Tag: M.W:200-300

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

15864-32-1, Commercially available 2-amino-6-bromobenzothiazole (2 g, 8.7 mmol) was diluted into methylene chloride (15 mL), combined with DMAP (1.1 g, 8.7 mmol) in tetrahydrofuran (10 mL), and treated with di-tert-butyl dicarbonate (2.1 g, 9.6 mmol) at 0 0C. The reaction mixture was warmed to room temperature and aged overnight. The mixture was then filtered, the filtrate concentrated in vacuo, and the solid purified by flash column chromatography (Biotage, SiO2, 5-10% EtOAc-hexane) to provide the tert-butylcarbamate-protected bromide intermediate. Commercially available methyl anthramlate was converted to the desired acrylamide using acryolyl chloride under similar conditions described in EXAMPLE 17. This acrylamide methyl ester (69 mg, 0.33 mmol) was then combined with the tert- butylcarbamate-protected bromide intermediate (110 mg, 0.33 mmol), diluted into dry degassed DMF (5 mL), treated with powdered sieves, t?ethylamine (0.14 mL, 0.99 mmol), Bu4NCl (92 mg, 0.33 mmol), palladium acetate (20 mg), P(O-tolyl)3 (40 mg), and the reaction mixture heated to 100 0C for 15 h in a sealed tube. The reaction mixture was cooled to room temperature and directly purified by flash column chromatography (Biotage, SiO2, 5-50% EtOAc-hexane) to provide the acrylamide methyl ester. This acrylamide intermediate (90 mg, 0.2 mmol) was reduced by the addition of p-toluenesulfonyl hydrazide (370 mg, 2.0 mmol) in methanol (50 mL). The reaction mixture was refluxed for 24 h, treated again with p-toluenesulfonyl hydrazide (200 mg, 1.1 mmol) and refluxed for an additional 24 h. The reaction mixture was then cooled to room temperature, and the product purified via preparative RPHPLC. The methyl ester intermediate (46 mg, 0 1 mmol) was then saponified with LiOH (IM, 2 mL) in (3 : 1 : 1) THF- MeOH-H2O (2 mL) for 4 h. The reaction mixture was then concentrated in vacuo, diluted with water (20 mL), extracted with chloroform (15 mL), the aqueous phase separated, acidified with cone. HCl to pH 3, and then extracted with 30% isopropanol-chloroform (50 mL). The organic partition was separated, dried over anhydrous sodium sulfate, concentrated in vacuo, and the residue was purified via preparative RPHPLC to give the desired product: 1H NMR (DMSO-d6, 500 MHz) delta 11.7 (s, IH), 11.2 (s, 1H), 8.44 (d, 1H), 7 94 (d, 1H), 7.79 (s, 1H), 7.57 (d, 1H), 7.53 (d, 1H), 7.28 (dd, 1H), 7.12 (t, 1H), 3.02 (t, 2H), 2 75 (t, 2H), 1.47 (s, 9H); LCMS m/z 440 (M+-1).

As the paragraph descriping shows that 15864-32-1 is playing an increasingly important role.

Reference：
Patent; MERCK & CO., INC.; WO2006/52555; (2006); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

96929-05-4, Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

96929-05-4, General procedure: An aqueous KOH (10%) solution was added to an ester solution in THF. The reaction mixture was stirred at rt until reagent disappearance was confirmed by TLC. HCl 1M was added until pH 4 and the solution was extracted with EtOAc. The organic layer was dried over MgSO4 and concentrated in vacuo to afford the acid.

As the paragraph descriping shows that 96929-05-4 is playing an increasingly important role.

Reference：
Article; Pena, Stella; Scarone, Laura; Manta, Eduardo; Serra, Gloria; Tetrahedron Letters; vol. 54; 22; (2013); p. 2806 – 2808;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1849-73-6, 7-Chlorobenzo[d]thiazole-2(3H)-thione is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of the 2-mercaptobenzo[d]thiazole (>1 g, 1 equiv) and sul-furyl chloride (10 equiv) was stirred at 20?25 °C for 15 min. Next, H 2 O(2 equiv) was added and the mixture was stirred at 20?25 °C for anadditional 3 h. A sample was taken, quenched with MeCN/H 2 O (2:1)and analyzed by HPLC. After completion of the reaction, the mixturewas diluted with MeCN (5 volumes) and slowly quenched with H 2 O(20 volumes). The product precipitated from the aqueous solution.The solid was collected and washed with H 2 O. Drying under vacuumafforded the pure product. In the case of the liquid product 2-chloro-benzo[d]thiazole (13), the reaction mixture was extracted withEtOAc. The organic layer was then dried and concentrated to affordthe product as an oil., 1849-73-6

1849-73-6 7-Chlorobenzo[d]thiazole-2(3H)-thione 11171663, athiazole compound, is more and more widely used in various fields.

Reference：
Article; Wimmer, Laurin; Parmentier, Michael; Riss, Bernard; Kapferer, Tobias; Ye, Chao; Li, Lei; Kim, Hongyong; Li, Jialiang; Synthesis; vol. 50; 10; (2018); p. 2027 – 2032;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 14070-51-0, Name is 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide, molecular formula is C7H4ClNO3S. In a Article，once mentioned of 14070-51-0, name: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

The electrophilicity parameters (E) of some trifluoromethylthiolating and difluoromethylthiolating reagents were determined by following the kinetics of their reactions with a series of enamines and carbanions with known nucleophilicity parameters (N, sN), using the linear free-energy relationship log k2=sN(N+E). The electrophilic reactivities of these reagents cover a range of 17 orders of magnitude, with Shen and Lu’s reagent 1 a being the most reactive and Billard’s reagent 1 h being the least reactive electrophile. While the observed electrophilic reactivities (E) of the amido-derived trifluoromethylthiolating reagents correlate well with the calculated Gibbs energies for heterolytic cleavage of the X?SCF3 bonds (Tt+DA), the cumol-derived reagents 1 f and 1 g are more reactive than expected from the thermodynamics of the O?S cleavage. The E parameters of the tri/difluoromethylthiolating reagents derived in this work provide an ordering principle for their use in synthesis.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.name: 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide. In my other articles, you can also check out more blogs about 14070-51-0

Reference：
Thiazole | C3H3101NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 112146-10-8, Name is 4-Bromo-2-methylbenzo[d]thiazole, molecular formula is C8H6BrNS. In a Patent，once mentioned of 112146-10-8, Quality Control of: 4-Bromo-2-methylbenzo[d]thiazole

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, R1, R2, R3, R7 and n of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer?s Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formula II and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-II.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Quality Control of: 4-Bromo-2-methylbenzo[d]thiazole. In my other articles, you can also check out more blogs about 112146-10-8

Reference：
Thiazole | C3H5117NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 80945-86-4, Name is 6-Bromo-2-chlorobenzothiazole,molecular formula is C7H3BrClNS, is a conventional compound. this article was the specific content is as follows.COA of Formula: C7H3BrClNS

Carboxy-substituted (hetero)aryl derivatives, pharmaceutical compositions comprising these compounds, and methods of preparing such compounds and compositions are provided. The compounds or compositions are useful in inhibiting xanthine oxidase and urate anion transporter 1, and also can be used in the treatment or prevention of diseases associated with high blood uric acid level in mammals, especially humans.

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Reference：
Thiazole | C3H10925NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.14070-51-0, Name is 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide, molecular formula is C7H4ClNO3S. In a Article，once mentioned of 14070-51-0, Application In Synthesis of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

This work describes the organocatalytic alpha-trifluoromethylthiolation of silylenol ethers using N-(trifluoromethylthio)saccharin as trifluoromethylthiolating reagent that is activated by the presence of catalytic amounts of a Lewis base. Tetrahydrothiophene was identified as the best organocatalyst and it was successfully employed to promote the synthesis of different alpha-trifluoromethylketones; the reaction has been performed under a traditional batch methodology and under continuous flow conditions. In general, yields obtained using the traditional batch process were higher than those observed when the reaction was performed under flow conditions. However, short reaction times, higher productivity and higher space time yields were observed when a flow system process was employed. Preliminary DFT calculations were also performed in order to elucidate the mechanism of the reaction.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 14070-51-0 is helpful to your research., Application In Synthesis of 2-Chlorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide

Reference：
Thiazole | C3H3088NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 50850-93-6, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 50850-93-6, C10H10N2O2S. A document type is Article, introducing its new discovery.

Novel methotrexate (MTX) derivatives bearing dihydro-2H-1,4- benzothiazine or dihydro-2H-1,4-benzoxazine were synthesized and tested for in vitro antiproliferative activities against human synovial cells (hSC) and human peripheral blood mononuclear cells (hPBMC) obtained from patients with rheumatoid arthritis and healthy volunteers, respectively. In vivo antiarthritic activities of these derivatives were also evaluated in a rat adjuvant arthritis model. N-[[4-[(2,4-Diaminopteridin-6-yl)methyl]-3,4- dihydro-2H-1,4-benzothiazin-7-yl]carbonyl]-L-glutamic acid (3c) exhibited more potent antiproliferative activities in hSC and hPBMC than MTX in vitro. Antiproliferative activities of N-[[4-[(2,4-diaminopteridin-6-yl)methyl]- 3,4-dihydro-2H-1,4-benzoxazin-7-yl]carbonyl]-L-homoglutamic acid (3b) and N- [[4-[(2,4-diaminopteridin-6-yl)methyl]-3,4-dihydro-2H-1,4-benzothiazin-7- yl]carbonyl]-L-homoglutamic acid (3d) (MX-68) were comparable to that of MTX in these in vitro assays. Compounds 3b,d (MX-68) significantly suppressed progression of the adjuvant arthritis in a dose-dependent manner ranging from 0.5 to 2.5 mg/kg (po). In addition, 3d (MX-68) completely suppressed this progression at the dose of 2.5 mg/kg (po). Importantly, 3d (MX-68) having benzothiazine and homoglutamate, as expected, did not undergo polyglutamation, a process which may be responsible for the associated side effects of MTX. These results suggest that 3d (MX-68) is a potent and safe candidate antirheumatic agent, absent of the side effects of MTX.

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Reference：
Thiazole | C3H10658NS – PubChem,
Thiazole | chemical compound | Britannica

Related Products of 61296-22-8. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 61296-22-8, Name is 2-Amino-5-bromothiazole monohydrobromide. In a document type is Patent, introducing its new discovery.

A new class of alkylsulfinyl thiazolides is described. These compounds show strong activity against hepatitis viruses

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Reference：
Thiazole | C3H2126NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 89336-46-9, Name is 2-(2-((tert-Butoxycarbonyl)amino)thiazol-4-yl)acetic acid,molecular formula is C10H14N2O4S, is a conventional compound. this article was the specific content is as follows.category: thiazole

The synthesis, antibacterial activity and oral absorption of 3-(1H-1,2,3-triazol-4-yl)thiomethylthio-3-cephem-4-carboxylic acids with various C-7 side chains (2) are described. The (1H-1,2,3-triazol-4-yl)thiomethylthio C-3 side chain was found to be an effective substituent for good oral absorption of cephalosporins with some C-7 side chains.

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Reference：
Thiazole | C3H357NS – PubChem,
Thiazole | chemical compound | Britannica