Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15864-32-1,2-Amino-6-bromobenzothiazole,as a common compound, the synthetic route is as follows.

Step 3) Formation of6-(4,4,5,delta-tetramethyl-1,3-dioxaborolan-2-yl)-1,3-henzoi.azol-2- amineTo a solution of 6-bromo~1 ,3-benzothiazoi-2~amine (10 g, 43.6 mmoi) in dioxane (50 mL) was added bispinacoiotodiboron (16.6 g, 65.4 mmol), potassium acetate (12.8 g, 130.8 mmol) and PdCI2dppf.DCM (3.55 g, 43.6 mmol) and the resulting mixture was stirred at 100&;C for 12 h. After cooiing to RT the reaction mixture was filtered through a plug of Celite which was further washed with EA. The combined filtrate was evaporated to dryness and the residue purified by column chromatography (PBEA1 85/15) to afford the title compound (5.1 g, 42%) as a white solid. 1H NMR (DMSO-dt, 400 MHz) delta 7.92 (s, 1 H)1 7.65 (bs, 2H)1 7.50 (d, J= 8.7 Hz1 1 H)1 7.29 (d, J = 8.2 Hz,1 H), 1.27 (s, 12H)., 15864-32-1

15864-32-1 2-Amino-6-bromobenzothiazole 85149, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; MERCK SERONO S.A.; SWINNEN, Dominique; JORAND-LEBRUN, Catherine; GRIPPI-VALLOTTON, Tania; GERBER, Patrick; GONZALEZ, Jerome; SHAW, Jeffrey; JEYAPRAKASHNARAYANAN, Seenisamy; WO2010/100144; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1094070-77-5,tert-Butyl (2-bromothiazol-5-yl)carbamate,as a common compound, the synthetic route is as follows.

Example 42 Preparation of di(tert-butyl) 2-bromo-1,3-thiazol-5-ylimidodicarbonate To a tetrahydrofuran (THF) (200 mL) solution of (2-bromo-thiazol-5-yl)-carbamic acid tert-butyl ester (19.8 g, 70.9 mmol) at 0 C (ice bath) was added NaH (3.12 g, 78 mmol, 60% dispersion in mineral oil) in one portion. Gas evolution was observed. The reaction was stirred for 30 minutes. (Boc)2O (17.0 g, 78 mmol) was added in one portion. The reaction was stirred for 5 minutes. The reaction vessel was pulled from the cooling bath and the reaction allowed to stir for 30 more minutes. Water and ethyl acetate were added to the reaction mixture. The layers were separated and the aqueous layer was extracted ethyl acetate (2 X). The combined organic layers were dried over MgSO4, filtered, and concentrated. Silica gel column chromatography (20 to 50% ethyl acetate/hexanes) afforded the final product as a white solid (25.0 g, 93% yield): mp 87-89 C; 1H NMR (300 MHz, CDCl3) delta 7.24 (s, 1H), 1.48 (s, 18H); ESIMS m/z 379, 381 (M+1)., 1094070-77-5

As the paragraph descriping shows that 1094070-77-5 is playing an increasingly important role.

Reference：
Patent; Dow AgroSciences, LLC; Trullinger, Tony; Hunter, Ricky; Garizi, Negar; Yap, Maurice; Buysse, Ann; Pernich, Dan; Johnson, Timothy; Bryan, Kristy; Deamicis, Carl; Zhang, Yu; Niyaz, Noormohamed; McLeod, CaSandra; Ross, Ronald; Zhu, Yuanming; Johnson, Peter; Eckelbarger, Joseph; Parker, Marshall; EP2604268; (2015); B1;,
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494769-34-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.494769-34-5,N-Boc-2-Amino-4-formylthiazole,as a common compound, the synthetic route is as follows.

(c) To a solution commercially available 3-iodopyridine (1.13 g, 5.5 mmol) in 15 mL of THF at 0 C was added a 2M solution of EtMgCl in THF (2.8 mL, 5.6 mmol) dropwise. After 1 h, added a solution of 42b (500 mg, 2.2 mmol) in 5 mL of THF. The reaction was allowed to warm to rt and stirred at for 1 hr. The reaction was quenched with water and extracted 2×EtOAC. The EtOAc extracts were dried over MgSO4, concentrated by rotary evaporator, and chromatographed on SiO2 using 50% hexanes in EtOAc then pure EtOAC to give 336 mg (50%) of 42c. MS found: (M+H)+=308.

494769-34-5 N-Boc-2-Amino-4-formylthiazole 23138686, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Sheppeck, James; Dhar, T.G. Murali; Doweyko, Lidia; Gilmore, John; Weinstein, David; Xiao, Hai-Yun; Yang, Bingwei V.; Doweyko, Arthur M.; US2006/154973; (2006); A1;,
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1849-73-6, 7-Chlorobenzo[d]thiazole-2(3H)-thione is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,1849-73-6

General procedure: A mixture of the 2-mercaptobenzo[d]thiazole (>1 g, 1 equiv) and sul-furyl chloride (10 equiv) was stirred at 20-25 C for 15 min. Next, H 2 O(2 equiv) was added and the mixture was stirred at 20-25 C for anadditional 3 h. A sample was taken, quenched with MeCN/H 2 O (2:1)and analyzed by HPLC. After completion of the reaction, the mixturewas diluted with MeCN (5 volumes) and slowly quenched with H 2 O(20 volumes). The product precipitated from the aqueous solution.The solid was collected and washed with H 2 O. Drying under vacuumafforded the pure product. In the case of the liquid product 2-chloro-benzo[d]thiazole (13), the reaction mixture was extracted withEtOAc. The organic layer was then dried and concentrated to affordthe product as an oil.

The synthetic route of 1849-73-6 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Wimmer, Laurin; Parmentier, Michael; Riss, Bernard; Kapferer, Tobias; Ye, Chao; Li, Lei; Kim, Hongyong; Li, Jialiang; Synthesis; vol. 50; 10; (2018); p. 2027 – 2032;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.131106-70-2,6-(Trifluoromethyl)benzo[d]thiazole,as a common compound, the synthetic route is as follows.

General procedure: In a two-necked flask equipped with a reflux condenser were placed RhH(PPh3)4 (4 mol%, 11.5 mg), 1,2-bis(diphenylphosphino)ethane (8 mol%, 8.0 mg), 1,3-benzothiazole 5 (0.25 mmol, 27.3 mL), and (alpha-phenylthio)isobutyrophenone 6 (0.25 mmol, 64.0 mg) in chlorobenzene (0.25 mL) under an argon atmosphere, and the solution was heated at reflux for 3 h. The mixture was purified by flash column chromatography on silica gel giving 7 (55.8 mg, 92%) and isobutyrophenone 8 (34.3 mg, 93%) with the recovery of 5 (3.5 mg, 10%) and 6 (0.8 mg, 1%).

131106-70-2, 131106-70-2 6-(Trifluoromethyl)benzo[d]thiazole 14810650, athiazole compound, is more and more widely used in various fields.

Reference：
Article; Arisawa, Mieko; Toriyama, Fumihiko; Yamaguchi, Masahiko; Tetrahedron Letters; vol. 52; 18; (2011); p. 2344 – 2347;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103878-58-6,5-Bromothiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

Intermediate 12 5-Bromothiazole-4-carboxylic acid (2.17g, 10.4mmol) was dissolved in dry dioxan (170ml_) and heated at 100C. To this, Lambda/,/V-dimethyl-formamide di-tert-butyl acetal (13.68g, 67.28mmol) was added drop wise and the mixture stirred at 100C for 1 hour. The mixture was cooled to room temperature and stirred for 18 hours. The volatile solvents were removed in vacuo and the residue partitioned between water and diethyl ether. The organic layer was washed with saturated NaHC03, dried with Na2S04, filtered and concentrated in vacuo to dryness. The residue was purified by chromatography on silica eluting with 0-20% ethyl acetate/cyclohexane. The fractions containing the desired product were combined and the solvents removed by evaporation in vacuo to give Intermediate 12 (2.8g) as a yellow solid. 1 H NMR (CDCIs) delta: 8.76 (1 H, s), 1 .63 (9H, s) LCMS (Method 2) Rt 3.23 min; m/z(M+H)+ 265

103878-58-6, 103878-58-6 5-Bromothiazole-4-carboxylic acid 21297375, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; ANTABIO SAS; LEMONNIER, Marc; DAVIES, David; PALLIN, David; WO2014/198849; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.96929-05-4,Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

96929-05-4, Compound 25 (13.47g, 47mmol) dissolved in ethanol (100 ml), lithium hydroxide (2.256g, 94mmol) aqueous solution (50 ml), stirring 6h decompression after ethanol turns on lathe , residue diluted with water, the ice-bath using 1M hydrochloric acid the pH is adjusted to 2 the […] 3, ethyl acetate extraction of the organic phase (150mLx3), combined with the phase, the organic phase with saturated salt water washing, dry anhydrous sodium sulfate, concentrated to obtain white solid compound 26 (12.13g, 100%).

The synthetic route of 96929-05-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences; JIANG, SHENG; TU, ZHENGCHAO; LI, XIANLIN; YAO, YIWU; QIU, YATAO; (24 pag.)CN103601742; (2016); B;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

824403-26-1, 5-Bromo-2-chlorobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

824403-26-1, A stirred mixture of 2-chloro-5-bromobenzothiazole (CAS No.824403-26-1, catalog No.20284, Daxian Chemical Institute Ltd., No.179, 10169 New Hampshire Ave., Silver Spring, Md. 20903, 2.485 g, 0.0100 mole), (R)-1-(pyrrolidin-3-yl)piperidine dihydrochloride (Reference Example 5c, 2.73 g, 0.0120 mole), and potassium carbonate (6.00 g, 0.04438 mole) in N,N-dimethylformamide (15 mL) is heated to 100 C. with an oil bath for 15 hours. The reaction mixture is cooled to room temperature then poured into water (300 mL). The resulting precipitate is collected by filtration and the filter cake is rinsed with water (600 mL). The solid is dissolved in dichloromethane and the solution is dried (MgSO4) and filtered. The filtrate is concentrated under reduced pressure to give a solid that is crystallized from hot ethyl acetate to give (R)-5-bromo-2-(3-(piperidin-1-yl)pyrrolidin-1-yl)benzo[d]thiazole.

As the paragraph descriping shows that 824403-26-1 is playing an increasingly important role.

Reference：
Patent; Abbott Laboratories; US2009/163464; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.96929-05-4,Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

96929-05-4, 33.5 g (0.18 mol) of thiazolyl ester are dissolved in 140 ml of methanol and 3 ml of water and, at 5-10 C., ammonia is introduced until the solution is saturated. The reaction mixture is stirred at room temperature overnight. The solvent is evaporated and the residue is, at 80 C., taken up in 100 ml of n-butanol. The mixture is cooled to 0 C. The precipitate is filtered off with suction, washed twice with in each case 35 ml of n-butanol and twice with in each case 35 ml of MTBE and dried under reduced pressure. Yield 17.3 g (58%), yield corrected for purity: 55% based on the thiazolidine employed. 1H-NMR (DMSO-d6): delta=8.2 (s, 1H, SCHCOOEt), 7.6, 7.7, 7.8 (3*s, 3*1H, 3*NH), 4.4 (s, 2H, CH2NH), 1.4 (s, 9H, tert-butyl) ppm.

As the paragraph descriping shows that 96929-05-4 is playing an increasingly important role.

Reference：
Patent; Abbott GmbH & Ci, KG; US6639081; (2003); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: Preparation of n-(6-Bromo-benzothiazol-2-yl)-acetamide A mixture of 6-bromo-benzothiazol-2-ylamine (3.0 g, 13 mmol), Ac2O (1.6 g, 16.5 mmol) and DMAP (2.4 g, 19.5 mmol) in CH2Cl2 (50 mL) was stirred at room temperature for 1 hr. Then the mixture was washed with HCl (2M), saturated Na2CO3, then brine and dried over Na2SO4. The CH2Cl2 phase was evaporated to give n-(6-Bromo-benzothiazol-2-yl)-acetamide (2.5 g, yield 71%) as a white solid., 15864-32-1

15864-32-1 2-Amino-6-bromobenzothiazole 85149, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Heald, Robert; Price, Stephen; Safina, Brian; Savy, Pascal Pierre Alexandre; Seward, Eileen Mary; Sutherlin, Daniel P.; Waszkowycz, Bohdan; US2012/202785; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica