Tag: M.W:200-300

72850-52-3, Ethyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

72850-52-3, EXAMPLE 49 STR65 Ethyl 2[(diphenylmethyl)amino]-4-(trifluoromethyl)-5thiazolecarboxylate A reaction vessel was charged with 120 ml of toluene and 11.0 g (42.4 mmol) of ethyl 2-chloro-4-trifluoromethyl-5-thiazolecarboxylate (prepared as described in U.S. Pat. No. 4,199,506). Then, 15.5 g (86 mmol) of aminodiphenylmethane was added in one portion. The resulting yellowish-orange solution was refluxed under nitrogen for 9 days. Then, solvent was removed from the mixture under reduced pressure to yield a yellowish-orange solid material, which was flash chromatographed (~38 ml/min) on silica gel using 10% ethyl acetate in hexane solvent. There was obtained 13.2 g of a thick yellow oil which solidified upon standing to a yellow solid product (m.p.=92-95 C.) identified in Table I.

As the paragraph descriping shows that 72850-52-3 is playing an increasingly important role.

Reference£º
Patent; Monsanto Company; US5000775; (1991); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1024583-33-2, Methyl 2-bromobenzo[d]thiazole-6-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-((((1R,3s,5S)-9-azabicyclo[3.3.1]decan-3-yl)oxy)methyl)-5-cyclopropyl-3-(2,6 -dichlorophenyl)isoxazole trifluoroacetate (500 mg, crude), methyl 2-bromobenzo[d]thiazole-6-carboxylate(272 mg, 1.0 mmol) and cesium carbonate (1.0 g, 3 mmol of) was added to the DMA (5 mL), the reaction microwave 120 0.5 hours, and pouredinto water (20mL), filtered (filter cake was purified by silica gel column chromatography in dichloromethane: methanol = 20: 1) to give the desired product ( 200 mg,two-step yield 49.2%).

1024583-33-2, The synthetic route of 1024583-33-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hainan Xuanzhu Pharmaceutical Technology Co., Ltd.; Fang Wenkui; Chen Bo; (66 pag.)CN109265471; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica