Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15864-32-1,2-Amino-6-bromobenzothiazole,as a common compound, the synthetic route is as follows.

To a stirred solution of 6-bromobenzo[d]thiazol-2-amine I-2 (229 g, 1.0 mol), pyridine (237 g, 3.0 mol) and DMAP (1.0 g) in anhydrous THF (1800 mL) at 10 C., CH3COCl (87 g, 1.1 mol) was added dropwise and the temperature was kept below 20 C. The resulting mixture was allowed to warm to RT and stirred overnight. The mixture was poured into H2O (2000 mL) and extracted with ethyl acetate (2000 mL). The organic layer was dried over Na2SO4 and filtered. The filtrate was concentrated in vacuo. The crude product was suspended in chloroform (1200 mL), heated to reflux for 20 min. and then cooled to RT. The precipitate was collected by filtration and further dried in vacuo to afford the desired product, N-(6-bromobenzo[d]thiazol-2-yl) acetamide (I-3) (231 g, 85% yield) as a white solid. ESI-MS (M+H)+ m/z: 270.95, 15864-32-1

As the paragraph descriping shows that 15864-32-1 is playing an increasingly important role.

Reference：
Patent; Intellikine LLC; Ren, Pingda; Liu, Yi; Wilson, Troy Edward; Li, Liansheng; Chan, Katrina; US2015/225407; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-38-6,2-Chloro-5-nitrobenzo[d]thiazole,as a common compound, the synthetic route is as follows.

Step: 100 mg, 0.67 mmol of benzo[c][1,2]oxaborol-1,5(3H)-diol was dissolved in 8 mL of acetonitrile.Then, 172 mg, 0.8 mmol of 2-chloro-5-nitrobenzothiazole and 329.1 mg, 1.01 mmol of cesium carbonate were added, and the mixture was stirred at 50 ° C overnight, cooled to room temperature, then added with water, and the solid was precipitated, and the crude product solid was prepared. Purification by phase separation to give 5-(5-nitrobenzothiazol-2-oxy)benzo[c][1,2]oxaborol-1(3H)-ol as a white solid 15 mg. The yield was 6.8percent., 3622-38-6

The synthetic route of 3622-38-6 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Guangzhou Baiting Pharmaceutical Technology Co., Ltd.; Wu Zhong; Li Jingrong; (16 pag.)CN108997394; (2018); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99073-88-8,Ethyl 2-bromo-6-benzothiazolecarboxylate,as a common compound, the synthetic route is as follows.

Step 3 6-Ethoxycarbonyl-2-mercaptobenzothiazole The crude 2-bromo-6-ethoxycarbonylbenzothiazole (1.90 g, 6.64 mmol) from Step 2 was suspended in absolute ethanol (35 mL) and treated with potassium hydrogen sulfide (0.96 g, 13.3 mmol). The mixture was placed under a nitrogen atmosphere, stirred, and heated in an oil bath at 80 C. The benzothiazole starring material gradually went into solution. After hearing for 30 minutes, the mixture was cooled in an ice bath, treated with 1N hydrochloric acid (13.5 mL), and evaporated under vacuum. The residue was partitioned between ethyl acetate (100 mL) and water (100 mL) and the aqueous phase extracted with more ethyl acetate (50 mL). The combined ethyl acetate solution was washed with brine (50 mL), dried over sodium sulfate, filtered and evaporated under vacuum to a yellow-tan solid (1.56 g). This material was triturated with diethyl ether and dried under vacuum to provide 6-ethoxycarbonyl-2-mercaptobenzothiazole (1.14 g) as a pale tan powder. 1 H NMR (DMSO-d6, 500 MHz) delta1.31 (t, CH3), 3.33 (br s, SH), 4.30(q, CH2), 7.35 (d, H-4), 7.94 (d, H-5), and 8.29 (s, H-7). 13 C NMR (DMSO-d6, 125.7 MHz) delta14.1, 60.9, 112.1,123.2, 125.5, 128.4, 129.7, 144.6, 165.0, and 191.8., 99073-88-8

As the paragraph descriping shows that 99073-88-8 is playing an increasingly important role.

Reference：
Patent; Merck & Co., Inc.; US5538964; (1996); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

131106-70-2, 6-(Trifluoromethyl)benzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

21n was dissolved under N2 in EtOH (72 mL). 85% hydrazinehydrate (13.2 g, 223.25 mmol) was added and the mixture wasrefluxed for 3 h. It was then cooled to 0 C and H2O (60 mL) wasadded. 50% acetic acid aqueous solution was added to pH 6e7 andthe mixturewas extracted with DCM. The organic layerwaswashedwith saturated aqueous NaCl and dried over Na2SO4. Then it wasconcentrated to get 5.6 g (Yield 98.2%) of 2-amino-5-(trifluoromethyl)benzenethiol (21m) as a yellow oil without furtherpurification. ES-LCMS m/z: 194.0 (MH).

131106-70-2, As the paragraph descriping shows that 131106-70-2 is playing an increasingly important role.

Reference：
Article; Cao, Hengyi; Zhu, Guangya; Sun, Lin; Chen, Ge; Ma, Xinxin; Luo, Xiao; Zhu, Jidong; European Journal of Medicinal Chemistry; vol. 183; (2019);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

494769-34-5, N-Boc-2-Amino-4-formylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,494769-34-5

Example 43; (a) To a solution commercially available 4-iodopyridine (0.82 g, 4.0 mmol) in 10 mL of THF at 0 C was added a 2M solution of EtMgCl in THF (2.0 mL, 4.0 mmol) dropwise. After 1 h, added a solution of 42b (456 mg, 2.0 mmol) in 5 mL of THF. The reaction was allowed to warm to rt and stirred at for 1 hr. The reaction was quenched with water and extracted 2×EtOAC. The EtOAc extracts were dried over MgSO4, concentrated by rotary evaporator, and chromatographed on SiO2 using 50% hexanes in EtOAc then pure EtOAC to give 138 mg (22%) of 43a. MS found: (M+H)+=308.

As the paragraph descriping shows that 494769-34-5 is playing an increasingly important role.

Reference：
Patent; Sheppeck, James; Dhar, T.G. Murali; Doweyko, Lidia; Gilmore, John; Weinstein, David; Xiao, Hai-Yun; Yang, Bingwei V.; Doweyko, Arthur M.; US2006/154973; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1094070-77-5,tert-Butyl (2-bromothiazol-5-yl)carbamate,as a common compound, the synthetic route is as follows.

[00299] 1 , 1 -Dimethylethyl (2-bromo- 1 ,3-thiazol-5 -y l)((2S)-2-(((( 1,1- dimethylethyl)oxy)carbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propyl)-carbamate: To a 250 mL round-bottomed flask was added tert-butyl 2-bromothiazol-5-ylcarbamate (0.75 g, 2.69 mmol), DMF (26.9 mL, 2.69 mmol), and cesium carbonate (1.75 g, 5.37 mmol). The mixture was warmed to 500C and 1,1-dimethylethyl 4-((4-(trifluoromethyl)phenyl)methyl)-l,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide (1.13 g, 2.96 mmol, Scheme 1) was added slowly in 10 mL DMF. After 1 hour, the mixture was cooled, diluted with ether (100 mL) and washed with brine (3×50 mL). The organic layer was dried over sodium sulfate, evaporated onto a plug of silica gel and purified by chromatography through a Redi-Sep pre-packed silica gel column (40 g), eluting with a gradient of 20 % to 100 % EtOAc in hexane, to provide the product (1.42 g, 91 % yield) as a white amorphous solid. LCMS (API-ES) m/z (%): 582 (100%, M+H).

1094070-77-5, The synthetic route of 1094070-77-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; AMGEN INC.; WO2009/11880; (2009); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103878-58-6,5-Bromothiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

(b) 5-bromo-N-cyclopropyl- 1, 3-thiazole-4-carboxam ide To a solution of 5-bromo-1,3-thiazole-4-carboxylic acid (3.09 g, 14.85 mmol) in DCM (75 mL) was added DIPEA (5.17 mL, 29.71 mmol) followed by cyclopropylamine (1.18 mL, 17.08 mmol) and HATU (6.21 g, 16.34 mmol). The reaction mixture was allowed to stir at room temperature for 6 h. The mixture was then diluted with H20 (50 mL) and the layers were separated. The aqueous layer was further extracted with DCM (3 x 25 mL) and the combined organics dried over MgSO4, filtered and concentrated under reduced pressure. The crude reaction product was purified by flash chromatography eluting with a gradient system of 0-50% EtOAc in Petroleum ether (40-60) to give 5-bromo-N-cyclopropyl-1,3- thiazole-4-carboxamide (2.88 g, 78 % yield) as a white solid. LC-MS (Method D) 247.2/249.2 [M+H] RT 1.82 mm

103878-58-6, The synthetic route of 103878-58-6 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; REDX PHARMA PLC; RATCLIFFE, Andrew; HUXLEY, Anthony; LYTH, David; NOONAN, Gary; KIRK, Ralph; UOSIS-MARTIN, Mario; STOKES, Neil; WO2015/155549; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2941-58-4, 2-Bromo-6-methoxybenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The corresponding 2-bromobenzothiazoles 10, 12-15 (0.66mmol, 1equiv) and the corresponding phenylboronic acid pinacol ester (0.79mmol, 1.2equiv) were dissolved in anhydrous DMF in the presence of K2CO3 (6.0equiv). After 1h under argon bubbling, Pd(dppf)Cl2·CH2Cl2 (0.033mmol, 0.05equiv) was introduced and the mixture was stirred at 80C or under microwave irradiation (monitoring by TLC or by GC-MS). Later, the mixture was then filtered on Celite, concentrated and dissolved in 4mL of 1N MeOH/HCl. Then 75mL of Et2O were introduced and a colour powder was isolated by filtration. The precipitate was poured into water and pH adjusted to 6. The expected compounds were isolated by filtration and purity was checked by HPLC., 2941-58-4

The synthetic route of 2941-58-4 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Bort, Guillaume; Sylla-Iyarreta Veitia, Maite; Ferroud, Clotilde; Tetrahedron; vol. 69; 35; (2013); p. 7345 – 7353;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

824403-26-1, 5-Bromo-2-chlorobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-bromo-2-chlorobenzo[d]thiazole (0.9 g, 3.62 mmol) in ethanol (12 mL) was added 4M methylamine solution (1 mL) and the mixture was heated for 90 minutes using a Biotage microwave oven at 100C. The reaction mixture was cooled to room temperature. The solvent was removed, the crude product was purified on a silica gel column using an EtOAc and heptane gradient (20/80 => 50/50) to afford the title compound as a solid (0.57 g, 65 %). (0511) 1H-NMR (400 MHz, Chloroform-c/) d = 7.68 (t, J = 2.0 Hz, 1 H), 7.46 (d, J = 8.3 Hz, 1 H), 7.22 (dd, J = 8.4, 1.9 Hz, 1 H), 5.90 (s, 1 H), 3.13 (s, 3H).

824403-26-1, The synthetic route of 824403-26-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; AC IMMUNE SA; NAMPALLY, Sreenivasachary; GABELLIERI, Emanuele; MOLETTE, Jerome; (220 pag.)WO2019/134978; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2941-58-4, 2-Bromo-6-methoxybenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 2-bromo-6-methoxybenzothiazole (0.67g) in drydichloromethane (30ml) at ambient temperature under an atmosphere of nitrogen wasadded dropwise a solution of boron tribromide in dichloromethane (5.5ml, 1M). Themixture was stirred for 2 hours at ambient temperature, stored for 2 days then poured intowater. The organic phase was separated, washed with water, dried over magnesiumsulphate then evaporated under reduced pressure to give 2-bromo-6-hydroxy-benzothiazole as a pale pink solid, 0.60g, m.p. 203-204C., 2941-58-4

2941-58-4 2-Bromo-6-methoxybenzothiazole 11218765, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; SYNGENTA LIMITED; WO2004/108663; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica