Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90533-23-6,4-(3-Chlorophenyl)thiazol-2-amine,as a common compound, the synthetic route is as follows.

General procedure: (iv) 10a-10n (2 mmol, 1.0 equiv.) wasdissolved in dry dichloromethane (10 mL), and the reaction was followed to add 5-nitro-2-furoicacid (2.4 mmol, 1.2 equiv.), DMAP (2.4 mmol, 1.2 equiv.), EDCI (4 mmol, 2.0 equiv.),then stirred under room temperature for 1 day. The reaction mixture wasquenched with H2O (10 mL) and extracted with dichloromethane (2*30 mL).The combined organic layers were washed in turn with 2N HCl (20 mL), H2O(20 mL) and brine (20 mL). The organic layer was collected, dried overanhydrous Na2SO4 and concentrated in vacuo. The residue waspurified by column chromatography on silica gel (hexane/EtOAc=8:1 to 4:1) toprovide 12a-12n. 11a and 11b were prepared by thesame way, just starting from 10b and replacing 5-nitro- furic with2-furoic acid and 4-nitrobenzoic acid. The yield was 29~80%., 90533-23-6

The synthetic route of 90533-23-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ran, Kai; Gao, Chao; Deng, Hongxia; Lei, Qian; You, Xinyu; Wang, Ningyu; Shi, Yaojie; Liu, Zhihao; Wei, Wei; Peng, Cuiting; Xiong, Lu; Xiao, Kunjie; Yu, Luoting; Bioorganic and Medicinal Chemistry Letters; vol. 26; 15; (2016); p. 3669 – 3674;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88982-82-5,4-Bromo-1,3-thiazole-2-carboxylic acid,as a common compound, the synthetic route is as follows.

88982-82-5, Step A:4-bromothiazole-2-carboxylic acid (1, 5.0 g, 24.0 mmol)Dissolved in ethylene glycol dimethyl ether (60mL)And water (20mL),Add 3,4-methyleneoxybenzeneboronic acid (29, 6.0 g, 36.0 mmol)And anhydrous potassium carbonate (5.0 g, 36 mmol),Then tetrakis(triphenylphosphine)palladium (1.4 g, 1.2 mmol) was added.The resulting mixture is heated under nitrogen toStir at 98 C for 24 hours.TLC analysis indicated the end of the reaction.The reaction solution was cooled to room temperature.Then add water (200 mL),The pH was adjusted to 2-3 with 6M hydrochloric acid.Filtered, the filter cake is dissolved in dichloromethane,The organic layer was washed with 20 mL of saturated sodium bicarbonate solution.Divide the water layer,The aqueous layer was adjusted to pH 2-3 with a 6M hydrochloric acid solution.Filter the solid,The filter cake is washed with water to neutrality.The filter cake was dried to give compound 30 (5.0 g).Yield: 84.0%.

88982-82-5 4-Bromo-1,3-thiazole-2-carboxylic acid 15122065, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Zhejiang Haizheng Pharmaceutical Co., Ltd.; Wang Haibo; Zheng Xiaohe; Cai Zhengjiang; Zheng Shan; Ye Zhengchun; Ma Huidan; Lin Haiming; (54 pag.)CN108623532; (2018); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

80945-86-4,80945-86-4, 6-Bromo-2-chlorobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[00394]6-Bromo-2-chlorobenzo[d]thiazole (701) (0.5 g, 2.0 mmol) was dissolved in methanamine solution (20 ml) in a sealed tube, and the resulting mixture was stirred at 60 C. overnight. The mixture was allowed to cool to RT, concentrated in vacuo and water (20 mL) was added. The solid was collected by filtration to afford the desired product, 6-bromo-N-methylbenzo[d]thiazol-2-amine (702) (0.43 g, 87.9% yield). ESI-MS (M+H)+m/z: 242.8.

80945-86-4 6-Bromo-2-chlorobenzothiazole 2049871, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Intellikine LLC; Ren, Pingda; Liu, Yi; Wilson, Troy Edward; Li, Liansheng; Chan, Katrina; US2015/225407; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-23-9,2,6-Dichloro-1,3-benzothiazole,as a common compound, the synthetic route is as follows.

REFERENCE EXAMPLE 76 To a solution of 5-chloro-1,3-benzenediamine (1.5 g) in tetrahydrofuran (30 ml) was added slowly a 1.5M solution of n-butyl lithium in n-hexane (5.61 ml) at 0 C. The resultant mixture was stirred for 30 minutes at 0 C. To the mixture was added a solution of 2,6-dichlorobenzothiazole (429 mg) in tetrahydrofuran (5 ml). After stirring for 15 minutes at 0 C. and for an hour at ambient temperature, the reaction mixture was poured into a mixture of water and ethyl acetate. The separated organic layer was washed well with 0.1N-hydrochloric acid (total 400 ml). After evaporation under reduced pressure, the residue was crystallized from methanol to give 5-chloro-N-(6-chlorobenzothiazol-2-yl)-benzene-1,3-diamine (171 mg). APCI-Mass: 312.20, 310.27 (m/z, (M+H)+) NMR(DMSO-d6, delta): 5.50(2H, s), 6.28(1H, t, J=1.9 Hz), 6.81(1H, t, J=1.9 Hz), 7.07(1H, t, J=1.9 Hz), 7.33(1H, dd, J=2.2, 8.6 Hz), 7.56(1H, d, J=8.6 Hz), 7.94(1H, d, J=2.2 Hz), 10.41(1H, s).

3622-23-9, The synthetic route of 3622-23-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Yamada, Akira; Spears, Glen; Hayashida, Hisashi; Tomishima, Masaki; Ito, Kiyotaka; Imanishi, Masashi; US2003/176454; (2003); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170235-26-4,Methyl 2-bromothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

Example 76; Preparation of Compound 76A and 76B; To a suspension of NaH (60% dispersion in oil, 10 mmol, 0.48 g.) in anhydrous dioxane (5 mL) was added a solution of indazole (10 mmol, 1.18 g) in dioxane (5 ml.) and the resulting reaction was allowed to stir for 30 minutes. A solution of 2- bromo-thiazole-4-carboxylic acid methyl ester (10.0 mmol, 2.22 g) in dioxane (5 mL) was then added dropwise and the reaction mixture was heated to 100C for 4 hrs. The reaction mixture was cooled to room temperature, quenched with water, and the solution was adjusted to pH 2 using 1 N HCI. The resulting basic solution was extracted with ethyl acetate and the organic phase was washed with water and brine, dried over anhydrous sodium sulfate, then filtered and concentrated. LCMS of the resulting residue showed two peaks for the acid indicating the formation of two regioisomers (Compounds 76A and 76B). HPLC-MS RT= 1.35 and 1.45 min, mass calculated for formula CnH7N3O2S 245.03, observed LCMS m/z 246.1 (M+H)., 170235-26-4

170235-26-4 Methyl 2-bromothiazole-4-carboxylate 2763213, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; SCHERING CORPORATION; WO2008/54749; (2008); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7238-62-2,Ethyl 2-chloro-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

EXAMPLE 39 Preparation of Ethyl 2-(2′,4′-Dichlorophenoxy)-4-Methyl-5-Thiazolecarboxylate. A mixture of 6.24 g (0.03 mole) of ethyl 2-chloro-4-methyl-5-thiazolecarboxylate, 4.89 g (0.03 mole) of 2,4-dichlorophenol, 4.14 g (0.03 mole) of potassium carbonate and 40 ml. of acetone was held at reflux for 89 hours. Acetone was removed under reduced pressure. The residue was treated with 50 ml. of water and extracted with ether. The ether solution was washed successively with saturated sodium bicarbonate, 30 ml. of 10% sodium hydroxide and 50 ml. of water. The ether solution was dried (MgSO4) and concentrated. The residue was recrystallized from hexane to give 5.8 g (58%) of ethyl 2-(2′,4′-dichlorophenoxy)-4-methyl-5-thiazolecarboxylate as a white solid, m.p. 71-73 C. Anal. Calc’d. for C13 H11 Cl2 NO3 S: C, 47.00; H, 3.34; N, 4.22; Cl, 21.34. Found: C, 47.04; H, 3.34; N, 4.21; Cl, 21.36., 7238-62-2

As the paragraph descriping shows that 7238-62-2 is playing an increasingly important role.

Reference£º
Patent; Monsanto Company; US4199506; (1980); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5198-88-9,2-Bromothiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.,5198-88-9

Compound 134 (0.96 g, 3.85 mmol) was dried in the tared reaction flask and weighed. This was dissolved in 30 mL dichloromethane, and 10 mL dimethylformamide was added along with a magnetic stir bar. 2-Bromothiazole-4-carboxylic acid (800.6 mg, 3.85 mmol) was weighed out and added. Diisopropylethylamine (1.0 mL, 5.7 mmol) was added followed by HATU (1.901 g, 5.00 mmol) and the reaction was stirred at room temperature overnight. This was concentrated directly onto silica and purified by column chromatography. Concentrating, then drying the pure fractions on high vacuum afforded 1.158 g of the title compound 136 (69% yield). 1H NMR (300 MHz, DMSO-d6) delta 12.14 (s, 1H), 8.57- 8.48 (m, 2H), 8.44 (s, 1H), 7.91 (ddd, J = 11.5, 8.4, 1.3 Hz, 1H), 7.52 (ddd, J = 8.4, 4.6, 3.8 Hz, 1H), 5.34 (d, J = 6.9 Hz, 1H), 4.52 (tt, J = 9.1, 7.3 Hz, 1H), 4.05 – 3.91 (m, 1H), 2.86- 2.72 (m, 2H), 2.39 (qd, J = 8.6, 2.8 Hz, 2H). m/z = 438/440 (M+H)+ (bromine isotopes).

As the paragraph descriping shows that 5198-88-9 is playing an increasingly important role.

Reference£º
Patent; RIGEL PHARMACEUTICALS, INC.; KELLEY, Ryan; LI, Hui; HECKRODT, Thilo; CHEN, Yan; MCMURTRIE, Darren; TSO, Kin; TAYLOR, Vanessa; SINGH, Rajinder; YEN, Rose; MAUNG, Jack; (256 pag.)WO2016/172560; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.133840-96-7,2-Chloro-6-(trifluoromethoxy)benzo[d]thiazole,as a common compound, the synthetic route is as follows.

In a 250-mL round-bottom flask, 2-chloro-6-trifluoromethoxy-1,3-benzothiazole (5.36 g, 21.14 mmol) and 4-bromo-2-fluoroaniline (4.82 g, 25.36 mmol) were combined in 100 mL n-butanol containing 1% 4.0 M HCl in dioxane, and heated at 90 C. overnight. The mixture was cooled to rt and the solvent was removed under reduced pressure. Ethyl acetate (50 mL) was added, and the mixture was ultrasonicated by suspending the flask in an ultrasonication bath for 30 minutes. The mixture was filtered, and the filtrate was concentrated under reduced pressure. Acetonitrile (50 mL) was added to the mixture, which was then ultrasonicated for 30 minutes and then filtered to provide the product as a white solid (5 g, 58%). LC-MS m/z 409.1 (MH+), ret. time 4.02 min.

133840-96-7, The synthetic route of 133840-96-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bayer Pharmaceuticals Corporation; US2004/224997; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

494769-44-7, tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The intermediate (3) (0.5 g, 0.00217 mol), EDCl (0.622 g, 0.00325 mol), DMAP (0.345 g, 0.0028 mol) were stirred in dichloromethane (6 mL) at 0 C, and the substituted acid (0.00217 mol) were dissolved in (4 mL) of dichloromethane and charged to the reaction mixture and stirred at room temperature for 8 h. The reaction completion was monitored by TLC. Reaction was completed. The reaction mixture was diluted with (10 mL) of dichloromethane, and was washed with 10% NaHCO3 (10 mL). Separated the organic layer and was washed with saturated brine solution (10 mL). The organic layer was dried over sodium sulfate and concentrated the organic layer under reduced pressure to afford compounds 4a-t. The spectral data of compounds 4(a-t) are given below.

494769-44-7, The synthetic route of 494769-44-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Karuvalam, Ranjith P.; Haridas, Karickal R.; Nayak, Susanta K.; Guru Row, Tayur N.; Rajeesh; Rishikesan; Kumari, N. Suchetha; European Journal of Medicinal Chemistry; vol. 49; (2012); p. 172 – 182;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1024583-33-2, Methyl 2-bromobenzo[d]thiazole-6-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred mixture of VIII-3 (200 mg, 0.738 mmol), VIII-4 (400 mg, 0.88 mmol), and Na2CO3 (233 mg, 2.198 mmol) in DME (6 mL) and H2O (2 mL) was added Pd(dppf)Cl2 (53.9 mg, 0.0738 mmol). The reaction mixture was flushed with nitrogen and heated to 80 C. overnight. The mixture was diluted with EtOAc (40 mL), washed with water and brine, dried over Na2SO4, filtered and concentrated. The residue was purified by column chromatography (PE:EA=10:1) to give VIII-5 (50 mg, yield: 13.15%). MS (ESI) m/z (M+H)+514.1., 1024583-33-2

As the paragraph descriping shows that 1024583-33-2 is playing an increasingly important role.

Reference£º
Patent; Buckman, Brad Owen; Nicholas, John Beamond; Emayan, Kumaraswamy; Seiwert, Scott D.; US2014/200215; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica