Tag: M.W:200-300

Reference of 92-36-4, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 92-36-4, C14H12N2S. A document type is Article, introducing its new discovery.

Adenosine 5?-monophosphate activated protein kinase (AMPK) has emerged as a major potential target for novel antidiabetic drugs. We studied the structure of 2-chloro-5-((Z)-((E)-5-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl) methylene)-4-oxothiazolidin-2-ylidene)amino)benzoic acid (PT-1), which attenuates the autoinhibition of the enzyme AMPK, for the design and synthesis of different benzothiazoles with potential antidiabetic activity. We synthesized several structurally related benzothiazole derivatives that increased the rate of glucose uptake in L6 myotubes in an AMPK-dependent manner. One compound, 2-(benzo[d]thiazol-2-ylmethylthio)-6-ethoxybenzo[d]thiazole (34), augmented the rate of glucose uptake up to 2.5-fold compared with vehicle-treated cells and up to 1.1-fold compared to PT-1. Concomitantly, it elevated the abundance of GLUT4 in the plasma membrane of the myotubes and activated AMPK. Subcutaneous administration of 34 to hyperglycemic Kuo Kondo rats carrying the Ay-yellow obese gene (KKAy) mice lowered blood glucose levels toward the normoglycemic range. In accord with its activity, compound 34 showed a high fit value to a pharmacophore model derived from the PT-1.

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Reference：
Thiazole | C3H561NS – PubChem,
Thiazole | chemical compound | Britannica

Related Products of 78485-37-7. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 78485-37-7, Name is Ethyl 2-chloro-6-benzothiazolecarboxylate

Substituted benzothiazoles play an important role in medicinal chemistry due to their pharmacological properties. Their 2-substituted derivatives are often prepared from 2-chlorobenzothiazoles, which in turn can be synthesized from the 2-mercapto precursor using sulfuryl chloride. In practice, this seemingly straightforward and widely used reaction can be impeded by poor reproducibility and low reaction yields. In this communication, we report that the simple addition of water to the reaction leads to remarkable improvements in reaction efficiency. We attribute this effect to the formation of acid through partial hydrolysis of sulfuryl chloride. This hypothesis is supported by the observation that improved yields were also obtained in the presence of some anhydrous acidic additives. The simple combination of sulfuryl chloride and water reproducibly provides excellent yields for a range of chlorinated products.

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Reference：
Thiazole | C3H8082NS – PubChem,
Thiazole | chemical compound | Britannica

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 50850-93-6, C10H10N2O2S. A document type is Patent, introducing its new discovery., Quality Control of: Ethyl 2-aminobenzo[d]thiazole-6-carboxylate

Provided is a phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt can selectively inhibit the protein-protein interaction between KRS and a laminin receptor (LR), thereby inhibiting migration of cancer cells. Therefore, the phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt may be usefully applied for preventing or treating the diseases associated with cancer cell metastasis.

Interested yet? Keep reading other articles of 50850-93-6!, Quality Control of: Ethyl 2-aminobenzo[d]thiazole-6-carboxylate

Reference：
Thiazole | C3H10656NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 69812-29-9, Name is 2-Acetamido-4-methylthiazole-5-sulfonyl chloride,molecular formula is C6H7ClN2O3S2, is a conventional compound. this article was the specific content is as follows.Computed Properties of C6H7ClN2O3S2

Chemical strategies are described for the design and automated high throughput synthesis of probe libraries of individual small molecules suitable for optimization into novel, potent, selective and orally bioavailable enzyme inhibitors. These libraries were directed towards serine proteases and were designed to incorporate novel scaffolds, structural diversity and other pharmacophoric features that served as peptide backbone replacements. The solid phase synthesis of probe libraries based on aryl scaffolds containing amides, sulfonamides, sulfonates, ureas, and guanidines are described. Screening of the libraries against a series of serine proteases including thrombin and factor Xa produced a number of useful hits appropriate for further optimization.

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Reference：
Thiazole | C3H1801NS – PubChem,
Thiazole | chemical compound | Britannica

344-72-9, Name is Ethyl 2-amino-4-(trifluoromethyl)thiazole-5-carboxylate, molecular formula is C7H7F3N2O2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 344-72-9, Application In Synthesis of Ethyl 2-amino-4-(trifluoromethyl)thiazole-5-carboxylate

2,4-Disubstituted-5-thiazolecarboxylic acids and derivatives thereof have been found to reduce herbicidal injury of corn, rice and sorghum plants due to the application thereto of acetamide herbicides.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of Ethyl 2-amino-4-(trifluoromethyl)thiazole-5-carboxylate. In my other articles, you can also check out more blogs about 344-72-9

Reference：
Thiazole | C3H7941NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 2103-99-3, An article , which mentions 2103-99-3, molecular formula is C9H7ClN2S. The compound – 4-(4-Chlorophenyl)thiazol-2-amine played an important role in people’s production and life.

A mild and highly efficient synthesis of thiazoles by the condensation of alpha-bromo ketones with thiourea in the presence of a catalytic amount of copper acetate at room temperature has been described. The method is applicable for a variety of aryl and alkyl alpha-bromo ketones. The catalyst is inexpensive, and substituted thiazoles are obtained in good yields.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 2103-99-3, help many people in the next few years., Application of 2103-99-3

Reference：
Thiazole | C3H10313NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.767-68-0, Name is 4-Bromobenzothiazole, molecular formula is C7H4BrNS. In a Patent，once mentioned of 767-68-0, Safety of 4-Bromobenzothiazole

The present invention provides Cephem compounds which have a wide antimicrobial spectrum and have potent antimicrobial activity against beta-lactamase producing Gram negative bacteria as follows: A compound of the formula: wherein, X is N, CH or C-Cl; T is S or the like; A and G are lower alkylene or the like; B is a single bond or the like; D is a single bond, -NR7-, -CO-, -CO-NR7-, -NR7-CO-, -NR7-CO-NR7-, or the like; E is optionally substituted lower alkylene; F is a single bond or optionally substituted phenylene; R3, R4, R5 and R6 each is independently hydrogen, halogene, nitrile, or the like; or an ester, a compound protected at the amino on the ring in the 7-side chain, a pharmaceutically acceptable salt, or a solvate thereof.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 767-68-0 is helpful to your research., Safety of 4-Bromobenzothiazole

Reference：
Thiazole | C3H5201NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 153719-23-4, Name is N-(3-((2-Chlorothiazol-5-yl)methyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene)nitramide, molecular formula is C8H10ClN5O3S. In a Patent，once mentioned of 153719-23-4, Formula: C8H10ClN5O3S

A method of protecting a plant propagation material and plant organs which grow at a later point in time against attack by a pest, which comprises treating the a plant propagation material with a pesticidal composition comprising one or more selected from isazofos, fosthiazate, cadusafos, fenamiphos, fensulfothion and aldicarb, and at least one auxiliary.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Formula: C8H10ClN5O3S. In my other articles, you can also check out more blogs about 153719-23-4

Reference：
Thiazole | C3H8973NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 153719-23-4, Name is N-(3-((2-Chlorothiazol-5-yl)methyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene)nitramide,molecular formula is C8H10ClN5O3S, is a conventional compound. this article was the specific content is as follows.Application In Synthesis of N-(3-((2-Chlorothiazol-5-yl)methyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene)nitramide

From the fruits of the tropical tree Aphanamixis grandifolia, five new evodulone-type limonoids, aphanalides I-M (1-5), one new apo-tirucallane-type triterpenoid, polystanin E (6), and three new chain-like diterpenoids, nemoralisins A-C (7-9), along with 12 known compounds were identified. The absolute configurations were determined by a combination of single-crystal X-ray diffraction studies, Mo2(OAc)4-induced electronic circular dichroism (ECD) data, the Mosher ester method, and calculated ECD data. The cytotoxicities of all the isolates and the insecticidal activities of the limonoids were evaluated.

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Reference：
Thiazole | C3H8920NS – PubChem,
Thiazole | chemical compound | Britannica

2103-99-3, Name is 4-(4-Chlorophenyl)thiazol-2-amine, molecular formula is C9H7ClN2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 2103-99-3, Formula: C9H7ClN2S

The invention relates 2-(benzimidazol-1-yl)-N-(4-phenylthiazol-2-yl)acetamide derivatives having the general Formula I wherein R1 is H, (C1-4)alkyl, (C1-4)alkyloxy or halogen; R2 represents 1-3 substituents selected from H, (C1-4)alkyl (optionally substituted with 1 or more halogens), (C1-4)alkyloxy (optionally substituted with 1 or more halogens), halogen, CF3 or cyano; or a pharmaceutically acceptable salt thereof; to pharmaceutical compositions comprising the same and to the use of said 2-(benzimidazol-1-yl)-N-(4-phenylthiazol-2-yl)acetamide derivatives in the treatment of TRPV1 mediated disorders.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Formula: C9H7ClN2S. In my other articles, you can also check out more blogs about 2103-99-3

Reference：
Thiazole | C3H10140NS – PubChem,
Thiazole | chemical compound | Britannica