Tag: M.W:200-300

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Wherein, 6-bromo-2-(4-nitrophenyl)benzothiazole can be prepared by steps of: 5 g of 6-bromo-2-amino-benzothiazole was added to 25 mL of a solution of potassium hydroxide at a concentration of 10 M, and then 5 mL of ethylene glycol was added to form a mixed solution which was stirred at 125 C. for 2 h to obtain 2-amino-bromophenyl mercaptan; 1H NMR: 400 MHz DMSO delta 7.21-7.26 (m, 1H), 6.99 (s, 1H), 6.81-6.72 (m, 1H), 6.39 (s, 1H), 5.72 (s, 2H)., 15864-32-1

15864-32-1 2-Amino-6-bromobenzothiazole 85149, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Neuboron Medtech Ltd.; LIU, Yuan-Hao; (14 pag.)US2018/298037; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.96929-05-4,Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.,96929-05-4

a. Tert-butyl N-[[4-(hydroxymethyl)thiazol-2-yl]methyl]carbamate To a stirred solution of ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate (1 g, 3.49 mmol) in THF (20 mL) was added LiAlH4 (7.0 mL, 6.98 mmol, 1M in THF) drop wise under nitrogen at 0 C and the reaction mixture was allowed stir at room temperature for 4 h. The reaction mixture was cooled to 0 C and quenched with EtOAc (30 mL) followed by saturated aqueous sodium sulphate solution. Then stirred at same temperature for 30 min., filtered and filtrate was evaporated. The crude was chromatographed on silica eluting with 40% EtOAc in petroleum ether affording a yellow solid (510 mg, 59%). M/z 245.1 (M+H)+.

The synthetic route of 96929-05-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Antabio SAS; The designation of the inventor has not yet been filed; (149 pag.)EP3628672; (2020); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1025700-49-5, 2-Amino-5-bromo-4-isopropylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3 5-Bromo-4-isopropyl-thiazole Concentrated nitric acid (4 mL) was slowly added to 5-bromo-4-isopropyl-thiazol-2-ylamine (2.05 g, 9 mmol), and concentrated phosphoric acid (14 mL) was added dropwise over five minutes. The mixture was cooled to -5 C., and a solution of sodium nitrite (0.768 g, 11 mmol) in 5 mL water was added dropwise over a 15 minute period. The reaction mixture was stirred at -5 C. for 30 minutes, and an aqueous solution of H3PO2 (6 mL, 50% weight in water) was slowly added. The reaction mixture was stirred at -5 C. for 2.5 hours, then stirred at room temperature for 18 hours. The reaction mixture was cooled to 0 C. and quenched by addition of aqueous NaOH (30% weight solution). The mixture was extracted with methylene chloride, and the combined organic extracts were washed with brine, dried (MgSO4), filtered and concentrated under reduced pressure. The resulting oil was chromatographed (10% EtOAc in hexanes) to give 236 mg of 5-bromo-4-isopropyl-thiazole as an oil, MS (M+H)=207., 1025700-49-5

The synthetic route of 1025700-49-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Chen, Li; Dillon, Michael Patrick; Feng, Lichun; Hawley, Ronald Charles; Yang, Minmin; US2012/22067; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1025700-49-5,2-Amino-5-bromo-4-isopropylthiazole,as a common compound, the synthetic route is as follows.,1025700-49-5

Step 3 5-Bromo-4-isopropyl-thiazole; Concentrated nitric acid (4 mL) was slowly added to 5-bromo-4-isopropyl-thiazol-2-yl- amine (2.05 g, 9 mmol), and concentrated phosphoric acid (14 mL) was added dropwise over 5 min. The mixture was cooled to -5C, and a solution of sodium nitrite (0.768 g, 11 mmol) in 5 mL water was added dropwise over a 15 min period. The reaction mixture was stirred at -5C for 30 min, and an aqueous solution of H3PO2 (6 mL, 50% weight in water) was slowly added. The reaction mixture was stirred at -5C for 2.5 h, then stirred at RT for 18 h. The reaction mixture was cooled to 00C and quenched by addition of aqueous NaOH (30% weight solution). The mixture was extracted with methylene chloride, and the combined organic extracts were washed with brine, dried (MgSO/O, filtered and concentrated under reduced pressure. The resulting oil was chromato- graphed (10% EtOAc in hexanes) to give 236 mg of 5-bromo-4-isopropyl-thiazole as an oil, MS (M+H) = 207.

As the paragraph descriping shows that 1025700-49-5 is playing an increasingly important role.

Reference：
Patent; F. HOFFMANN-LA ROCHE AG; WO2008/55840; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Compound 1 (500 mg, 2.18 mmol, 1 eq) and B2Pin2 (665.06 mg, 2.62 mmol, 1.2 eq) in dioxane (8 mL) was added Pd(dppf)Cl2 (159.69 mg, 218.25 mumol, 0.1 eq) and KOAc (321.29 mg, 3.27 mmol, 1.5 eq). The mixture was stirred at 110 C. for 12 hr under N2. The reaction mixture was concentrated under reduced pressure to remove solvent. The residue was diluted with brine 50 mL and extracted with EA 20 mL (20 mL*3). The combined organic layers was filtered and concentrated under reduced pressure to give a residue. The residue was purified by column chromatography (SiO2, Petroleum ether:Ethyl acetate=5:1 to 3:1). Compound 2 (907 mg, 1.55 mmol, 71% yield, 47% purity) was obtained as a light yellow solid. 1H NMR (400 MHz, CDCl3) 5=8.06 (s, 1H), 7.77-7.74 (m, 1H), 7.60 (d, J=7.2 Hz, 1H), 4.13 (q, J=7.2 Hz, 2H), 1.28 (s, 12H).

15864-32-1, 15864-32-1 2-Amino-6-bromobenzothiazole 85149, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; 1ST Biotherapeutics, Inc.; LEE, Jinhwa; KIM, Jae Eun; JO, Suyeon; LEE, Gwibin; LIM, Keonseung; PARK, A Yeong; KIM, Misoon; JUNG, Gyooseung; LIM, Seung Mook; LEE, Minwoo; YANG, Heekyoung; KIM, Hyonam; KIM, Hyeongjun; LI, Wanjun; FAN, Mingzhu; (82 pag.)US2019/100500; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15864-32-1,2-Amino-6-bromobenzothiazole,as a common compound, the synthetic route is as follows.

2. A suspension of 6-bromobenzothiazol-2-ylamine (2. 29 g, 10 mmol) prepared above in sodium hydroxide (40 mL of a 6 M solution, 240 mmol) was refluxed under argon overnight. The reaction mixture was cooled in an ice bath and was acidified to between pH 3 and 5 with conc. HCI. The resulting precipitate was isolated by filtration, washed with water and dried under high vacuum to afford the crude product that was used in the following reaction without further purification., 15864-32-1

As the paragraph descriping shows that 15864-32-1 is playing an increasingly important role.

Reference：
Patent; KINETEK PHARMACEUTICALS, INC.; WO2004/11460; (2004); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15864-32-1,2-Amino-6-bromobenzothiazole,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of 6-bromobenzo[d]thiazol-2-amine (470 mg, 2.01 mmol) and CuBr2 (760 mg, 3.42 mmol) in MeCN (10 mL) at 0 C, was added iso-pentyl nitrite (280 mg, 2.41 mmol) dropwise. The reaction mixture was stirred at 0 C for 1 h and then H2O (100 mL) was added. The resulting precipitate was filtered and dried in vacuum to give the title compound (515 mg, 87%) as a brown solid., 15864-32-1

As the paragraph descriping shows that 15864-32-1 is playing an increasingly important role.

Reference：
Article; Yang, Zhaohui; Ma, Haikuo; Sun, Zhijian; Luo, Lusong; Tian, Sheng; Zheng, Jiyue; Zhang, Xiaohu; Bioorganic and Medicinal Chemistry Letters; vol. 25; 17; (2015); p. 3665 – 3670;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15864-32-1,2-Amino-6-bromobenzothiazole,as a common compound, the synthetic route is as follows.

15864-32-1, Step 6; To a solution of 2-amino-6-bromobenzothiazole (10 g, 0.044 mol) in dichloromethane (150 mL), DMAP (7 g) and acetic anhydride (18 g) were added. The solution was then refluxed overnight. The reaction mixture was concentrated, and then water was added thereto. The precipitate was collected by filtration, then washed with water and dried to yield target compound 50 (10.2 g, y. 85%).

As the paragraph descriping shows that 15864-32-1 is playing an increasingly important role.

Reference：
Patent; Shionogi & Co., Ltd.; EP2426135; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.494769-34-5,N-Boc-2-Amino-4-formylthiazole,as a common compound, the synthetic route is as follows.

TFA (2.0 mL) was added to a 0 C. solution of Part A compound (0.64 g; 2.80 mmol) in DCM (4.0 mL). After 20 h at RT the reaction mixture was concentrated in vacuo. The residue was partitioned between EtOAc (10 mL) and sat. aqueous NaHCO3 (8 mL). The aqueous phase was isolated and extracted with EtOAc (5×8 mL). The combined organic extracts were dried (MgSO4) and concentrated in vacuo to give Part B compound (0.30 g; 83%) as a yellow solid., 494769-34-5

As the paragraph descriping shows that 494769-34-5 is playing an increasingly important role.

Reference：
Patent; Bristol-Myers Squibb Company; US2008/9465; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.824403-26-1,5-Bromo-2-chlorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.

824403-26-1, Intermediate 1: Step b3-((5-Bromobenzo [d] thiazol-2-yl)amino)-4-methoxybenzonitrileCommercially available 5-bromo-2-chlorobenzo[d]thiazole (2.0 g, 8.05 mmol) in phenol (4 g) was treated with 3-amino-4-methoxybenzonitrile (1.31 g, 8.85 mmol, intermediate 1, step a). The mixture was heated to 100 C overnight. The resulting red-brown solution was cooled to room temperature. To the solid formed upon cooling was added EtOAc and saturated aqueous NaHCC solution. The mixture was stirred for 1 h to dissolve the solid. The aqueous layer was separated out. The organic layer was washed with IN NaOH solution for 5 times to get rid of phenol. The organic layer was dried (MgS04) and concentrated in vacuo to obtain the title compound as a solid.

The synthetic route of 824403-26-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; JANSSEN PHARMACEUTICA NV; JACKSON, Paul, Francis; MAHAROOF, Umar, S.M.; LEONARD, Kristi, Anne; BAXTER, Ellen; TOUNGE, Brett, Andrew; HAWKINS, Michael; WO2012/162463; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica