Tag: M.W:200-300

88982-82-5,88982-82-5, 4-Bromo-1,3-thiazole-2-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 4-Bromothiazole-2-carboxylic acid (compound 1, 1 eq) and boronic acid derivatives (compound 2a-g, 1.5 eq) were suspended in dimethoxy ethane (DME)/H2O (16 volume, 3:1). Then, Pd(PPh3)4 (0.05 eq) and K2CO3 (1.5 eq) were added to the suspension. The obtained mixture was heated to about 100 C and stirred for about 24 h under nitrogen atmosphere. The solution was cooled to room temperature and acidified with concentrated hydrochloric acid. Then, the precipitate was filtered and washed with water. The obtained wet cake was redissolved in dichloromethane. The organic phase was washed with saturated sodium bicarbonate (NaHCO3) aqueous solution for 30 min. Then, the aqueous phase was acidified again with concentrated hydrochloric acid, and the precipitate was filtered to obtained compounds 3a-g.

The synthetic route of 88982-82-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Haibo; Cai, Zhengjiang; Zheng, Shan; Ma, Huidan; Lin, Haiming; Zheng, Xiaohe; Letters in drug design and discovery; vol. 15; 4; (2018); p. 388 – 397;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4175-77-3,2,4-Dibromothiazole,as a common compound, the synthetic route is as follows.

A flask containing 238 mg of tetrakis(triphenylphosphine)palladium, 0.55 g of phenylboronic acid, and 1.00 g of 2,4-dibromothiazole was purged with nitrogen and then charged with 30 ml of toluene, 6.1 ml of ethanol, and 9.1 ml of a 2 M aqueous solution of sodium carbonate, and the mixture was stirred under reflux for 6 hours. After cooling to room temperature, 50 ml of water was added to the reaction mixture and two extractions were conducted with 50 ml of ethyl acetate. After being washed with 30 ml of saturated brine, the organic layer was dried over magnesium sulfate. After filtering the magnesium sulfate, the organic layer was concentrated and the residue was purified by column chromatography (Wakogel C-200; hexane:ethyl acetate=14:1) to give 0.71 g of 2-phenyl-4-bromothiazole., 4175-77-3

4175-77-3 2,4-Dibromothiazole 2763297, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; SDS Biotech K.K.; Sakai, Masaaki; Matsumura, Tomoaki; Midorikawa, Satohiro; Nomoto, Takashi; Muraki, Tomoko; Katsuki, Ryutaro; US2013/296271; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4175-77-3,2,4-Dibromothiazole,as a common compound, the synthetic route is as follows.

Frame-dried 200 mL four-necked flask was purged with nitrogen and Xantphos (Xantphos, 220 mg, 0.38 mmol),Tris (dibenzylideneacetone) dipalladium (0) (Pd 2 (dba) 3,840 mg, 0.38 mmol) and dry tetrahydrofuran (dry THF, 75 mL) were added and stirred for 5 minutes, Thereby preparing a THF solution.Another flame-dried 200 mL four-necked flask was purged with nitrogen, 2,4-dibromothiazole (Compound 101 in the following formula (A), 3.6 g, 15 mmol),Phenylboronic acid (1.9 g, 16 mmol),Triopotassium phosphate (9.6 g, 45 mmol),The above THF solution was added, And the mixture was heated under reflux at 60 C. for 18 hours.After returning to room temperature,Celite filtration was carried out using dichloromethane. Removal of the solvent and purification by column chromatography gave the compound of the following formula (A), And 2.4 g of a white solid compound represented by “102” (yield: 66%).

4175-77-3, As the paragraph descriping shows that 4175-77-3 is playing an increasingly important role.

Reference£º
Patent; Nara Institute of Science and Technology; Kawai, Tsuyoshi; Asato, Ryousuke; Yanagida, Takayuki; Okada, Go; Nakajima, Takuya; (35 pag.)JP2018/140974; (2018); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.117724-63-7,2-Methyl-4-(trifluoromethyl)thiazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.,117724-63-7

9-Dichloromethylidene-5-amino-benzonorbomene (175 mg, 0.73 mmol), 2- methyl-4-trifluoromethyl-thiazole-5-carboxylic acid (162 mg, 0.77 mmol, 1.05 eq.) and triethylamine (184 mg, 1.8 mmol, 2.5 eq.) were reacted with bis-(2-oxo-3-oxazolidinyl)- phosphinic acid chloride (278 mg, 1.09 mmol, 1.5 eq.) in dichloromethane (10 ml) at 25 0C for 20 hours. The reaction mixture in ethyl acetate was washed successively with water and saturated. Sodium chloride solution, dried over sodium sulphate, evaporated and purified on silica gel (ethyl acetate-hexane-(l:2) to give 250 mg colourless crystals (m.p. 136-139 0C).

The synthetic route of 117724-63-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SYNGENTA PARTICIPATIONS AG; WO2007/48556; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.911466-96-1,2-(Ethoxycarbonyl)thiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

Isobutyl chloroformate (1.16 ml, 8.95 mmol) was added to an ice-cooled (0C) suspension of 2- (ethoxycarbonyl)-1 ,3-thiazole-4-carboxylic acid (216) (1.5 g, 7.46 mmol) and TEA (1 .25 ml, 8.95 mmol) in THF (60 ml). The reaction was stirred at 0C for 1 h. The reaction was filtered through a plug of Celite and NaBH4 (0.705 g, 18.64 mmol) was added to the filtrate and stirred for 2h. The reaction was diluted with sat. aq. Na2C03 solution and stirred for 10 mins, then extracted with EtOAc. The combined organic layers were washed with brine, dried (Na2S04), filtered and the solvent evaporated. Purification by flash column chromatography (eluting with a gradient of 40-50% EtOAc-Heptane) gave the titled compound (0.734 g, 52.6%) as a crystalline solid. 1 H-NMR (DMSO-d6, 500 MHz) d[ppm]= 7.85 (s, 1 H), 5.50 (t, J = 5.8 Hz, 1 H), 4.63 (dd, J = 5.8, 0.8 Hz, 2H), 4.37 (q, J = 7.1 Hz, 2H), 1.33 (d, J = 7.1 Hz, 3H) HPLCMS (ESI+): [m/z]: 187.90 [M+H], 911466-96-1

911466-96-1 2-(Ethoxycarbonyl)thiazole-4-carboxylic acid 53487863, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; VIFOR (INTERNATIONAL) AG; DUeRRENBERGER, Franz; BUHR, Wilm; BURCKHARDT, Susanna; BURGERT, Michael; KALOGERAKIS, Aris; REIM, Stefan; MANOLOVA, Vania; BOYCE, Susan; YARNOLD, Christopher John; PENA, Paula; SHEPHERD, Jon; LECCI, Cristina; JARJES-PIKE, Richard; SCOTT, John; (416 pag.)WO2017/68089; (2017); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1123-99-5, 2-Iodobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under a nitrogen atmosphere, in 25 ml substrate is added into the test tube reactor 3dfm (0.2mmol, 52.0 mg), 1-chloro-butane (3.0mmol, 276.0 mg), PdCl2(dppf) (0.02mmol, 14.6 mg), DPPF (0.01mmol, 5.6 mg), Cs2CO3(0.3mmol, 195.0 mg), Na2S2O35H2O (0.5mmol, 248.0 mg), DMSO (4.0 ml) and glycol (0.1 ml). Heating the reaction system to 120 C for reaction. TLC detection after the reaction is ended, the system is cooled to room temperature. Hydrosolvent quenching reaction with saturated ammonium chloride, extracted with ethyl acetate (3*10 ml), column chromatography purification to obtain the product 3df (62%)., 1123-99-5

1123-99-5 2-Iodobenzo[d]thiazole 827981, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; East China Normal University; JIANG, XUE FENG; QIAO, ZONG JUN; (33 pag.)CN103848767; (2016); B;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.383865-57-4,4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

4-Oxo-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide Using 4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine and piperidin-4-one the title compound was obtained as white solid (38%). MS: m/e=391 (M+H+).

383865-57-4, As the paragraph descriping shows that 383865-57-4 is playing an increasingly important role.

Reference£º
Patent; Alanine, Alexander; Flohr, Alexander; Miller, Aubry Kern; Norcross, Roger David; Riemer, Claus; US2002/45615; (2002); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

19654-14-9, 2-(3-Bromophenyl)benzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 1,3,5-tris(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene (4) (500 mg, 1.14 mmol), 2-(3-bromophenyl)benzo[d]thiazole (7) (1.15 g, 3.98 mmol), tetrakis(triphenylphosphine)palladium (140 mg, 0.12 mmol), sodium carbonate (1.51 g, 14.2 mmol), THF (25 mL), and water (14 mL) was degassed for 25 minutes. The mixture was heated at reflux (80 C.) overnight under argon. After cooling, the mixture was poured into ethyl acetate (125 mL) then washed with saturated sodium bicarbonate solution (100 mL), water (100 mL), and brine (100 mL). A flash column (gradient of 5 to 10% acetone in hexanes) and precipitation from methylene chloride/methanol gave 611 mg of material (ET-3) in 76% yield., 19654-14-9

19654-14-9 2-(3-Bromophenyl)benzothiazole 6382460, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Zheng, Shijun; US2011/196158; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2103-99-3,4-(4-Chlorophenyl)thiazol-2-amine,as a common compound, the synthetic route is as follows.

3,4-Dibutyryloxybenzoic acid (216 mg, 0.73 mmol) was dissolved in dichloromethane (5 mL). DMF (50 muL) and 2 M oxalyl chloride in CH2Cl2 (0.6 mL) were added to it at RT The mixture became a yellowish solution. After 0.5 hour stirring, the solvent was removed in vacuo. The residue was dissolved in dioxane (10 mL). 2-Amino-4-(4-chlorophenyl)thiazole (210 mg, 1.0 mmol) was added to it, followed by addition of pyridine (150 uL). The mixture was heated at 100¡ã C. for 1 hour. After cooling down to RT, the solvent was removed in vacuo. The residue was dissolved in EtOAc (50 mL) and washed with water (50 mL). The EtOAc solution was dried over sodium sulfate. After filtration and concentration, the residue was purified by chromatography eluted with CHCl3. The collected fractions were concentrated and purified again by chromatotron (silica) eluted with CHCl3 to afford the product (120 mg, Y=34percent). 1H NMR (CDCl3) delta 10.01 (bs, 1 H), 7.70-7.80 (m, 4 H), 7.35 (d, J=8.7 Hz, 2 H), 7.30 (dd, J=8.44 Hz, J=1.8 Hz, 1 H), 7.18 (s, 1 H), 2.55 (t, d=7.5 Hz, 2 H), 2.54 (t, d=7.5 Hz, 2 H), 1.70-1.86 (m, 4 H), 1.06 (t, d=7.5 Hz, 3 H), 1.05 (t, d=75 Hz, 3 H); 13C NMR (CDCl3) delta 170.5, 170.2, 163.0, 158.2, 148.9, 145.7, 142.3, 133.7, 132.5, 130.0, 128.7 (2 C), 127.2 (2 C), 125.4, 123.9, 123.1, 108.5, 35.9, 35.8, 18.5, 18.4, 13.7 (2 C); MS (MALDI-TOF) m/z calcd for C24H24ClN2O5S (M+H+) 487, found 487., 2103-99-3

The synthetic route of 2103-99-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Apogee Biotechnology Corporation; US2007/32531; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.777-12-8,6-(Trifluoromethyl)benzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

777-12-8, 102031 5 -chloro-2-methoxy-3 -ethylbenzoic acid (100mg, 0 .467mmo1) was dissolved in DMF (5m1). HBTU (2 13mg, 0.56 immol) was added followed by DIPEA (244u1, 1.4Ommol). The resulting mixture was stirred at rt for l5mins, then 6- (trifluoromethyl)benzo[d]thiazol-2-amine (102mg, 0 .467mmo1) was added. The resulting mixture was stirred at 120¡ãC for 24h. Saturated NH4C1 solution was added and extracted with EA for two times. The combined EA layer was dried over Na2504 and concentrated under reduced pressure. The residue was purified via silica gel column chromatography to give title compound as a yellow powder (115mg, 62percent). ?H NIVIR (300 IVIFIz, Acetone-d6) 8.40 (s, 1H), 8.10 (s, 1H), 7.90 (d, J = 8.7 Hz, 1H), 7.81 (d, J = 8.1 Hz, 1H), 7.39 (s, 1H), 2.72 (q, J=9.OHz, 2H), 1.24 (t, J = 9.0 Hz, 3H). MS (ESI) [M+H]requires m/z 401.03, found m/z400.6.

As the paragraph descriping shows that 777-12-8 is playing an increasingly important role.

Reference£º
Patent; JIN, Shengkan; AUGERI, David J.; CAO, Bin; TAO, Hanlin; (126 pag.)WO2017/201313; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica