Tag: M.W:200-300

Synthetic Route of 2941-48-2, Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.2941-48-2, Name is 2,5-Dichlorobenzothiazole, molecular formula is C7H3Cl2NS. In a patent, introducing its new discovery.

Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

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Reference：
Thiazole | C3H1726NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 27149-27-5. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 27149-27-5, Name is 2-(4-Bromophenyl)thiazole

A number of 4?-heterocyclic biphenylsulfonamide derivatives, formally derived from BMS-193884 (1) by replacing the oxazole ring with other heterocyclic rings, are potent and selective endothelin A (ETA) receptor antagonists. Among the analogues examined, the pyrimidine derivative 18 is the most potent (Ki=0.9 nM) and selective for the ETA receptor, approximately equivalent to 1.

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Reference：
Thiazole | C3H578NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of 16112-21-3, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 16112-21-3, C14H11NS. A document type is Article, introducing its new discovery.

The condensation of several aldehydes wtih 2-aminothiophenol on silica gel/nitrobenzene or montmorillonite K10/nitrobenzene under microwave irradiation afforded 2-arylbenzothiazoles in good yields and high purity.

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Reference：
Thiazole | C3H663NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 78441-62-0, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 78441-62-0, Name is 2-(((2-((Dimethylamino)methyl)thiazol-4-yl)methyl)thio)ethanamine, molecular formula is C9H17N3S2. In a Patent，once mentioned of 78441-62-0

Histamine H 2-antagonists of the formula STR1 wherein p is 1 or 2; R 1 is hydroxy, amino, substituted amino or a 5-to 9-membered fully saturated nitrogen-containing heterocyclic ring attached via its nitrogen atom; m is an integer of from 0 to 2, n is an integer of from 2 to 4; Z is sulfur, oxygen or methylene; and A is an optionally substituted phenyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, thiadiazolyl, oxadiazolyl, furyl, thienyl or pyridyl ring; and nontoxic pharmaceutically acceptable salts, hydrates, solvates or N-oxides thereof are novel anti-ulcer agents. Intermediates and processes for their preparation are disclosed.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 78441-62-0 is helpful to your research., Synthetic Route of 78441-62-0

Reference：
Thiazole | C3H352NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 566169-93-5, Name is 2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol, molecular formula is C14H12N2OS. In a Patent，once mentioned of 566169-93-5, Recommanded Product: 566169-93-5

This invention provides compounds and methods of imaging amyloid deposits using radiolabeled compounds. This invention also provides a method of inhibiting the aggregation of amyloid proteins to form amyloid plaques or deposits, a method of determining a therapeutic compound’s ability to inhibit aggregation of amyloid protein, and a method of delivering a therapeutic agent to amyloid deposits.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Recommanded Product: 566169-93-5. In my other articles, you can also check out more blogs about 566169-93-5

Reference：
Thiazole | C3H430NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of 4175-77-3. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 4175-77-3, Name is 2,4-Dibromothiazole

Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.

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Reference：
Thiazole | C3H1361NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 51618-29-2, Name is 6-Chlorobenzo[d]thiazole-2-thiol, molecular formula is C7H4ClNS2. In a Article，once mentioned of 51618-29-2, Application In Synthesis of 6-Chlorobenzo[d]thiazole-2-thiol

Starting from 2-amino-1,3-mercaptobenzothiazoles recently reported (1a, 1b, 1c, 1d, 1e, 1f, 1g, 1h), a series of the corresponding 2-mercapto-1,3-benzothiazole isosters (2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h) were screened for their in vitro antibacterial and antifungal activities. Results underline that the presence of the mercapto moiety at the 2-position of the heterocyclic nucleus is crucial for activity against bacteria. The biological screening against Candida spp. identified commercial 2f as the most promising compound as antifungal against Candida albicans and tropicalis. Molecular modeling studies supported these results. Then, to enlarge structure-activity relationship (SAR) studies on series 1, newly synthesized compounds (1k, 1l, 1m, 1n, 1o, 1p) were reported. All the compounds belonging to this series and bearing a bulky substituent at the 6-position of the aryl moiety showed high antifungal activity.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Application In Synthesis of 6-Chlorobenzo[d]thiazole-2-thiol, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 51618-29-2, in my other articles.

Reference：
Thiazole | C3H6997NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 153719-23-4, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 153719-23-4, Name is N-(3-((2-Chlorothiazol-5-yl)methyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene)nitramide, molecular formula is C8H10ClN5O3S. In a Patent，once mentioned of 153719-23-4

The invention relates to a suspended seed coating agent, its effective ingredient is chlorine insect benzamide, fipronil, thiamethoxam, benzamide chlorine insect the total quality of the composition 5% – 20%, fluoro gehin the nitrile occupies the group the total quality of the composition 5% – 20%, of the total mass of the total composition the thiamethoxam 10% – 40%, the rest is pesticide adjuvant; pesticide composition of this invention can be effectively prevented after seeding of the peanut harm on the pests to the seedling stage, improve the seeding seedling. (by machine translation)

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 153719-23-4 is helpful to your research., Synthetic Route of 153719-23-4

Reference：
Thiazole | C3H8798NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 2103-99-3. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 2103-99-3, Name is 4-(4-Chlorophenyl)thiazol-2-amine. In a document type is Article, introducing its new discovery.

The Vilsmeier-Haack reaction of 2-amino -4-(4-substituted phenyl)-thiazoles 1, in the presence of micellar media, gives formylated derivatives 2, which upon hydrolysis afforded thiazole-5-carboxaldehydes 3. Microwave-assisted Knoevenagel condensation of 3 with active methylene compounds, in the presence of piperidine as catalyst, gives excellent yields of ylidenenitrile compounds 4. The structures of the newly synthesized compounds were established on the basis of elemental analysis, IR, 1H NMR, and 13C NMR spectral analysis. All newly synthesized compounds were screened for antibacterial activity using two Gram-positive and one Gram-negative bacterial species and their antifungal activity was screened using two fungal species. Taylor & Francis Group, LLC.

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Reference：
Thiazole | C3H10119NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 59937-01-8, An article , which mentions 59937-01-8, molecular formula is C12H11NO2S. The compound – Ethyl 2-phenylthiazole-4-carboxylate played an important role in people’s production and life.

In order to discover novel hypoxia-inducible factor 1 (HIF-1) inhibitors for the cancer metastasis treatment, 68 new aryl carboxamide compounds were synthesized and evaluated for their inhibitory effect by dual luciferase-reporter assay. Based on five rounds of investigation on structure-activity relationships step by step, compound 30m was discovered as the most active inhibitor (IC50 = 0.32 muM) with no obvious cytotoxicity (CC50 > 50 muM). It effectively attenuated hypoxia-induced HIF-1alpha protein accumulation and reduced transcription of vascular epidermal growth factor in a dose-dependent manner, which was further demonstrated by its inhibitory potency on capillary-like tube formation, angiogenesis of zebrafish as well as cellular migration and invasion. Importantly, compound 30m exhibited antimetastatic potency in breast cancer lung metastasis in the mice model, indicating its promising therapeutic potential for prevention and treatment of tumor metastasis. These results definitely merit attention for further rational design of more efficient HIF-1 inhibitors in the future.

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Reference：
Thiazole | C3H8211NS – PubChem,
Thiazole | chemical compound | Britannica