Tag: M.W:200-300

Related Products of 317318-97-1, An article , which mentions 317318-97-1, molecular formula is C12H9ClF3NS. The compound – 5-(Chloromethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole played an important role in people’s production and life.

The free fatty acid receptor 1 (FFA1) is a potential target due to its function in enhancement of glucose-stimulated insulin secretion. Takeda’s compound 1 has robustly in vitro activity for FFA1, but it has been suffered from poor pharmacokinetic (PK) profiles because the phenylpropanoic acid is vulnerable to beta-oxidation. To identify orally available agonists, we tried to interdict the metabolically labile group by incorporating two deuterium atoms at the alpha-position of phenylpropionic acid. Interestingly, the differences of physicochemical properties between hydrogen and deuterium are quite small, but there are many differences in the structure-activity relationship between phenylpropionic acid series and present deuterated series. Further optimizations of deuterated series led to the discovery of compound 18, which exhibited a superior balance in terms of in vitro activity, lipophilicity, and solubility. Better still, compound 18 revealed a lower clearance (CL = 0.44 L/h/kg), higher maximum concentration (Cmax = 7584.27 mug/L), and longer half-life (T1/2 = 4.16 h), resulting in a >23-fold exposure than compound 1. In subsequent in vivo pharmacodynamic studies, compound 18 showed a robustly glucose-lowering effect in rodent without the risk of hypoglycemia.

The free fatty acid receptor 1 (FFA1) is a potential target due to its function in enhancement of glucose-stimulated insulin secretion. Takeda’s compound 1 has robustly in vitro activity for FFA1, but it has been suffered from poor pharmacokinetic (PK) profiles because the phenylpropanoic acid is vulnerable to beta-oxidation. To identify orally available agonists, we tried to interdict the metabolically labile group by incorporating two deuterium atoms at the alpha-position of phenylpropionic acid. Interestingly, the differences of physicochemical properties between hydrogen and deuterium are quite small, but there are many differences in the structure-activity relationship between phenylpropionic acid series and present deuterated series. Further optimizations of deuterated series led to the discovery of compound 18, which exhibited a superior balance in terms of in vitro activity, lipophilicity, and solubility. Better still, compound 18 revealed a lower clearance (CL = 0.44 L/h/kg), higher maximum concentration (Cmax = 7584.27 mug/L), and longer half-life (T1/2 = 4.16 h), resulting in a >23-fold exposure than compound 1. In subsequent in vivo pharmacodynamic studies, compound 18 showed a robustly glucose-lowering effect in rodent without the risk of hypoglycemia.

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Reference£º
Thiazole | C3H6002NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2103-99-3, Name is 4-(4-Chlorophenyl)thiazol-2-amine, molecular formula is C9H7ClN2S. In a Article£¬once mentioned of 2103-99-3, Recommanded Product: 2103-99-3

A few 3-aryl-6-carbethoxythiazolo<3,2-a>– (4) and 2-aryl-6-carbethoxy-1,3,4-oxa/thiadiazolo<3,2-a>pyrimidin-5(H)-ones (5,6) have been synthesized by the reactions of aminothiazoles and aminooxa/thiadiazoles respectively with diethyl ethoxymethylenemalonate.The reaction of these amines with ethyl benzoylacetate furnishes 7-phenylpyrimidin-5(H)-one derivatives (10-12).The structures of these compounds have been established by spectral data and isolation of the intermediates.

A few 3-aryl-6-carbethoxythiazolo<3,2-a>– (4) and 2-aryl-6-carbethoxy-1,3,4-oxa/thiadiazolo<3,2-a>pyrimidin-5(H)-ones (5,6) have been synthesized by the reactions of aminothiazoles and aminooxa/thiadiazoles respectively with diethyl ethoxymethylenemalonate.The reaction of these amines with ethyl benzoylacetate furnishes 7-phenylpyrimidin-5(H)-one derivatives (10-12).The structures of these compounds have been established by spectral data and isolation of the intermediates.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 2103-99-3, you can also check out more blogs about2103-99-3

Reference£º
Thiazole | C3H10318NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 27149-27-5. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 27149-27-5, Name is 2-(4-Bromophenyl)thiazole. In a document type is Article, introducing its new discovery.

Cross coupling protocols were applied for the synthesis of 3-(4-heteroaryl-phenyl)-8-oxabicyclo[3.2.1]oct-2-ene-2-carboxylic acid methyl esters. Stille conditions produced the corresponding products in reasonable yields. Samarium iodide reduction of the resulting coupling products produced the 2beta-carbomethoxy-3alpha-aryl-8-oxabicyclo[3.2.1]octane diastereoisomers as the major, and the 2beta-carbomethoxy-3beta-aryl-8- oxabicyclo[3.2.1]octane diastereoisomer as the minor products. Both diastereomers manifested inhibition of the dopamine (DAT) and serotonin (SERT) transporters, with some selectivity for SERT inhibition.

Cross coupling protocols were applied for the synthesis of 3-(4-heteroaryl-phenyl)-8-oxabicyclo[3.2.1]oct-2-ene-2-carboxylic acid methyl esters. Stille conditions produced the corresponding products in reasonable yields. Samarium iodide reduction of the resulting coupling products produced the 2beta-carbomethoxy-3alpha-aryl-8-oxabicyclo[3.2.1]octane diastereoisomers as the major, and the 2beta-carbomethoxy-3beta-aryl-8- oxabicyclo[3.2.1]octane diastereoisomer as the minor products. Both diastereomers manifested inhibition of the dopamine (DAT) and serotonin (SERT) transporters, with some selectivity for SERT inhibition.

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Reference£º
Thiazole | C3H577NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 61296-22-8, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 61296-22-8, Name is 2-Amino-5-bromothiazole monohydrobromide, molecular formula is C3H4Br2N2S. In a Patent£¬once mentioned of 61296-22-8

Compounds having the formula (I), [image] and pharmaceutically acceptable salts, and solvates thereof, are useful as kinase inhibitors, wherein:

• two of X1, X2, and X3 are N, and the remaining one of X1, X2, and X3 is ?CR1;
• R1 is hydrogen or ?CN; and
• N, G, Z, R2, R3, R4, R5, and R6 are described in the specification. Also disclosed are pharmaceutical compositions containing compounds of formula (I), and methods of treating conditions associated with the activity of p38 kinase and/or conditions associated with the activity of LIM kinase.

  Compounds having the formula (I), [image] and pharmaceutically acceptable salts, and solvates thereof, are useful as kinase inhibitors, wherein:

  • two of X1, X2, and X3 are N, and the remaining one of X1, X2, and X3 is ?CR1;
  • R1 is hydrogen or ?CN; and
  • N, G, Z, R2, R3, R4, R5, and R6 are described in the specification. Also disclosed are pharmaceutical compositions containing compounds of formula (I), and methods of treating conditions associated with the activity of p38 kinase and/or conditions associated with the activity of LIM kinase.

    The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 61296-22-8 is helpful to your research., Application of 61296-22-8

    Reference£º
    Thiazole | C3H2114NS – PubChem,
    Thiazole | chemical compound | Britannica

Application of 2516-40-7. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 2516-40-7, Name is 2-Bromobenzothiazole. In a document type is Article, introducing its new discovery.

An efficient halogenation of electron-deficient (hetero)arenes is described. The reaction utilizes common t-BuONa as a catalyst (for iodination) or a promoter (for bromination and chlorination), and perfluorobutyl iodide, CBr4 or CCl4 as the readily-available halogenating agents, respectively. The protocol features broad scope, high efficiency, mild conditions and gram scalability. An ionic pathway involving halogen bond formation and halophilic attack is proposed. The utility of the resulting iodinated heteroarenes is demonstrated in visible light-mediated Caryl-Caryl cross-coupling reaction.

An efficient halogenation of electron-deficient (hetero)arenes is described. The reaction utilizes common t-BuONa as a catalyst (for iodination) or a promoter (for bromination and chlorination), and perfluorobutyl iodide, CBr4 or CCl4 as the readily-available halogenating agents, respectively. The protocol features broad scope, high efficiency, mild conditions and gram scalability. An ionic pathway involving halogen bond formation and halophilic attack is proposed. The utility of the resulting iodinated heteroarenes is demonstrated in visible light-mediated Caryl-Caryl cross-coupling reaction.

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Reference£º
Thiazole | C3H2736NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 62473-92-1, Name is 6-Bromobenzo[d]isothiazol-3(2H)-one 1,1-dioxide, molecular formula is C7H4BrNO3S. In a Article£¬once mentioned of 62473-92-1, Product Details of 62473-92-1

A simple and efficient method of N-alkylation, using either conventional heating or microwave irradiation, was applied successfully to the alkylation of several substituted saccharins. Subsequent t-butoxide-induced condensation of these products led to the formation of fused polycyclic sultams, which could be a privileged framework in the field of medicinal chemistry because of their favorable hydrophilic nature and straightforward functionalization. Copyright Taylor & Francis Group, LLC.

A simple and efficient method of N-alkylation, using either conventional heating or microwave irradiation, was applied successfully to the alkylation of several substituted saccharins. Subsequent t-butoxide-induced condensation of these products led to the formation of fused polycyclic sultams, which could be a privileged framework in the field of medicinal chemistry because of their favorable hydrophilic nature and straightforward functionalization. Copyright Taylor & Francis Group, LLC.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Product Details of 62473-92-1, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 62473-92-1, in my other articles.

Reference£º
Thiazole | C3H6852NS – PubChem,
Thiazole | chemical compound | Britannica

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 153719-23-4, Name is N-(3-((2-Chlorothiazol-5-yl)methyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene)nitramide, Recommanded Product: 153719-23-4.

The invention discloses a containing tetrazole amide and neonicotinoid insecticide composition, this composition is characterized in that: comprising an active ingredient A, active ingredient B. Wherein the active ingredient A is tetrazole amide, active ingredient is thiamethoxam B, Imidacloprid, acetamiprid, pymetrozine, dinotefuran, clothianidine in any of a, and the active ingredient A and active ingredient B in a weight ratio of 1:80 – 80:1, composition made wettable powder, water dispersible granule, a suspending agent, suspension emulsion, aqueous emulsion, micro-emulsion. The compositions of the invention can be used for preventing a plurality of pests on the crops, and has obvious synergistic action, and has reduced the pesticide dosage, safe to people and animals, without damage, and good environmental compatibility; preparation improved adhesion, erosion-resistant. (by machine translation)

The invention discloses a containing tetrazole amide and neonicotinoid insecticide composition, this composition is characterized in that: comprising an active ingredient A, active ingredient B. Wherein the active ingredient A is tetrazole amide, active ingredient is thiamethoxam B, Imidacloprid, acetamiprid, pymetrozine, dinotefuran, clothianidine in any of a, and the active ingredient A and active ingredient B in a weight ratio of 1:80 – 80:1, composition made wettable powder, water dispersible granule, a suspending agent, suspension emulsion, aqueous emulsion, micro-emulsion. The compositions of the invention can be used for preventing a plurality of pests on the crops, and has obvious synergistic action, and has reduced the pesticide dosage, safe to people and animals, without damage, and good environmental compatibility; preparation improved adhesion, erosion-resistant. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Recommanded Product: 153719-23-4. In my other articles, you can also check out more blogs about 153719-23-4

Reference£º
Thiazole | C3H8861NS – PubChem,
Thiazole | chemical compound | Britannica

153719-23-4, Name is N-(3-((2-Chlorothiazol-5-yl)methyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene)nitramide, molecular formula is C8H10ClN5O3S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 153719-23-4, Quality Control of: N-(3-((2-Chlorothiazol-5-yl)methyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene)nitramide

The invention provides a of thiamethoxam and azoxystrobin pesticide composition, wherein the thiamethoxam content is 1 – 85%, azoxystrobin content is 1 – 85%. The invention two kinds of pesticide composition can effectively control the various aphid, leafhopper, plant hopper class, Dialeurodes, beetle larvae, potato beetles, nematode, ground beetle, the pests such as leaf, at the same time to powdery mildew, rust, ying dry sickness, blotch, downy mildew, rice blast or the like have good activity, can be used for stem leaf atomization, seed treatment, can also soil treatment. (by machine translation)

The invention provides a of thiamethoxam and azoxystrobin pesticide composition, wherein the thiamethoxam content is 1 – 85%, azoxystrobin content is 1 – 85%. The invention two kinds of pesticide composition can effectively control the various aphid, leafhopper, plant hopper class, Dialeurodes, beetle larvae, potato beetles, nematode, ground beetle, the pests such as leaf, at the same time to powdery mildew, rust, ying dry sickness, blotch, downy mildew, rice blast or the like have good activity, can be used for stem leaf atomization, seed treatment, can also soil treatment. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Quality Control of: N-(3-((2-Chlorothiazol-5-yl)methyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene)nitramide. In my other articles, you can also check out more blogs about 153719-23-4

Reference£º
Thiazole | C3H8822NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 16112-21-3, Name is 2-(4-Methylphenyl)benzothiazole, molecular formula is C14H11NS. In a Article£¬once mentioned of 16112-21-3, Formula: C14H11NS

Ammonium nickel sulphate [(NH4)2SO4.NiSO4.6H2O] was found as a new catalyst to synthesis 2-aryl benzimidazole, 2-aryl benzothiazole and 2-aryl benzoxazole in aqueous media under sonication irradiation. The procedure is an eco-friendly, efficient and provides simple workup and good yield.

Ammonium nickel sulphate [(NH4)2SO4.NiSO4.6H2O] was found as a new catalyst to synthesis 2-aryl benzimidazole, 2-aryl benzothiazole and 2-aryl benzoxazole in aqueous media under sonication irradiation. The procedure is an eco-friendly, efficient and provides simple workup and good yield.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Formula: C14H11NS. In my other articles, you can also check out more blogs about 16112-21-3

Reference£º
Thiazole | C3H789NS – PubChem,
Thiazole | chemical compound | Britannica

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 153719-23-4, C8H10ClN5O3S. A document type is Patent, introducing its new discovery., Formula: C8H10ClN5O3S

The present invention relates to novel active compound combinations comprising of at least two fungicidal components A and B and at least one insecticidal component C. A, B and C may be selected from the following compounds: A) the compounds of the general formula (I) in which the radicals R1 and R2 have the meanings given in the description, B) an acylalanine of the general formula (II) in which R3 represents benzyl, furyl or methoxymethyl and * represents a carbon in the R- or S-configuration, the S-configuration being preferred, or fludioxonil or azoxystrobin C) a chloronicotinyl of the general formula (III) where the radicals Het, R, X and A have the meanings given in the description, or rynaxapyr, fipronil, tefluthrin. The active compound combinations are highly suitable for controlling unwanted phytopathogenic fungi and for controlling animal pests. The active compound combinations according to the invention are particularly suitable for treating seed.

The present invention relates to novel active compound combinations comprising of at least two fungicidal components A and B and at least one insecticidal component C. A, B and C may be selected from the following compounds: A) the compounds of the general formula (I) in which the radicals R1 and R2 have the meanings given in the description, B) an acylalanine of the general formula (II) in which R3 represents benzyl, furyl or methoxymethyl and * represents a carbon in the R- or S-configuration, the S-configuration being preferred, or fludioxonil or azoxystrobin C) a chloronicotinyl of the general formula (III) where the radicals Het, R, X and A have the meanings given in the description, or rynaxapyr, fipronil, tefluthrin. The active compound combinations are highly suitable for controlling unwanted phytopathogenic fungi and for controlling animal pests. The active compound combinations according to the invention are particularly suitable for treating seed.

Interested yet? Keep reading other articles of 153719-23-4!, Formula: C8H10ClN5O3S

Reference£º
Thiazole | C3H8714NS – PubChem,
Thiazole | chemical compound | Britannica