Tag: M.W:200-300

78502-71-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78502-71-3,Ethyl 2-(bromomethyl)thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

Example 7; 2-{(3-phenyl-1H-indazol-1-yl)methyl}thiazole-4-carboxylic acidSodium hydride (added with 40% mineral oil, 9 mg, manufactured by Kanto Chemical Co., Inc.) was added to a solution of 3-phenyl-1H-indazole (40 mg), which had been synthesized according to the literature (T. Edward, C., et al., Tetrahedron, 1991, 47, 9599-9620), in N,N-dimethylformamide (1 mL, manufactured by Kanto Chemical Co., Inc.) under ice cooling, and the mixture was stirred for 5 minutes at the same temperature. Subsequently, ethyl 2-bromomethylthiazole-4-carboxylate (51 mg) synthesized according to the method of the literature (K. Benno, et al., Leibigs. Ann. Chem., 1981, 4, 623-632) was added thereto, and the mixture was stirred overnight at room temperature. Water (1 mL) was added to the reaction solution, and the mixture was extracted with ethyl acetate (3¡Á2 mL), washed with brine (10 mL), and dried (MgSO4). The solvent was then evaporated. The resulting residue was purified by PTLC (hexane:ethyl acetate=2:1), to give 7.2 mg of the title compound. LC-MS: HPLC retention time 4.08 minutes, m/z 336 (M+H), condition A-1.

The synthetic route of 78502-71-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASAHI KASEI PHARMA CORPORATION; US2010/29733; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

913836-22-3, Methyl 5-bromothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

913836-22-3, To a stirred solution of methyl 5-bromo-1 ,3-thiazole-4-carboxylate (5.00 g, 22.52 mmol) in THF (80 mL) was added an aq. solution of LiOH.H20 (2.70 g, 1 12.58 mmol) in H20 (20 mL). The reaction mixture was stirred at room temperature for 18 h. DCM (50 mL) and H2O (20 mL) were then added and the reaction mixture acidified to pH~2 with 2 M aqueous HCI, followed by extraction with DCM (3 chi 20 mL). The combined organic extracts were washed with brine (20 mL), dried over MgSCU, filtered and concentrated under reduced pressure to give 5-bromo-1 ,3-thiazole-4-carboxylic acid (3.09 g, 66 % yield) as a yellow solid, which was used without further purification. LC-MS (Method D) 208.3/210.3 [M+H]+; RT 1.36 min

The synthetic route of 913836-22-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; REDX PHARMA PLC; STOKES, Neil; (163 pag.)WO2017/46603; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80945-86-4,6-Bromo-2-chlorobenzothiazole,as a common compound, the synthetic route is as follows.,80945-86-4

To a solution of 6-bromo-2-chlorobenzo[d]thiazole (0.8 g, 3.2 mmol) in ethanol (12 mL) was added isopropylamine solution (1 mL) and the mixture was heated for 45 minutes using a Biotage microwave oven at 100C. The reaction mixture was cooled to room temperature. The solvent was removed, the crude product was crystalized from EtOAc and n-heptane mixture to afford the title compound as a solid (0.663 g, 75.8 %). (0500) 1H-NMR (400 MHz, Chloroform-d) d = 7.69 (t, J = 1.3 Hz, 1 H), 7.38 (d, J = 1.3 Hz, 2H), 7.27 (s, 1 H), 5.51 – 5.26 (m, 1 H), 3.92 (h, J = 6.5 Hz, 1 H), 1.33 (d, J = 6.4 Hz, 6H).

As the paragraph descriping shows that 80945-86-4 is playing an increasingly important role.

Reference£º
Patent; AC IMMUNE SA; NAMPALLY, Sreenivasachary; GABELLIERI, Emanuele; MOLETTE, Jerome; (220 pag.)WO2019/134978; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

170235-26-4, Methyl 2-bromothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: 2-Bromo-1,3-thiazole-4-carboxylic Acid A mixture of methyl 2-bromo-1,3-thiazole-4-carboxylate (4.2 g, 18.9 mmol), THF (120 mL) and 1N lithium hydroxide (50 mL) was heated at 70 C. for 1 h. The organic solvent was removed in vacuo. The residual aqueous solution was cooled to 0-5 C. and acidified to pH1 with 1N HCl solution. The tile compound was obtained by filtration, as a white solid. 1H NMR (400 MHz, DMSO-d6) delta ppm 8.43 (s, 1H) 13.30 (s, 1H)., 170235-26-4

As the paragraph descriping shows that 170235-26-4 is playing an increasingly important role.

Reference£º
Patent; Smithkline Beecham Corporation; US2011/124559; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63837-11-6,5-Bromo-2-methylbenzothiazole,as a common compound, the synthetic route is as follows.

63837-11-6, EXAMPLE 56A 5-bromo-2-ethyl-1,3-benzothiazole A 0 C. solution of diisopropylamine (340 muL, 2.41 mmol) in THF (3 mL) was treated with 2.5M n-butyllithium in hexanes (0.88 mL), stirred for 20 minutes, added to a -78 C. solution of 5-bromo-2-methyl-1,3-benzothiazole (250 mg, 1.10 mmol) in THF (3 mL), stirred for 30 minutes, treated with iodomethane (340 muL, 5.50 mmol), and stirred for 1 hour. The mixture was diluted with ethyl acetate (50 mL), washed sequentially with 1M HCl (5 mL), water (5 mL), and brine (5 mL), dried (MgSO4), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 30% hexanes/dichloromethane to provide the desired product. MS (DCI) m/e 242 (M+H)+.

63837-11-6 5-Bromo-2-methylbenzothiazole 3017457, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Augeri, David J.; Baumeister, Steven A.; Bruncko, Milan; Dickman, Daniel A.; Ding, Hong; Dinges, Jurgen; Fesik, Stephen W.; Hajduk, Philip J.; Kunzer, Aaron R.; McClellan, William; Nettesheim, David G.; Oost, Thorsten; Petros, Andrew M.; Rosenberg, Saul H.; Shen, Wang; Thomas, Sheela A.; Wang, Xilu; Wendt, Michael D.; US2002/55631; (2002); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

32137-76-1, Ethyl 1,3-benzothiazole-2-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 6Synthesis of benzothiazole-2-carboxamide (8)Benzothiazole-2-carboxamide was synthesized from ethyl benzothiazole-2-carboxylate according to the following reaction scheme. In particular, commercially available ethyl benzothiazole-2-carboxylate 6 (2.4 mmol, 0.5 g) was dissolved in 34 mL MeOH and purged with NH3 gas. Conversion to the product was monitored by TLC (3 Hexane: 2 EtOAc). Following complete conversion to the product 8 (30 min), the solvent was removed in vacuo. Agilent HPLC displayed 100% conversion to the desired product 8 with a single peak at 8.0 min. The solid white compound was used in the subsequent step without purification. ESI-MS: m/z calcd for C8H6N2OS 179.02 (M+H)+, 179.88 found (100%) (see LC/MS spectra of FIG. 17A and NMR spectra of FIG. 17B)., 32137-76-1

32137-76-1 Ethyl 1,3-benzothiazole-2-carboxylate 640708, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; GRYSHUK, Amy L.; Perkins, Julie; LaTour, John V.; US2011/224442; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.913836-22-3,Methyl 5-bromothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

913836-22-3, Process 24 In a microwave vessel, methyl 5-bromothiazole-4-carboxylate (1.0 eq, 97 mg, 0.44 mmol), 2-amino-3-methoxycarbonyl phenyl boronic acid HCl (1.1 eq, 111 mg, 0.48 mmol), sodium acetate (3.0 eq, 107 mg, 1.31 mmol) and PdCl2(dppf) (0.05 eq, 11 mg, 0.022 mmol) were mixed together in anhydrous DMF (1 ml). The mixture was heated in a microwave oven at 120 C. for 10 nm. Water was added and the material extracted with CH2Cl2. The combined extracts were washed with brine, dried over Na2SO4 and the solvents removed by evaporation. The material was dissolved in a mixture of CH2Cl2 and MeOH and the solution filtered through a pad of celite. Evaporation of the volatiles afforded crude methyl 4-oxo-4,5-dihydrothiazolo[4,5-c]quinoline-7-carboxylate as a black solid (44 mg, 39% yield). A small part of the compound was subjected to preparative HPLC for analytical purpose. LCMS (ES): 95% pure, m/z 261 [M+1]+.

The synthetic route of 913836-22-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Cylene Pharmaceuticals, Inc.; US2009/93465; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

90533-23-6,90533-23-6, 4-(3-Chlorophenyl)thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Iodine(18.80 g, 74.1 mmol) was added to 1-(2,5-dichlorophenyl)ethanone (10.67 ml,74.1 mmol) and thiourea (11.27 g, 148.0mmol). Thereaction mixture was stirred and heatedto 100 C overnight. After cooling to room temperature, the reaction mixture was triturated with diethylether (about 50 mL) to remove any unreacted iodine and1-(2,5-dichlorophenyl)ethanone. Thesolid residue was put in cold distilled water (100 mL) and treated withammonium solution to pH 9-10. The precipitated thiazole was collected togive 4-(2,5-dichlorophenyl)-1,3-thiazol-2-amine (11.2 g, 62%yield) as a yellow solid. MS(ES+) m/z 245.0, 247.0 (MH+).A solution of[4-(ethylsulfonyl)phenyl]acetic acid (0.239 g, 1.1 mmol), 4-(2,5-dichlorophenyl)-1,3-thiazol-2-amine(0.245 g, 1.0 mmol), EDC (0.230 g, 1.2 mmol) and HOBt (0.184 g, 1.2 mmol) in dichloromethane(DCM) (10 mL) was stirred at room temperature overnight. The mixture was pouredinto water, and extracted with DCM. The organic phase was washed with water andbrine, dried over anhydrous sodium sulfate, filtered and concentrated under reducedpressure to give the crude product. The crude was purified by mass directedautopreparation (MDAP) to afford N-[4-(2,5-dichlorophenyl)-1,3-thiazol-2-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide(6a) (177 mg, 37% yield) as a white solid.

90533-23-6 4-(3-Chlorophenyl)thiazol-2-amine 675261, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Wang, Yonghui; Cai, Wei; Zhang, Guifeng; Yang, Ting; Liu, Qian; Cheng, Yaobang; Zhou, Ling; Ma, Yingli; Cheng, Ziqiang; Lu, Sijie; Zhao, Yong-Gang; Zhang, Wei; Xiang, Zhijun; Wang, Shuai; Yang, Liuqing; Wu, Qianqian; Orband-Miller, Lisa A.; Xu, Yan; Zhang, Jing; Gao, Ruina; Huxdorf, Melanie; Xiang, Jia-Ning; Zhong, Zhong; Elliott, John D.; Leung, Stewart; Lin, Xichen; Bioorganic and Medicinal Chemistry; vol. 22; 2; (2014); p. 692 – 702;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

117724-63-7, 2-Methyl-4-(trifluoromethyl)thiazole-5-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Under nitrogen atmosphere, carboxylic acid II (3mmol), EDCI (3.3 mmol), HOBT (3.3 mmol)and Et3N (1.8 mmol) were placed in a three-necked flask with 40 mL CH2Cl2, and stirred for 2 hat 0 C; then, compound I (2.4 mmol) was added to the flask and allowed to react for 3 h at 0 C.The reaction was monitored by thin-layer chromatography (TLC) (all reactions could be completed in3 h) and, on completion of the reaction, the mixture was washed with saturated NaHCO3 solutionand water, respectively. Then, it was dried over anhydrous Na2SO4, filtered and evaporated onrotavapor in vacuum. Subsequently, crude products III-1-III-18 were purified by silica gel columnchromatography [V (CH2Cl2): V (EA) = 3:1] and crude products III-19-III-36 were purified by silicagel column chromatography [V (PE): V (EA) = 3:1]. Finally, products were recrystallized with thedichloromethane/petroleum ether to obtain pure target compounds.

117724-63-7, As the paragraph descriping shows that 117724-63-7 is playing an increasingly important role.

Reference£º
Article; Zhang, Shen; Meng, Siqi; Xie, Yong; Yang, Yonggui; Zhang, Yumeng; He, Lu; Wang, Kai; Qi, Zhiqiu; Ji, Mingshan; Qin, Peiwen; Li, Xinghai; Molecules; vol. 24; 14; (2019);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

161798-01-2, Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example – 1: Preparation of Ethyl-2-(3-cyano-4-isobutoxy phenyl)-4-methyI thiozole -5-carboxylateA mixture of 10. Og of Ethyl -2-(3-formyl-4-hydroxy phenyl)-4-methyl thiozole -5- carboxylate and 2.85 g of hydroxylamine hydrochloride were stirred for 30 minutes in 40 g of Dimethyl sulfoxide. To this reaction mixture 3.3 grams of acetyl chloride was added and stirred at 70 -80¡ãC for 2-3 hours. Reaction mass was cooled to room temperature and to this 19 g of potassium carbonate and 19 g of isobutyl bromide was added successively. The reaction mass was stirred for 5 hours at 70-80¡ãC. Reaction mass was diluted with 200 ml of purified water. The reaction mass was filtered and washed with purified water to give 10.0 g of Ethyl-2-(3-cyano-4-isobutoxy phenyl)-4-methyl thiozole -5-carboxyltae (yield 84.0percent)

161798-01-2, 161798-01-2 Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 135404723, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; MATRIX LABORATORIES LTD; VELLENKI, Siva Rama Prasad; ARABINDA, Sahu; RAAVI, Satyanarayana; NUCHU, Ravi; DANDALA, Ramesh; WO2012/66561; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica