Tag: M.W:200-300

96929-05-4, Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,96929-05-4

To compound 388 (4.70 g, 16.4 mmol) dissolved in EtzO (140 mL) was added lithium borohydride (1.43 g, 65.7 mmol) and MeOH (2.10 g, 2.7 mL, 65.7 mmol). Refluxed for 16 h, cooled to room temperature, and concentrated. Added water (100 mL), extracted with CH2Cl2, dried combined organic extracts (MgS04), filtered, and concentrated. Purified by silica gel chromatography (eluant: 2% MeOH-CH2C12 to 5% MeOH-CH2CI2) to give 3.70 g (92%) of the product 389 as a yellow solid. MS m/e: 245 (M+H). For n=2: MS m/e: 259 (M+H)

As the paragraph descriping shows that 96929-05-4 is playing an increasingly important role.

Reference：
Patent; SCHERING CORPORATION; WO2005/121130; (2005); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.133692-16-7,2-Amino-5-bromo-4-methylthiazole hydrochloride,as a common compound, the synthetic route is as follows.

EXAMPLE 65 A mixture of 2-amino-5-bromo-4-methylthiazole hydrochloride (4.5 g), 2-mercaptopyridine (2.3 g) and potassium carbonate (7.0 g) in N,N-dimethylformamide (100 ml) was heated at 90 C. for 3 hours with stirring. The reaction mixture was concentrated under reduced pressure and water was added to this residue. The mixture was extracted with a mixture of tetrahydrofuran and ethyl acetate, washed with aqueous saturated sodium chloride and dried over magnesium sulfate. The solvent was concentrated under reduced pressure to give solid. The solid was subjected to column chromatography on silica gel (silica gel 60, 70-230 mesh; Merck: 300 g) and eluted with a mixture of chloroform and methanol (10:1). The fractions containing the objective compound were combined and concentrated under reduced pressure to give oil. Again the oil was subjected to column chromatography on silica gel (silica gel 60, 70-230 mesh; Merck: 200 g) and eluted with a mixture of dichloromethane and acetone (5:1). The fractions containing the objective compound were combined and concentrated under reduced pressure to give 2-amino-4-methyl-5-(2-pyridylthio)thiazole (2.1 g, yield: 47.9%). NMR (DMSO-d6, 200 MHZ, ppm): 2.13 (3H, s), 6.97 (1H, m), 7.15 (1H, m), 7.28 (2H, s), 7.65 (1H, m), 8.40 (1H, m) Mass: M+1 224, M 223, m/e 208, 190, 181, 145, 111

133692-16-7, The synthetic route of 133692-16-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Fujisawa Pharmaceutical Co., Ltd.; US5256675; (1993); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

824403-26-1, 5-Bromo-2-chlorobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

824403-26-1, Step 1 : 5-Bromo-2-cyclopropylbenzo[ |thiazole [00332] To a solution of 5-bromo-2-chlorobenzo[d]thiazole (0.50 g, 2.02 mmol) and Pd(PPh3)4 (70 mg, 0.06 mmol) in THF (5 mL) was added dropwise cyclopropyl zinc bromide (0.5 M in THF, 4.0 mL, 2.02 mmol), over 15 min. The reaction mixture heated to 60 C under N2 for 1 8 h. The reaction mixture was cooled to 0 C and quenched with saturated sodium hydrogen carbonate solution (1 0 mL). The corresponding solution was partitioned with ethyl acetate (50 mL), washed with saturated sodium hydrogen carbonate solution (30 mL), dried over MgS04 and concentrated to give an orange solid. The crude reaction material was purified by flash silica chromatography (gradient elution /’-hex to 50% EtOAc in /-hex) to give the title compound as a pale yellow solid (0.45 g, 88%). LCMS (ES+) consistent with target (M+H)+.

824403-26-1 5-Bromo-2-chlorobenzo[d]thiazole 20251269, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; CHDI FOUNDATION, INC.; DOMINGUEZ, Celia; MUNOZ-SAN JUAN, Ignacio; MAILLARD, Michel; RAPHY, Gilles; HAUGHAN, Alan, F.; LUCKHURST, Christopher, A.; JARVIS, Rebecca, E.; BURLI, Roland, W.; WISHART, Grant; HUGHES, Samantha, J.; ALLEN, Daniel, R.; PENROSE, Stephen, D.; BRECCIA, Perla; WO2014/159224; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

96929-05-4, Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,96929-05-4

Aqueous ammonia (28% w/w, 3,1 mL, 40 mmol) was added to a solution of ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate2 3 (381 mg, 1.33 mmol) in methanol (1,3 mL). After 16 h at 45C, the reaction mixture was concentrated affording the title compound as a brown oil (315mg, 92%) which was used directn y in the next step. 1H NMR (400 MHz, Methanol-d4) delta 8.10 (s, 1H), 4.49 (s, 2H), 1.45 (s, 9H).

96929-05-4 Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate 9925901, athiazole compound, is more and more widely used in various fields.

Reference：
Article; Iyer, Shankar S.; Gensollen, Thomas; Gandhi, Amit; Oh, Sungwhan F.; Neves, Joana F.; Collin, Frederic; Lavin, Richard; Serra, Carme; Glickman, Jonathan; de Silva, Punyanganie S.A.; Sartor, R. Balfour; Besra, Gurdyal; Hauser, Russell; Maxwell, Anthony; Llebaria, Amadeu; Blumberg, Richard S.; Cell; vol. 173; 5; (2018); p. 1123 – 11,1134;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To the stirring solution of 6-bromo-1 ,3-benzothiazol-2-amine (5 g, 21.825 mmol) in 1 ,4-Dioxane (80 mL) was added potassium acetate (3 g, 32.737 mmol) and 4,4,5,5-tetramethyl-2-(4,4,5,5-tetramethyl- 1 ,3,2-dioxaborolan-2-yl)-1 ,3,2-dioxaborolane (8.3 g, 32.737 mmol). The reaction mixture was degassed with nitrogen for 20 min followed by addition of Pd(PPh3)2Cl2 (850 mg, 1 .0912 mmol). The reaction mixture was again degassed for 10 min and then refluxed at 100C for overnight. The reaction mass was then diluted with water and extracted with dichloromethane (3 x 100 mL). The combined organic layers were then dried over sodium sulphate and concentrated under reduced pressure followed by column chromatography to obtain the title compound as solid (5 g). (0645) H NMR (400 MHz, CDCI3: delta 1 .35 (s, 12H), 5.45 (br. s, 2H), 7.53 (d, 1 H), 7.75 (d, 1 H), 8.06 (s, 1 H) LC/MS (method E) m/z: 277 [M + H]+, Rt = 0.96 min., 15864-32-1

As the paragraph descriping shows that 15864-32-1 is playing an increasingly important role.

Reference：
Patent; SYNGENTA PARTICIPATIONS AG; PITTERNA, Thomas; JEANGUENAT, Andre; BENFATTI, Fides; RAWAL, Girish; (89 pag.)WO2018/15328; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1849-73-6, 7-Chlorobenzo[d]thiazole-2(3H)-thione is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 3-necked round bottomed flask, containing a magnetic stirrer, 32 mg (0.7 mmol) of [3-(5-amino-2-bromo-4-carbamoyl-imidazol-1 -yl)-propyl]-isopropyl- carbamic acid tert-butyl ester, 34 mg (0.4 mmol) of LiBr, 22 mg (0.17 mmol) of potassium te/t-butoxide and 28 mg (0.14 mmol) of 7-chloro-benzothiazole-2- thiol were weighted. The flask was purged with argon and 6 ml_ of distilled DMF were added by syringe. The resulting suspension was stirred overnight at 13O0C. After this, the solvent was removed under high vacuum and the crude was purified through flash chromatography (SiO2, CH2CbZMeOH: 96/4) affording the 3-[5-amino-4-carbamoyl-2-(7-chloro-benzothiazol-2-ylsulfanyl)- imidazol-1-yl]-propyl}-isopropyl-carbamic acid tert-butyl ester compound (14 mg, 34percent) as a foam. 1H-NMR [ CD3OD, delta, ppm]: 7.77 (m, 1 H), 7.38 (m, 1 H), 7.28 (m, 1 H), 4.00 (m, 2H), 3.10 (m, 1 H), 1.90 (m, 4H), 1.42 (s, 9H), 1.01-1.04 (2s, 6H)., 1849-73-6

The synthetic route of 1849-73-6 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; CRYSTAX PHARMACEUTICALS, S.L.; WO2009/7399; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3622-30-8, 2,4-Dichlorobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 164 (+)-(4aR)-(10bR)-4-methyl-8-(4-chloro-2-benzothiazolylthio)-10b-methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one A 15 mL round bottom flask was charged with (+)-(4aR)-(10bR)-4-methyl-8-mercapto-10b-methyl-1,2,3,4,4a,-5,6,10b-octahydrobenzo[f]quinolin-3-one (100 mg, 0.38 mmol), potassium carbonate (158 mg, 1.14 mmol), 2,4-dichlorobenzo-thiazole (94 mg, 0.46 mmol) and 1 mL of anhydrous dimethyl formamide, fitted with a reflux condenser, and the stirred mixture was heated at 60°, under nitrogen, for 48 h. The mixture was cooled, diluted with ethyl acetate (75 mL) and washed with brine (2*25 mL). The combined organic extracts were dried over sodium sulfate, concentrated, and purified by silica gel chromatography (80percent ethyl acetate/hexanes eluent) to give 80 mg (49percent) of the title compound as an amorphous solid. mp 207°-209°. FDMS: m/e=429 alpha[D]589 =+63.86 (c=0.57, chloroform).

3622-30-8, 3622-30-8 2,4-Dichlorobenzothiazole 77177, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Eli Lilly and Company; US5550134; (1996); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.907545-27-1,Ethyl 2-chloro-5-methylthiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

(38b) Ethyl cis(+/-)-2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidin-1-yl)-5-methyl-1,3-thiazole-4-carboxylate tert-Butyl cis(+/-)-4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidine-1-carboxylate obtained by the method described in Example (1g) (80 mg, 0.21 mmol) was dissolved in methanol (1 mL). A 4 N hydrochloric acid/ethyl acetate solution (3 mL) was added, and the mixture was stirred at room temperature for one hour. Following concentration under reduced pressure, the residue was dissolved in DMF (2 mL). Diisopropylethylamine (0.16 mL, 0.92 mmol) and ethyl 2-chloro-5-methyl-1,3-thiazole-4-carboxylate obtained in Example (38a) (70 mg, 0.34 mmol) were added, and the mixture was stirred using a microwave reactor at 160C for three hours. Dilute hydrochloric acid was added to the reaction solution, followed by extraction with ethyl acetate. The organic layer was washed with water, saturated aqueous sodium bicarbonate solution and brine, and dried over anhydrous sodium sulfate. Following concentration under reduced pressure, the residue was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate = 4/1, 1/1, ethyl acetate) to obtain 15.3 mg of the title compound as a pale yellow solid (16%). 1H NMR spectrum (400 MHz, CDCl3) delta ppm: 1.26 (3H, t, J = 7.60 Hz), 1.37 (3H, t, J = 7.11 Hz), 1.76-1.78 (1H, m), 2.03-2.07 (1H, m), 2.59 (3H, s), 2.69 (2H, q, J = 7.60 Hz), 3.06 (1H, dd, J = 14.21, 1.38 Hz), 3.12-3.16 (1H, m), 3.43 (3H, s), 3.49 (1H, br s), 3.91-3.94 (1H, m), 4.19-4.28 (1H, m), 4.30-4.40 (3H, m), 7.49 (1H, d, J = 8.71 Hz), 11.19 (1H, br s).

907545-27-1, The synthetic route of 907545-27-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Daiichi Sankyo Company, Limited; EP2226322; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2941-58-4,2-Bromo-6-methoxybenzothiazole,as a common compound, the synthetic route is as follows.

Under N2, in a sealed tube, to 22 (19.7 mmol) in DMF 50 ml, 1-iodo-4-nitrobenzene (21.6 mmol), cesium carbonate (19.6 mmol), palladium acetate (0.98 mmol), copper bromide (0.2 mmol) and tributylphosphine (1.9 mmol) were added. The reaction was stirred at 150 C. overnight and, after cooling to room temperature, the mixture was extracted with ethyl acetate. The organic layer was then washed (3 times) with water, dried over Na2SO4 and the solvent removed via a rotary evaporator. The residue was purified by chromatography on silica gel using 9:1 hexane/ethyl acetate as the eluent to yield 4.62 g (81%) of 23 as a yellow solid. NMR 1H (DMSO), delta=3.83 (3H, s); 7.21 (1H, J=8.6 Hz); 7.73 (s, 1 H); 8.04 (2H, d, J=8.7 Hz); 8.25 (1H, d, J=8.6 Hz); 8.35 (2H, d, J=8.7 Hz). NMR ?13C(DMSO), delta=55.3; 104.7; 115.7; 1 16.7; 123.4; 124.1 (2C); 124.5; 127.8; 128.6 (2C); 144.0; 147.5; 157.5., 2941-58-4

The synthetic route of 2941-58-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Tamagnan, Gilles D.; Alagille, David; Costa, Herve Da; US2007/258887; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

942631-50-7, tert-Butyl thiazol-5-ylcarbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

942631-50-7, [0003 10] Synthesis of thiazol-5-amine hydrochloride (380): To a stirred solution of compound 379 (300 mg, 1.5 mmol) in MeOH (5 mL) was added 4 N HC1 in 1, 4-Dioxane (5 mL) under argon atmosphere at 0 C; warmed to RT and stirred for 3 h. The reaction was monitored by TLC; after completion of the reaction, the volatiles were removed in vacuo to obtain the crude. The crude was washed with n-pentane (2 x 5 mL) and dried in vacuo to afford compound 380 (150 mg, HC1 salt) as pale yellow solid. TLC: 50% EtOAc/ hexanes (R 0.1); 1H-NMR (DMSO-d6, 500 MHz): oe 9.10 (s, 1H), 7.22 (s, 1H).

942631-50-7 tert-Butyl thiazol-5-ylcarbamate 53432624, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION; ASSEMBLY BIOSCIENCES, INC.; TURNER, William W.; ARNOLD, Lee Daniel; MAAG, Hans; ZLOTNICK, Adam; WO2015/138895; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica