Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20358-02-5,4-Bromobenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

General procedure: Compound 4 (1mmol) added to dry CH2Cl2 (15mL) was stirred at 0C and oxalyl chloride (2.0mmol) was dripped into the mixture and stirred at the same temperature for 12h. After the reaction, the solvent and excess oxalyl chloride was evaporated under the reduced pressure, then add CHCl3. Compounds 2 (1mmol) and triethylamine (1.5mmol) were added to the mixture and reflux at 65C for 5h. After the reaction, the solvent was evaporated under reduced pressure, and the crude product was purified by chromatography on silica gel eluted with petroleum CH2Cl2/CH3OH (V: V=60:1) to offer the target compounds 6a-6k in good yields., 20358-02-5

20358-02-5 4-Bromobenzo[d]thiazol-2-amine 2049888, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Jin, Le; Huang, Rizhen; Huang, Xiaochao; Zhang, Bin; Ji, Min; Wang, Hengshan; Bioorganic and Medicinal Chemistry; vol. 26; 8; (2018); p. 1759 – 1775;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.133046-46-5,Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

Ethyl 2-(trifluoromethyl)-1,3-thiazole-4-carboxylate (80 mg) in ethanol (1 ml) was treated with 2N sodium hydroxide (0.706 ml) and the solution stirred at room temperature for 18 h. 2M Hydrochloric acid (0.54 ml) was added and the mixture blown down to dryness. The residue was dried under vacuum over phosphorous pentoxide and was then suspended in dry dichloromethane (1 ml) and treated at room temperature with oxalyl chloride (0.032 ml) and DMF (1 drop). The mixture was stirred at room temperature for 30 mins and then added dropwise to a solution of Intermediate 16 (98 mg) in acetonitrile (2 ml) and the mixture was stirred at room temperature for 22 h. The mixture was diluted with dichloromethane (15 ml), washed with brine (2¡Á15 ml) and blown down to dryness. The residue was purified by mass directed autoprep HPLC followed by SPE cartridge (5 g, aminopropyl) eluting with methanol. The eluent was blown down to dryness to give Example 339 as a brown gum (96 mg). LCMS showed MH+=483; TRET=2.57 min.

133046-46-5, The synthetic route of 133046-46-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Edlin, Christopher David; Holman, Stuart; Jones, Paul Spencer; Keeling, Suzanne Elaine; Lindvall, Mika Kristian; Mitchell, Charlotte Jane; Trivedi, Naimisha; US2009/131431; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1235406-28-6,3-Cyano-4-fluoro-N-(thiazol-2-yl)benzenesulfonamide,as a common compound, the synthetic route is as follows.

General procedure: A 0.2M solution in DMSO of the compound of formula (IV) (500 muL, 100 mumol) was added to a 0.2M solution in DMSO of the compound of formula (II) (500 muL, 100 mumol) followed by anhydrous potassium phosphate (64 mg, 300 mumol). The reaction mixture was heated to 80 C. for 16 hours before concentrating in vacuo. The residue was dissolved in DMSO (1 mL) and purified using preparative HPLC as described below to afford the desired compound of formula (I). The compounds of the Examples in the table belowwere prepared from the appropriate sulphonamide and: (a)3-cyano-4-fluorophenol; (b) 3,4-difluorophenol or (c)3-chioro-4-cyanophenol; according to Library Protocol 3.1., 1235406-28-6

1235406-28-6 3-Cyano-4-fluoro-N-(thiazol-2-yl)benzenesulfonamide 58042268, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER LIMITED; Owen, Robert McKenzie; Storer, Robert Ian; US2014/315933; (2014); A1;,
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Thiazole | chemical compound | Britannica

61296-22-8, 2-Amino-5-bromothiazole monohydrobromide is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of sodium bicarbonate (5.8 kg, 69.04 mol, 3.00 equiv) in water (30 L) and dichloromethane (20 L) was added 5-bromo-l,3-thiazol-2-amine hydrobromide (6 kg, 23.08 mol, 1.00 equiv) in batches. The resulting mixture was stirred at room temperature for 4 h and extracted with dichloromethane. The combined organic layers were dried over anhydrous sodium sulfate and concentrated under vacuum to afford 5-bromo-l,3-thiazol-2-amine as a gray solid (2.9 kg, 70%)., 61296-22-8

As the paragraph descriping shows that 61296-22-8 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; YU, Jiang; WU, Guosheng; YUEN, Po-Wai; VILLEMURE, Elisia; SCHWARZ, Jacob; LY, Cuong; SELLERS, Benjamin; VOLGRAF, Matthew; WO2015/52226; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

63837-11-6, 5-Bromo-2-methylbenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

63837-11-6, N-Bromosuccinimide (4.45 g, 25 mmol, 1.4 equiv.) and subsequently alpha,alpha’~ azoisobutyronitrile (110 mg, 0.7 mmol, 0.04 equiv.) were added to a solution of 5- bromo-2-methyl-benzothiazole (4.07 g, 17.85 mmol, 1 equiv.) in CCI4 (110 ml). The reaction mixture was stirred at reflux for 24 hrs. After cooling, succinimide was removed by filtration and was rinsed with CCI4 (100 ml). The filtrate was evaporated to dryness under reduced pressure and the orange solid residue was purified by column chromatography on silica, eluted with CH2CI2/hexane (20%-70% gradient), to give the desired product as a white solid, 2.15 g (39% yield). Mp 116-117, HPLC-MS (method 1): m/z 308 [M+H]+, Rt = 4.84 min. The reaction gave also 1.40 g (20% yield) of the by-product 5-bromo-2-dibromomethyl-benzothiazole, as well as 0.89 g (22%) of un-reacted starting material.

As the paragraph descriping shows that 63837-11-6 is playing an increasingly important role.

Reference£º
Patent; PROLYSIS LTD; WO2007/107758; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

4175-77-3, 2,4-Dibromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

he mixture of compound 433a (5 g, 20.5 mmol), cyclopropyl boronic acid (2.12 g, 24.7 mmol), K3P04 (13.1 g, 61.7 mmol), Xantphos (0.6 g, 1.04 mmol) and Pd(OAc)2 (0.23 g, 1.04 mmol) in THF (140 mL) was stirred at 80 ¡ãC under N2 for about 15 hours. The reaction was complete detected by TLC (Petroleum Ether/EtOAc = 30: 1) and LCMS. The mixture was extracted with EtOAc (100 mL), water (50 mL). The combined organics was dried over Na2S04, purified with silica gel (Petroleum Ether /EtOAc = 50: 1) to provide compound 433b as oil (3.48 g, yield: 83.3percent)

4175-77-3, As the paragraph descriping shows that 4175-77-3 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; YU, Wensheng; TONG, Ling; KOZLOWSKI, Joseph A.; SELYUTIN, Oleg; CHEN, Lei; KIM, Jae-Hun; SHA, Deyou; RIZVI, Razia; SHANKAR, Bandarpalle; HU, Bin; ZHONG, Bin; WAI, Dahai; HAO, Jinglai; WEI, Wei; JI, Tao; ZAN, Shuai; WO2014/110705; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.133840-96-7,2-Chloro-6-(trifluoromethoxy)benzo[d]thiazole,as a common compound, the synthetic route is as follows.

General procedure: 2-Chloro-6-trifluoromethoxy-benzothiazole (1.27 g, 5 mmol)was dissolved in 10 mL ethylamine aqueous solution. Theresultant mixture was stirred at room temperature overnight.The solvent was removed under reduced pressure. Theresidue was dissolved in CH2Cl2 and washed three timeswith water, dried over anhydrous Na2SO4, filtered and thesolvent completely removed. The crude material was purifiedby column chromatography over silica used dichloromethaneas eluent to give compound 4a as a whiteamorphous powder (1.11 g, 84.7%). Compounds 4b-4iwere also prepared by the same procedure from compound3 with n-butylamine, diaethylamin, cyclohexylamine, pyrrolidine,piperidine, morpholine, and 4-methylpiperidine,respectively. Spectroscopic data of N-alkylated derivativesof riluzole were given as follow., 133840-96-7

133840-96-7 2-Chloro-6-(trifluoromethoxy)benzo[d]thiazole 10037924, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Wu, Xiang-Long; Liu, Liu; Li, You-Jia; Luo, Jie; Gai, Dong-Wei; Lu, Ting-Li; Mei, Qi-Bing; Medicinal Chemistry Research; vol. 27; 5; (2018); p. 1374 – 1383;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

199475-45-1, 5-Bromobenzo[d]thiazol-2(3H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-bromo-3H-1,3-benzothiazol-2-one (94.4 mg,0.410 mmol)in water(2.1 mL)was added NaOH (16.4 mg,0.410 mmol)and then dimethyl sulfate (62.1 mg,0.492mmol). After stirring at room temperature for 3 h,the resulting precipitate was filtered,washedwith water,and dried under reduced pressure to give the title compound (89.3 mg,89%)as awhite powder that required no further purification. 1H NMR (400 MHz,CDCl3)8 7.32- 7.2915 (m,2H),7.20 (dd,J = 1.5,0.6 Hz,1H),3.45 (s,3H).

199475-45-1, 199475-45-1 5-Bromobenzo[d]thiazol-2(3H)-one 2801273, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; CYR, Patrick; BRONNER, Sarah; ROMERO, F. Anthony; MAGNUSON, Steven; TSUI, Vickie Hsiao-Wei; WAI, John; LAI, Kwong Wah; WANG, Fei; (251 pag.)WO2017/205536; (2017); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

63837-11-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63837-11-6,5-Bromo-2-methylbenzothiazole,as a common compound, the synthetic route is as follows.

EXAMPLE 17A 4-(2-methyl-1,3-benzothiazol-5-yl)benzoic acid The desired product was prepared by substituting 5-bromo-2-methyl-1,3-benzothiazole for 6-bromoindole in Example 4A. MS (DCI) m/e 270 (M+H)+.

The synthetic route of 63837-11-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Augeri, David J.; Baumeister, Steven A.; Bruncko, Milan; Dickman, Daniel A.; Ding, Hong; Dinges, Jurgen; Fesik, Stephen W.; Hajduk, Philip J.; Kunzer, Aaron R.; McClellan, William; Nettesheim, David G.; Oost, Thorsten; Petros, Andrew M.; Rosenberg, Saul H.; Shen, Wang; Thomas, Sheela A.; Wang, Xilu; Wendt, Michael D.; US2002/55631; (2002); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

80945-86-4,80945-86-4, 6-Bromo-2-chlorobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

intermediate 69:6-bromo-W-[2-chloro-6-{4-morpholinylmeth^amineIn an atmosphere of nitrogen, an ice-cooled solution of a mixture of 2-ch.oro-6-(4- morpholinylmethyl)-4-pyrimidinamine (1.356 g, 5.93 mmol) and 6-bromo-2-chloro-1 ,3- benzothiazo.e (1 ,474 g, 5.93 mmol) in dry A/,A/-dimethy.forrnamide (30 mL) was treated portionwise over 5 minutes with sodium hydride (60% w/w in mineral oil, 0.474 g, 1 1.86 mmol). The reaction mixture was stirred with cooling for 1 hour and at ambient temperature for a further 1 hour. The mixture was treated cautiously with saturated ammonium chloride (7.5 mL). Saturated aqueous sodium carbonate was added (aqueous pH=11 ) and the product was extracted with dichloromethane (2 x 100 mL). The organic layers were combined, dried using a hydrophobic frit and evaporated to dryness. The residue was purified by chromatography on silica using a gradient elution from 0 to 100 % ethyl acetate in cyciohexane followed by 0 to 30 % methanol in dichloromethane to afford the title compound (1.7 g, 3.86 mmol, 65 % yield). LCMS (Method D): Rt 1.19 minutes; m/z 440, 442 (MH+).

The synthetic route of 80945-86-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; BARTON, Nicholas Paul; CAMPOS, Sebastien Andre; CARR, Robin Arthur; HARLING, John David; SMITH, Ian Edward David; WO2012/35055; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica