Tag: M.W:200-300

Related Products of 83435-58-9. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Boc-D-Prolinol, is researched, Molecular C10H19NO3, CAS is 83435-58-9, about Structure-Activity Studies on 2-Methyl-3-(2(S)-pyrrolidinylmethoxy)pyridine (ABT-089): An Orally Bioavailable 3-Pyridyl Ether Nicotinic Acetylcholine Receptor Ligand with Cognition-Enhancing Properties. Author is Lin, Nan-Horng; Gunn, David E.; Ryther, Keith B.; Garvey, David S.; Donnelly-Roberts, Diana L.; Decker, Michael W.; Brioni, Jorge D.; Buckley, Michael J.; Rodrigues, A. David.

2-Methyl-3-(2(S)-pyrrolidinylmethoxy)pyridine, ABT-089 (S-4), a member of the 3-pyridyl ether class of nicotinic acetylcholine receptor (nAChR) ligands, shows pos. effects in rodent and primate models of cognitive enhancement and a rodent model of anxiolytic activity and possesses a reduced propensity to activate peripheral ganglionic type receptors. The profiles of S-4, its N-Me analog, and the corresponding enantiomers across several measures of cholinergic channel function in vitro and in vivo are presented, together with in vitro metabolism and in vivo bioavailability data. On the basis of its biol. activities and favorable oral bioavailability, S-4 is an attractive candidate for further evaluation as a treatment for cognitive disorders.

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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography, published in 2009-08-13, which mentions a compound: 83435-58-9, mainly applied to leukotriene hydrolase inhibitor drug discovery metabolomics crystallog structure activity; drug screening leukotriene hydrolase inhibitor preparation structure activity crystallog, Computed Properties of C10H19NO3.

We describe a novel fragment library termed fragments of life (FOL) for structure-based drug discovery. The FOL library includes natural small mols. of life, derivatives thereof, and biaryl protein architecture mimetics. The choice of fragments facilitates the interrogation of protein active sites, allosteric binding sites, and protein-protein interaction surfaces for fragment binding. We screened the FOL library against leukotriene A4 hydrolase (LTA4H) by X-ray crystallog. A diverse set of fragments including derivatives of resveratrol, nicotinamide, and indole were identified as efficient ligands for LTA4H. These fragments were elaborated in a small number of synthetic cycles into potent inhibitors of LTA4H representing multiple novel chemotypes for modulating leukotriene biosynthesis. Anal. of the fragment-bound structures also showed that the fragments comprehensively recapitulated key chem. features and binding modes of several reported LTA4H inhibitors.

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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Anderson, M. R.; Andringa, S.; Anselmo, L.; Arushanova, E.; Asahi, S.; Askins, M.; Auty, D. J.; Back, A. R.; Barnard, Z.; Barros, N.; Bartlett, D.; Barao, F.; Bayes, R.; Beier, E. W.; Bialek, A.; Biller, S. D.; Blucher, E.; Bonventre, R.; Boulay, M.; Braid, D.; Caden, E.; Callaghan, E. J.; Caravaca, J.; Carvalho, J.; Cavalli, L.; Chauhan, D.; Chen, M.; Chkvorets, O.; Clark, K. J.; Cleveland, B.; Cookman, D.; Connors, C.; Coulter, I. T.; Cox, M. A.; Cressy, D.; Dai, X.; Darrach, C.; Davis-Purcell, B.; Deluce, C.; Depatie, M. M.; Descamps, F.; Dittmer, J.; Lodovico, F. Di; Duhaime, N.; Duncan, F.; Dunger, J.; Earle, A. D.; Fabris, D.; Falk, E.; Farrugia, A.; Fatemighomi, N.; Fischer, V.; Fletcher, E.; Ford, R.; Frankiewicz, K.; Gagnon, N.; Gaur, A.; Gilje, K.; Gonzalez-Reina, O. I.; Gooding, D.; Gorel, P.; Graham, K.; Grant, C.; Grove, J.; Grullon, S.; Guillian, E.; Hall, S.; Hallin, A. L.; Hallman, D.; Hans, S.; Hartnell, J.; Harvey, P.; Hedayatipour, M.; Heintzelman, W. J.; Heise, J.; Helmer, R. L.; Horne, D.; Hreljac, B.; Hu, J.; Hussain, A. S. M.; Iida, T.; Inacio, A. S.; Jackson, C. M.; Jelley, N. A.; Jillings, C. J.; Jones, C.; Jones, P. G.; Kamdin, K.; Kaptanoglu, T.; Kaspar, J.; Keeter, K.; Kefelian, C.; Khaghani, P.; Kippenbrock, L.; Klein, J. R.; Knapik, R.; Kofron, J.; Kormos, L. L.; Korte, S.; Krar, B.; Kraus, C.; Krauss, C. B.; Kroupova, T.; Labe, K.; Lafleur, F.; Lam, I.; Lan, C.; Land, B. J.; Lane, R.; Langrock, S.; LaTorre, A.; Lawson, I.; Lebanowski, L.; Lefeuvre, G. M.; Leming, E. J.; Li, A.; Lidgard, J.; Liggins, B.; Lin, Y. H.; Liu, X.; Liu, Y.; Lozza, V.; Luo, M.; Maguire, S.; Maio, A.; Majumdar, K.; Manecki, S.; Maneira, J.; Martin, R. D.; Marzec, E.; Mastbaum, A.; Mauel, J.; McCauley, N.; McDonald, A. B.; Mekarski, P.; Meyer, M.; Miller, C.; Mills, C.; Mlejnek, M.; Mony, E.; Morton-Blake, I.; Mottram, M. J.; Nae, S.; Nirkko, M.; Nolan, L. J.; Novikov, V. M.; O’Keeffe, H. M.; O’Sullivan, E.; Gann, G. D. Orebi; Parnell, M. J.; Paton, J.; Peeters, S. J. M.; Pershing, T.; Petriw, Z.; Petzoldt, J.; Pickard, L.; Pracsovics, D.; Prior, G.; Prouty, J. C.; Quirk, S.; Reichold, A.; Riccetto, S.; Richardson, R.; Rigan, M.; Robertson, A.; Rose, J.; Rosero, R.; Rost, P. M.; Rumleskie, J.; Schumaker, M. A.; Schwendener, M. H.; Scislowski, D.; Secrest, J.; Seddighin, M.; Segui, L.; Seibert, S.; Semenec, I.; Shaker, F.; Shantz, T.; Sharma, M. K.; Shokair, T. M.; Sibley, L.; Sinclair, J. R.; Singh, K.; Skensved, P.; SMILESy, M.; Sonley, T.; Stainforth, R.; Strait, M.; Stringer, M. I.; Svoboda, R.; Sorensen, A.; Tam, B.; Tatar, J.; Tian, L.; Tolich, N.; Tseng, J.; Tseung, H. W. C.; Turner, E.; Van Berg, R.; Veinot, J. G. C.; Virtue, C. J.; von Krosigk, B.; Vazquez-Jauregui, E.; Walker, J. M. G.; Walker, M.; Walton, S. C.; Wang, J.; Ward, M.; Wasalski, O.; Waterfield, J.; Weigand, J. J.; White, R. F.; Wilson, J. R.; Winchester, T. J.; Woosaree, P.; Wright, A.; Yanez, J. P.; Yeh, M.; Zhang, T.; Zhang, Y.; Zhao, T.; Zuber, K.; Zummo, A.; SNO& Collaboration published an article about the compound: 2,5-Diphenyloxazole( cas:92-71-7,SMILESS:C1(C2=CC=CC=C2)=NC=C(C3=CC=CC=C3)O1 ).Electric Literature of C15H11NO. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:92-71-7) through the article.

A liquid scintillator consisting of linear alkylbenzene as the solvent and 2,5-diphenyloxazole as the fluor was developed for the SNO+ experiment This mixture was chosen as it is compatible with acrylic and has a competitive light yield to pre-existing liquid scintillators while conferring other advantages including longer attenuation lengths, superior safety characteristics, chem. simplicity, ease of handling, and logistical availability. Its properties have been extensively characterized and are presented here. This liquid scintillator is now used in several neutrino physics experiments in addition to SNO+.

