Tag: M.W:200-300

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 6-bromobenzo[J]thiazol-2-amine (2.50 g, 10.7 mmol) and DMAP (1.33 g, 12.8 mmol) in 20 mL dichloromethane at 0 C, AC2O (1.23 mL, 13.0 mmol) was added drop wise. After carried out at r.t. overnight, the mixture was quenched with 100 mL 1 N HC1. The resulting precipitate was filtered. The cake was washed with water and dried under vacuum to give A42-1 as a white solid (2.30 g, 79%). H NMR(300 MHz, CDC13) delta 9.90 (br s, 1H), 7.94 (s, 1H), 7.61 (d, / = 10.4 Hz, 1H), 7.54 (d, / = 10.4 Hz, 1H), 2.30 (s, 3H)., 15864-32-1

As the paragraph descriping shows that 15864-32-1 is playing an increasingly important role.

Reference：
Patent; ZHANG, Xiaohu; ACCRO BIOSCIENCE INC.; MA, Haikuo; ZHENG, Jiyue; HE, Sudan; (95 pag.)WO2018/17435; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

99073-88-8, Ethyl 2-bromo-6-benzothiazolecarboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,99073-88-8

Under nitrogen atmosphere, to a solution of this compound (4.00 g) in DMSO (100 mL)-CH3CN (100 mL) were added successively Pd(PPh3)4(485 mg) and sodium formate (4.76 g), and the mixture was stirred at 100 C. for 75 minutes. The solvent was evaporated under reduced pressure, and thereto was added water, and the mixture was extracted four times with Et2O, and dried over MgSO4. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column (hexane/ethyl acetate=10/1) to give ethyl 1,3-benzothiazole-6-carboxylate (1.21 g, 42%). 1H NMR (CDCl3, 400 MHz) delta 9.15 (s, 1H), 8.71 (dd, 1H, J=1.6, 0.5 Hz), 8.21 (dd, 1H, J=8.6, 1.6 Hz), 8.17 (dd, 1H, J=8.6, 0.5 Hz), 4.44 (q, 2H, J=7.1 Hz), 1.44 (t, 3H, J=7.1 Hz).

As the paragraph descriping shows that 99073-88-8 is playing an increasingly important role.

Reference：
Patent; Tokunaga, Teruhisa; Hume, William Ewan; Kitoh, Makoto; Nagata, Ryu; US2003/181496; (2003); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.99073-88-8,Ethyl 2-bromo-6-benzothiazolecarboxylate,as a common compound, the synthetic route is as follows.

Heat a degassed solution of ethyl 2-bromobenzothiazole-6- carboxylate (Step 1, 7.75 G, 27.1 mmol), tetrakis (TRIPHENYLPHOSPHINE) palladium (0) (1.7 g, 1.5 mmol), 4- (trifluoromethyl) phenylboronic acid (6.2 g, 32.6 mmol) and 2 M aqueous sodium carbonate solution (120 mL) in DME (90 mL) at reflux under nitrogen for 19 h. Dilute the cooled mixture with 1 N NAOH (1.2 L) and extract with methylene chloride (2 x 500 ML). Dry the combined organic extracts over MGS04, remove the solvents under reduced pressure and purify the residue by flash column chromatography on silica gel, eluting with hexanes/ethyl acetate (98: 2), to afford ethyl 2- (4-trifluoromethylphenyl) benzothiazole-6-carboxylate as a white solid (2.62 g, 27%) : 1H NMR (CDC13) 5 1.40 (t, 3H), 4.40 (q, 2H), 7.80 (d, 2H), 8.10 (d, 1H), 8.20 (m, 3H), 8.60 (s, 1H)., 99073-88-8

The synthetic route of 99073-88-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ELI LILLY AND COMPANY; WO2004/63155; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

103878-58-6, 5-Bromothiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of compound LXXX 2 (0.7 g, 3.37 mmol), compound LXXX-2A (0.53 g, 4.36 mmol), TEA (677 mg, 6.7 mmol) in toluene (10 mL) was added DPPA (1.2 g, 4.36 mmol) under nitrogen. After the addition, the solution was heated to reflux under nitrogen over night. The solution was concentrated. The residue was purified by column chromatography on silica gel (Petroleum ether:EtOAc = 3: 1) to afford compound LXXX-3 (0.76 g, yield 69%). MS (ESI) m/z (M+Na)+ 350.9., 103878-58-6

103878-58-6 5-Bromothiazole-4-carboxylic acid 21297375, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.; WO2013/25733; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

103878-58-6, 5-Bromothiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-bromo-1 ,3-thiazole-4-carboxylic acid (3.09 g, 14.85 mmol) in DCM (75 mL) was added DIPEA (5.17 mL, 29.71 mmol) followed by cyclopropylamine (1.18 mL, 17.08 mmol) and HATU (6.21 g, 16.34 mmol). The reaction mixture was allowed to stir at room temperature for 6 h. The mixture was then diluted with H2O (50 mL) and the layers were separated. The aqueous layer was further extracted with DCM (3 chi 25 mL) and the combined organics dried over MgSCU, filtered and concentrated under reduced pressure. The crude reaction product was purified by flash chromatography eluting with a gradient system of 0-50% EtOAc in Petroleum ether (40-60) to give 5-bromo-N-cyclopropyl-1 ,3- thiazole-4-carboxamide (2.88 g, 78 % yield) as a white solid.LC-MS (Method D) 247.2/249.2 [M+H]+; RT 1.82 min, 103878-58-6

103878-58-6 5-Bromothiazole-4-carboxylic acid 21297375, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; REDX PHARMA PLC; STOKES, Neil; (163 pag.)WO2017/46603; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1194374-25-8,2-Bromo-5-methylthiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

2-Bromo-5-methylthiazole-4-carboxylic acid (118 mg, 0.5 32 mmol) was suspended in anhydrous DCM (5 mL), and a drop a DMF was added. Then, oxalyl chloride (2 M in DCM) (0.725 mL, 1.45 mmol) was added dropwise, and the reactionmixture was stirred for 1 h at rt (bubbling observed; the mixture became homogeneous). Then, DCM was removed under reduced pressure, and the obtained acid chloride (brown syrup) was used in the subsequent step. In a separate flask, to a suspension of Intermediate 2, HC1 (141 mg, 0.483 mmol) in THF (5 mL), was added DIEA (0.084 mL, 0.483 mmol) and trimethylsilyl cyanide (0.644 mL, 4.83 mmol). The resultant solutionwas stirred at rt for 10 mm, and then was treated with a solution of acid chloride obtained as described above in THF (5 mL). The mixture was stirred at 50 C for 1.5 h. The reaction mixture was concentrated, then trifluoroethanol (10 mL) was added. The residue was purified by flash chromatography (solid loading on CELITE, 0-100% EtOAc/Hex) affording Intermediate 24 (86 mg, 39% yield) as a off-white solid. MS(ESI) m/z: 459.0(M+H) ?H NMR: (400 MHz, CDC13) oe ppm 9.91 (s, 1H), 8.46 (dd, J7.8, 1.0 Hz, 1H),7.86 – 7.80 (m, 1H), 7.80 – 7.74 (m, 1H), 7.70 (d, J8.1 Hz, 1H), 7.37 (br d, J=7.9 Hz,1H), 4.47 (sxt, J=8.2 Hz, 1H), 3.83 (quin, J8.5 Hz, 1H), 2.77 – 2.69 (m, 1H), 2.63 – 2.34(m, 5H), 2.17 (dd,J=10.8, 8.8 Hz, 1H), 2.04- 1.97 (m, 1H), 1.60 (s, 3H)., 1194374-25-8

As the paragraph descriping shows that 1194374-25-8 is playing an increasingly important role.

Reference：
Patent; BRISTOL-MYERS SQUIBB COMPANY; LADZIATA, Vladimir; GLUNZ, Peter W.; HU, Zilun; WANG, Yufeng; (0 pag.)WO2016/10950; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.131106-70-2,6-(Trifluoromethyl)benzo[d]thiazole,as a common compound, the synthetic route is as follows.

[00181] A solution of 6-(trifluoromethyl)benzo[d]thiazole (3) (830 mg, 4.08 mmol) and hydrazine monohydrate (1.52 g, 30.6 mmol) in ethanol (20 mL) was heated to reflux for 1.5 h. The mixture was added to a solution of acetic acid (3 mL) in water (100 mL) and extracted with DCM. The organic extract was dried over Na2S04and concentrated under reduced pressure. The crude material was purified by silica gel chromatography to afford 670 mg (84%) of the title compound as a yellow oil. NMR (400 MHz, CDCI3) delta 7.62 (d, J= 1.2 Hz, 1H), 7.39 (dd, J = 8.4, 2.0 Hz, 1H), 6.75 (d, J= 8.4 Hz, 1H), 4.49 (s, 2H), 2.95 (s, 1H).

131106-70-2, The synthetic route of 131106-70-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; NOGRA PHARMA LIMITED; VITI, Francesca; BELLINVIA, Salvatore; DEMARTIS, Salvatore; (104 pag.)WO2015/197861; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

15864-32-1, Under a nitrogen atmosphere a solution of 2-amino-6-brombromobenzothiazole (2, 0.00213 mol),acetonitrile (5 mL), and acetic anhydride (0.003 mol) was stirred at 60 C for 40 min with the additionof few drops of conc. H2SO4, After 40 min distilled water (15-20 mL) was added to form a precipitateand stirring was continued for one hour at room temperature. The solution was filtered and washedwith water and the product further analyzed by spectroscopic techniques [25].

The synthetic route of 15864-32-1 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Gull, Yasmeen; Rasool, Nasir; Noreen, Mnaza; Nasim, Faiz-Ul-Hassan; Yaqoob, Asma; Kousar, Shazia; Rashid, Umer; Bukhari, Iftikhar Hussain; Zubair, Muhammad; Islam, Md. Saiful; Molecules; vol. 18; 8; (2013); p. 8845 – 8857;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15864-32-1,2-Amino-6-bromobenzothiazole,as a common compound, the synthetic route is as follows.

Example 10; Preparation of 7V-(6-Phenylbenzo[15864-32-1

The synthetic route of 15864-32-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; DONG, Qing; GONG, Xianchang; HIROSE, Masaaki; JIN, Bohan; ZHOU, Feng; WO2010/8847; (2010); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1) Formation of tert-butyl (6-bromo-1 ,3-benzothiazol-2-yl) carbamate2-Amino-6-bromobenzothiazole (2.0 g; 8.7 mmol) was suspended in DCM (40 ml.) to which were added di-te/f-butyl dicarbonate (2.86 g; 13.1 mmol) and DMAP (4 mg; 0.03 mmol). The resulting mixture was stirred at RT for 16 h then concentrated in vacuo. The residue was suspended in 2M NH3 in MeOH and stirred at RT for 2 h then concentrated in vacuo. The residue was triturated in water and filtered to afford the title compound (2.64 g, 92%) as a white solid. 1H NMR (DMSOd6, 300 MHz) delta 1 1.86 (s, 1 H), 8.19 (d, J = 2.0 Hz, 1 H), 7.60 (d, J = 8.5 Hz, 1 H), 7.52 (dd, J = 2.0, 8.5 Hz, 1 H), 1.51 (s, 9H).

15864-32-1, The synthetic route of 15864-32-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; MERCK SERONO S.A.; SWINNEN, Dominique; JORAND-LEBRUN, Catherine; GRIPPI-VALLOTTON, Tania; GERBER, Patrick; GONZALEZ, Jerome; SHAW, Jeffrey; JEYAPRAKASHNARAYANAN, Seenisamy; WO2010/100144; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica