Tag: M.W:200-300

30132-15-1, 2-(2-Aminobenzo[d]thiazol-6-yl)acetic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of (2-ami?o-benzothiazol-6-yl)-acetic acid (0.61 mmol, as prepared by Meyer et al. in J. Med. Chem. 1997, 40, 1060) in absolute etha?ol (10 mL) was treated with 3 drops of concentrated H2SO4 and. ca. 1 g of dry 4 A molecular sieves, and heated to reflux for 3 d. The reaction was concentrated to dryness in vacuo, partitioned between CHaCl2 and saturated aqueous NaHCO3, filtered, and phases separated. The aqueous layer was extracted with CH2CI2, and the combined organic layers were washed with water and brine, dried over Na2SO4, filtered, and the filtrate concentrated in vacuo giving the title compound as a yellow solid. 1H NMR (CDCI3) S 7.50 (IH, m), 7.41 (IH, d, J = 8.3 Hz), 7.20 (IH, dd, / = 8.2 Hz, 1.9 Hz), 4.15 (2H, q, J = 7.2 Hz), 3.65 (2H, s), 3.42 (4H, s [NH2 + H2O]), 1.26 (3H, t, J = 7.1 Hz). ESI-MS (m/z): Calcd for CnHi2N2O2S: 236.1; found 237.1 (M+H)., 30132-15-1

As the paragraph descriping shows that 30132-15-1 is playing an increasingly important role.

Reference：
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2007/75567; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

103878-58-6, 5-Bromothiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

150 mg (0.43 mmol) of 5-bromo-thiazole-4-carboxylic acid and 81.4 mg (0.87 mmol) of pyridin-3-yl-amine were dissolved in 6 ml dimethyl formamide. 0.09 mL (0.65 mmol) of triethyl amine followed by 225 mg (0.43 mmol) of 1H-benzotriazol-1-yloxytri-pyrrolidinophosphonium hexafluorophosphate (PyBOP) were added and the reaction mixture was stirred at room temperature for 16 h. Brine was added and the reaction mixture was extracted two times with dichloromethane. The combined organic layers were dried over sodium sulfate, filtered and the solvent was removed under reduced pressure. The obtained residue was purified by flash column chromatography (silica, gradient elution cyclohexane?ethyl acetate?methanol) to give 90 mg (66%, 90% purity) of the title compound

103878-58-6, As the paragraph descriping shows that 103878-58-6 is playing an increasingly important role.

Reference：
Patent; BASF SE; Le Vezouet, Ronan; Soergel, Sebastian; Defieber, Christian; Gross, Steffen; Koerber, Karsten; Culbertson, Deborah L.; Anspaugh, Douglas D.; US9125414; (2015); B2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Acetic anhydride (4.95 ml_, 52.4 mmol) was added to a solution of 2-amino-6- bromobenzothiazole (3.00 g, 13.2 mmol) in anhydrous pyridine (30 ml) at 00C. The resulting mixture was stirred at RT for 48 hours. The reaction mixture was poured into water (300 ml_) and stirred for 30 minutes. Then the precipitate was washed with water (5x) and dried under reduced pressure to give the title compound as a white powder (3.44 g, 97%). HPLC, Rt: 3.3 min (purity: 99.1 %). UPLC/MS, M+(ESI): 270.1 and 272.1 , M-(ESI): 269.1 and 271.1.

15864-32-1, As the paragraph descriping shows that 15864-32-1 is playing an increasingly important role.

Reference：
Patent; MERCK SERONO S.A.; WO2009/133127; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

99073-88-8,99073-88-8, Ethyl 2-bromo-6-benzothiazolecarboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3 6-Ethoxycarbonyl-2-mercaptobenzothiazole The crude 2-bromo-6-ethoxycarbonylbenzothiazole (1.90 g, 6.64 mmol) from Step 2 was suspended in absolute ethanol (35 mL) and treated with potassium hydrogen sulfide (0.96 g, 13.3 mmol). The mixture was placed under a nitrogen atmosphere, stirred, and heated in an oil bath at 80 C. The benzothiazole starting material gradually went into solution. After heating for 30 minutes,the mixture was cooled in an ice bath, treated with IN hydrochloric acid (13.5 mL), and evaporated under vacuum. The residue was partitioned between ethyl acetate (100 mL) and water (100 mL) and the aqueous phase extracted with more ethyl acetate (50 mL). The combined ethyl acetate solution was washed with brine (50 mL), dried over sodium sulfate, filtered and evaporated under vacuum to a yellow-tan solid (1.56 g). This material was triturated with diethyl ether and dried under vacuum to provide 6-ethoxycarbonyl-2-mercaptobenzothiazole (1.14 g) as a pale tan powder. 1 H NMR (DMSO-d6, 500 MHz) delta1.31 (t, CH3), 3.33 (br s, SH), 4.30(q, CH2), 7.35 (d, H-4), 7.94 (d, H-5), and 8.29 (s, H-7). 13 C NMR (DMSO-d6, 125.7 MHz) delta14.1, 60.9, 112.1,123.2, 125.5, 128.4, 129.7, 144.6, 165.0, and 191.8.

The synthetic route of 99073-88-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Merck & Co., Inc.; US5498777; (1996); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

96929-05-4, Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

96929-05-4, a 2-(N-t-butoxycarbonylamino)methylthiazol-4-carboxylic acid A 20 ml portion of a 2N aqueous sodium hydroxide solution was added to 100 ml of an ethanol solution containing 5.727 g of ethyl 2-(N-t-butoxycarbonylamino)methylthiazol-4-carboxylate, and the mixture was then stirred at room temperature for 45 minutes. After adjustment to pH 5 with 2N hydrochloric acid, the solvent was evaporated under reduced pressure. Further, the solution was dissolved in 300 ml of ethanol under heating, and after the removal of a salt by filtration, the solvent was evaporated under reduced pressure to obtain 4.228 g of 2-(N-t-butoxycarbonylamino)methylthiazol-4-carboxylic acid as a milky white solid. NMR (DMSO-d6) delta: 1.41 (9H, s), 4.39 (2H, d, J=6.0 Hz), 7.86 (1H, br.t, J=6.0 Hz), 8.34 (1H, s), 13.0 (1H, br.s) MS (EI): 258 (M+)

96929-05-4 Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate 9925901, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Meiji Seika Kabushiki Kaisha; US5990101; (1999); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3622-38-6, 2-Chloro-5-nitrobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: GP4-1: A mixture of substituted2-chlorobenzothiazole (1.0eq), N-Bocpiperazine (1.05 eq) and Na2CO3 (1.2 eq) inDMF (10 volume) was heated up at 100 0C for hours, the process ofwhich was monitored by TLC. The mixture was diluted by EA and added by water.After extraction by EA (2 times), the collected organic layers were washed by10percent citric acid, and then brine, dried over Na2SO4 andconcentrated to give crude product, which could be used directly withoutfurther purification.GP4-2: N-Bocprotected amine in DCM (5 volume) was added by TFA (2.5 volume). The mixturewas stirred at rt for four hours and monitored by TLC. After consumption ofstarting material, volatile solvent was removed under reduced pressure and theresidue was neutralized by saturated Na2CO3 solution toobtain the slurry, which was extracted by 10percent methanol in DCM (3 times). Theorganic layers were collected, dried and concentrated to give the desired freeamine, for direct use for next step.GP4-3: Free amine (1.0 eq) suspendedin DCM (10 volume) was added by aldehyde (1.1 eq) under N2atmosphere. The mixture was stirred at rt 15 min. Then trimethylsilylazide?(TMSN3, 1.1 eq) was added, and stirring was kept foranother 15 min, followed by addition of isonitrile (1.0 eq). The mixture wasstirred at for 12 h. After removal of solvent, the residue was purified bypreparative TLC (DCM/MeOH as eluent) to give the product, which could bere-purified by trituration with ether., 3622-38-6

As the paragraph descriping shows that 3622-38-6 is playing an increasingly important role.

Reference：
Article; Lv, Fengping; Li, Zhi-Fang; Hu, Wenhao; Wu, Xiaohua; Bioorganic and Medicinal Chemistry; vol. 23; 24; (2015); p. 7661 – 7670;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

30132-15-1, 2-(2-Aminobenzo[d]thiazol-6-yl)acetic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 8; 3-(2-Fluorophenyl)-4-(2-(isopropylamino)benzo[d]thiazol-6-yl)-lH-pyrazol-5-oI; 1. Methyl 2-(2-aminobenzo[d]thiazol-6-yl)acetate[00175] A mixture of 2-(2-aminobenzo[d]thiazol-6-yl)acetic acid (95%, 10.0 g, 45.6 mmol), methanol (50 mL), 4 N HCl/l,4-dioxane (12.0 mL, 48.0 mmol) in 1,4- dioxane (30 mL) was heated at 750C for 9 hr and then concentrated under vacuum. The residue was suspended into water (50 mL) and basified to pH 9 with IN NaOH solution. The title compound (8.19 g, 81% yield) was collected as a pale solid by suction filtration and dried under vacuum at 5O0C.

30132-15-1, The synthetic route of 30132-15-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2007/16392; (2007); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.209459-11-0,Methyl 2-aminobenzo[d]thiazole-7-carboxylate,as a common compound, the synthetic route is as follows.

Isoamyl nitrite (22.0 mmol) is added to a solution of 2-amino-benzothiazole-7-carboxylic acid methyl ester (10.1 mmol) in THF (29 mL). The mixture is heated to reflux for 4h, the solvents are removed in vacuo and the residue is purified by flash chromatography (gradient: heptane to EtOAc/heptane 4/6) to give the desired product. LC-MS: tR = 0.85 min; [M+H]+ = 194.0., 209459-11-0

As the paragraph descriping shows that 209459-11-0 is playing an increasingly important role.

Reference：
Patent; ACTELION PHARMACEUTICALS LTD; WO2008/81399; (2008); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2941-58-4, 2-Bromo-6-methoxybenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 2-bromo-6-methoxy-l,3-benzothiazole (0.300 g, 1.23 mmol), 5-(4,4,5- trimethyl-l,3,2-dioxaborolan-2-yl)pyrimidin-2-amine (0.326 g, 1.47 mmol), Pd(dppf)Cl2*DCM (50 mg, 0.061 mmol) and 2 M aq. K2CO3 (3 mL) in DMF (7 mL) was o stirred under argon at 80 C for 1 h. The reaction mixture was allowed to reach rt and was filtered through silica. The filter cake was washed with DCM and DMF. The filtrate was concentrated under vacuum. Flash chromatography (Heptane/EtOAc gradient) of the residue gave the title compound (0.171 g) as a yellow solid. 1H NMR delta ppm 8.83 (s, 2 H) 7.87 (d, 1 H) 7.70 (d, 1 H) 7.35 (br s, 2 H) 7.11 (dd, 1 H) 3.84 (s, 3 H); MS m/z (M+H) s 259., 2941-58-4

As the paragraph descriping shows that 2941-58-4 is playing an increasingly important role.

Reference：
Patent; ASTRAZENECA AB; WO2007/86800; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.96929-05-4,Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: KOH aq. (10%) was added to a solution of the ester in THF and the reaction mixture was stirred at room temperature for 1h. The pH was brought to 4 by addition of 5M HCl and then extracted with EtOAc. The organic layer was dried over MgSO4 and concentrated in vacuo to afford the acid., 96929-05-4

96929-05-4 Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate 9925901, athiazole compound, is more and more widely used in various fields.

Reference：
Article; Pena, Stella; Scarone, Laura; Manta, Eduardo; Stewart, Lindsay; Yardley, Vanessa; Croft, Simon; Serra, Gloria; Bioorganic and Medicinal Chemistry Letters; vol. 22; 15; (2012); p. 4994 – 4997;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica