Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2516-40-7,2-Bromobenzothiazole,as a common compound, the synthetic route is as follows.

General procedure: A 10 mL Schlenk tube equipped with a stir bar was sealed with a rubber septum,It was dried using a heat gun under reduced pressure (about 400 ¡ã C.)It was then filled with argon.Further, reduced pressure – argon filling was repeated twice to make the inside of the Schlenk tube completely under an argon atmosphere.0.5 mL of N, N’-dimethylpropyleneurea (hereinafter referred to as DMPU) as a solvent,0.71 mL of diethylzinc (1.02 M hexane solution: 1.5 eq),386.25 mg of nonafluorobutyl iodide (1.125 mmol, 2.25 eq) were sequentially added at room temperature using a syringe.Further, 0.5 mmol of 208.2 mg of dodecyl 2-iodobenzoate (0.5 mmol, 1 equivalent) as an electrophile,9.5 mg of copper iodide (0.05 mmol: 0.1 eq) was added,After replacing the rubber septum with a glass stopper, it was heated at 90 ¡ã C. for 16 hours.After allowing the reaction mixture to cool to room temperature, the reaction was stopped with 20 mL of 1 N hydrochloric acid,And extracted three times with diethyl ether having a total volume of 100 mL.The combined organic layer was washed with saturated brine,After drying with magnesium sulfate, the solvent was distilled off with a rotary evaporator.The crude product was purified by flash column chromatography (methylene chloride / hexane 1: 7)226.2 mg of the desired product was obtained (89percent, pale yellow oil)., 2516-40-7

2516-40-7 2-Bromobenzothiazole 612040, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; THE UNIVERSITY OF TOKYO; UCHIYAMA, MASANOBU; HIRANO, KEIICHI; (29 pag.)JP2015/86221; (2015); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5304-21-2,6-Bromo-2-methylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.,5304-21-2

Compound 11 (114 mg, 0.500 mmol)Was dissolved in methanol (5.00 mL), And benzaldehyde (51.0 muL, 0.500 mmol),Sodium hydroxide (60.0 mg, 1.50 mmol) was added,And heated under reflux for 14 hours under stirring.Precipitated crystals were collected by filtration,And washed with methanol and purified water to obtain Compound 12 in a yield of 50.0 mg (31.8percent).

As the paragraph descriping shows that 5304-21-2 is playing an increasingly important role.

Reference£º
Patent; Kyoto University; Nihon Medi-Physics Co.,Ltd.; Saji, Hideo; Ono, Masahiro; Inohara, Tadashi; Seki, Ikuya; (24 pag.)JP2016/79108; (2016); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

61296-22-8,61296-22-8, 2-Amino-5-bromothiazole monohydrobromide is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Key Intermediate 1 Clnt-l A”) : 2-bromo-5-(3-ethoxy-benzesulfonylVthiazole [0103] Part A: A mixture of 3-ethoxythiophenol (10.0 g, 0.065 mol), 2-amino-5- bromothiazole monohydrobromide (17.7 g, 0.068 mol), 1 M aqueous NaOH (200 mL), and THF (200 mL) was stirred at RT for 15 min. The reaction mixture was warmed to 55 0C over Ih, cooled to RT and concentrated under reduced pressure to remove THF. The residue was partitioned between EtOAc (ca. 500 mL) and water (ca 100 mL), and the layers were separated. The organic phase was washed with saturated aqueous NaCl (1 x 200 mL), dried (Na2SO4), and concentrated under reduced pressure to give a solid. The solid was triturated with CH2Cl2.”hexanes (ca. 10:1) to provide 5-(3-ethoxy-phenylsulfanyl)-thiazol-2-ylamine (13.2 g, 80%) as a light brown solid. LCMS (m/z): 253 (M+H)+

As the paragraph descriping shows that 61296-22-8 is playing an increasingly important role.

Reference£º
Patent; ICAGEN, INC.; WO2007/75852; (2007); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

61830-21-5, Ethyl 2-amino-5-bromothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,61830-21-5

General procedure: A mixture of 2-aminothiazole derivatives 2a-h and 3a-e (1.0 mmol) and K2CO3 (4.0 mmol) was stirred at room temperature with drop-wise addition of 4-chlorobutyryl chloride (4.0 mmol) in chloroform for 48 h. The reaction mixture was monitored by TLC (using chloroform/ethyl acetate 9:1). Ammoniated water was added, and the organic layer was separated and dried over anhydrous Na2SO4, and the solvent was removed in vacuum. The resulting precipitate was crystallized from ethanol to give crystals of pure N-(thiazole-2-yl)-4-chlorobutanamide derivatives.

The synthetic route of 61830-21-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ghabbour, Hazem A.; Kadi, Adnan A.; Eltahir, Kamal E. H.; Angawi, Rihab F.; El-Subbagh, Hussein I.; Medicinal Chemistry Research; vol. 24; 8; (2015); p. 3194 – 3211;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

911466-96-1,911466-96-1, 2-(Ethoxycarbonyl)thiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of Compound 3A (0.300 g, 1.49 mmol) was dissolved in N,N- dimethylformamide (2.98 mL), and then treated successively with PYBOP (0.854 g, 1.64 mmol), 4-methylmorpholine (0.492 mL, 4.47 mmol) and 1,2,3,4- tetrahydroquinoline (0.218 mL, 1.64 mmol). The reaction was stirred overnight at room temperature and was then slowly added to 15 mL of water, The aqueous layer was extracted with CH2CI2 (3 x 15 mL). The combined organic layer was washed with saturated aqueous NaHCO3 solution (25 mL) and brine (25 mL). The organic layer was dried over Na2SO4, filtered and concentrated. The product was purified by flash chromatography using a gradient of 0-40% ethyl acetate-hexanes to provide compound 4A (0.121 g, 26% yield).

The synthetic route of 911466-96-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SCHERING CORPORATION; WO2009/58730; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

78502-81-5, 5-Bromo-2-methyl-4-phenylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 27A (40 mg, 0.116 mmol), 5-bromo-2-methyl-4-phenylthiazole (59 mg, 0.232 mmol), Pd(PPh3)4(13 mg, 0.012 mmol) and K2CO3 (48 mg, 0.349 mmol) in THF (3 mL) and water (1 mL) was heated in a microwave reactor at 130 C. for 20 min. under Ar, then was cooled to rt. The reaction was diluted with water (5 mL), and extracted with EtOAc (4¡Á10 mL). The combined organic fractions were dried over MgSO4, and concentrated in vacuo to give the crude title compound. This material was used directly for the next step without further purification. LCMS, [M+H]+=392.1., 78502-81-5

The synthetic route of 78502-81-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; Shi, Yan; Cheng, Peter T.W.; Wang, Ying; Jusuf, Sutjano; Tao, Shiwei; Zhang, Hao; Wu, Shung C.; Robl, Jeffrey A.; (87 pag.)US2017/253554; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3855-95-6,2-Chloro-6-benzothiazolecarboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of di-tert-butyl dicarbonate (1.2 mL, 5.0 mmol) and 2-chlorobenzo[d]thiazole-6-carboxylic acid (0.53 g, 2.5 mmol) in anhydrous t-butanol (10 mL) was added dimethylaminopyridine (91 mg, 0.74 mmol) and the mixture stirred for 1 h. The reaction was concentrated under reduced pressure and purified by silica gel chromatography eluting with 0-50% EtOAc/hexanes to give Compound 1 88a (0.56 g, 84% yield) as a clear oil. LCMS = 2.22 mm using analytical method (B), 270.0 (M+H).1H NMR (400MHz, CDC13) oe 8.45 (d, J=1.5 Hz, 1H), 8.12 (dd, J8.6, 1.8 Hz, 1H), 7.97 (d, J8.6 Hz, 1H), 1.55 – 1.42 (m, 9H)., 3855-95-6

The synthetic route of 3855-95-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; JOHNSON, James A.; JIANG, Ji; KIM, Soong-Hoon; PI, Zulan; QIAO, Jennifer X.; TORA, George O.; WANG, Tammy C.; FINLAY, Heather; WO2014/11513; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3292-77-1, 2-Bromo-1-(thiazol-2-yl)ethanone is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 2-bromo-1-(thiazol-2-yl)ethanone (2.5 g; 12 mmol), acetonitrile (70 ml) and imidazole (1.65 g; 24 mmol) was stirred at ambient temperature for 1 hour. The mixture was evaporated to dryness and the residue partitioned between dichloromethane and water. The organic phase was separated, washed with saturated brine and evaporated to give 2-(imidazol-1-yl)-1-(thiazol-2-yl)-ethanone as a brown solid (1.17 g; 50%). MP: 109-112 C. 1H NMR (DMSO d6, 400 MHz) delta: 5.6 (2H,s); 6.85-8.1 (5H,m).

3292-77-1, 3292-77-1 2-Bromo-1-(thiazol-2-yl)ethanone 2795212, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; AstraZeneca UK Limited; Zeneca-Pharma SA; US6342765; (2002); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

72850-52-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.72850-52-3,Ethyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

2-Chloro-4-trifluoromethyl-thiazole-5-carboxylic acid ethyl ester (259 mg, 1.0mmol), sodium ethoxide (23% by weight in ethanol) (0.33 ml, 1.1 mmol) and ethanol (2ml) were heated under reflux for 2 hours. The mixture was partitioned between water andethyl acetate. The organic phase was dried over magnesium sulfate and concentrated togive the product as a yellow gum (187 mg, 70% yield). ^-NMR (400 MHz, CDC13):1.36 (3H, t, Me), 1.45 (3H, t, Me), 4.35 (2H, q, CH2), 4.55 (2H, q, CH2).

As the paragraph descriping shows that 72850-52-3 is playing an increasingly important role.

Reference£º
Patent; SYNGENTA LIMITED; WO2006/24820; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

170961-15-6, tert-Butyl thiazol-2-ylcarbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To tetrahydrofuran solution (100 ml) of 47 (10.0 g, 49.9 mmol), t-butoxy potassium (6.72 g, 59.9 mmol) was added at 0C while stirring, stirred for 10 min at the same temperature, added iodomethane (4.66 ml, 74.9 mmol), and stirred for 16 hours at room temperature. The insolubles were removed by filtering the reaction mixture, and the filtrate was evaporated to dryness under reduced pressure. The residue was purified by silica gel column chromatography (solvent: n-hexane/ethyl acetate = 9/1), to obtain 48 (6.53 g, 61%) of colorless solid substance. mp 51?52 C, 1H NMR(500MHz, DMSO-D6)delta 1.53(9H,s),3.47(3H,s),7.25(1H,d,J=3.5Hz),7.45(1H,d,J=3.5Hz) ,IR(Neat)1734cm-1, APCI-MS m/z 215[M+H]+, 170961-15-6

The synthetic route of 170961-15-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Tohoku University; EP2103611; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica