activated receptor gammahas well-validated therapeutic potential in metabolic, inflammatory, and neurodegenerative pathologies, but its activation is also associated with marked adverse effects and novel modes of PPARgammamodulation are required. Here, we report the discovery and profiling of a new PPARgammamodulator chemotype endowed with remarkable potency and a distinct binding mode in the orthosteric PPARgammaligand-binding site. Its R-enantiomer evolved as a eutomer regarding PPARgammaactivation with a high eudysmic ratio. The new PPARgammamodulator revealed outstanding selectivity over the PPARalpha and PPARdeltasubtypes and did not promote adipogenesis in primary human fibroblasts, discriminating it from established agonists.

Do you like my blog? If you like, you can also browse other articles about this kind. category: thiazole. Thanks for taking the time to read the blog about 4845-58-3

Reference£º
Thiazole | C3H7350NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 302964-02-9, Name is 2-Boc-Aminothiazole-5-carboxylic acid, molecular formula is C9H12N2O4S. In a Article£¬once mentioned of 302964-02-9, COA of Formula: C9H12N2O4S

Sponges of the genus Agelas produce compounds that modulate the activity of voltage-gated sodium ion channels and contribute novel scaffolds for the development of compounds with activity against a plethora of biological targets. In particular, clathrodin and dibromosceptrin were reported to decrease the average maximum amplitude of inward sodium currents in isolated chick embryo sympathetic ganglia cells; we envisaged these compounds as a starting point to design novel Nav channel modulators. This endeavor was part of our long-term goal of designing a comprehensive library of Agelas alkaloid analogs that would cover a broader chemical space and allow us to examine the activity of such compounds on Nav channels. Our series of compounds was designed by maintaining the terminal structural features found in clathrodin while rigidizing the central part of the molecule and replacing the 3-aminopropene linker with a 4-methylenepiperazine moiety. Synthesised compounds were screened for inhibitory action against the human voltage-gated sodium channel isoforms Nav 1.3, Nav 1.4, cardiac Nav 1.5, and Nav 1.7 using an automated patch clamp electrophysiology technique. The results demonstrate that we have obtained a series of compounds with a modest but selective inhibitory activity against the Nav 1.3 channel isoform. The most potent compound showed selective activity against the Nav 1.3 channel isoform with an IC50 of 19 muM and is a suitable starting point for further development of selective Nav 1.3 channel modulators. Such compounds could prove to be beneficial as a pharmacological tool towards the development of novel therapeutically useful compounds in the treatment of pain.

Sponges of the genus Agelas produce compounds that modulate the activity of voltage-gated sodium ion channels and contribute novel scaffolds for the development of compounds with activity against a plethora of biological targets. In particular, clathrodin and dibromosceptrin were reported to decrease the average maximum amplitude of inward sodium currents in isolated chick embryo sympathetic ganglia cells; we envisaged these compounds as a starting point to design novel Nav channel modulators. This endeavor was part of our long-term goal of designing a comprehensive library of Agelas alkaloid analogs that would cover a broader chemical space and allow us to examine the activity of such compounds on Nav channels. Our series of compounds was designed by maintaining the terminal structural features found in clathrodin while rigidizing the central part of the molecule and replacing the 3-aminopropene linker with a 4-methylenepiperazine moiety. Synthesised compounds were screened for inhibitory action against the human voltage-gated sodium channel isoforms Nav 1.3, Nav 1.4, cardiac Nav 1.5, and Nav 1.7 using an automated patch clamp electrophysiology technique. The results demonstrate that we have obtained a series of compounds with a modest but selective inhibitory activity against the Nav 1.3 channel isoform. The most potent compound showed selective activity against the Nav 1.3 channel isoform with an IC50 of 19 muM and is a suitable starting point for further development of selective Nav 1.3 channel modulators. Such compounds could prove to be beneficial as a pharmacological tool towards the development of novel therapeutically useful compounds in the treatment of pain.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.COA of Formula: C9H12N2O4S. In my other articles, you can also check out more blogs about 302964-02-9

Reference£º
Thiazole | C3H2384NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 937369-77-2. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 937369-77-2, Name is 5-Phenylthiazole-2-carboxylic acid. In a document type is Patent, introducing its new discovery.

The invention relates to a series of compounds with particular activity as inhibitors of the serine-threonine kinase AKT. Also provided are pharmaceutical compositions comprising same as well as methods for treating cancer

The invention relates to a series of compounds with particular activity as inhibitors of the serine-threonine kinase AKT. Also provided are pharmaceutical compositions comprising same as well as methods for treating cancer

If you are interested in 937369-77-2, you can contact me at any time and look forward to more communication.Reference of 937369-77-2

Reference£º
Thiazole | C3H6638NS – PubChem,
Thiazole | chemical compound | Britannica