Tag: M.W:200-300

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 25 mL of a 10 M potassium hydroxide solution, 5 g of 2-amino-6-bromo-benzothiazole was added, and then a mixed solution of 5 mL of ethylene glycol was added thereto, and the mixture was stirred at 125 C for 2 hours.Obtaining 2-amino-5-bromobenzenethiol;

15864-32-1, As the paragraph descriping shows that 15864-32-1 is playing an increasingly important role.

Reference：
Patent; Nanjing Zhongpengliankang Medical Treatment Technology Co., Ltd.; Liu Yuanhao; (20 pag.)CN108239100; (2018); A;,
Thiazole | C3H3NS – PubChem
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.81569-46-2,Methyl 2-bromo-5-ethylthiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

81569-46-2, 4-(5-ethyl-4-(methoxycarbonyl)-1,3-thiazol-2-yl)benzoic acid The desired product was prepared by substituting methyl 2-bromo-5-ethylthiazole-4-carboxylate (prepared according to the procedure described in J. Chem. Soc. Perkin I 1982, 159-164) for 6-bromoindole in Example 4A.

81569-46-2 Methyl 2-bromo-5-ethylthiazole-4-carboxylate 13015592, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Augeri, David J.; Baumeister, Steven A.; Bruncko, Milan; Dickman, Daniel A.; Ding, Hong; Dinges, Jurgen; Fesik, Stephen W.; Hajduk, Philip J.; Kunzer, Aaron R.; McClellan, William; Nettesheim, David G.; Oost, Thorsten; Petros, Andrew M.; Rosenberg, Saul H.; Shen, Wang; Thomas, Sheela A.; Wang, Xilu; Wendt, Michael D.; US2002/55631; (2002); A1;; ; Patent; Augeri, David J.; Baumeister, Steven A.; Bruncko, Milan; Dickman, Daniel A.; Ding, Hong; Dinges, Jurgen; Fesik, Stephen W.; Hajduk, Philip J.; Kunzer, Aaron R.; McClellan, William; Nettesheim, David G.; Oost, Thorsten; Petros, Andrew M.; Rosenberg, Saul H.; Shen, Wang; Thomas, Sheela A.; Wang, Xilu; Wendt, Michael D.; US2002/86887; (2002); A1;,
Thiazole | C3H3NS – PubChem
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15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 25 mL of 10 M potassium hydroxide solution was added 5 g of 2-amino-6-bromo-benzothiazole,After adding 5 mL of ethylene glycol, the mixture was stirred at 125 C. for 2 h to obtain 2-amino-5-bromobenzenethiol, 15864-32-1

The synthetic route of 15864-32-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; NEUBORON MEDTECH LTD.; LIU, YUAN HAO; CHEN, JUI FEN; HE, JING; (35 pag.)TW2017/22441; (2017); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.96929-05-4,Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

96929-05-4, Asolution of HCl (4 M) in dioxane was added to the protected amino compound and the mixture was stirred at rt under N2 atmosphere for 2-4 h. The solvent was removed under reduced pressure.

As the paragraph descriping shows that 96929-05-4 is playing an increasingly important role.

Reference：
Article; Pena, Stella; Scarone, Laura; Manta, Eduardo; Serra, Gloria; Tetrahedron Letters; vol. 54; 22; (2013); p. 2806 – 2808;,
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908591-25-3, 1-(2-Isopropylthiazol-4-yl)-N-methylmethanamine hydrochloride is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,908591-25-3

2-Isopropyl-4-(((N-methyl)amino)methyl)thiazole hydrochloride prepared from Example 4 (6.0 g) was suspended in THF (100 ml). N-(((4-nitrophenyl)oxy)carbonyl)-L- valine methyl ester from Example 5 (12.4 g), dimethylaminopyridine (0.6 g), and triethylamine (5.85 g) were mixed with the suspension and the mixture heated to about 70C for 8 hours. The solid impurities were filtered and the filtrate concentrated under reduced pressure. The oil obtained was dissolved in dichloromethane (50 ml) and washed thrice with 10% potassium carbonate solution (30 ml) and thrice with water (30 ml). The organic layer was concentrated completely under reduced pressure to provide the title compound as a light brown color oil.Yield: 12 g

908591-25-3 1-(2-Isopropylthiazol-4-yl)-N-methylmethanamine hydrochloride 11622565, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; RANBAXY LABORATORIES LIMITED; WO2006/90270; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6294-52-6,5,6-Dimethoxybenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

General procedure: Corresponding benzo[d]thiazol-2-amine (3 and 4) (0.025 mol) and triethylamine (0.030 mol,4.24 mL) were dissolved in THF (50 mL). This mixture was kept on an ice bath andchloroacetyl chloride (0.030 mol, 2.37 mL) in THF (10 ml) was added dropwise with constantstirring. After this stage, the content was allowed to stir for an additional 1 h at roomtemperature. THF was evaporated, the raw product was washed with water, dried andrecrystallized from ethanol.2,3, 6294-52-6

6294-52-6 5,6-Dimethoxybenzo[d]thiazol-2-amine 94938, athiazole compound, is more and more widely used in various fields.

Reference：
Article; Demir Oezkay, Uemide; Can, Oezguer Devrim; Sa?l?k, Beguem Nurpelin; Acar Cevik, Ulviye; Levent, Serkan; Oezkay, Yusuf; Ilg?n, Sinem; Atl?, Oezlem; Bioorganic and Medicinal Chemistry Letters; vol. 26; 22; (2016); p. 5387 – 5394;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1849-73-6,7-Chlorobenzo[d]thiazole-2(3H)-thione,as a common compound, the synthetic route is as follows.

In a 3-necked round bottomed flask, containing a magnetic stirrer, 80 mg (0.36mmol) of delta-amino^-bromo-i -methyl-I H-imidazole^- carboxamide, 0.16 g (1.83 mmol) of LiBr, 98 mg (0.80 mmol) of potassium te/t-butoxide and 8.85g (64mmol) of 7-chloro-benzothiazole-2-thiol were weighted. The flask was purged with argon and 6ml of distilled DMF were added by syringe. The resulting suspension was stirred overnight at 13O0C. After this, the solvent was removed under high vacuum and the crude was purified through flash chromatography (SiO2, CH2CI2/MeOH : 96/4 affording the 5-amino-2-(7- chloro-benzothiazol-2-ylsulfanyl)-1 -methyl-1 H-imidazole-4-carboxamide compound (38 mg, 31 percent) as a foam. 1H-NMR [CD3OD, delta, ppm]: 7.81 (m, 1 H), 7.48 (m, 1 H), 7.42 (m, 1 H), 3.56 (s, 3H, CH3). MS (El, m/z) 340 (M++1 )., 1849-73-6

As the paragraph descriping shows that 1849-73-6 is playing an increasingly important role.

Reference：
Patent; CRYSTAX PHARMACEUTICALS, S.L.; WO2009/7399; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

824403-26-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.824403-26-1,5-Bromo-2-chlorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.

To a solution of 5-bromo-2-chlorobenzo[cf]thiazole (0.9 g, 3.62 mmol) in ethanol (12 ml), was added 4 M methyl amine solution (1 ml_) and the reaction mixture was heated at 150 C for 45 min using a Biotage microwave. The reaction mixture was cooled to room temperature. The solvent was removed under reduced pressure, and the crude reaction mixture was purified by flash column chromatography using hexane: ethyl acetate (50:50) to afford the title compound as a solid (0.57 g, 65%).1H-NMR (400 MHz, CDCI3) d = 7.68 (t, J = 2.0 Hz, 1 H), 7.46 (d, J = 8.3 Hz, 1 H), 7.29 (d, J = 0.7 Hz, 1 H), 7.22 (dd, J = 8.4, 1.9 Hz, 1 H), 5.90 (s, 1 H), 3.13 (s, 3H).

824403-26-1 5-Bromo-2-chlorobenzo[d]thiazole 20251269, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; AC IMMUNE SA; NAMPALLY, Sreenivasachary; GABELLIERI, Emanuele; MOLETTE, Jerome; (0 pag.)WO2019/233883; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

933720-87-7,933720-87-7, 2-Bromo-4-methylthiazole-5-carbaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

PREPARATION 991-(2-Bromo-4-meth lthiazol-5-yl)ethanolTo a mixture of 2-bromo-4-methylthiazole-5-carbaldehyde of preparation 98 (1.8 g, 8.8 mmol) in dry THF (50 mL) was added dropwise MeMgBr in EfeO (3M, 2.9 mL, 8.8 mmol) at -40C under N2. After the addition, the mixture was stirred at room temperature for 1 hr. TLC (petroleum ether/EtOAc = 5:1 ) showed most of the starting material was consumed. To the reaction mixture was added saturated NH4CI (60 mL). The mixture was extracted with EtOAc (50 ml_x2). The combined organic layers were washed with brine (80 mL), dried over sodium sulfate and concentrated in vacuum. The residue was purified by a Biotage silica gel cartridge (EA/PE 48%, Rf = 0.5) to give the titlecompound as a yellow oil (1.7 g, 87%).1H NMR (400 MHz, CDCI3): delta ppm 5.09-5.06 (q, 1 H), 2.29-2.28 (d, 4H), 1.46-1.45 (d, 3H). MS: m/z 223.6 [MH]+.

As the paragraph descriping shows that 933720-87-7 is playing an increasingly important role.

Reference：
Patent; PFIZER INC.; BUNNAGE, Mark, Edward; COOK, Andrew, Simon; CUI, Jingrong, Jean; DACK, Kevin, Neil; DEAL, Judith, Gail; GU, Danlin; HE, Mingying; JOHNSON, Patrick, Stephen; JOHNSON, Ted, William; LE, Phuong, Thi, Quy; PALMER, Cynthia, Louise; SHEN, Hong; WO2011/138751; (2011); A2;,
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Thiazole | chemical compound | Britannica

6294-52-6, 5,6-Dimethoxybenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6294-52-6, 4.1.1.4 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-N-(5,6-dimethoxybenzo[d]thiazol-2-yl)benzamide 4d Obtained from the reaction of 2d with 3, yellow solid, yield 82% (072?gm), mp 155-156?C. 1HNMR (400?MHz, DMSO-d6) delta 9.97 (s, 1H, NH exchanged with D2O), 7.72 (s, 1H, Ar H), 7.62 (d, J?=?1.8, 8.2, 1H, Ar H), 7.40 (s, 1H, Ar H), 7.31 (d, J?=?1.8, 1H, Ar H), 7.22 (d, J?=?8.2, 1H, Ar H), 7.02 (s, 1H, CHF2), 3.98 (d, J?=?6.92, 2H, CH2), 3.81 (s, 3H, OCH3), 3.76 (s, 3H, OCH3), 1.30 (m, 1H, CH), 0.61 (m, 2H, 2 CH), 0.38 (m, 2H, 2 CH). 13C NMR (100?MHz, DMSO-d6) delta 164.80, 149.97, 148.64, 148.45, 142.84, 132.44, 129.51, 120.94, 119.56, 116.99, 115.45, 114.42, 114.03, 113.10, 111.59, 73.72, 56.50, 56.31, 10.43, 3.52. IR (KBr) upsilonmax?cm-1: 3259 (NH), 1647 (C=O). Elemental analysis calcd (%) for C21H20F2N2O5S (450.46): C, 55.99; H, 4.48; N, 6.22. Found: C, 56.23; H, 4.62; N, 6.39.

As the paragraph descriping shows that 6294-52-6 is playing an increasingly important role.

Reference：
Article; Moussa, Bahia A.; El-Zaher, Asmaa A.; El-Ashrey, Mohamed K.; Fouad, Marwa A.; European Journal of Medicinal Chemistry; vol. 148; (2018); p. 477 – 486;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica