Tag: M.W:200-300

In an article, published in an article, once mentioned the application of 66947-92-0, Name is Methyl 2-amino-1,3-benzothiazole-6-carboxylate,molecular formula is C9H8N2O2S, is a conventional compound. this article was the specific content is as follows.HPLC of Formula: C9H8N2O2S

The invention discloses a FXR receptor agonists. The invention belongs to the field of medical technology, in particular of formula (I) compound of formula, its pharmaceutically acceptable salt, an ester thereof or a stereoisomer thereof, R1 , R2 , R3 , M, L, L1 , W, A, B, Q, m, n as defined in the specification; the invention also relates to methods of preparing such compounds, pharmaceutical preparation and in medicaments for the treatment and/or prevention by the FXR receptor-mediated non-alcoholic fatty liver, primary biliary cirrhosis, disorders of the lipid metabolism, such as diabetic complications and malignant tumor diseases related to the application of the medicament. (by machine translation)

The invention discloses a FXR receptor agonists. The invention belongs to the field of medical technology, in particular of formula (I) compound of formula, its pharmaceutically acceptable salt, an ester thereof or a stereoisomer thereof, R1 , R2 , R3 , M, L, L1 , W, A, B, Q, m, n as defined in the specification; the invention also relates to methods of preparing such compounds, pharmaceutical preparation and in medicaments for the treatment and/or prevention by the FXR receptor-mediated non-alcoholic fatty liver, primary biliary cirrhosis, disorders of the lipid metabolism, such as diabetic complications and malignant tumor diseases related to the application of the medicament. (by machine translation)

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Reference£º
Thiazole | C3H8388NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 54045-76-0, Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.54045-76-0, Name is 2-Bromothiazole-5-carboxylic acid, molecular formula is C4H2BrNO2S. In a patent, introducing its new discovery.

Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

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Reference£º
Thiazole | C3H2819NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.777-12-8, Name is 6-(Trifluoromethyl)benzo[d]thiazol-2-amine, molecular formula is C8H5F3N2S. In a Article£¬once mentioned of 777-12-8, HPLC of Formula: C8H5F3N2S

Some (un)substituted imidazo[2,1-b]benzothiazole carboxylic or acetic acids and some related compounds, i.e. imidazo[2,1-b]naphtho[2,1-d]thiazole, 4H-imidazo[2,1-c][1,4]benzothiazine, 4,5-dihydroimidazo[2,1-d][1,5]benzothiazepine carboxylic and acetic acids were synthesized and tested in vivo in order to study the structure-activity relationships (SAR) of their antiinflammatory and analgesic activities. Pharmacological assays confirmed the interest of this class of compounds as potential antiinflammatory and analgesic drugs with low side effects.

Some (un)substituted imidazo[2,1-b]benzothiazole carboxylic or acetic acids and some related compounds, i.e. imidazo[2,1-b]naphtho[2,1-d]thiazole, 4H-imidazo[2,1-c][1,4]benzothiazine, 4,5-dihydroimidazo[2,1-d][1,5]benzothiazepine carboxylic and acetic acids were synthesized and tested in vivo in order to study the structure-activity relationships (SAR) of their antiinflammatory and analgesic activities. Pharmacological assays confirmed the interest of this class of compounds as potential antiinflammatory and analgesic drugs with low side effects.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.HPLC of Formula: C8H5F3N2S, you can also check out more blogs about777-12-8

Reference£º
Thiazole | C3H6699NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 16112-21-3, An article , which mentions 16112-21-3, molecular formula is C14H11NS. The compound – 2-(4-Methylphenyl)benzothiazole played an important role in people’s production and life.

Herein, nickel-based metal-organic framework, Ni-MOF-74, was synthesized by a solvothermal method and its properties was characterized by a host of techniques. Ni-MOF-74 exhibited exceptional catalytic activity toward the direct arylation of azoles via C[sbnd]H activation while other Ni-MOFs, nickel-based heterogeneous systems, and homogeneous counter parts displayed lower activity. Optimal conditions involved the use of Li2CO3 or KCl salts in diglyme solvent in 18 h and no additional ligand is required. This is the first and unprecedented report using KCl salt as promoter for arylation of heterocycles. By avoiding the use of strong bases and oxidants, optimized conditions are compatible with wide range of functional groups and heterocycles. Furthermore, by taking advantage of large aperture size of Ni-MOF-74, we are able to utilize optimized conditions to successfully synthesize several bioactive arylated azole derivatives. Previous studies using heterogeneous catalysts to approach these bioactive compounds are not performed in the literature. Leaching tests indicated that homogeneous catalysis via leached active nickel species is unlikely. Thus, the catalyst was facilely separated from the reaction mixture and reused several times without significant degradation of the catalytic reactivity.

Herein, nickel-based metal-organic framework, Ni-MOF-74, was synthesized by a solvothermal method and its properties was characterized by a host of techniques. Ni-MOF-74 exhibited exceptional catalytic activity toward the direct arylation of azoles via C[sbnd]H activation while other Ni-MOFs, nickel-based heterogeneous systems, and homogeneous counter parts displayed lower activity. Optimal conditions involved the use of Li2CO3 or KCl salts in diglyme solvent in 18 h and no additional ligand is required. This is the first and unprecedented report using KCl salt as promoter for arylation of heterocycles. By avoiding the use of strong bases and oxidants, optimized conditions are compatible with wide range of functional groups and heterocycles. Furthermore, by taking advantage of large aperture size of Ni-MOF-74, we are able to utilize optimized conditions to successfully synthesize several bioactive arylated azole derivatives. Previous studies using heterogeneous catalysts to approach these bioactive compounds are not performed in the literature. Leaching tests indicated that homogeneous catalysis via leached active nickel species is unlikely. Thus, the catalyst was facilely separated from the reaction mixture and reused several times without significant degradation of the catalytic reactivity.

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Reference£º
Thiazole | C3H723NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.302964-02-9, Name is 2-Boc-Aminothiazole-5-carboxylic acid, molecular formula is C9H12N2O4S. In a Article£¬once mentioned of 302964-02-9, SDS of cas: 302964-02-9

A series of substituted 2-(aminoheteroaryl)-thiazole-5-carboxamide analogs have been synthesized as novel, potent inhibitors of the Src-family kinase p56Lck. Among them, compound 2 displayed superior in vitro potency and excellent in vivo efficacy. A series of substituted 2-(aminoheteroaryl)- thiazole-5-carboxamide analogs have been synthesized as novel, potent inhibitors of the Src-family kinase p56Lck. Among them, compound 2 displayed superior in vitro potency and excellent in vivo efficacy.

A series of substituted 2-(aminoheteroaryl)-thiazole-5-carboxamide analogs have been synthesized as novel, potent inhibitors of the Src-family kinase p56Lck. Among them, compound 2 displayed superior in vitro potency and excellent in vivo efficacy. A series of substituted 2-(aminoheteroaryl)- thiazole-5-carboxamide analogs have been synthesized as novel, potent inhibitors of the Src-family kinase p56Lck. Among them, compound 2 displayed superior in vitro potency and excellent in vivo efficacy.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 302964-02-9 is helpful to your research., SDS of cas: 302964-02-9

Reference£º
Thiazole | C3H2393NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 913836-22-3, Name is Methyl 5-bromothiazole-4-carboxylate, molecular formula is C5H4BrNO2S. In a Patent£¬once mentioned of 913836-22-3, name: Methyl 5-bromothiazole-4-carboxylate

The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, and modulating protein kinase activity. Molecules of the invention can modulate casein kinase (CK) activity. The invention also relates in part to methods for using such molecules

The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, and modulating protein kinase activity. Molecules of the invention can modulate casein kinase (CK) activity. The invention also relates in part to methods for using such molecules

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.name: Methyl 5-bromothiazole-4-carboxylate. In my other articles, you can also check out more blogs about 913836-22-3

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Thiazole | C3H8495NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 767-68-0, Name is 4-Bromobenzothiazole,molecular formula is C7H4BrNS, is a conventional compound. this article was the specific content is as follows.Quality Control of: 4-Bromobenzothiazole

Compounds of formula (I) and their use in therapy, particularly for the treatment of a disorder responsive to inhibition of Aurora kinase A and/or B. Formula (I) wherein R 1 , R 2 , R 3 , R 4 and R 5 are independently selected from hydrogen, hydroxy, C 1 – C 3 alkyl, fluoro(C 1 -C 3 )alkyl, hydroxy(C 1 -C 3 )alkyl, C 1 -C 3 alkoxy, fluoro(C 1 – C 3 )alkoxy, hydroxyC 1 -C 3 alkoxy, -N(R 6 J-R 7 , – AIk-N(R 6 )-R 7 , -0-AIk-N(R 6 )-R 7 , – C(=O)OH, carboxy(C 1 -C 3 )alkyl, or -C(=O)-NH-R 8 ; R 6 , R 7 ,R 8 and -AIk- are as defined herein; R is hydrogen or C 1 C 3 alkyl; one of A and B is hydrogen and the other is a group -Z-Ar; -Z- is -C(=O)-NH-, -NH-C(=O)-, -C(=O)-N(-CH 3 )-, or -N(-CH 3 )-C(=O)-; and Ar is aryl or heteroaryl, optionally substituted with one or more halogen atoms, C 1 -C 3 alkyl radicals or trifluoromethyl radicals; or a pharmaceutically acceptable salt, hydrate or solvate thereof.

Compounds of formula (I) and their use in therapy, particularly for the treatment of a disorder responsive to inhibition of Aurora kinase A and/or B. Formula (I) wherein R 1 , R 2 , R 3 , R 4 and R 5 are independently selected from hydrogen, hydroxy, C 1 – C 3 alkyl, fluoro(C 1 -C 3 )alkyl, hydroxy(C 1 -C 3 )alkyl, C 1 -C 3 alkoxy, fluoro(C 1 – C 3 )alkoxy, hydroxyC 1 -C 3 alkoxy, -N(R 6 J-R 7 , – AIk-N(R 6 )-R 7 , -0-AIk-N(R 6 )-R 7 , – C(=O)OH, carboxy(C 1 -C 3 )alkyl, or -C(=O)-NH-R 8 ; R 6 , R 7 ,R 8 and -AIk- are as defined herein; R is hydrogen or C 1 C 3 alkyl; one of A and B is hydrogen and the other is a group -Z-Ar; -Z- is -C(=O)-NH-, -NH-C(=O)-, -C(=O)-N(-CH 3 )-, or -N(-CH 3 )-C(=O)-; and Ar is aryl or heteroaryl, optionally substituted with one or more halogen atoms, C 1 -C 3 alkyl radicals or trifluoromethyl radicals; or a pharmaceutically acceptable salt, hydrate or solvate thereof.

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Thiazole | C3H5220NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 72850-52-3, Name is Ethyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate,molecular formula is C7H5ClF3NO2S, is a conventional compound. this article was the specific content is as follows.Recommanded Product: 72850-52-3

2-(Heteroamino)-4,5-substituted-oxazole/thiazole compounds are antidotes for thiocarbamate, triazine and acetamide herbicides. These antidote compounds are especially effective to safen acetamide herbicides used to control grassy weeds in sorghum.

2-(Heteroamino)-4,5-substituted-oxazole/thiazole compounds are antidotes for thiocarbamate, triazine and acetamide herbicides. These antidote compounds are especially effective to safen acetamide herbicides used to control grassy weeds in sorghum.

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Thiazole | C3H8070NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.16112-21-3, Name is 2-(4-Methylphenyl)benzothiazole, molecular formula is C14H11NS. In a Article£¬once mentioned of 16112-21-3, COA of Formula: C14H11NS

A mild and efficient substrate-assisted C-H bond cyanation of 2-arylbenzothiazoles has been developed using CuCN as cyano-group source. The reaction exhibits broad functional groups tolerance giving the desired products in moderate to excellent yields. Regioselective cyanation was in favor of the less sterically hindered position to those meta-substituted substrate.

A mild and efficient substrate-assisted C-H bond cyanation of 2-arylbenzothiazoles has been developed using CuCN as cyano-group source. The reaction exhibits broad functional groups tolerance giving the desired products in moderate to excellent yields. Regioselective cyanation was in favor of the less sterically hindered position to those meta-substituted substrate.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.COA of Formula: C14H11NS, you can also check out more blogs about16112-21-3

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Thiazole | C3H864NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.131748-91-9, Name is 2-Bromo-5-(bromomethyl)thiazole, molecular formula is C4H3Br2NS. In a Patent£¬once mentioned of 131748-91-9, Application In Synthesis of 2-Bromo-5-(bromomethyl)thiazole

The present invention relates to a compound according to general formula (I), which acts as an inhibitor of PqsR (the currently only known receptor for the Pseudomonas Quinolone Signal (PQS)); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament, e.g. the use in the treatment or prophylaxis of a bacterial infection, especially a Pseudomonas aeruginosa or Burkholderia infection.

The present invention relates to a compound according to general formula (I), which acts as an inhibitor of PqsR (the currently only known receptor for the Pseudomonas Quinolone Signal (PQS)); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament, e.g. the use in the treatment or prophylaxis of a bacterial infection, especially a Pseudomonas aeruginosa or Burkholderia infection.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 131748-91-9 is helpful to your research., Application In Synthesis of 2-Bromo-5-(bromomethyl)thiazole

Reference£º
Thiazole | C3H2477NS – PubChem,
Thiazole | chemical compound | Britannica