There is still a lot of research devoted to this compound(SMILES：C1(C2=CC=CC=C2)=NC=C(C3=CC=CC=C3)O1)Electric Literature of C15H11NO, and with the development of science, more effects of this compound(92-71-7) can be discovered.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2,5-Diphenyloxazole(SMILESS: C1(C2=CC=CC=C2)=NC=C(C3=CC=CC=C3)O1,cas:92-71-7) is researched.Category: benzisoxazole. The article 《Long-range exciton diffusion in molecular non-fullerene acceptors》 in relation to this compound, is published in Nature Communications. Let’s take a look at the latest research on this compound (cas:92-71-7).

The short exciton diffusion length associated with most classical organic semiconductors used in organic photovoltaics (5-20 nm) imposes severe limits on the maximum size of the donor and acceptor domains within the photoactive layer of the cell. Identifying materials that are able to transport excitons over longer distances can help advancing our understanding and lead to solar cells with higher efficiency. Here, we measure the exciton diffusion length in a wide range of nonfullerene acceptor mols. using two different exptl. techniques based on photocurrent and ultrafast spectroscopy measurements. The acceptors exhibit balanced ambipolar charge transport and surprisingly long exciton diffusion lengths in the range of 20 to 47 nm. With the aid of quantum-chem. calculations, we are able to rationalize the exciton dynamics and draw basic chem. design rules, particularly on the importance of the end-group substituent on the crystal packing of nonfullerene acceptors.

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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Application In Synthesis of 2,5-Diphenyloxazole. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2,5-Diphenyloxazole, is researched, Molecular C15H11NO, CAS is 92-71-7, about Unveiling the role of short-range exact-like exchange in the optimally tuned range-separated hybrids for fluorescence lifetime modeling. Author is Alipour, Mojtaba; Damiri, Samaneh.

Several variants are proposed and validated of the optimally tuned range-separated hybrid functionals (OT-RSHs) including different d. functional approximations for predicting the fluorescence lifetimes of different categories of fluorophores within the time-dependent d. functional theory (TD-DFT) framework using both the polarizable continuum and state-specific solvation models. The main idea originates from performing the optimal tuning in the presence of a contribution of the exact-like exchange at the short-range part, which, in turn, leads to the small values of the range-separation parameter, and computing the fluorescence lifetimes using the models including no or small portions of the short-range exact-like exchange. Particular attention is also paid to the influence of the geometries of emitters on fluorescence lifetime computations. The developed OT-RSHs along with the polarizable continuum model can be considered as the promising candidates within the TD-DFT framework for the prediction of fluorescence lifetimes for various fluorophores. The proposed models not only outperform their standard counterparts but also provide reliable data better than or comparable to the conventional hybrid functionals with both the fixed and interelectronic distance-dependent exact-like exchanges. When the excited state geometries come into play, more accurate descriptions of the fluorescence lifetimes can be achieved. (c) 2020 American Institute of Physics.

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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 92-71-7, is researched, Molecular C15H11NO, about Time response of water-based liquid scintillator from X-ray excitation, the main research direction is diphenyloxazole linear alkylbenzene water based liquid scintillator Xray excitation.Quality Control of 2,5-Diphenyloxazole.

Water-based liquid scintillators (WbLS) present an attractive target medium for large-scale detectors with the ability to enhance the separation of Cherenkov and scintillation signals from a single target. This work characterizes the scintillation properties of WbLS samples based on LAB/PPO liquid scintillator (LS). X-ray luminescence spectra, decay profiles, and relative light yields are measured for WbLS of varying LS concentration as well as for pure LS with a range of PPO concentrations up to 90 g/L. The scintillation properties of the WbLS are related to the precursor LAB/PPO: starting from 90 g/L PPO in LAB before synthesis, the resulting WbLS have spectroscopic properties that instead match 10 g/L PPO in LAB. This could indicate that the concentration of active PPO in the WbLS samples depends on their processing.

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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Boc-D-Prolinol, is researched, Molecular C10H19NO3, CAS is 83435-58-9, about The Discovery of Phthalazinone-Based Human H1 and H3 Single-Ligand Antagonists Suitable for Intranasal Administration for the Treatment of Allergic Rhinitis, the main research direction is phthalazinone derivative preparation intranasal antihistamine H1 H3 allergic rhinitis.Quality Control of Boc-D-Prolinol.

A series of potent phthalazinone-based human H1 and H3 bivalent histamine receptor antagonists, suitable for intranasal administration for the potential treatment of allergic rhinitis, were identified. Blockade of H3 receptors is thought to improve efficacy on nasal congestion, a symptom of allergic rhinitis that is currently not treated by current antihistamines. Two analogs (56a and 56b) had slightly lower H1 potency (pA2 9.1 and 8.9, resp., vs 9.7 for the clin. gold-standard azelastine), and H3 potency (pKi 9.6 and 9.5, resp., vs 6.8 for azelastine). Compound 56a had longer duration of action than azelastine, low brain penetration, and low oral bioavailability, which coupled with the predicted low clin. dose, should limit the potential of engaging CNS-related side-effects associated with H1 or H3 antagonism.

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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

SDS of cas: 92-71-7. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2,5-Diphenyloxazole, is researched, Molecular C15H11NO, CAS is 92-71-7, about A validated high performance liquid chromatography method for simultaneous determination of PPO and POPOP in plastic scintillators. Author is Ergun, Ece; Kantoglu, Omer; Aydin, Busra.

Plastic scintillators are the solid solutions of active additives to polymer matrixes and widely used in various fields of science and technol. such as high-energy physics, radiation chem., nuclear-power engineering, dosimetry and medical imaging. 2,5-diphenyloxazole (PPO) and 1,4-bis(5-phenyl-2- oxazolyl)benzen (POPOP) are the most widely used fluorescent additives (fluors) which lead to scintillation. Since the composition of the fluors determines the photon yield and optical properties of the scintillators, it is important to determine their concentration in the fabricated material. This paper describes a method, for the first time, for accurate determination of PPO and POPOP in plastic scintillators. A complete validation of the anal. procedure (sample preparation + HPLC method) has been performed using three spiking levels at 0.1, 10 and 100 mg L-1 and real plastic scintillator samples. Based on the results, calibration plots of PPO and POPOP were linear over the 0.01 to 150 mg L-1 concentration ranges. The limit of detection and limit of quantification were 0.92 and 2.80μg L-1 for PPO and 2.11 and 6.39μg L-1 for POPOP, resp. The performance of the anal. procedure was also verified through the determination of fluors in a plastic scintillator fabricated via bulk thermal polymerization As a consequence, the data indicate that the proposed anal. procedure for PPO and POPOP determination in plastic scintillators provides good linearity, sensitivity, accuracy, precision and robustness, which allows a novel, simple, fast, economical, and reliable qual. and quant. anal.

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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 92-71-7, is researched, Molecular C15H11NO, about Chiral Hypervalent Iodine Catalysis Enables an Unusual Regiodivergent Intermolecular Olefin Aminooxygenation, the main research direction is oxazoline preparation regioselective; alkene amide intermol aminooxygenation iodine catalyst.Product Details of 92-71-7.

A novel iodide-catalyzed intermol. aminooxygenation strategy was described here. Amide was used as the O- and N- source to probe for regiocontrol strategies. Notably, simple additives could be selectively introduced to achieve regiodivergent oxyamination processes for electronically activated alkenes while being regio-complementary for unactivated alkenes. Our preliminary data demonstrates that this regiocontrol strategy based on nucleophile could also be applied in asym. processes using chiral hypervalent iodine catalysis.

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Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Development, characterisation, and deployment of the SNO+ liquid scintillator, published in 2021-05-31, which mentions a compound: 92-71-7, Name is 2,5-Diphenyloxazole, Molecular C15H11NO, Electric Literature of C15H11NO.

A liquid scintillator consisting of linear alkylbenzene as the solvent and 2,5-diphenyloxazole as the fluor was developed for the SNO+ experiment This mixture was chosen as it is compatible with acrylic and has a competitive light yield to pre-existing liquid scintillators while conferring other advantages including longer attenuation lengths, superior safety characteristics, chem. simplicity, ease of handling, and logistical availability. Its properties have been extensively characterized and are presented here. This liquid scintillator is now used in several neutrino physics experiments in addition to SNO+.

There is still a lot of research devoted to this compound(SMILES：C1(C2=CC=CC=C2)=NC=C(C3=CC=CC=C3)O1)Electric Literature of C15H11NO, and with the development of science, more effects of this compound(92-71-7) can be discovered.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica