Tag: M.W:200-300

Reference of 14070-51-0. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 14070-51-0, Name is 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

The invention discloses a trifluoro-methylthio arene or azacalixarene compound and a preparation method thereof. The preparation method of the trifluoro-methylthio arene or azacalixarene compound comprises the following steps: in an organic solvent, carrying out substitution reaction on a compound shown in a formula I and nitrogen-trifluoro-methylthio saccharin shown in a formula II in presence of a catalyst, so that a compound shown in a formula III is obtained. The preparation method of the trifluoro-methylthio arene or azacalixarene compound has the advantages that reaction materials can be easily controlled to be in single substitution, toxicity is low, and environmental protection is realized; meanwhile, application range of substrate is wide, equipment requirement is low, and operation is simple. The general formula (I), the general formula (II) and the formula (III) are described in the specification.

The invention discloses a trifluoro-methylthio arene or azacalixarene compound and a preparation method thereof. The preparation method of the trifluoro-methylthio arene or azacalixarene compound comprises the following steps: in an organic solvent, carrying out substitution reaction on a compound shown in a formula I and nitrogen-trifluoro-methylthio saccharin shown in a formula II in presence of a catalyst, so that a compound shown in a formula III is obtained. The preparation method of the trifluoro-methylthio arene or azacalixarene compound has the advantages that reaction materials can be easily controlled to be in single substitution, toxicity is low, and environmental protection is realized; meanwhile, application range of substrate is wide, equipment requirement is low, and operation is simple. The general formula (I), the general formula (II) and the formula (III) are described in the specification.

If you are hungry for even more, make sure to check my other article about 14070-51-0. Reference of 14070-51-0

Reference£º
Thiazole | C3H3097NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 5331-91-9, Name is 5-Chlorobenzo[d]thiazole-2(3H)-thione, molecular formula is C7H4ClNS2. In a Article£¬once mentioned of 5331-91-9, Computed Properties of C7H4ClNS2

During the last five decades, a large number of BT (Benzothiazole) derivatives formed one of the eligible structures in medicinal chemistry as anticancer agents. Most of the studies reveal that various substitutions at specific positions on BT scaffold modulate the antitumor property. The potential of BTs encouraged us to synthesize a number of new 2-((5-substitutedbenzothiazol-2-yl)thio)-N?-(2-(4-(substitutedphenyl)ethylidene)acetohydrazide derivatives and investigate their probable anticancer activity. 4-Substitued benzaldehyde derivatives (1a?1e) were afforded by the reaction of appropriate secondary amine and 4-fluorobenzaldehyde in DMF. Equimolar quantitates of 5-substitutedbenzothiazole-2-thiol, ethyl chloroacetate and K2CO3 were refluxed in acetone to obtain 2-((5-substitutedbenzothiazol-2-yl)thio)acetate derivatives (2a,2b), which reacted with excess of hydrazine hydrate to get 2-((5-substitutebenzothiazol-2-yl)thio)acetohydrazides (3a,3b). In the last step, 2-((5-substitutedbenzothiazol-2-yl)thio)-N?-(4-substitutedbenzylidene)acetohydrazide derivatives (4a?4j) were synthesized by the reaction of 1a?1e and 3a?3b in EtOH. The anticancer activity of target compounds was evaluated in three steps. First, an MTT test (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) was performed to observe cytotoxic activity of the compounds against carcinogenic C6 (Rat brain glioma cell line), A549 (Human lung adenocarcinoma epithelial cell line), MCF-7 (Human breast adenocarcinoma cell line), and HT-29 (Human colorectal adenocarcinoma cell line) cancer cell lines. Healthy NIH3T3 (Mouse embryo fibroblast cell line) cells were also subjected to MTT assay to determine selectivity of the compounds towards carcinogenic cell lines. Secondly, inhibitory effects of selected compounds 4d, 4e, and 4h on DNA synthesis of C6 cells were investigated. Finally, flow cytometric analysis were performed to identify the death pathway of the carcinogenic cells.

During the last five decades, a large number of BT (Benzothiazole) derivatives formed one of the eligible structures in medicinal chemistry as anticancer agents. Most of the studies reveal that various substitutions at specific positions on BT scaffold modulate the antitumor property. The potential of BTs encouraged us to synthesize a number of new 2-((5-substitutedbenzothiazol-2-yl)thio)-N?-(2-(4-(substitutedphenyl)ethylidene)acetohydrazide derivatives and investigate their probable anticancer activity. 4-Substitued benzaldehyde derivatives (1a?1e) were afforded by the reaction of appropriate secondary amine and 4-fluorobenzaldehyde in DMF. Equimolar quantitates of 5-substitutedbenzothiazole-2-thiol, ethyl chloroacetate and K2CO3 were refluxed in acetone to obtain 2-((5-substitutedbenzothiazol-2-yl)thio)acetate derivatives (2a,2b), which reacted with excess of hydrazine hydrate to get 2-((5-substitutebenzothiazol-2-yl)thio)acetohydrazides (3a,3b). In the last step, 2-((5-substitutedbenzothiazol-2-yl)thio)-N?-(4-substitutedbenzylidene)acetohydrazide derivatives (4a?4j) were synthesized by the reaction of 1a?1e and 3a?3b in EtOH. The anticancer activity of target compounds was evaluated in three steps. First, an MTT test (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) was performed to observe cytotoxic activity of the compounds against carcinogenic C6 (Rat brain glioma cell line), A549 (Human lung adenocarcinoma epithelial cell line), MCF-7 (Human breast adenocarcinoma cell line), and HT-29 (Human colorectal adenocarcinoma cell line) cancer cell lines. Healthy NIH3T3 (Mouse embryo fibroblast cell line) cells were also subjected to MTT assay to determine selectivity of the compounds towards carcinogenic cell lines. Secondly, inhibitory effects of selected compounds 4d, 4e, and 4h on DNA synthesis of C6 cells were investigated. Finally, flow cytometric analysis were performed to identify the death pathway of the carcinogenic cells.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Computed Properties of C7H4ClNS2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 5331-91-9, in my other articles.

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Thiazole | C3H6335NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 2103-99-3, Name is 4-(4-Chlorophenyl)thiazol-2-amine, molecular formula is C9H7ClN2S. In a Article£¬once mentioned of 2103-99-3, name: 4-(4-Chlorophenyl)thiazol-2-amine

The reaction of thioureas with ketones in the presence of N-bromosuccinimide furnishes 2-aminothiazoles.The method is quick, convenient and versatile.

The reaction of thioureas with ketones in the presence of N-bromosuccinimide furnishes 2-aminothiazoles.The method is quick, convenient and versatile.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.name: 4-(4-Chlorophenyl)thiazol-2-amine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 2103-99-3, in my other articles.

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Thiazole | C3H10125NS – PubChem,
Thiazole | chemical compound | Britannica

2516-40-7, Name is 2-Bromobenzothiazole, molecular formula is C7H4BrNS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 2516-40-7, HPLC of Formula: C7H4BrNS

For the purpose of obtaining orally potent VLA-4 inhibitors, we have carried out structural modification of the (N?-phenylureido)phenyl group in compound 1, where the group was found to be attributed to poor pharmacokinetic profile in our previous research. Through modification, we have identified several compounds with both potent in vitro activity and improved oral exposure. In particular, compound 7e with 7-fluoro-2-(1-methyl-1H-indol-3- yl)-1,3-benzoxazolyl group as a novel replacement of the (N?-phenylureido) phenyl group significantly inhibited eosinophil infiltration into bronchoalveolar lavage fluid at 15 mg/kg in an Ascaris-antigen-induced murine bronchial inflammatory model, and its efficacy was comparable to that of the anti-mouse alpha4 antibody (R1-2).

For the purpose of obtaining orally potent VLA-4 inhibitors, we have carried out structural modification of the (N?-phenylureido)phenyl group in compound 1, where the group was found to be attributed to poor pharmacokinetic profile in our previous research. Through modification, we have identified several compounds with both potent in vitro activity and improved oral exposure. In particular, compound 7e with 7-fluoro-2-(1-methyl-1H-indol-3- yl)-1,3-benzoxazolyl group as a novel replacement of the (N?-phenylureido) phenyl group significantly inhibited eosinophil infiltration into bronchoalveolar lavage fluid at 15 mg/kg in an Ascaris-antigen-induced murine bronchial inflammatory model, and its efficacy was comparable to that of the anti-mouse alpha4 antibody (R1-2).

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.HPLC of Formula: C7H4BrNS. In my other articles, you can also check out more blogs about 2516-40-7

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Thiazole | C3H2713NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.16112-21-3, Name is 2-(4-Methylphenyl)benzothiazole, molecular formula is C14H11NS. In a Article£¬once mentioned of 16112-21-3, SDS of cas: 16112-21-3

Abstract: A simple, convenient, and highly efficient multicomponent one-pot synthesis of highly functionalized piperidines has been developed via tandem reactions of beta-keto esters, aromatic aldehydes, and various amines in ethanol at room temperature using catalytic amount (10?mol%) of a chromium(III)-salen complex nanoparticles supported on AlPO4. The heterogeneous catalyst exhibited excellent activity and reusability (up to 8 times) in the synthesis of highly functionalized piperidines. Also, synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles have been efficiently developed under mild condition from o-phenylenediamines or 2-aminothiophenol with aryl aldehydes via one-step process using catalytic amount (2.0?mol%) of nanocatalyst in air atmosphere as a green oxidant. The heterogeneous catalyst was characterized by scanning electron microscopy, atomic force microscopy, inductively coupled plasma spectrometry, thermogravimetry for analysis of nitrogen adsorption, and FT-IR spectroscopy. Graphical Abstract: [Figure not available: see fulltext.].

Abstract: A simple, convenient, and highly efficient multicomponent one-pot synthesis of highly functionalized piperidines has been developed via tandem reactions of beta-keto esters, aromatic aldehydes, and various amines in ethanol at room temperature using catalytic amount (10?mol%) of a chromium(III)-salen complex nanoparticles supported on AlPO4. The heterogeneous catalyst exhibited excellent activity and reusability (up to 8 times) in the synthesis of highly functionalized piperidines. Also, synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles have been efficiently developed under mild condition from o-phenylenediamines or 2-aminothiophenol with aryl aldehydes via one-step process using catalytic amount (2.0?mol%) of nanocatalyst in air atmosphere as a green oxidant. The heterogeneous catalyst was characterized by scanning electron microscopy, atomic force microscopy, inductively coupled plasma spectrometry, thermogravimetry for analysis of nitrogen adsorption, and FT-IR spectroscopy. Graphical Abstract: [Figure not available: see fulltext.].

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.SDS of cas: 16112-21-3, you can also check out more blogs about16112-21-3

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Thiazole | C3H795NS – PubChem,
Thiazole | chemical compound | Britannica

Related Products of 302964-02-9, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 302964-02-9, Name is 2-Boc-Aminothiazole-5-carboxylic acid, molecular formula is C9H12N2O4S. In a Article£¬once mentioned of 302964-02-9

A novel series of 2-amino-5-carboxamidothiazoles were identified as inhibitors of Lck. Structure-activity studies demonstrate the structural requirements for potent Lck activity. Cyclopropylamide 11d is a potent Lck inhibitor having sub-micromolar activity in a PBL proliferation assay.

A novel series of 2-amino-5-carboxamidothiazoles were identified as inhibitors of Lck. Structure-activity studies demonstrate the structural requirements for potent Lck activity. Cyclopropylamide 11d is a potent Lck inhibitor having sub-micromolar activity in a PBL proliferation assay.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 302964-02-9 is helpful to your research., Related Products of 302964-02-9

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Thiazole | C3H2395NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2516-40-7, Name is 2-Bromobenzothiazole, molecular formula is C7H4BrNS. In a Patent£¬once mentioned of 2516-40-7, Application In Synthesis of 2-Bromobenzothiazole

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides heterocycles, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson”s disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, seizure, retinal degeneration, hearing and vision loss, Alzheimer”s disease, age-related memory loss, learning deficiencies, anxiety, neuronal degeneration and motor neuron diseases, maintaining bladder control or treating urinary incontinence) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides heterocycles, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson”s disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, seizure, retinal degeneration, hearing and vision loss, Alzheimer”s disease, age-related memory loss, learning deficiencies, anxiety, neuronal degeneration and motor neuron diseases, maintaining bladder control or treating urinary incontinence) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 2516-40-7 is helpful to your research., Application In Synthesis of 2-Bromobenzothiazole

Reference£º
Thiazole | C3H2723NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 92-36-4, Name is 2-(4-Aminophenyl)-6-methylbenzothiazole, molecular formula is C14H12N2S. In a Patent£¬once mentioned of 92-36-4, category: thiazole

Disclosed are stabilized aqueous polymer compositions containing A) a stabilizing amount of at least a first stabilizer comprising a heterocyclic condensed ringsystem containing nitrogen and sulphur ring heteroatoms with the exception of a phenothiazine compound or containing a stabilizing amount of said first stabilizer with a phenothiazine compound; and B) at least one polymer comprising groups which are capable of complex formation with ions. The aqueous polymer compositions are stabilized against thermal or other degradation processes of the polymer by addition of component A) to allow their use even under harsh conditions.

Disclosed are stabilized aqueous polymer compositions containing A) a stabilizing amount of at least a first stabilizer comprising a heterocyclic condensed ringsystem containing nitrogen and sulphur ring heteroatoms with the exception of a phenothiazine compound or containing a stabilizing amount of said first stabilizer with a phenothiazine compound; and B) at least one polymer comprising groups which are capable of complex formation with ions. The aqueous polymer compositions are stabilized against thermal or other degradation processes of the polymer by addition of component A) to allow their use even under harsh conditions.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.category: thiazole. In my other articles, you can also check out more blogs about 92-36-4

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Thiazole | C3H550NS – PubChem,
Thiazole | chemical compound | Britannica

62473-92-1, Name is 6-Bromobenzo[d]isothiazol-3(2H)-one 1,1-dioxide, molecular formula is C7H4BrNO3S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 62473-92-1, Computed Properties of C7H4BrNO3S

This invention relates to N-1-cyano-2-(phenyl)ethyl)-2-azabicyclo[2.2.1]heptane-3-carboxamides of formula I, and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of respiratory diseases.

This invention relates to N-1-cyano-2-(phenyl)ethyl)-2-azabicyclo[2.2.1]heptane-3-carboxamides of formula I, and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of respiratory diseases.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Computed Properties of C7H4BrNO3S. In my other articles, you can also check out more blogs about 62473-92-1

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Thiazole | C3H6831NS – PubChem,
Thiazole | chemical compound | Britannica

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 777-12-8, C8H5F3N2S. A document type is Patent, introducing its new discovery., SDS of cas: 777-12-8

The invention discloses substituted aromatic amine compounds which are shown in a general formula I as described in the specification. Each substituent in the general formula I is defined in the specification. The compounds as shown in the general formula I have excellent bactericidal activity and can be used for preparing medicines used for preventing and treating bacteria in agriculture, forestry or the health care industry.

The invention discloses substituted aromatic amine compounds which are shown in a general formula I as described in the specification. Each substituent in the general formula I is defined in the specification. The compounds as shown in the general formula I have excellent bactericidal activity and can be used for preparing medicines used for preventing and treating bacteria in agriculture, forestry or the health care industry.

Interested yet? Keep reading other articles of 777-12-8!, SDS of cas: 777-12-8

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Thiazole | C3H6694NS – PubChem,
Thiazole | chemical compound | Britannica